shRNA Citations

OriGene产品已被全世界的科学家广泛使用,以提高他们的研究效率。 为了供您参考,我们收集了一些使用OriGene产品发表过的代表性的引用文献,将其发布在此页面上。

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这是研究人员使用OriGene产品后最新发表的一些论文。

靶点 研究论文 杂志 产品类型 货号
THOC2 expression and its impact on 5-fluorouracil resistance in glioblastoma multiforme American Journal of Cancer Research shRNA TR30021
A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial-mesenchymal transition International Journal of Oncology shRNA TR30021
An epigenetic switch controls an alternative NR2F2 isoform that unleashes a metastatic program in melanoma Nature Communications shRNA TR30021
A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling The EMBO Journal shRNA TR30015
Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. Oncology reports shRNA TR30021
In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma Nature Communications shRNA TR30012
Hippocampal dendritic spines express the RyR3 but not the RyR2 ryanodine receptor isoform. Biochemical and biophysical research communications shRNA TR30015
Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin International Journal of Oncology shRNA TR30021
A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Developmental cell shRNA TR30021
Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. Journal of advanced research shRNA TR30021
Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia JCI Insight shRNA TR30021
Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer Scientific Reports shRNA TR30021
Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity Journal for Immunotherapy of Cancer shRNA TR30021
The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells Cancers shRNA TR30021
The STIM1/2-Regulated Calcium Homeostasis Is Impaired in Hippocampal Neurons of the 5xFAD Mouse Model of Alzheimer’s Disease International Journal of Molecular Sciences shRNA TR30021
Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. PLoS biology shRNA TR30012
Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. PLoS biology shRNA TR30013
BAG3 Attenuates Ischemia-Induced Skeletal Muscle Necroptosis in Diabetic Experimental Peripheral Artery Disease International Journal of Molecular Sciences shRNA TR30013
DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting Cell reports shRNA TR30021
The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy shRNA TR30021
Cadherin‐3 is a novel oncogenic biomarker with prognostic value in glioblastoma Molecular Oncology shRNA TR30021
The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus eLife shRNA TR30021
Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer Cancers shRNA TR30021
Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR Methods in molecular biology (Clifton, N.J.) shRNA TR30013
Attenuation of MAMLD1 Expression Suppresses the Growth and Migratory Properties of Gonadotroph Pituitary Adenomas. Pathology oncology research : POR shRNA TR30021
Usp9X Controls Ankyrin-repeat Domain Protein Homeostasis during Dendritic Spine Development Neuron shRNA TR30015
The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo The Journal of Physiology shRNA TR30021
Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons Frontiers in Cellular Neuroscience shRNA TR30021
Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression. Cancer gene therapy shRNA TR30003
Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling Cell metabolism shRNA TR30012
Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain The Journal of Cell Biology shRNA TR30012
Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation. Cell reports shRNA TR30003
Regulation of estrogen signaling and breast cancer proliferation by an ubiquitin ligase TRIM56 Oncogenesis shRNA TR30013
Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas Oncotarget shRNA TR30012
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single Step Transformation by KRAS Mutations Cancer cell shRNA TR30012
Laminin α1 orchestrates VEGFA functions in the ecosystem of colorectal carcinoma. Biology of the cell shRNA TR30021
Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.) shRNA TR30021
Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery eLife shRNA TR30012
The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications shRNA TR30021
A large-scale RNAi screen identifies LCMR1 as a critical regulator of Tspan8-mediated melanoma invasion. Oncogene shRNA TR30012
Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle PLoS ONE shRNA TR30013
Suppression of Vimentin Phosphorylation by the Avian Reovirus p17 through Inhibition of CDK1 and Plk1 Impacting the G2/M Phase of the Cell Cycle PLoS ONE shRNA TR30007
Decreasing CNPY2 Expression Diminishes Colorectal Tumor Growth and Development through Activation of p53 Pathway. The American journal of pathology shRNA TR30003
Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype Nat. Immunol. shRNA TR30012
Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. shRNA TR30015
Displacement correlations between a single mesenchymal-like cell and its nucleus effectively link subcellular activities and motility in cell migration analysis Sci Rep shRNA TR30015
Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease Mol. Psychiatry shRNA TR30021
Platelet integrin a6ß1 controls lung metastasis through direct binding to cancer cell-derived ADAM9 JCI Insight shRNA TR30021
Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/ syndecan-1/TGF-ß autocrine loop Oncotarget shRNA TR30021
Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice Gastroenterology shRNA TR30007
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. shRNA TR30014
Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. shRNA TR30015
Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential Horm Cancer shRNA TR30008
IMP2 axonal localization, RNA interactome, and function in the development of axon trajectories Development shRNA TR30012
Regulation of post-Golgi LH3 trafficking is essential for collagen homeostasis Nat Commun shRNA TR30012
Nm23H1 mediates tumor invasion in esophageal squamous cell carcinoma by regulation of CLDN1 through the AKT signaling Oncogenesis shRNA TR20003
High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 Biochem. Biophys. Res. Commun. shRNA TR30013
Epstein-Barr Virus Oncoprotein LMP1 Mediates Epigenetic Changes in Host Gene Expression through PARP1 J. Virol. shRNA TR30021
Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells Cancer Cell shRNA TR30021
Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells Stem Cells shRNA TR30013
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. shRNA TR30003
SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. shRNA TR30012
Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma Oncogene shRNA TR30012
Characterization of SKAP/Kinastrin isoforms - The N-terminus defines tissue specificity and Pontin binding Hum. Mol. Genet. shRNA TR30021
Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death Sci Rep shRNA TR30013
Upregulation of long noncoding RNA LOC100507661 promotes tumor aggressiveness in thyroid cancer Mol. Cell. Endocrinol. shRNA Custom shRNA for ncRNA
Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells PLoS ONE shRNA TR30013
HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells Mol Med Rep shRNA TR30013
OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene shRNA TR30021
FOXE3 contributes to Peters anomaly through transcriptional regulation of an autophagy-associated protein termed DNAJB1 Nature Communications shRNA TR30021
Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. shRNA TR20003
Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. shRNA TR30003
Regulación del Uniportador de Calcio Mitocondrial por MICU1 y MICU2 thesis shRNA TR30014
Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture J. Biol. Chem. shRNA TR30007
CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor Oncogene shRNA TR30013
Mutual inhibition of insulin signaling and PHLPP-1 determines cardioprotective efficiency of Akt in aged heart Aging (Albany NY) shRNA TR30023
aCP binding to a cytosine-rich subset of polypyrimidine tracts drives a novel pathway of cassette exon splicing in the mammalian transcriptome Nucleic Acids Res. shRNA TR30007
Development of a novel HAC-based gain of signal quantitative assay for measuring chromosome instability (CIN) in cancer cells Oncotarget shRNA TR30007
Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone Neurobiol. Dis. shRNA TR20003
NF-YA splice variants have different roles on muscle differentiation Biochim. Biophys. Acta shRNA TR30021
IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs Oncotarget shRNA TR30007
MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. Cancer letters shRNA TR30013
A Conserved Function in Phosphatidylinositol Metabolism for Mammalian Vps13 Family Proteins PLoS ONE shRNA TR30015
Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis shRNA TR30012
Synergistic restoring effects of isoproterenol and magnesium on KCNQ1-inhibited bradycardia cell models cultured in microelectrode array. Cardiology shRNA TR30013
KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells Neoplasia (New York, N.Y.) shRNA TR30013
VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2–dependent Ca 2+ signaling Proceedings of the National Academy of Sciences of the United States of America shRNA TR30012
The Transcription Factor GLI1 Interacts with SMAD Proteins to Modulate Transforming Growth Factor β-Induced Gene Expression in a p300/CREB-binding Protein-associated Factor (PCAF)-dependent Manner The Journal of Biological Chemistry shRNA TR30013
Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis Journal of the American Society of Nephrology : JASN shRNA TR30012
Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ. Journal of cell science shRNA TR30013
APLP2 regulates neuronal stem cell differentiation during cortical development. Journal of cell science shRNA TR30012
miR-126&126* Restored Expressions Play a Tumor Suppressor Role by Directly Regulating ADAM9 and MMP7 in Melanoma PLoS ONE shRNA TR30013
Phox activity of differentiated PLB-985 cells is enhanced, in an agonist specific manner, by the PLA2 activity of Prdx6-PLA2. European journal of immunology shRNA TR30003
Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation Carcinogenesis shRNA TR30003
Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2. Journal of cancer research and clinical oncology shRNA TR30003
Selenoprotein W depletion induces a p53- and p21-dependent delay in cell cycle progression in RWPE-1 prostate epithelial cells. Journal of cellular biochemistry shRNA TR30012
B7-H3 contributes to the metastatic capacity of melanoma cells by modulation of known metastasis-associated genes. International journal of cancer shRNA TR30003
Deacetylation of FOXO3 by SIRT1 or SIRT2 leads to Skp2-mediated FOXO3 ubiquitination and degradation. Oncogene shRNA TR30003
The G protein-coupled receptor GPR30 mediates the proliferative and invasive effects induced by hydroxytamoxifen in endometrial cancer cells. Biochemical and biophysical research communications shRNA TR30003
The bone morphogenetic protein antagonist Gremlin is overexpressed in human malignant mesothelioma. Oncology reports shRNA TR30012
Phosphorylation of microtubule-associated protein tau by AMPK-related kinases. Journal of neurochemistry shRNA TR30013
Endogenous hydrogen sulfide is involved in asymmetric dimethylarginine-induced protection against neurotoxicity of 1-methyl-4-phenyl-pyridinium ion. Neurochemical research shRNA TR30012
Proteomic analysis of testis biopsies in men treated with transient scrotal hyperthermia reveals the potential targets for contraceptive development. Proteomics shRNA TR30003
Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER)α Protein Degradation in Breast Cancer Cells Disrupting an ERα-GATA3 Transcriptional Cross-Regulatory Loop Molecular Biology of the Cell shRNA TR30003
Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components Proceedings of the National Academy of Sciences of the United States of America shRNA TR30003
Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer science shRNA TR30003
Telomerase reverse transcriptase regulates the expression of a key cell cycle regulator, cyclin D1. Biochemical and biophysical research communications shRNA TR30003
ABCB1 Targeted co-delivery of paclitaxel and anti P-gp shRNA by low molecular weight PEI decorated with L-3,4-dihydroxyphenylalanine. Biotechnology progress shRNA TF315032
ABCB1 Temozolomide competes for P-glycoprotein and contributes to chemoresistance in glioblastoma cells Cancer Lett. shRNA TF315032
ABCC4 Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer Oncotarget shRNA TR315025
ABCC6 Dysregulation of gene expression in ABCC6 knockdown HepG2 cells Cell. Mol. Biol. Lett. shRNA TR315023
ABCG2 Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 Exp. Mol. Med. shRNA TR315016
Abhd6 Serine Hydrolase Inhibitors Block Necrotic Cell Death by Preventing Calcium Overload of the Mitochondria and Permeability Transition Pore Formation J. Biol. Chem. Dec 2013. shRNA TG306904
ABI1 PTEN dephosphorylates Abi1 to promote epithelial morphogenesis J. Cell Biol. shRNA TG513768
Abi1 PTEN dephosphorylates Abi1 to promote epithelial morphogenesis The Journal of Cell Biology shRNA TL513768
ABI1 PTEN suppresses epithelial-mesenchymal transition and cancer stem cell activity by downregulating Abi1 Sci Rep shRNA TF315014
ABI2 PTEN dephosphorylates Abi1 to promote epithelial morphogenesis J. Cell Biol. shRNA TF508429
Abi2 PTEN dephosphorylates Abi1 to promote epithelial morphogenesis The Journal of Cell Biology shRNA TL508429
ACKR2 A novel ACKR2-dependent role of fibroblast-derived CXCL14 in epithelial-to-mesenchymal transition and metastasis of breast cancer Clin. Cancer Res. shRNA TF503412
ACKR3 CXCR7 maintains osteosarcoma invasion after CXCR4 suppression in bone marrow microenvironment Tumour Biol. shRNA TR305345
ACKR3 The chemokine receptor CXCR7 interacts with EGFR to promote breast cancer cell proliferation Mol. Cancer shRNA TR305345
ACKR3 Use of shRNA for Stable Suppression of Chemokine Receptor Expression and Function in Human Cancer Cell Lines Methods Mol. Biol. shRNA TG305345
ACLY ATP-Citrate Lyase Reduction Mediates Palmitate-induced Apoptosis in Pancreatic Beta Cells J. Biol. Chem., Oct 2010; 285: 32606 - 32615 shRNA TR505684
ACP5 ACP5, a direct transcriptional target of FoxM1, promotes tumor metastasis and indicates poor prognosis in hepatocellular carcinoma Oncogene doi:10.1038/onc.2013.90 shRNA TG314985
ACTN4 Alpha-actinin-4 is Required for Amoeboid-type Invasiveness of Melanoma Cells J. Biol. Chem. shRNA TG314967
ACVRL1 The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes Cell. Mol. Biol. Lett. shRNA TG710699
ADAM12 A disintegrin and metalloprotease 12 contributes to colorectal cancer metastasis by regulating epithelial-mesenchymal transition International Journal of Oncology shRNA TL306850
ADAM8 ADAM8 expression in breast cancer derived brain metastases: Functional implications on MMP-9 expression and transendothelial migration in breast cancer cells Int. J. Cancer shRNA TF314948
ADAM8 ADAM8 as a drug target in pancreatic cancer Nat Commun shRNA TF314948
Adamts12 Identification of relevant genetic alterations in cancer using topological data analysis Nature Communications shRNA TL510190
ADAMTS15 Genetic Inactivation of ADAMTS15 Metalloprotease in Human Colorectal Cancer Cancer Res., Jun 2009; 69: 4926 - 4934 shRNA TR306839
ADAR ADAR1 restricts LINE-1 retrotransposition Nucleic Acids Res. shRNA TG306828
ADAR Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma Nature Medicine 19, 209-216 doi:10.1038/nm.3043 shRNA TG306828
Adcy5 Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation J. Cell Sci., Jan 2012; 125: 176 - 188. shRNA TG506651
Adcyap1 Age-Related Decline of Autocrine Pituitary Adenylate Cyclase-Activating Polypeptide Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J. Gerontol. A Biol. Sci. Med. Sci. shRNA TR709809
ADIPOR1 Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression Clin Exp Metastasis. 2013 Oct 5 shRNA TG306815
ADM2 Adrenomedullin2 (ADM2)/Intermedin (IMD): A potential role in the pathophysiology of Preeclampsia J. Clin. Endocrinol. Metab. shRNA TR306813
ADORA2A Targeting the adenosine 2A receptor enhances chimeric antigen receptor T cell efficacy J. Clin. Invest. shRNA TF314920
ADPRH Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair JCI Insight shRNA TG512261
ADRB2 Housing temperature-induced stress drives therapeutic resistance in murine tumour models through ß2-adrenergic receptor activation Nat Commun shRNA TG314911
ADRM1 Regulation of NF-{kappa}B activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13) PNAS, Aug 2010; 107: 13854 - 13859 shRNA TR306807
AGBL3 Structural modeling and functional characterization of mammalian cytosolic carboxypeptidases 2 and 3 Thesis shRNA TG318365
Ager RAGE ablation attenuates glioma progression and enhances tumor immune responses by suppressing galectin-3 expression. Neuro-oncology shRNA TL515756
AGXT In Silico Modeling of Liver Metabolism in a Human Disease Reveals a Key Enzyme for Histidine and Histamine Homeostasis Cell Rep shRNA TR314885
Ahnak Neurite outgrowth induced by NGF or L1CAM via activation of the TrkA receptor is sustained also by the exocytosis of enlargeosomes Proc. Natl. Acad. Sci. U.S.A. shRNA TR514924
Ahnak2 AHNAK2 Participates in the Stress-Induced Nonclassical FGF1 Secretion Pathway J. Cell. Biochem. shRNA TG512658
AHR The aryl hydrocarbon receptor is a novel negative regulator of interleukin-17-mediated signaling and inflammation in vitro FEBS Lett. shRNA TG320259
AHR Interleukin-24 as a target cytokine of environmental aryl hydrocarbon receptor agonist exposure in the lung Toxicol. Appl. Pharmacol shRNA TR320259
AHR Indole-3-Carbinol Triggers Aryl Hydrocarbon Receptor-dependent Estrogen Receptor (ER){alpha} Protein Degradation in Breast Cancer Cells Disrupting an ER{alpha}-GATA3 Transcriptional Cross-Regulatory Loop Mol. Biol. Cell, Apr 2010; 21: 1166 - 1177 shRNA TR320259
AHRR Wood Smoke Enhances Cigarette Smoke-Induced Inflammation by Inducing the Aryl Hydrocarbon Receptor Repressor in Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol. shRNA TR306787
AIFM1 Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR302572
AIM2 Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation J. Biol. Chem., Nov 2011; 286: 39033 - 39042. shRNA TR314876
AKIRIN2 A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo Genesis shRNA TF805514
AKT1 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer shRNA TR320260
Alas1 Heterochromatin protein (HP)1γ is not only in the nucleus but also in the cytoplasm interacting with actin in both cell compartments Biochim. Biophys. Acta shRNA TG500071
ALDH1B1 Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma Pancreas shRNA TF314844
ALDH1B1 ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/ß-Catenin, Notch and PI3K/Akt Signaling Pathways PLoS ONE shRNA TF314844
ALKBH3 Human ALKBH3-induced m1A demethylation increases the CSF-1 mRNA stability in breast and ovarian cancer cells Biochim Biophys Acta Gene Regul Mech shRNA TR306757
ALOX12 Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection Proc. Natl. Acad. Sci. U.S.A. shRNA TR314824
ALOX15 Mechanistic Contribution of Ubiquitous 15-Lipoxygenase-1 Expression Loss in Cancer Cells to Terminal Cell Differentiation Evasion Cancer Prevention Research, Dec 2011; 4: 1961 - 1972. shRNA TR314822
AMER1 Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression Nat Commun shRNA TG307603
AMPH AMPH-1 is a tumor suppressor of lung cancer by inhibiting Ras-Raf-MEK-ERK signal pathway Lasers Med Sci shRNA TR306724
ANG2 Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon Cereb Cortex, Jul 2011; 21: 1695 - 1702. shRNA TR500092
ANGPT1 Oct4-dependent FoxC1 Activation Improves the Survival and Neovascularization of Mesenchymal Stem Cells under Myocardial Ischemia Research Square shRNA TR711949
Angpt2 Angiopoietin-2 Regulates Cortical Neurogenesis in the Developing Telencephalon Cereb Cortex, Dec 2010; 10.1093/cercor/bhq243 shRNA TR514004
Angptl4 Mechanisms involved in biological behavior changes associated with Angptl4 expression in colon cancer cell lines. Oncology reports shRNA TL713738
ANK Antagonistic interactions between osterix and pyrophosphate during cementum formation Bone shRNA TR500093
ANO5 Deficiency of Anoctamin 5/TMEM16E causes nuclear positioning defect and impairs Ca2+ signaling of differentiated C2C12 myotubes Korean J. Physiol. Pharmacol. shRNA TG509067
Ano6 Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine Cell Host Microbe shRNA TF511035
Ano6 Calcium-dependent phospholipid scrambling by TMEM16F Nature 468, 834-838 (24 November 2010) doi:10.1038/nature09583 Letter shRNA TR511035
ANXA1 The Effect of Annexin A1 as a Potential New Therapeutic Target on Neuronal Damage by Activated Microglia Molecules and cells shRNA TG513843
ANXA1 Hydrodynamic stress stimulates growth of cell clusters via the ANXA1/PI3K/AKT axis in colorectal cancer Sci Rep shRNA TR314775
ANXA1 Differential expression of ANXA1 in benign human gastrointestinal tissues and cancers BMC Cancer July 2014 shRNA TR314775
Anxa2 Annexin A2 Enhances Complement Activation by Inhibiting Factor H J. Immunol. shRNA TF500250
ANXA2 Annexin A2 is a C-terminal PCSK9 binding protein that regulates endogenous LDL receptor levels J. Biol. Chem., Sep 2008; 10.1074/jbc.M805971200. shRNA TR314772
ANXA2R The Annexin a2 Promotes Development in Arthritis through Neovascularization by Amplification Hedgehog Pathway PLoS ONE shRNA TG315286
ANXA6 Balancing functions of annexin A6 maintain equilibrium between hypertrophy and apoptosis in cardiomyocytes Cell Death Dis shRNA TG314768
ANXA6 Cytosolic dynamics of annexin A6 triggers feedback regulation of hypertrophy via atrial natriuretic peptide in cardiomyocytes J. Biol. Chem., Jan 2014. shRNA TG314768
AP2A1 Constitutive Clathrin-mediated Endocytosis of CTLA-4 Persists during T Cell Activation J. Biol. Chem., Mar 2012; 287: 9429 - 9440. shRNA TR314754
AP2M1 Pharmacologically diverse antidepressants facilitate TRKB receptor activation by disrupting its interaction with the endocytic adaptor complex AP-2 J. Biol. Chem. shRNA TG712191
AP2M1 Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2 BioRxiv shRNA TG712191
APBB1 A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer\'s disease pathologies Brain : a journal of neurology shRNA TG306652
APBB1 Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation Sci Rep shRNA TG306652
APCS Complex formation with Pentraxin-2 regulates Factor X plasma levels and macrophage interactions Blood shRNA TR501968
APOBEC3 Oncolytic virotherapy induced CSDE1 neo-antigenesis restricts VSV replication but can be targeted by immunotherapy Nature communications shRNA TG505334
APOBEC3 APOBEC3 mediates resistance to oncolytic viral therapy Molecular Therapy - Oncolytics shRNA TR505334
APOE Inhibition of Lung Tumor Development in ApoE Knockout Mice via Enhancement of TREM-1 Dependent NK Cell Cytotoxicity Front Immunol shRNA TG500118
APOE Apolipoprotein E3 (ApoE3) but Not ApoE4 Protects against Synaptic Loss through Increased Expression of Protein Kinase C J. Biol. Chem., May 2012; 287: 15947 - 15958. shRNA TR314721
APRT Activation of AMP-Activated Protein Kinase by Adenine Alleviates TNF-Alpha-Induced Inflammation in Human Umbilical Vein Endothelial Cells PLoS ONE shRNA TG320095
Aqp1 Aquaporin 1 is Important for Maintaining Secretory Granule Biogenesis in Endocrine Cells Mol. Endocrinol., Aug 2008; 22: 1924 - 1934 shRNA TR500121
AQP3 Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line Oncol Lett shRNA TF314712
AR Stromal Hyaluronan Interaction with Epithelial CD44 Variants Promotes Prostate Cancer Invasiveness by Augmenting Expression and Function of Hepatocyte Growth Factor and Androgen Receptor J. Biol. Chem., Jun 2010; 285: 19821 - 19832 shRNA TR320265
ARF6 A critical role of Arf6 in the response of commissural axons to Slit Development shRNA TR500130
Arf6 Arf6 regulates the cycling and the readily releasable pool of synaptic vesicles at hippocampal synapse Elife shRNA TF710999
Arf6 Antagonistic Functions of Dishevelleds Regulate Frizzled3 Endocytosis via Filopodia Tips in Wnt-Mediated Growth Cone Guidance J. Neurosci. Dec 2013. shRNA TG500130
ARHGAP15 Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway Cancer Sci shRNA TR306620
ARHGDIA Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression Nat Commun shRNA TG314680
ARHGEF17 Phosphorylation of Cdc42 Effector Protein-4 (CEP4) by Protein Kinase C Promotes Motility of Human Breast Cells J. Biol. Chem. shRNA TG314673
ARHGEF9 RhoGEF9 splice isoforms influence neuronal maturation and synapse formation downstream of α2 GABAA receptors PLoS Genet.2017 shRNA TF517554
ARID1A A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment Oncotarget shRNA TG306603
Arid1a BAF complexes facilitate decatenation of DNA by topoisomerase IIa Nature 497, 624-627 doi:10.1038/nature12146 shRNA TG306603
ARID2 Essential Role of ARID2 Protein-containing SWI/SNF Complex in Tissue-specific Gene Expression J. Biol. Chem., Feb 2012; 287: 5033 - 5041. shRNA TR306601
ARNTL Circadian Modulation of 8-Oxoguanine DNA Damage Repair Sci Rep shRNA TR314656
ARRB1 A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons ACS Chem Neurosci shRNA TG510701
ARRB1 Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling International Journal of Biological Science shRNA TG510701
ARRB1 Downregulation of β-arrestin 1 suppresses glioblastoma cell growth and glycolysis via inhibition of Src signaling Exp. Cell Res. shRNA TR306568
ARRB1 β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition J. Biol. Chem shRNA TG306568
ARRB1 Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer EMBO J. shRNA TG306568
ARRB1 Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. shRNA TR306568
ARRB1 ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR306568
ARRB2 A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons ACS Chem Neurosci shRNA TG517061
ARRB2 Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling International Journal of Biological Science shRNA TF517061
ARRB2 β-Arrestin 1 has an essential role in neurokinin-1 receptor-mediated glioblastoma cell proliferation and G2/M phase transition J. Biol. Chem shRNA TG306567
ARRB2 Beta-Arrestin-2 Counters CXCR7-mediated EGFR Transactivation and Proliferation Mol. Cancer Res. shRNA TG306567
ARRB2 Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. shRNA TR306567
ARRB2 ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR306567
ART1 Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair JCI Insight shRNA TG512773
ASB4 Expression of ankyrin repeat and SOCS box containing 4 (ASB4) confers migration and invasion properties of hepatocellular carcinoma cells Biosci Trends shRNA TG306546
ASCL1 Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 Nat Commun shRNA TR314633
ASF1B Transcriptional coactivator HCF-1 couples the histone chaperone Asf1b to HSV-1 DNA replication components PNAS, Feb 2010; 107: 2461 - 2466 shRNA TR317316
Asns Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series Genome Med shRNA TG709676
ASPN The dual role of asporin in breast cancer progression Oncotarget shRNA TR306531
ASXL1 ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Sci Adv shRNA TG306527
ATAT1 Tubulin Acetyltransferase aTAT1 Destabilizes Microtubules Independently of Its Acetylation Activity Mol. Cell. Biol., Mar 2013; 33: 1114 - 1123. shRNA TR314302
ATF6 Insulin demand regulates ß cell number via the unfolded protein response J. Clin. Invest. shRNA TR314613
ATG10 Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity J. Virol., Mar 2011; 10.1128/JVI.02032-10 shRNA TR306517
ATG5 ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage bioRxiv shRNA TR314610
ATG5 Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer Cell death & disease shRNA TG314610
ATG5 An analog of glibenclamide selectively enhances autophagic degradation of misfolded α1-antitrypsin Z PLoS ONE shRNA TR314610
ATG5 Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy Autophagy shRNA TG314610
ATG5 Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells J. Cell. Mol. Med. shRNA TF314610
Atg5 Autophagic Clearance of Mitochondria in the Kidney Copes with Metabolic Acidosis Journal of the American Society of Nephrology : JASN shRNA TR500113
ATG5 Human adenovirus type 5 induces cell lysis through autophagy and autophagy-triggered caspase activity J. Virol., Mar 2011; 10.1128/JVI.02032-10 shRNA TR314610
ATG5 Short-chain fatty acids induced autophagy serves as an adaptive strategy for retarding mitochondria-mediated apoptotic cell death Cell Death and Differentiation (8 October 2010) doi:10.1038/cdd.2010.117 Original Paper shRNA TR314610
ATG5 Energy Restriction as an Antitumor Target of Thiazolidinediones J. Biol. Chem., Mar 2010; 285: 9780 - 9791 shRNA TR314610
ATG7 ATGs ubiquitination is required for circumsporozoite protein to subvert host innate immunity against malaria liver stage bioRxiv shRNA TR314609
ATG7 Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells J Cell Physiol shRNA TG504956
ATG7 Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer Nat Commun shRNA TG504956
ATG7 Metformin prevents cell tumorigenesis through autophagy-related cell death Sci Rep shRNA TG314609
Atg7 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife shRNA TG504956
Atg7 Inhibition of dipeptidyl peptidase 8/9 impairs preadipocyte differentiation Scientific Reports shRNA TF504956
Atg7 Autophagy is required and protects against apoptosis during myoblast differentiation Biochem. J. shRNA TG504956
ATG7 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 shRNA TG314609
ATG7 Epoxyeicosatrienoic acids protect cardiac cells during starvation by modulating an autophagic response shRNA TG504956
Atg7 Immunohistochemical detection of cytoplasmic LC3 puncta in human cancer specimens Autophagy shRNA TR504956
ATG7 Energy Restriction as an Antitumor Target of Thiazolidinediones J. Biol. Chem., Mar 2010; 285: 9780 - 9791 shRNA TR314609
ATG7 Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 shRNA TR504956
ATM ATM expression predicts Veliparib and Irinotecan sensitivity in gastric cancer by mediating P53 independent regulation of cell cycle and apoptosis Mol. Cancer Ther. shRNA TR320267
ATM ATM regulation of IL-8 links oxidative stress to cancer cell migration and invasion Elife shRNA TG320267
ATP5PF Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer PLoS One. 2013 Oct 4;8(10):e76846 shRNA TR314579
Atp5pf Over-Expression of the ATP5J Gene Correlates with Cell Migration and 5-Fluorouracil Sensitivity in Colorectal Cancer PLoS ONE shRNA TL712002
ATP6AP2 (Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations Br. J. Cancer shRNA TR314574
ATP7A A Role for the ATP7A Copper-transporting ATPase in Macrophage Bactericidal Activity J. Biol. Chem., Dec 2009; 284: 33949 - 33956 shRNA TR314562
ATP7A Copper transport into the secretory pathway is regulated by oxygen in macrophages J. Cell Sci., May 2009; 122: 1315 - 1321. shRNA TR314562
Atp7a Cell-specific ATP7A transport sustains copper-dependent tyrosinase activity in melanosomes Nature 454, 1142 - 1146 (23 Jul 2008), doi: 10.1038/nature07163, Letter shRNA TR314562
ATP7B Copper ions are novel therapeutic agents for uterine leiomyosarcoma Am. J. Obstet. Gynecol. shRNA TF314561
AURKA A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport Cell reports shRNA TL320538
AURKA Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy shRNA TR320538
AURKB Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy shRNA TR320607
B2M A Subset of Human Autoreactive CD1c-Restricted T Cells Preferentially Expresses TRBV4-1+ TCRs J. Immunol. shRNA TR314543
B2M Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PLoS ONE shRNA TR314543
B3GALNT1 Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor, Globotetraosylceramide Infect. Immun., Nov 2010; 78: 4488 - 4499 shRNA TR306471
Babam2 Anti-apoptotic protein BRE/BRCC45 attenuates apoptosis through maintaining the expression of caspase inhibitor XIAP in mouse Lewis lung carcinoma D122 cells Apoptosis, Jan 2014. shRNA TG505808
BAG3 A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy Cell Death Dis shRNA TR314524
BAK1 Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability Mol. Neurobiol. shRNA TF712171
BAK1 BAX/BAK–Independent Mitoptosis during Cell Death Induced by Proteasome Inhibition Mol. Cancer Res., Aug 2009; 7: 1268 - 1284 shRNA TR314515
BAX Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax J. Biochem. Mol. Toxicol. shRNA TR306440
BAX Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability Mol. Neurobiol. shRNA TF709871
BAZ1B DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. shRNA TG306439
BAZ1B PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature shRNA TG306439
BCDIN3D BCDIN3D regulates tRNAHis 3' fragment processing PLoS Genet. shRNA TR317908
BCL11B A novel 4-dimensional live-cell imaging system to study leukocyte-endothelial dynamics in ANCA-associated vasculitis Autoimmunity shRNA TR306424
Bcl11b Striatal Neurodevelopment Is Dysregulated in Purine Metabolism Deficiency and Impacts DARPP-32, BDNF/TrkB Expression and Signaling: New Insights on the Molecular and Cellular Basis of Lesch-Nyhan Syndrome PLoS ONE shRNA TL515999
BCL2 IL-13 in LPS-Induced Inflammation Causes Bcl-2 Expression to Sustain Hyperplastic Mucous cells Sci Rep shRNA TG316461
BCL2 Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner J. Allergy Clin. Immunol. shRNA TR316461
BCL2 Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in BclxL silenced glioma cell lines Molecular carcinogenesis shRNA TR316461
BCL2 Parecoxib Protects Mouse Cortical Neurons Against OGD/R Induced Neurotoxicity by Up-Regulating Bcl-2 Neurochem. Res. shRNA TG316461
Bcl2a1 The Stress-Inducible BCL2A1 Is Required for Ovarian Cancer Metastatic Progression in the Peritoneal Microenvironment Cancers shRNA TL712645
BCL2L11 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy shRNA TG306422
BDNF A unique homeostatic signaling pathway links synaptic inactivity to postsynaptic mTORC1 J. Neurosci. shRNA TG306410
BECN1 Autophagy Exacerbates Muscle Wasting in Cancer Cachexia and Impairs Mitochondrial Function J. Mol. Biol. shRNA TG503112
BECN1 HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells Cell Death Dis shRNA TG314484
BECN1 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy shRNA TG314484
BECN1 Beclin-1-p53 interaction is crucial for cell fate determination in embryonal carcinoma cells J. Cell. Mol. Med. shRNA TF314484
BECN1 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 shRNA SC117750
BECN1 From autophagy to senescence and apoptosis in Angiotensin II-treated vascular endothelial cells APMIS shRNA TG314484
BECN1 Enhancement of Autophagy during Lytic Replication by the Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription Activator J. Virol., Aug 2010; 84: 7448 - 7458 shRNA TR314484
BECN1 Eradication of Intracellular Salmonella Typhimurium with a Small-Molecule, Host Cell-Directed Agent Antimicrob. Agents Chemother., Oct 2009; 10.1128/AAC.00555-09 shRNA TR314484
BID Inhibition of O-GlcNAcase sensitizes apoptosis and reverses bortezomib resistance in mantle cell lymphoma through modification of truncated Bid Mol. Cancer Ther.2017 shRNA TF314477
BIK Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria Nat Commun shRNA TF500209
BIRC5 Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells Cancer Biology & Therapy shRNA TR315477
BIRC5 Molecular Chaperone gp96 Is a Novel Therapeutic Target of Multiple Myeloma Clin Cancer Res. 2013 Nov 15;19(22):6242-51 shRNA TG315477
BIRC5 IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin Blood, Jan 2011; 117: 352 - 361 shRNA TR315477
BLM ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1-BLM Interaction. Cells shRNA TR314471
BMF Bmf Facilitates Protein Degradation and Reduces Beclin1 Ubiquitination to Inhibit Autophagy Independent of mTOR bioRxiv shRNA TR314463
BMI1 Polycomb protein BMI1 regulates osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells downstream of GSK3 Stem Cells Dev. shRNA TG314462
BMI1 BMI1-mediated histone ubiquitylation promotes DNA double-strand break repair J. Cell Biol., Oct 2010; 191: 45 - 60 shRNA TR314462
BMP4 BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells Mol Ther Nucleic Acids shRNA TF306390
BMP4 Growth and metastasis of lung adenocarcinoma is potentiated by BMP4-mediated immunosuppression OncoImmunology shRNA TG516759
BMP4 BMP4 depletion by miR-200 inhibits tumorigenesis and metastasis of lung adenocarcinoma cells Mol. Cancer shRNA TG516759
BMX BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs Cancer Res. shRNA TR320275
BMX Bone Marrow X Kinase–Mediated Signal Transduction in Irradiated Vascular Endothelium Cancer Res., Apr 2008; 68: 2861 - 2869. shRNA TR320275
BNIP3 Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats Oncotarget shRNA TG316465
BNIP3 Autophagy Induction Results in Enhanced Anoikis-resistance in Models of Peritoneal Disease Mol. Cancer Res. shRNA TR316465
BNIP3 Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis J. Cell Biol., Jul 2012; 198: 103 - 114. shRNA TR316465
Bnip3 Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis The Journal of Cell Biology shRNA TG500221
BNIP3L Role of HIF-1a in regulating autophagic cell survival during cerebral ischemia reperfusion in rats Oncotarget shRNA TG316466
BRAF Lactate Dehydrogenase A as a Potential New Biomarker for Thyroid Cancer Endocrinology and metabolism (Seoul, Korea) 2021 shRNA TR320276
Brca1 A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular cell shRNA TF515706
BSG Secreted cyclophilin A mediates G1/S phase transition of cholangiocarcinoma cells via CD147/ERK1/2 pathway Tumour Biol. shRNA TG314429
BST2 The interferon-induced protein BST-2/CD317 restricts release of virions from infected cells and is down-regulated from the cell surface by HIV-1 Vpu Cell Host Microbe. 2008 April 17; 3(4): 245-252 shRNA TR314427
C10orf90 FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage Oncogene shRNA TG315108
CA2 Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy J Am Heart Assoc shRNA TG314258
CA9 Inhibition of carbonic anhydrase IX (CA9) sensitizes renal cell carcinoma to ionizing radiation Oncol. Rep. shRNA TG314250
CA9 Carbonic Anhydrase IX Promotes Tumor Growth and Necrosis In Vivo and Inhibition Enhances Anti-VEGF Therapy Clin. Cancer Res., Jun 2012; 18: 3100 - 3111. shRNA TR314250
CA9 Specific inhibition of carbonic anhydrase IX activity enhances the in vivo therapeutic effect of tumor irradiation. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology shRNA TR314250
CABP7 Modulation of Phosphatidylinositol 4-Phosphate levels by CaBP7 controls cytokinesis in mammalian cells Mol. Biol. Cell shRNA TG305684
CACNA1C STIM1 deficiency is linked to Alzheimer's disease and triggers cell death in SH-SY5Y cells by upregulation of L-type voltage-operated Ca2+ entry J. Mol. Med. shRNA TF314247
CACNA1F Mutation of an L-Type Calcium Channel Gene Leads to a Novel Human Primary Cellular Immunodeficiency BioRxiv shRNA TG314244
CALCR Amylin Modulates the Mesolimbic Dopamine System toControl Energy Balance Neuropsychopharmacology shRNA TG712173
CALCR Reductions of the components of the calreticulin/calnexin quality-control system by proteasome inhibitors and their relevance in a rodent model of Parkinson's disease J. Neurosci. Res. shRNA TG314223
CALD1 Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 shRNA TR305670
CALR Calreticulin Regulates Syncytialization Through Control of the Synthesis and Transportation of E-Cadherin in BeWo Cells Endocrinology shRNA TR314216
CALU Enhanced Functional Recombinant Factor VII Production by HEK 293 Cells Stably Transfected with VKORC1 where the Gamma-Carboxylase Inhibitor Calumenin is Stably Suppressed by shRNA Transfection shRNA TR314215
CALU Enhanced Functional Recombinant Factor VII Production by HEK 293 Cells Stably Transfected with VKORC1 where the Gamma-Carboxylase Inhibitor Calumenin is Stably Suppressed by shRNA Transfection shRNA TL314215
CALU Enhanced functional recombinant factor VII production by HEK 293 cells stably transfected with VKORC1 where the gamma-carboxylase inhibitor calumenin is stably suppressed by shRNA transfection Thrombosis Research Volume 122, Issue 3, 2008, Pages 405-410 shRNA TR314215
CALY Coupling of microtubule motors with AP-3 generated organelles in axons by NEEP21 Family Member Calcyon Mol. Biol. Cell shRNA TG712969
CAMKK2 Growth inhibition of human gastric adenocarcinoma cells in vitro by STO-609 is independent of calcium/calmodulin-dependent protein kinase kinase-beta and adenosine monophosphate-activated protein kinase Am J Transl Res shRNA TF320643
CAMP Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production Gut Microbes shRNA TG314213
CAMP Human cathelicidin improves colonic epithelial defenses against Salmonella typhimurium by modulating bacterial invasion, TLR4 and pro-inflammatory cytokines Cell Tissue Res. shRNA TG314213
CAMP Cathelicidin senses enteric pathogen Salmonella typhimurium/LPS for colonic chemokine generation: a new innate immune role for a host defense peptide bioRxiv shRNA TG314213
Car1 Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity Journal for Immunotherapy of Cancer shRNA TL510087
Car2 Carbonic anhydrase activation is associated with worsened pathological remodeling in human ischemic diabetic cardiomyopathy J Am Heart Assoc shRNA TG710298
CARD11 MiR-539 inhibits thyroid cancer cell migration and invasion by directly targeting CARMA1 Biochem. Biophys. Res. Commun. shRNA TG305653
CASK The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons Neurosci. Lett. shRNA TG516864
CASK CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry shRNA TG516864
CASK Lateral Membrane-Specific MAGUK CASK Down-Regulates NaV1.5 Channel in Cardiac Myocytes Circ. Res. shRNA TF320586
CASK Organisation et régulation des canaux sodiques et potassiques cardiaques par les protéines MAGUK Thesis shRNA TF320586
CASP1 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TG305640
CASP12 Modulation of Plasmid DNA Vaccine Antigen Clearance by Caspase 12 RNA interference (RNAi) Potentiates Vaccination Clin. Vaccine Immunol., Feb 2011; 10.1128/CVI.00390-10 shRNA TR500273
CASP6 Several Nuclear Events during Apoptosis Depend on Caspase-3 Activation but Do Not Constitute a Common Pathway PLoS ONE 4(7): e6234. doi:10.1371/journal.pone.0006234 shRNA TR307410
CASP8 Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice J. Exp. Med. shRNA TG305635
CASR Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H Proc. Natl. Acad. Sci. U.S.A. shRNA TF513061
CAT Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism Sci Rep shRNA TR314184
CAT Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TG314184
CAT Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TR314184
CAT Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. shRNA TG314184
CAT Role of reactive oxygen species in arsenic-induced transformation of human lung bronchial epithelial (BEAS-2B) cells Biochem. Biophys. Res. Commun. shRNA TF314184
CAV1 Chrysotobibenzyl inhibition of lung cancer cell migration through Caveolin-1-dependent mediation of the integrin switch and the sensitization of lung cancer cells to cisplatin-mediated apoptosis Phytomedicine shRNA TG314183
CAV1 Loss of caveolin-1 in cancer associated fibroblasts promotes hepatocellular carcinoma development Int J Clin Exp Med shRNA TG314183
CAV1 Aberrant Promoter Methylation of Caveolin-1 Is Associated with Favorable Response to Taxane-Platinum Combination Chemotherapy in Advanced NSCLC PLoS ONE shRNA TF314183
CAV1 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein J. Biol. Chem., Sep 2011; 286: 30780 - 30794. shRNA TR314183
Cav1 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein The Journal of Biological Chemistry shRNA TL500281
CAVIN1 Cavin-1 and Caveolin-1 are both required to support cell proliferation, migration and anchorage-independent cell growth in rhabdomyosarcoma Lab. Invest. shRNA TR310045
CAVIN1 SDPR induces membrane curvature and functions in the formation of caveolae Nat Cell Biol. 2009 Jul;11(7):807-14. shRNA TR310045
CAVIN4 MURC/cavin-4 Is Co-Expressed with Caveolin-3 in Rhabdomyosarcoma Tumors and Its Silencing Prevents Myogenic Differentiation in the Human Embryonal RD Cell Line PLoS ONE shRNA TG315318
Cbfb Functions of Smad Transcription Factors in TGF-ß1-Induced Selectin Ligand Expression on Murine CD4 Th Cells J. Immunol. shRNA TR500286
CBLN4 Cerebellin 4, a synaptic protein that enhances inhibitory activity and resistance of neurons to Amyloid beta toxicity Neurobiology of Aging shRNA TG516844
CBX4 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage Nucleic Acids Res., Mar 2012; 10.1093/nar/gks222. shRNA TR314171
CBX8 Upregulated CBX8 promotes cancer metastasis via the WNK2/MMP2 pathway Molecular Therapy - Oncolytics shRNA TF317361
CCAR2 ML216 Prevents DNA Damage-Induced Senescence by Modulating DBC1-BLM Interaction. Cells shRNA TR303704
Ccl17 Intratumoral IFN-α gene delivery reduces tumor-infiltrating regulatory T cells through the downregulation of tumor CCL17 expression. Cancer gene therapy shRNA TL501986
CCL19 CCR7/CCL19 Controls Expression of EDG-1 in T Cells J. Biol. Chem., Apr 2012; 287: 11656 - 11664. shRNA TR319889
CCN4 WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor- (TNF-)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF--induced Cardiomyocyte Death J. Biol. Chem., May 2009; 284: 14414 - 14427 shRNA TR300454
CCNA2 CCNA2 facilitates epithelial-to-mesenchymal transition via the integrin αvβ3 signaling in NSCLC International Journal of Clinical and Experimental Pathology shRNA TL315479
Ccna2 CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article shRNA TR712084
CCND1 PAC exhibits potent anti-colon cancer properties through targeting cyclin D1 and suppressing epithelial-to-mesenchymal transition Mol. Carcinog. shRNA TG305536
CCND3 L-Arginine availability regulates T lymphocyte cell cycle progression Blood. 2007 Feb 15;109(4):1568-73. shRNA TR320286
CCNI CDK6 is activated by the atypical cyclin I to promote E2F ‐mediated gene expression and cancer cell proliferation Molecular Oncology shRNA TL314135
CCR4 A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer J. Clin. Invest shRNA TR314127
CCR4 A CCR4 antagonist reverses the tumor-promoting microenvironment of renal cancer J. Clin. Invest shRNA TR500386
CCR7 The role of CCL21/CCR7 chemokine axis in breast cancer-induced lymphangiogenesis Molecular Cancer shRNA TF314124
CD109 CD109 plays a role in osteoclastogenesis PLoS ONE Apr2013 shRNA TG507140
CD2 Epigenetic Inactivation of the BRCA1 Interactor SRBC and Resistance to Oxaliplatin in Colorectal Cancer J. Natl. Cancer Inst. shRNA TG314102
CD24 Comparative global immune-related gene profiling of somatic cells, human pluripotent stem cells and their derivatives: implication for human lymphocyte proliferation Exp. Mol. Med. shRNA TG321436
CD24 Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents PLoS ONE shRNA TR321436
Cd274 Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. Oncology reports shRNA TL503436
CD274 Inhibition of Tumor Growth and Sensitization to Sunitinib by RNA Interference Targeting Programmed Death-ligand 1 in Mouse Renal Cell Carcinoma RenCa Model Anticancer Res. shRNA TG314098
CD274 PD‐L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation International Journal of Cancer shRNA TR314098
CD274 Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells Mol. Cancer shRNA TG314098
CD274 Investigating the role of PD-L1 pathway in human ovarian cancer Thesis shRNA TG314098
CD276 Role of MYC-miR-29-B7-H3 in Medulloblastoma Growth and Angiogenesis J Clin Med shRNA TR317545
CD36 Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: an early event prior to insulin resistance Theranostics shRNA TG314090
CD38 Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes J. Cell. Mol. Med. shRNA TR314088
CD40 Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation Cytokine shRNA TR314082
CD44 CD44-shRNA recombinant adenovirus inhibits cell proliferation, invasion, and migration, and promotes apoptosis in HCT116 colon cancer cells Int. J. Oncol shRNA TG314080
CD44 Targeting Cancer Stem Cells in Castration-Resistant Prostate Cancer Clin. Cancer Res shRNA TG314080
CD44 Impacts of CD44 knockdown in cancer cells on tumor and host metabolic systems revealed by quantitative imaging mass spectrometry Nitric Oxide shRNA TR314080
CD44 alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 shRNA TG314080
CD44 CD44 Proteolysis Increases CREB Phosphorylation and Sustains Proliferation of Thyroid Cancer Cells Cancer Res., Mar 2012; 72: 1449 - 1458. shRNA TR314080
CD44 Neutrophil Migration across Intestinal Epithelium: Evidence for a Role of CD44 in Regulating Detachment of Migrating Cells from the Luminal Surface J. Immunol., Dec 2010; 185: 7026 - 7036 shRNA TR314080
CD44 Stimulation of TLRs by LMW-HA induces self-defense mechanisms in vaginal epithelium Immunology and Cell Biology (23 November 2010) doi:10.1038/icb.2010.140 Original Article shRNA TR314080
Cd47 High expression of CD47 predicts adverse prognosis in Chinese patients and suppresses immune response in melanoma. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie shRNA TL501123
CD9 Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion Sci Rep shRNA TR314060
CD9 Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 Biochim. Biophys. Acta shRNA TR314060
CDC42 Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression Nat Commun shRNA TG305497
Cdc42 Integrating transient cellular and nuclear motions to comprehensively describe cell migration patterns Sci Rep shRNA TF510719
CDC42 IQGAP1 regulates cell proliferation through a novel CDC42-mTOR pathway J. Cell Sci., Jun 2009; 122: 2024 - 2033 shRNA TR305497
CDC73 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG305495
CDC73 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR305495
CDH1 Downregulation of E-cadherin is an essential event in activating bold beta-catenin/Tcf-dependent transcription and expression of its target genes in Pdcd4 knockdown cells Oncogene advance online publication 28 September 2009; doi: 10.1038/onc.2009.302 shRNA TR314042
CDH11 Reciprocal regulation of the Cadherin-11/Stat3 axis by caveolin-1 in mouse fibroblasts and lung carcinoma cells Biochim. Biophys. Acta shRNA TF509242
CDH2 Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow Life science alliance shRNA TF314034
CDH2 The FGFR4-388arg Variant Promotes Lung Cancer Progression by N-Cadherin Induction Sci Rep shRNA HC138304
CDH26 Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity Cell Discov shRNA TF305478
Cdh3 A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Developmental cell shRNA TL500332
CDH3 A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Developmental cell shRNA TL314033
CDH3 HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin Mol. Cancer July 2014 shRNA TG314033
CDIP1 Expression of the p53 Target CDIP Correlates with Sensitivity to TNFa-Induced Apoptosis in Cancer Cells Cancer Res., May 2012; 72: 2373 - 2382. shRNA TR315650
CDK4 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG320293
CDK5 The HU177 Collagen Epitope Controls Melanoma Cell Migration and Experimental Metastasis by a CDK5/YAP-Dependent Mechanism Am. J. Pathol. shRNA TG515615
CDKN1A Chloroquine reverses chemoresistance via upregulation of p21WAF1/CIP1 and autophagy inhibition in ovarian cancer Cell death & disease shRNA TG305469
CDKN1A 15-PGDH inhibits hepatocellular carcinoma growth through 15-keto-PGE2/PPAR?-mediated activation of p21WAF1/Cip1 Oncogene doi:10.1038/onc.2013.69 shRNA TG305469
CDKN1A Vorinostat and bortezomib exert synergistic antiproliferative and proapoptotic effects in colon cancer cell models Mol. Cancer Ther., Feb 2009; 8: 342 - 349 shRNA TR305469
CDKN1A Enhanced Antitumor Therapy by Inhibition of p21waf1 in Human Malignant Mesothelioma Clin. Cancer Res., Aug 2008; 14: 5099 - 5107 shRNA TR305469
CDKN1B Kaposi's Sarcoma-Associated Herpesvirus Transactivator Rta Induces Cell Cycle Arrest in G0/G1 Phase by Stabilizing and Promoting Nuclear Localization of p27kip J. Virol. 13226-38 shRNA TR314022
CDKN1B KSHV encoded Rta induces cell cycle arrest J. Virol. Dec 2013. shRNA TG314022
CDKN2B Runx1 and p21 synergistically limit the extent of hair follicle stem cell quiescence in vivo PNAS, Mar 2013; 110: 4634 - 4639. shRNA TG320299
CEBPA Regulation of the Flt3 Gene in Haematopoietic Stem and Early Progenitor Cells PLoS ONE shRNA TF316491
CEBPB Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer Journal of Experimental & Clinical Cancer Research : CR shRNA TL320301
CEBPB A delta-secretase-truncated APP fragment activates CEBPB, mediating Alzheimer\'s disease pathologies Brain : a journal of neurology shRNA TR710974
Cebpb Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF500345
Cebpd Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF500346
CEL Oncogenic mutations and dysregulated pathways in obesity-associated hepatocellular carcinoma Oncogene shRNA TR313998
Cela1 Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development American Journal of Physiology - Lung Cellular and Molecular Physiology shRNA TL709197
CELF1 Translational derepression of Elavl4 isoforms at their alternative 5\' UTRs determines neuronal development Nat Commun shRNA TF514753
Celf1 Regulation of cyclin-dependent kinase 4 translation through CUG-binding protein 1 and microRNA-222 by polyamines Mol. Biol. Cell, Sep 2011; 22: 3055 - 3069. shRNA TR514753
CENPB A two-step mechanism for epigenetic specification of centromere identity and function Nature Cell Biology doi:10.1038/ncb2805 shRNA TG313993
CENPJ Cenpj/CPAP regulates progenitor divisions and neuronal migration in the cerebral cortex downstream of Ascl1 Nat Commun shRNA TG305452
CEP55 Suppression of CEP55 reduces cell viability and induces apoptosis in human lung cancer Oncol. Rep. shRNA TR305437
CEPT1 Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets Nature communications shRNA TR313975
CFLAR Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR313960
CFLAR Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates Nat. Med shRNA TG500356
CFLAR TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine shRNA TR313960
CFLAR Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin J. Biol. Chem., Jun 2010; 285: 19162 - 19172 shRNA TR313960
CFTR High CFTR expression in Philadelphia chromosome-positive acute leukemia protects and maintains continuous activation of BCR-ABL and related signaling pathways in combination with PP2A Oncotarget shRNA TG313958
CFTR High level of CFTR expression is associated with tumor aggression and knockdown of CFTR suppresses proliferation of ovarian cancer in vitro and in vivo Oncol. Rep. shRNA TG313958
CGAS Somatic gene mutations expose cytoplasmic DNA to co-opt the cGAS/STING/NLRP3 axis in myelodysplastic syndromes. JCI insight shRNA TL305813
CHCHD3 ChChd3, an Inner Mitochondrial Membrane Protein, Is Essential for Maintaining Crista Integrity and Mitochondrial Function J. Biol. Chem., Jan 2011; 286: 2918 - 2932 shRNA TR305418
CHCHD4 Glutathionylated and Fe-S cluster containing hMIA40 (CHCHD4) regulates ROS and mitochondrial complex III and IV activities of the electron transport chain Redox biology shRNA TG305417
CHCHD4 Human Mitochondrial MIA40 (CHCD4) is a component of Fe/S cluster export machinery Biochem. J. shRNA TR305417
CHD1 The Role of CHD1 in DNA Rearrangements and Progression of Prostate Cancer Grant shRNA TR313946
CHD4 CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells International journal of molecular sciences shRNA TR313943
CHEK1 Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma Translational Oncology shRNA TR320302
CHI3L1 YKL-40 regulated epithelial-mesenchymal transition and migration/invasion enhancement in non-small cell lung cancer BMC Cancer shRNA TR316497
CHPT1 Long-term autophagy is sustained by activation of CCTβ3 on lipid droplets Nature communications shRNA TR305398
CHRM3 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. shRNA TR313926
CHRM4 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. shRNA TR313925
CHRNA3 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. shRNA TR313921
CHRNA3 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer shRNA TG313921
CHRNA4 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer shRNA TG313920
CHRNA7 Apolipoprotein (a)/Lipoprotein(a)-Induced Oxidative-Inflammatory α 7-nAChR/p38 MAPK/IL-6/RhoA-GTP Signaling Axis and M1 Macrophage Polarization Modulate Inflammation-Associated Development of Coronary Artery Spasm Oxidative Medicine and Cellular Longevity shRNA TG313917
CHRNA7 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. shRNA TR313917
CHRNA7 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer shRNA TG313917
CHRNA9 Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression Int. Immunopharmacol. shRNA TR305392
CHRNA9 Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors BMC Cancer shRNA TG305392
CIITA Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis Clinical & Translational Immunology (2013) 2, e7 shRNA TR313899
CISH MicroRNA-98 and let-7 Confer Cholangiocyte Expression of Cytokine-Inducible Src Homology 2-Containing Protein in Response to Microbial Challenge J. Immunol., Aug 2009; 183: 1617 - 1624 shRNA TR316498
CITED1 CITED1 promotes proliferation of papillary thyroid cancer cells via the regulation of p21 and p27 Cell Biosci shRNA TR313896
CKAP4 The Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancer Cell Death Dis shRNA TG506478
Ckmt1 A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling The EMBO Journal shRNA TF512727
CLDN1 Claudin-1 induces epithelial–mesenchymal transition through activation of the c-Abl-ERK signaling pathway in human liver cells Oncogene doi: 10.1038/onc.2012.505 shRNA TR305370
Cldn3 Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells J Mol Cell Biol shRNA TG711499
Cldn4 Claudin-4 is required for AMPK-modulated paracellular permeability in submandibular gland cells J Mol Cell Biol shRNA TG701533
Cltc Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning Dev. Cell2017 shRNA TF710306
Cltc Dysregulation of nectin-2 in the testicular cells: An explanation of cadmium-induced male infertility Biochim. Biophys. Acta July 2014 shRNA TG516542
CNR1 The role of CB1 in intestinal permeability and inflammation The FASEB Journal shRNA TR316500
CNR1 Cannabinoid Receptors Modulate Neuronal Morphology and AnkyrinG Density at the Axon Initial Segment Front Cell Neurosci shRNA TG512614
CNR1 Protective Role of Cannabinoid Receptor Type 2 in a Mouse Model of Diabetic Nephropathy Diabetes, Sep 2011; 60: 2386 - 2396. shRNA TR316500
CNTNAP2 The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons Neurosci. Lett. shRNA TG510300
CNTNAP2 CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry shRNA TG510300
Cntnap2 Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2 /Caspr2 knockout neurons Proceedings of the National Academy of Sciences of the United States of America shRNA TL510300
COG4 Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene PNAS, Aug 2009; 106: 13329 - 13334 shRNA TR317052
Col1a2 Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. Oncology reports shRNA TL500407
COL23A1 Collagen XXIII: A Potential Biomarker for the Detection of Primary and Recurrent Non–Small Cell Lung Cancer Cancer Epidemiol. Biomarkers Prev., May 2010; 19: 1362 - 1372 shRNA TR317712
COL6A1 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. shRNA TF500404
COL6A1 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. shRNA MG223027
COMMD7 COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma Oncotarget shRNA TR305276
COPRS Myc and Omomyc functionally associate with the Protein Arginine Methyltransferase 5 (PRMT5) in glioblastoma cells Sci Rep shRNA TF306098
COPS5 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer shRNA TR313776
COQ4 Haploinsufficiency of COQ4 causes coenzyme Q10 deficiency J. Med. Genet., Mar 2012; 49: 187 - 191. shRNA TR305264
CPT1C Carnitine palmitoyltransferase 1C promotes cell survival and tumor growth under conditions of metabolic stress Genes & Dev., May 2011; 25: 1041 - 1051 shRNA TR305235
CRBN Lenalidomide Stabilizes the Erythropoietin Receptor by Inhibiting the E3 Ubiquitin Ligase RNF41 Cancer Research shRNA TG305228
CREB1 Dopaminergic control of ADAMTS2 expression through cAMP/CREB and ERK: molecular effects of antipsychotics Transl Psychiatry shRNA TG313740
CREB1 Genetic Evidence for Critical Roles of P38a Protein in Regulating Mast Cell Differentiation and Chemotaxis through Distinct Mechanisms J. Biol. Chem., Jun 2012; 287: 20258 - 20269. shRNA TR313740
CREB3L3 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell Rep shRNA TF513785
CREBBP Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells Cell Death Dis shRNA TF712619
CREBBP Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer Nature Genetics 44, 1104-1110 doi:10.1038/ng.2396 shRNA TR313738
CREG1 CREG1 promotes lysosomal biogenesis and function Autophagy shRNA TF510293
Creg1 CREG promotes vasculogenesis by activation of VEGF/PI3K/Akt pathway Frontiers in Bioscience shRNA TG510293
CRYAB Inhibition of the Expression of the Small Heat Shock Protein aB-crystallin Inhibits Exosome Secretion in Human Retinal Pigment Epithelial Cells in Culture J. Biol. Chem. shRNA TG313715
CSF1 miR-1254 inhibits progression of glioma in vivo and in vitro by targeting CSF-1 J. Cell. Mol. Med. shRNA TG305200
CSF1 Colony-stimulating factor 1 potentiates lung cancer bone metastasis Lab. Invest., Jan 2014. shRNA TG305200
CSF2 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. shRNA TF313703
CSF2 Immune-Dependent and Independent Antitumor Activity of GM-CSF Aberrantly Expressed by Mouse and Human Colorectal Tumors Cancer Res., Jan 2013; 73: 395 - 405. shRNA MC208342
Csk Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response. Biochemical and biophysical research communications shRNA TG510981
CSK SRC-family kinases are activated in non-small cell lung cancer and promote the survival of epidermal growth factor receptor-dependent cell lines Am J Pathol. 2007 Jan;170(1):366-76. shRNA TR320311
CSMD1 Loss of CSMD1 expression is associated with high tumour grade and poor survival in invasive ductal breast carcinoma Breast Cancer Res Treat DOI 10.1007/s10549-009-0500-4 shRNA TR305196
CSNK2A1 Transcriptional Regulation of PIK3CD and PIKFYVE in T-Cell Acute Lymphoblastic Leukemia by IKAROS and Protein Kinase CK2 International journal of molecular sciences shRNA TG320317
CSNK2A1 Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia Int J Mol Sci shRNA TG514070
CSNK2A1 Casein kinase 2 inhibition sensitizes medulloblastoma to temozolomide Oncogene shRNA TG320317
CSNK2A1 Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia Oncotarget shRNA TG320317
CTCF Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. shRNA TR313675
CTCFL Downregulation of BORIS/CTCFL leads to ROS-dependent cellular senescence and drug sensitivity in MYCN-amplified neuroblastoma. The FEBS journal shRNA TR305184
CTCFL BORIS Binding to the Promoters of Cancer Testis Antigens, MAGEA2, MAGEA3, and MAGEA4, Is Associated with Their Transcriptional Activation in Lung Cancer Clin. Cancer Res., Jul 2011; 17: 4267 - 4276. shRNA TR305184
CTCFL Widespread Expression of BORIS/CTCFL in Normal and Cancer Cells PLoS ONE shRNA TG305184
CTCFL BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression Mol. Cell. Biol. 2008; 28(21): p. 6720-6729 shRNA TR305184
CTCFL DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation Cancer Res., Apr 2008; 68: 2726 - 2735 shRNA TR305184
CTH Dysregulation of cystathionine γ-lyase promotes prostate cancer progression and metastasis EMBO Rep. shRNA TF313670
CTNNB1 Cell dynamics in Hertwig\'s epithelial root sheath are regulated by β-catenin activity during tooth root development Journal of cellular physiology shRNA TG500280
CTNNB1 Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death Cell Death Dis shRNA TG313664
CTNNB1 ß-Catenin Activates the HOXA10 and CDX4 Genes in Myeloid Progenitor Cells J. Biol. Chem., Nov 2012; 287: 39589 - 39601. shRNA TG313664
Ctnnb1 HSulf-1 inhibits cell proliferation and invasion in human gastric cancer. Cancer science shRNA TL711793
CTNND1 P120ctn may participate in epithelial-mesenchymal transition in OSCC Indian J Cancer shRNA TF313663
CTNND2 d-Catenin promotes prostate cancer cell growth and progression by altering cell cycle and survival gene profiles Molecular Cancer 2009, 8:19 shRNA TR313662
CTR9 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG313659
CTR9 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR313659
CTSA Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 PLoS Genet. shRNA TF501716
CTSL Cathepsin L inactivation leads to multimodal inhibition of prostate cancer cell dissemination in a preclinical bone metastasis model Int. J. Cancer shRNA TG305172
CUL5 Cullin 5 is a novel candidate tumor suppressor in renal cell carcinoma involved in the maintenance of genome stability Oncogenesis shRNA TR313638
custom BCL2 Nicotine increases the resistance of lung cancer cells to cisplatin through enhancing Bcl-2 stability Br. J. Cancer, Feb 2014. shRNA
custom OMA1 Stress-triggered Activation of the Metalloprotease Oma1 Involves its C-terminal Region and is Important for Mitochondrial Stress Protection in Yeast J. Biol. Chem. shRNA
custom VPU The Expression of HIV-1 Vpu in Monocytes Causes Increased Secretion of TGF-β that Activates Profibrogenic Genes in Hepatic Stellate Cells PLoS ONE, Feb 2014. shRNA
Cx3cr1 Emergent role of the fractalkine axis in dissemination of peritoneal metastasis from epithelial ovarian carcinoma Oncogene shRNA TR509718
CXCL10 Tumor-Suppressive Effects of Natural-type Interferon-ß through CXCL10 in Melanoma Biochem. Biophys. Res. Commun. shRNA TG313633
CXCL12 CXCL12 secreted from glioma stem cells regulates their proliferation J. Neurooncol., Jan 2014. shRNA TR501994
CXCL17 The role and clinical significance of the CXCL17-CXCR8 (GPR35) axis in breast cancer. Biochemical and biophysical research communications shRNA TL307883
CXCL8 A Novel TNF-mediated Mechanism of Direct Epithelial Sodium Channel Activation Am. J. Respir. Crit. Care Med. July 2014 shRNA TG319476
CXCL8 Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells Oncotarget July 2014 shRNA TG319476
CXCR1 IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness Oncotarget shRNA TG312158
CXCR2 IL-8, GRO and MCP-1 produced by hepatocellular carcinoma microenvironment determine the migratory capacity of human bone marrow-derived mesenchymal stromal cells without affecting tumor aggressiveness Oncotarget shRNA TG312157
CXCR2 CXCR2 Expression in Tumor Cells Is a Poor Prognostic Factor and Promotes Invasion and Metastasis in Lung Adenocarcinoma Cancer Res., Jan 2013; 73: 571 - 582. shRNA TG312157
CXCR4 EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma Nat Commun shRNA TR313630
CYBB Early and Late Events Induced by PolyQ-expanded Proteins: IDENTIFICATION OF A COMMON PATHOGENIC PROPERTY OF POLYQ-EXPANDED PROTEINS J. Biol. Chem., Feb 2011; 286: 4727 - 4741 shRNA TR313616
CYGB Cytoglobin, the Newest Member of the Globin Family, Functions as a Tumor Suppressor Gene Cancer Research 68, 7448, September 15, 2008 shRNA TR305139
Cyp11a1 Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease PNAS, May 2013; 110: 8152 - 8157. shRNA TG500467
CYP19A1 Brain-synthesized estrogens regulate cortical migration in a sexually divergent manner BioRxiv shRNA TG509276
CYP3A4 Cytochrome P450 3A5 Plays a Prominent Role in the Oxidative Metabolism of the Anti-Human Immunodeficiency Virus Drug Maraviroc Drug Metabolism and Disposition shRNA TL305124
CYTH1 A critical role of Arf6 in the response of commissural axons to Slit Development shRNA TR517243
CYTH2 A critical role of Arf6 in the response of commissural axons to Slit Development shRNA TR501756
CYTH3 A critical role of Arf6 in the response of commissural axons to Slit Development shRNA TR501757
DAPK1 Bik reduces hyperplastic cells by increasing Bak and activating DAPk1 to juxtapose ER and mitochondria Nat Commun shRNA TF504327
DDR1 Tumor DDR1 deficiency reduces liver metastasis by colon carcinoma and impairs stromal reaction American journal of physiology. Gastrointestinal and liver physiology shRNA TG320280
DDR1 Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer Matrix Biology Plus shRNA TG320280
DDR2 Amplification of DDR2 mediates sorafenib resistance through NF-κB/c-Rel signaling in hepatocellular carcinoma Cell biology international shRNA TG320440
DDR2 DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1 J. Exp. Clin. Cancer Res. shRNA TR320440
DDX56 Oncogenic splicing abnormalities induced by DEAD-Box Helicase 56 amplification in colorectal cancer Cancer Sci. shRNA TR307148
DDX58 Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion J. Virol., Dec 2011; 85: 13019 - 13026. shRNA TR313514
DDX6 The RNA helicase DDX6 regulates cell-fate specification in neural stem cells via miRNAs Nucleic Acids Res. shRNA TG313512
DEDD Regulation of the HPV-18 E6/E6AP Ubiquitin Ligase Complex by the HECT domain-containing protein EDD J. Virol., Jan 2011; 10.1128/JVI.02004-10 shRNA TR313510
Depdc5 DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting Cell reports shRNA TL508165
Depdc5 DEPDC5-dependent mTORC1 signaling mechanisms are critical for the anti-seizure effects of acute fasting Cell reports shRNA TL705799
DEPDC5 DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons Neurobiol. Dis. shRNA TG508165
DIAPH3 mDia2 formin selectively interacts with catenins and not E-cadherin to regulate Adherens Junction formation bioRxiv shRNA TG304992
Dicer1 Rescuing Dicer expression in inflamed colon tissues alleviates colitis and prevents colitis-associated tumorigenesis Theranostics shRNA TL514154
DICER1 Impaired DICER1 function promotes stemness and metastasis in colon cancer Oncogene. 2013 Oct 7. shRNA TR304991
Dicer1 Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J Gerontol A Biol Sci Med Sci, Aug 2013; 68: 877 - 891. shRNA TR304991
DICER1 Aging-Induced Dysregulation of Dicer1-Dependent MicroRNA Expression Impairs Angiogenic Capacity of Rat Cerebromicrovascular Endothelial Cells J Gerontol A Biol Sci Med Sci, Dec 2012; 10.1093/gerona/gls242. shRNA TG304991
DICER1 Dicer-Mediated Upregulation of BCRP Confers Tamoxifen Resistance in Human Breast Cancer Cells Clin. Cancer Res., Oct 2011; 17: 6510 - 6521. shRNA TR304991
DKK1 A Positive Feedback Loop Regulates the Expression of Polycomb Group Protein BMI1 via WNT Signaling Pathway J. Biol. Chem., Feb 2013; 288: 3406 - 3418. shRNA TG313465
DKK1 Tobacco Smoke Induces Polycomb-Mediated Repression of Dickkopf-1 in Lung Cancer Cells Cancer Res., Apr 2009; 69: 3570 - 3578 shRNA TR313465
Dkk3 DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways. International journal of oncology shRNA TL502835
DLAT Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation Cell Rep shRNA TG507127
DLC1 Aberrant DNA methylation of alternative promoter of DLC1 isoform 1 in meningiomas J. Neurooncol shRNA TG304982
DLG1 Differential Regulation of Two Isoforms of the Glial Glutamate Transporter EAAT2 by DLG1 and CaMKII J. Neurosci. shRNA TF313458
DLG4 Spatial coupling tunes NMDA receptor responses via Ca2+ diffusion J. Neurosci. shRNA TG710382
DLGAP5 Prognostic value of DLGAP5 in colorectal cancer Int J Colorectal Dis shRNA TG316879
Dll1 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife shRNA TG500534
DLL4 Delta-like ligand 4 in hepatocellular carcinoma intrinsically promotes tumour growth and suppresses hepatitis B virus replication World J. Gastroenterol. shRNA TG304977
DLL4 Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7. Neurobiology of aging shRNA TF304977
DLX3 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell Rep shRNA TF500537
DLX4 The Homeoprotein DLX4 Stimulates NF-?B Activation and CD44-Mediated Tumor-Mesothelial Cell Interactions in Ovarian Cancer Am. J. Pathol. shRNA TG313449
DLX4 Homeodomain protein DLX4 counteracts key transcriptional control mechanisms of the TGF-ß cytostatic program and blocks the antiproliferative effect of TGF-ß Oncogene (7 February 2011) doi:10.1038/onc.2011.4 Original Article shRNA TR313449
DNAIC2 Dynein axonemal intermediate chain 2 plays a role in gametogenesis by activation of Stat3 J. Cell. Mol. Med. shRNA TR517468
DNM2 Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules J. Virol., Dec 2012; 86: 13653 - 13661. shRNA TG313406
DNM2 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein J. Biol. Chem., Sep 2011; 286: 30780 - 30794. shRNA TG313406
DNMBP Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a bioRxiv shRNA TF515449
DNMT1 Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O 6 -methylguanine DNA-methyltransferase, in breast cancer cells Scientific Reports shRNA TF313404
DNMT1 CD66+ cells in cervical pre-cancers are partially differentiated progenitors with neoplastic traits Cancer Res. shRNA TR313404
DNMT1 Cell Entry of Avian Reovirus Follows a Caveolin-1-mediated and Dynamin-2-dependent Endocytic Pathway That Requires Activation of p38 Mitogen-activated Protein Kinase (MAPK) and Src Signaling Pathways as Well as Microtubules and Small GTPase Rab5 Protein The Journal of Biological Chemistry shRNA TG313404
DNMT3A Dnmt3a is required for the tumor stemness of B16 melanoma cells Acta Biochim. Biophys. Sin. (Shanghai) 2019 shRNA TF304938
DPYSL2 A Collapsin Response Mediator Protein 2 Isoform Controls Myosin II-Mediated Cell Migration and Matrix Assembly by Trapping ROCK II Mol. Cell. Biol., May 2012; 32: 1788 - 1804. shRNA TR313374
DSP Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-catenin signaling pathway in human lung cancer Carcinogenesis, Aug 2012; 10.1093/carcin/bgs226. shRNA TR313354
DUOX2 Contribution of Dual Oxidase 2 (DUOX2) to Hyper-Radiosensitivity in Human Gastric Cancer Cells Radiat. Res. shRNA TR313350
DUOXA1 Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation Cell Commun. Signal, Jan 2014. shRNA TR304888
DUSP10 mTORC2 modulates feedback regulation of p38 MAPK activity via DUSP10/MKP5 to confer differential responses to PP242 in glioblastoma Genes Cancer shRNA TG304883
Dusp10 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. shRNA TG513100
DUSP19 USP17 regulates Ras activation and cell proliferation by blocking RCE 1 activity J. Biol. Chem., Feb 2009; 10.1074/jbc.M807216200. shRNA TR304880
Dusp2 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. shRNA TG514083
DUSP4 Statins affect ETS1-overexpressing triple-negative breast cancer cells by restoring DUSP4 deficiency Sci Rep shRNA TG304875
Dusp6 Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. shRNA TG514782
E2F1 An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells Sci Rep shRNA TG509487
E2F1 Cooperative Activation of Tissue-Specific Genes by pRB and E2F1 Cancer Res., Apr 2013; 73: 2150 - 2158. shRNA TG320325
E2F1 Transcriptional Regulation of the Human Tumor Suppressor DOK1 by E2F1 Mol. Cell. Biol., Dec 2012; 32: 4877 - 4890. shRNA TG320325
E2F6 A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members Genome Res. 2007 Nov;17(11):1550-61. shRNA TR316522
EDD Regulation of the Human Papillomavirus Type 18 E6/E6AP Ubiquitin Ligase Complex by the HECT Domain-Containing Protein EDD J. Virol., Apr 2011; 85: 3120 - 3127 shRNA
EDEM1 Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation Journal of Virology shRNA TL313302
EGFP The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability Nucleic Acids Res. shRNA TR30001
EGFR Expression level of EGFR and MET receptors regulates invasiveness of melanoma cells J. Cell. Mol. Med. shRNA TG320326
EGFR Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers Cell Stem Cell shRNA TR509941
EGFR Modification of cytokine-induced killer cells with chimeric antigen receptors (CARs) enhances antitumor immunity to epidermal growth factor receptor (EGFR)-positive malignancies Cancer Immunol. Immunother. shRNA TG320326
EGFR EGFR signaling defines Mcl(-)1 survival dependency in neuroblastoma Cancer Biol. Ther. shRNA TG320326
EGFR Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development J. Biol. Chem. shRNA TG320326
EGFR Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells PNAS. published 10 December 2008, 10.1073/pnas.0804723105 shRNA TR320326
EGFR Polyethylene glycol-mediated colorectal cancer chemoprevention: roles of epidermal growth factor receptor and Snail Mol. Cancer Ther., Sep 2008; 7: 3103 - 3111 shRNA TR320326
EGR3 Opposing role for egr3 in nucleus accumbens cell subtypes in cocaine action J. Neurosci. shRNA TG500585
Ehmt2 Inhibition of G9a Histone Methyltransferase Converts Bone Marrow Mesenchymal Stem Cells to Cardiac Competent Progenitors Stem Cells International May 2015 shRNA TG505922
EIF2AK2 Identification of the PKR Nuclear Interactome Reveals Roles in Ribosome Biogenesis, mRNA Processing and Cell Division J. Cell. Physiol. Dec 2013. shRNA TG320493
Eif2ak4 Genetic or Pharmacological Reduction of PERK Enhances Cortical-Dependent Taste Learning J. Neurosci. shRNA TG511649
EIF4A1 miR-133a acts as a tumor suppressor in colorectal cancer by targeting eIF4A1 Tumour Biol. shRNA TG313247
ELAVL1 The alternative spliced 3'-UTR mediated differential secretion of macrophage colony stimulating factor in breast cancer cells Biochem. Biophys. Res. Commun. shRNA TR313235
ELAVL1 Posttranscriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer Mol. Cell. Biol., Jan 2011; 31: 215 - 225 shRNA TR313235
ELAVL1 Post-Transcriptional Suppression of Proto-Oncogene c-fms Expression by Vigilin in Breast Cancer Mol. Cell. Biol., Oct 2010; 10.1128/MCB.01031-10 shRNA TR313235
ELAVL1 Regulation of non-AU-rich element containing c-fms proto-oncogene expression by HuR in breast cancer Oncogene (19 Jan 2009), doi: 10.1038/onc.2008.469 shRNA TR313235
ELAVL4 Prenatal Deletion of the RNA-Binding Protein HuD Disrupts Postnatal Cortical Circuit Maturation and Behavior J. Neurosci. shRNA TG501025
ELAVL4 The role of HuD, a post-transcriptional regulator, in the development and function of the murine neocortex Thesis. January 2014 shRNA TG501025
ELF3 A transcriptional repressive role for epithelial-specific ETS factor ELF3 on estrogen receptor-alpha in breast cancer cells BIOCHEMICAL JOURNAL shRNA TG313232
ELK1 GADD45a-Targeted Suicide Gene Therapy for the Prevention or Treatment of Non-Small Cell Lung Carcinoma Thesis shRNA TR320328
ELMO1 A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis Nat. Immunol. shRNA TG320622
EMILIN1 EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation J. Cell Biol., Sep 2011; 10.1083/jcb.201008013. shRNA TR510314
EMX2 EMX2 Is a Predictive Marker for Adjuvant Chemotherapy in Lung Squamous Cell Carcinomas PLoS ONE shRNA TF313216
EMX2 EMX2 is epigenetically silenced and suppresses growth in human lung cancer Oncogene (9 August 2010) doi:10.1038/onc.2010.330 Short Communication shRNA TR313216
ENPP1 Antagonistic interactions between osterix and pyrophosphate during cementum formation Bone shRNA TG501613
Entpd1 cAMP/CREB-mediated Transcriptional Regulation of Ectonucleoside Triphosphate Diphosphohydrolase 1 (CD39) Expression J. Biol. Chem., May 2010; 285: 14791 - 14805 shRNA TR500312
EP300 Histone Acetyltransferase (HAT) P300/CBP Inhibitors Induce Synthetic Lethality in PTEN-Deficient Colorectal Cancer Cells through Destabilizing AKT Int. J. Biol. Sci. shRNA TG313197
EP300 ANALYSIS OF THE UPSTREAM SIGNALLING PATHWAY CONTROLLING DELTANP63ALPHA PROTEIN STABILITY AND FUNCTION Thesis shRNA TR313197
EPAS1 Modulation of the mevalonate pathway by Akt regulates macrophage survival and development of pulmonary fibrosis J. Biol. Chem. shRNA TG315484
EPHA2 Progranulin/EphA2 axis: A novel oncogenic mechanism in bladder cancer Matrix Biol. shRNA TR320327
EPHA2 EphA2 receptor is a key player in the metastatic onset of Ewing sarcoma Int. J. Cancer shRNA TR320327
EPHA2 A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target Transl Oncol shRNA TR320327
EPHA2 A Genome-Wide Screen Reveals Functional Gene Clusters in the Cancer Genome and Identifies EphA2 as a Mitogen in Glioblastoma Cancer Res., Nov 2006; 66: 10815-10823. shRNA TR320327
EPHB2 Effects of Toxicologically Relevant Xenobiotics and the Lipid-Derived Electrophile 4-Hydroxynonenal on Macrophage Cholesterol Efflux: Silencing Carboxylesterase 1 Has Paradoxical Effects on Cholesterol Uptake and Efflux Chem. Res. Toxicol. shRNA TG320337
EPHB4 Erythropoietin Promotes Bone Formation through EphrinB2/EphB4 Signaling J. Dent. Res. shRNA TG500619
EPHX2 Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens Thesis shRNA TR313191
EPHX2 Maresin biosynthesis and identification of maresin 2, a new anti-inflammatory and pro-resolving mediator from human macrophages PLoS ONE July 2014 shRNA TR313191
ERAP1 ERAP1 reduces accumulation of aberrant and disulfide-linked forms of HLA-B27 on the cell surface Mol. Immunol. shRNA TG307017
ERBB3 A phosphoproteomic screen demonstrates differential dependence on HER3 for MAP kinase pathway activation by distinct PIK3CA mutations Proteomics shRNA TR320343
ERBB3 microRNA-205 Regulates HER3 in Human Breast Cancer Cancer Res., Mar 2009; 69: 2195 - 2200 shRNA TR320343
ERCC6 Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane FASEB J, Feb 2010; 10.1096/fj.09-147991 shRNA TR313176
ERCC6 Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. shRNA TR313176
ERN1 Insulin demand regulates ß cell number via the unfolded protein response J. Clin. Invest. shRNA TG320345
ERO1A Cancer-associated oxidoreductase ERO1-α promotes immune escape through up-regulation of PD-L1 in human breast cancer Oncotarget shRNA TR313168
ERO1a Hypoxia augments MHC class I antigen presentation via facilitation of ERO1-a-mediated oxidative folding in murine tumor cells Eur. J. Immunol. shRNA TR502816
ERO1A Cancer-associated oxidoreductase ERO1-a drives the production of VEGF via oxidative protein folding and regulating the mRNA level Br. J. Cancer shRNA TR313168
ERO1A Cancer-Associated Oxidase ERO1-a Regulates the Expression of MHC Class I Molecule via Oxidative Folding J. Immunol. shRNA TR313168
Ero1a Cancer-associated oxidoreductase ERO1-α drives the production of tumor-promoting myeloid-derived suppressor cells via oxidative protein folding. Journal of immunology (Baltimore, Md. : 1950) shRNA TR502816
ERO1A Real-time monitoring of redox changes in the mammalian endoplasmic reticulum J. Cell Sci., Jul 2011; 124: 2349 - 2356. shRNA TR313168
ERRFI1 The induction of MIG6 under hypoxic conditions is critical for dormancy in primary cultured lung cancer cells with activating EGFR mutations Oncogene shRNA TR304737
ESR1 Estrogen-dependent DLL1-mediated Notch signaling promotes luminal breast cancer Oncogene shRNA TR320346
ESR1 RIZ1 is regulated by estrogen and suppresses tumor progression in endometrial cancer Biochem. Biophys. Res. Commun. shRNA TR320346
ESR1 Knockdown of estrogen receptor-a induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death FASEB J. shRNA TR320346
ESR1 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG320346
ESR2 Expression of Estrogen Receptor Beta Predicts Oncologic Outcome of pT3 Upper Urinary Tract Urothelial Carcinoma Better Than Aggressive Pathological Features Sci Rep shRNA TG320347
ESR2 Biologic Roles of Estrogen Receptor-ß and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer BioMed Research International shRNA TG320347
Esrrg Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR{gamma} Nucleic Acids Res., Oct 2008; 36: 5727 - 5735. shRNA TR502584
Esrrg Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERR Nucleic Acids Res., Sep 2008; 10.1093/nar/gkn567. shRNA TR502584
Esrrg Orphan nuclear receptor estrogen-related receptor-? suppresses in vitro and in vivo growth of prostate cancer cells via p21WAF1/CIP1 induction and as a potential therapeutic target in prostate cancer Oncogene 27, 3313 - 3328 (10 Dec 2007) shRNA TR502584
ETS1 ETS1 transcriptional activity is increased in advanced prostate cancer and promotes the castrate-resistant phenotype Carcinogenesis, Mar 2012; 33: 572 - 580. shRNA TR313153
ETS2 Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion The EMBO Journal shRNA TG320351
ETS2 Inactivation of Rb in stromal fibroblasts promotes epithelial cell invasion The EMBO Journal doi:10.1038/emboj.2012.153 shRNA TR320351
Etv4 Pea3 Expression Promotes the Invasive and Metastatic Potential of Colorectal Carcinoma World Journal of Gastroenterology July 2014 shRNA TG509137
EWSR1 Ewing sarcoma breakpoint region 1 prevents transcription-associated genome instability bioRxiv Dec2015 shRNA TG313142
EXO1 Phospholipase C-ε regulates bladder cancer cells via ATM/EXO1 American journal of cancer research shRNA TR304725
Exoc4 CREG1 Interacts with Sec8 to Promote Cardiomyogenic Differentiation and Cell-Cell Adhesion Stem Cells shRNA TR502000
EXTL3 Regenerating Islet-derived 1a (Reg-1a) Protein Is New Neuronal Secreted Factor That Stimulates Neurite Outgrowth via Exostosin Tumor-like 3 (EXTL3) Receptor J. Biol. Chem., Feb 2012; 287: 4726 - 4739. shRNA TG313126
EYA1 EYA1's conformation-specificity in dephosphorylating phosphothreonine in Myc and its activity on Myc stabilization in breast cancer Mol. Cell. Biol. shRNA TR304716
EYA1 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304716
EYA2 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304715
EYA3 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR316534
EYA4 Regulation of the innate immune response by threonine-phosphatase of Eyes absent Nature. 2009 Jul 23;460(7254):520-4. shRNA TR304714
EZH2 Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma The Journal of Clinical Investigation shRNA TL304713
EZH2 Maternal regulation of SATB2 in osteo‐progeniters impairs skeletal development in offspring FASEB j. shRNA TG509722
EZH2 EZH2-mediated loss of miR-622 determines CXCR4 activation in hepatocellular carcinoma Nat Commun shRNA TR304713
EZH2 C-type lectin-like domain and fibronectin-like type II domain of phospholipase A2 receptor 1 modulate binding and migratory responses to collagen FEBS Lett. shRNA TG304713
Ezh2 NFIB-Mediated Repression of the Epigenetic Factor Ezh2 Regulates Cortical Development J. Neurosci., Feb 2014. shRNA TF304713
EZH2 EZH2/miR-30d/KPNB1 pathway regulates malignant peripheral nerve sheath tumor cell survival and tumorigenesis J Pathol. 2013 Oct 16 shRNA TG304713
EZH2 GATA-1 Utilizes Ikaros and Polycomb Repressive Complex 2 To Suppress Hes1 and To Promote Erythropoiesis Mol. Cell. Biol., Sep 2012; 32: 3624 - 3638. shRNA TR304713
F11r Inhibition of junctional adhesion molecule-A/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia/reperfusion injury Neurobiol. Dis. shRNA TG501134
FABP5 Role of Fatty Acid Binding Protein 5 (FABP5) in Breast Cancer Progression and Metastasis Thesis shRNA TG316535
FADD RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy shRNA TG320593
FADS1 Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling Cell metabolism shRNA TR313102
FADS2 Polyunsaturated Fatty Acid Desaturation Is a Mechanism for Glycolytic NAD + Recycling Cell metabolism shRNA TR313101
Faf2 A Ubiquitin-like Domain Recruits an Oligomeric Chaperone to a Retrotranslocation Complex in Endoplasmic Reticulum-associated Degradation J. Biol. Chem., Jun 2013; 288: 18068 - 18076. shRNA TG509324
FAF2 Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets Mol. Biol. Cell, Mar 2012; 23: 800 - 810. shRNA TR308511
FAIM2 Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple-negative breast cancer cells Biomed. Pharmacother. shRNA TG313099
FAM107A Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development Biochemical and biophysical research communications shRNA TG702872
FANCA Upregulated ATM Gene Expression and Activated DNA Crosslink–Induced Damage Response Checkpoint in Fanconi Anemia: Implications for Carcinogenesis Mol Med 14 (3-4) 167-174 shRNA TR313071
FANCA Ataxia Telangiectasia Mutated (ATM) Gene Expression Is Reversibly Up-Regulated in FANCA-Mutant Patient Fibroblasts by an Indirect Mechanism Blood (ASH Annual Meeting Abstracts), Nov 2007; 110: 1679. shRNA TR313071
FANCD2 HPV-16 E7 Reveals a Link between DNA Replication Stress, Fanconi Anemia D2 Protein, and Alternative Lengthening of Telomere–Associated Promyelocytic Leukemia Bodies Cancer Res., Dec 2008; 68: 9954 - 9963. shRNA TR313068
FANCF F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie shRNA TF304585
FASN Up-Regulated FASN Expression Promotes Transcoelomic Metastasis of Ovarian Cancer Cell through Epithelial-Mesenchymal Transition Int J Mol Sci July 2014 shRNA TR313058
FBXL5 F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway Biomed. Pharmacother. shRNA TF304567
FBXO28 LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 J. Cell. Sci. shRNA TG313036
Fbxo46 The SCF FBXO46 ubiquitin ligase complex mediates degradation of the tumor suppressor FBXO31 and thereby prevents premature cellular senescence The Journal of Biological Chemistry shRNA TL702960
FCN1 Secreted M-Ficolin Anchors onto Monocyte Transmembrane G Protein-Coupled Receptor 43 and Cross Talks with Plasma C-Reactive Protein to Mediate Immune Signaling and Regulate Host Defense J. Immunol., Dec 2010; 185: 6899 - 6910 shRNA TR313015
FCRL1 Fc Receptor-Like 1 as a Promising Target for Immunotherapeutic Interventions of B-Cell-Related Disorders Biomark Insights. shRNA TG304533
FDX1 Mitochondrial Targeting of Cytochrome P450 (CYP) 1B1 and its Role in Polycyclic Aromatic Hydrocarbon-Induced Mitochondrial Dysfunction J. Biol. Chem., Feb 2014. shRNA TG313008
FFAR1 Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells J. Recept. Signal Transduct. Res. shRNA TR313001
FFAR1 Induction of GPR40 positively regulates cell motile and growth activities in breast cancer MCF-7 cells J. Recept. Signal Transduct. Res. shRNA TR313001
FFAR1 Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells Exp. Cell Res. shRNA TF313001
FFAR1 Diverse effects of G-protein-coupled free fatty acid receptors on the regulation of cellular functions in lung cancer cells Exp. Cell Res. shRNA TR313001
FFAR1 Negative effects of G-protein-coupled free fatty acid receptor GPR40 on cell migration and invasion in fibrosarcoma HT1080 cells Mol. Carcinog. shRNA TR313001
FFAR1 Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells Biochem. Biophys. Res. Commun. shRNA TR313001
FFAR2 Dysregulated Free Fatty Acid Receptor 2 Exacerbates Colonic Adenoma Formation in Apc\n Min/+\n Mice: Relation to Metabolism and Gut Microbiota Composition Journal of cancer prevention shRNA TR313000
FFAR2 Free fatty acids receptors 2 and 3 control cell proliferation by regulating cellular glucose uptake World J Gastrointest Oncol shRNA TR313000
FFAR4 Regulation of cell survival through free fatty acid receptor 1 (FFA1) and FFA4 induced by endothelial cells in osteosarcoma cells J. Recept. Signal Transduct. Res. shRNA TF307824
FFAR4 Involvement of FFA1 and FFA4 in the regulation of cellular functions during tumor progression in colon cancer cells Exp. Cell Res. shRNA TF307824
FFAR4 Different effects of G-protein-coupled receptor 120 (GPR120) and GPR40 on cell motile activity of highly migratory osteosarcoma cells Biochem. Biophys. Res. Commun shRNA TR307824
FFAR4 Different effects of GPR120 and GPR40 on cellular functions stimulated by 12-O-tetradecanoylphorbol-13-acetate in melanoma cells Biochem. Biophys. Res. Commun. shRNA TF307824
FFAR4 Different roles of GPR120 and GPR40 in the acquisition of malignant properties in pancreatic cancer cells Biochem. Biophys. Res. Commun. shRNA TF307824
Ffar4 Opposite effects of GPR120 and GPR40 on cell motile activity induced by ethionine in liver epithelial cells Biochem. Biophys. Res. Commun. shRNA TG703763
Ffar4 Role of GPR120 in cell motile activity induced by 12-O-tetradecanoylphorbol-13-acetate in liver epithelial WB-F344 cells Mol. Cell. Biochem. shRNA TG703763
FGF2 Oct4-dependent FoxC1 Activation Improves the Survival and Neovascularization of Mesenchymal Stem Cells under Myocardial Ischemia Research Square shRNA TR710311
FGF7 Regulation of Epithelial Differentiation and Proliferation by the Stroma: A Role for the Retinoblastoma Protein Journal of Investigative Dermatology doi:10.1038/jid.2012.201 shRNA TR312988
FGFR1 FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy EBioMedicine shRNA TF320354
FGFR2 Neutralizing antibody to FGFR2 can act as a selective biomarker and potential therapeutic agent for gastric cancer with FGFR2 amplification Am J Transl Res shRNA TG318702
FGFR4 FGFR1 and FGFR4 oncogenicity depends on n-cadherin and their co-expression may predict FGFR-targeted therapy efficacy EBioMedicine shRNA TR320356
FGFR4 FGFR4 increases EGFR oncogenic signaling in lung adenocarcinoma, and their combined inhibition is highly effective Lung Cancer shRNA TR320356
Fhl2 FHL2 anchors mitochondria to actin and adapts mitochondrial dynamics to glucose supply The Journal of Cell Biology shRNA TL711478
FIGNL1 FIGNL1 is overexpressed in small cell lung cancer patients and enhances NCI-H446 cell resistance to cisplatin and etoposide Oncol. Rep. shRNA TR304505
FKBP2 The Function of FK506-Binding Protein 13 in Protein Quality Control Protects Plasma Cells from Endoplasmic Reticulum Stress-Associated Apoptosis Front Immunol shRNA TG500710
FKBP3 The prolyl isomerase FKBP25 regulates microtubule polymerization impacting cell cycle progression and genomic stability Nucleic Acids Res. shRNA TR319727
FLT1 Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma Hepatology shRNA TG320360
Flt1 miR-200 Inhibits Lung Adenocarcinoma Cell Invasion and Metastasis by Targeting Flt1/VEGFR1 Mol. Cancer Res., Jan 2011; 9: 25 - 35 shRNA TG514364
FLT4 Neuropilin-2 mediates lymphangiogenesis of colorectal carcinoma via a VEGFC/VEGFR3 independent signaling Cancer Lett. shRNA TG320362
FN1 Cellular fibronectin 1 promotes VEGF-C expression, lymphangiogenesis and lymph node metastasis associated with human oral squamous cell carcinoma Clin. Exp. Metastasis shRNA TR304489
Fnbp1 Clathrin Assembly Defines the Onset and Geometry of Cortical Patterning Dev. Cell2017 shRNA TF712968
FNBP1 Collective membrane dynamics emerging from curvature-dependent spatial coupling bioRxiv shRNA TG712968
FOLR1 Modification of cytokine-induced killer cells with folate receptor alpha (FRα)-specific chimeric antigen receptors enhances their antitumor immunity toward FRα-positive ovarian cancers Mol. Immunol. shRNA TR304479
FOLR1 Folate Receptor Alpha Upregulates Oct4, Sox2 and Klf4 and Downregulates miR-138 and miR-let-7 in Cranial Neural Crest Cells Stem Cells shRNA TG304479
FOS GLP2 Promotes Directed Differentiation from Osteosarcoma Cells to Osteoblasts and Inhibits Growth of Osteosarcoma Cells Mol Ther Nucleic Acids shRNA TG312946
FOS Glucagon-like peptide 2 promotes directed-differentiation from osteosarcoma cells to osteoblast and inhibits growth of osteosarcoma cells Molecular Therapy-Nucleic Acids shRNA TG312946
FOSB Activation of the Transcription Factor FosB/Activating Protein-1 (AP-1) Is a Prominent Downstream Signal of the Extracellular Nucleotide Receptor P2RX7 in Monocytic and Osteoblastic Cells J. Biol. Chem., Oct 2010; 285: 34288 - 34298 shRNA TR312945
Fox-3 Identification of Neuronal Nuclei (Neun) As Fox-3, a new member of the Fox-1 gene family of splicing factors JBC Papers doi: 10.1074/jbc.M109.052969 shRNA
FOXA1 Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer Onco Targets Ther shRNA TR312942
FOXD3 FOXD3 is a tumor suppressor of colon cancer by inhibiting EGFR-Ras-Raf-MEK-ERK signal pathway Oncotarget shRNA TR312939
FOXD3 Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia PNAS, Aug 2009; 106: 13433 - 13438 shRNA TR312939
FOXK1 FOXK1 and FOXK2 regulate aerobic glycolysis Nature shRNA TR501358
FOXK2 FOXK1 and FOXK2 regulate aerobic glycolysis Nature shRNA TR517739
FOXO3 β-amyloid-induced gonadotropin-releasing hormone decline involving Forkhead transcription factor FOXO3a and nuclear factor-κB Neuroreport shRNA TR320359
FOXO3 Regulation of the Tumor Suppressor FOXO3 by the Thromboxane-A2 Receptors in Urothelial Cancer PLoS ONE shRNA TF320359
FOXO3 Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation Sci Rep July 2014 shRNA TR320359
FOXO3 AMPK Reverses the Mesenchymal Phenotype of Cancer Cells by Targeting the Akt-MDM2-Foxo3a Signaling Axis Cancer Res. July 2014 shRNA TR320359
FOXO3 Role of TRPM2 in cell proliferation and susceptibility to oxidative stress Am J Physiol Cell Physiol, Mar 2013; 304: C548 - C560. shRNA TG320359
FOXP1 FOXP1 is a key regulator of quiescence in healthy human CD3(+) CD4(+) T Cells and is constitutively repressed in CD3(-) CD4(+) T cells from patients with lymphoproliferative disorders Eur. J. Immunol. shRNA TR304471
FOXP3 Forkhead box P3 regulates ARHGAP15 expression and affects migration of glioma cells through the Rac1 signaling pathway Cancer Sci shRNA TF317157
FOXP3 Endogenous FOXP3 inhibits cell proliferation, migration and invasion in glioma cells Int J Clin Exp Med shRNA TF317157
FRK Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG517143
FRMPD2 PDZ-domain-directed basolateral targeting of the peripheral membrane protein FRMPD2 in epithelial cells J. Cell Sci., Aug 2009; 10.1242/jcs.046854 shRNA TR312922
fscn2 Fascin2 regulates cisplatin-induced apoptosis in NRK-52E cells Toxicol. Lett shRNA TG705644
Fundc1 A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy Redox Biology shRNA TR702819
FURIN Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF / MEK signaling Molecular Oncology shRNA TR312903
FURIN Human α-L-fucosidase-1 attenuates the invasive properties of thyroid cancer Oncotarget shRNA TG312903
Furin Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF312903
FUT4 Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis J. Neurooncol. shRNA TG312897
FUT7 Fucosyltransferase 4 and 7 mediates adhesion of non-small cell lung cancer cells to brain-derived endothelial cells and results in modification of the blood-brain-barrier: in vitro investigation of CD15 and CD15s in lung-to-brain metastasis J. Neurooncol. shRNA TG312894
FYCO1 The role of FYCO1-dependent autophagy in lens fiber cell differentiation. Autophagy shRNA TL304437
FZD10 FZD10 regulates cell proliferation and mediates Wnt1 induced neurogenesis in the developing spinal cord BioRxiv shRNA TF312885
FZD2 Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation Int. J. Oncol. shRNA TR312884
FZD2 Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA Int. J. Oncol. shRNA TR312884
FZD2 Short hairpin RNA of frizzled-2 suppresses the proliferation of hepatocellular carcinoma cells ONCOLOGY LETTERS shRNA TR312884
FZD2 Frizzled-2: A potential novel target for molecular pancreatic cancer therapy Oncology Letters 74 shRNA TR312884
FZD2 Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362 shRNA TR312884
FZD5 Frizzled-5: a high affinity receptor for secreted frizzled-related protein-2 activation of nuclear factor of activated T-cells c3 signaling to promote angiogenesis Angiogenesis shRNA TG312882
FZD7 Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs Cells shRNA TG500742
G3bp1 GTPase Activating Protein (Sh3 Domain) Binding Protein 1 Regulates the Processing of MicroRNA-1 during Cardiac Hypertrophy PLoS ONE shRNA TL515376
GABPA Argininosuccinate lyase drives activation of mutant TERT promoter in glioblastomas. Molecular cell shRNA TL312871
Galm Topological analysis of metabolic networks integrating co-segregating transcriptomes and metabolomes in type 2 diabetic rat congenic series Genome Med shRNA TG700891
GAS2 The Interferon Consensus Sequence Binding Protein (ICSBP) Decreases Bcatenin-Activity in Myeloid Cells By Repressing GAS2 Transcription Mol. Cell. Biol., Oct 2010; 30: 4575 - 4594 shRNA TR511218
Gata3 Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity Journal for Immunotherapy of Cancer shRNA TL513036
GATA4 GATA-4 upregulates glucose-dependent insulinotropic polypeptide expression in cells of pancreatic and intestinal lineage Mol Cell Endocrinol. 2008 June 11; 287(1-2): 20–29 shRNA TR500773
GB200002 DAB2IP regulates cancer stem cell phenotypes through modulating stem cell factor receptor and ZEB1 Oncogene July 2014 shRNA HC121827
GBP5 GBP5 promotes NLRP3 inflammasome assembly and immunity in mammals. Science (New York, N.Y.) shRNA TG304384
GCLC EPITHELIAL AND MESENCHYMAL CELL BIOLOGY: Endogenous Hydrogen Peroxide Regulates Glutathione Redox via Nuclear Factor Erythroid 2-Related Factor 2 Downstream of Phosphatidylinositol 3-Kinase during Muscle Differentiation Am. J. Pathol., Jun 2008; 172: 1529 - 1541. shRNA TR312813
GDF15 Hypoxia Induces Growth Differentiation Factor 15 to Promote the Metastasis of Colorectal Cancer via PERK-eIF2α Signaling BioMed Research International shRNA TR312802
GFP PKR Regulates B56{alpha}-mediated BCL2 Phosphatase Activity in Acute Lymphoblastic Leukemia-derived REH Cells J. Biol. Chem., Dec 2008; 283: 35474 - 35485. shRNA
GFP-tagged siRNA Motoneurons Secrete Angiogenin to Induce RNA Cleavage in Astroglia J. Neurosci., Apr 2012; 32: 5024 - 5038. shRNA
GHITM TMBIM5 is the Ca 2+ /H + antiporter of mammalian mitochondria EMBO Reports shRNA TR315671
GHR Growth hormone receptor (GHR) promotes breast cancer progression via the BRAF/MEK/ERK signaling pathway FEBS Open Bio shRNA TR312779
GHR Silencing growth hormone receptor inhibits estrogen receptor negative breast cancer through ATP-binding cassette sub-family G member 2 Exp. Mol. Med. shRNA TR312779
Ghrl Voluntary exercise attenuates obesity-associated inflammation through ghrelin expressed in macrophages. Biochemical and biophysical research communications shRNA TL503386
GHSR The suppression of ghrelin signaling mitigates age-associated thermogenic impairment Aging (Albany NY) shRNA TG506242
GINS4 Partial loss-of-function mutations in GINS4 lead to NK cell deficiency with neutropenia JCI Insight shRNA TL304343
GJA1 Specific N-cadherin-dependent pathways drive human breast cancer dormancy in bone marrow Life science alliance shRNA TF312771
GJA1 Connexin hemichannel and pannexin channel electrophysiology: How do they differ? FEBS Lett., Jan 2014. shRNA TR312771
GJA1 Context dependent reversion of tumor phenotype by connexin-43 expression in MDA-MB231 cells and MCF-7 cells: Role of Beta-catenin/connexin43 association Exp Cell Res. 2013 Dec 10;319(20):3065-80 shRNA TR312771
GJA1 Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors J. Neurosci., Mar 2010; 30: 4197 - 4209 shRNA TR500808
GJB2 Gap junction β‑2 expression is negatively associated with the estrogen receptor status in breast cancer tissues and is a regulator of breast tumorigenesis Oncol Rep shRNA TR312766
GLI1 Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells J. Immunol. shRNA TG312756
GLI1 Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells Cancer Res., Feb 2011; 71: 1092 - 1102 shRNA TR312756
GLI2 Novel Molecular Mechanism of Regulation of CD40 Ligand by the Transcription Factor GLI2 J. Immunol. shRNA TR312755
GLI2 Hedgehog and TGFß signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma Oncotarget shRNA TR312755
GLI2 Modulation of the IL-6 Receptor a Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells J. Immunol. shRNA TG312755
GLI2 Hedgehog Signaling Drives Cellular Survival in Human Colon Carcinoma Cells Cancer Res., Feb 2011; 71: 1092 - 1102 shRNA TR312755
GOLGA2 GOLGA2/GM130, cis-Golgi Matrix Protein, is a Novel Target of Anticancer Gene Therapy Molecular Therapy doi:10.1038/mt.2012.125 shRNA TR312706
GOT1 Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells Sci Rep shRNA TF709215
Got1 Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling Cell Death Dis shRNA TF709215
GOT2 Endogenous sulfur dioxide alleviates collagen remodeling via inhibiting TGF-ß/Smad pathway in vascular smooth muscle cells Sci Rep shRNA TF709767
Got2 Sulfur dioxide inhibits vascular smooth muscle cell proliferation via suppressing the Erk/MAP kinase pathway mediated by cAMP/PKA signaling Cell Death Dis shRNA TF709767
GPAT3 GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis J. Lipid Res., Jul 2010; 51: 1971 - 1981 shRNA TR307398
GPAT4 GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis J. Lipid Res., Jul 2010; 51: 1971 - 1981 shRNA TR306795
Gpbar1 The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. Journal of immunology (Baltimore, Md. : 1950) shRNA TG506766
GPER1 Stabilization of MORC2 by estrogen and antiestrogens through GPER1- PRKACA-CMA pathway contributes to estrogen-induced proliferation and endocrine resistance of breast cancer cells Autophagy shRNA TG316565
GPER1 Estrogenic transmembrane receptor of GPR30 mediates invasion and carcinogenesis by endometrial cancer cell line RL95-2. Journal of cancer research and clinical oncology shRNA TG316565
GPER1 The G protein-coupled receptor GPR30 mediates the proliferative and invasive effects induced by hydroxytamoxifen in endometrial cancer cells. Biochemical and biophysical research communications shRNA TG316565
GPER1 Estrogenic G protein-coupled receptor 30 signaling is involved in regulation of endometrial carcinoma by promoting proliferation, invasion potential, and interleukin-6 secretion via the MEK/ERK mitogen-activated protein kinase pathway. Cancer science shRNA TG316565
GPNMB The Potential Role of the Glycoprotein Osteoactivin/Glycoprotein Nonmetastatic Melanoma Protein B in Pancreatic Cancer Pancreas shRNA TG312675
Gpr119 Western diet contributes to the pathogenesis of non-alcoholic steatohepatitis in male mice via remodeling gut microbiota and increasing production of 2-oleoylglycerol Nature Communications shRNA TL507165
GPR132 Serum-borne lipids amplify TLR-activated inflammatory responses J. Leukoc. Biol. shRNA TG312669
GPR68 Reciprocal regulation of two G protein-coupled receptors sensing extracellular concentrations of Ca2+ and H Proc. Natl. Acad. Sci. U.S.A. shRNA TF507234
GPSM1 G Protein-Coupled Receptor Kinase-6 Interacts with Activator of G Protein Signaling-3 To Regulate CXCR2-Mediated Cellular Functions J. Immunol., Feb 2014. shRNA TG713072
Gpx4 Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy. Cell metabolism shRNA TL508967
GPX4 Ferroptosis heterogeneity in triple-negative breast cancer reveals an innovative immunotherapy combination strategy. Cell metabolism shRNA TR316568
GPX4 DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer Nature shRNA TR316568
GREM1 The bone morphogenetic protein antagonist Gremlin is overexpressed in human malignant mesothelioma. Oncology reports shRNA TR312620
GRHL1 EGFR-ERK induced activation of GRHL1 promotes cell cycle progression by up-regulating cell cycle related genes in lung cancer Cell death & disease shRNA TR304207
GRM1 GRM1 is An Androgen-Regulated Gene and its Expression Correlates with Prostate Cancer Progression in Pre-Clinical Models Clin. Cancer Res. shRNA RG214400
GRN The perlecan-interacting growth factor progranulin regulates ubiquitination, sorting, and lysosomal degradation of sortilin Matrix Biol. shRNA TR312595
GRN Sortilin regulates progranulin action in castration-resistant prostate cancer cells Endocrinology shRNA TR312595
GRN Proepithelin is an autocrine growth factor for bladder cancer Carcinogenesis, May 2009; 30: 861 - 868. shRNA TR312595
GSK3A Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease J. Neurosci., May 2012; 32: 7392 - 7402. shRNA TR320375
GSTM4 Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A. shRNA TR304180
GSTP1 Glutathione transferase P silencing promotes neuronal differentiation of retinal R28 cells J. Cell. Physiol. shRNA TG709221
GSTT2 GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage Molecular Nutrition & Food Research Volume 53 Issue 10, Pages 1245 - 1253 shRNA TR312581
GTF2I DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. shRNA TG304176
GTF2I PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature shRNA TG304176
Gucy1b1 The β subunit of soluble guanylyl cyclase GUCY1B3 exerts cardioprotective effects against ischemic injury via the PKCε/Akt pathway. Journal of cellular biochemistry shRNA TL503002
Gys1 The stress-responsive gene GDPGP1/mcp-1 regulates neuronal glycogen metabolism and survival The Journal of Cell Biology shRNA TF509807
HABP2 Hyaluronic Acid Binding Protein 2 Is a Novel Regulator of Vascular Integrity Arterioscler Thromb Vasc Biol, Mar 2010; 30: 483 - 490 shRNA TR312532
HAND1 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR316857
HAX1 Hax-1 is required for Rac1-Cortactin interaction and ovarian carcinoma cell migration Genes Cancer March 2014 shRNA TF312515
HCAR2 Hippuric acid and 3-(3-hydroxyphenyl) propionic acid inhibit murine osteoclastogenesis through RANKL-RANK independent pathway J. Cell. Physiol. shRNA TR511005
HDAC1 Chronic sun exposure is associated with distinct histone acetylation changes in human skin Br. J. Dermatol.2017 shRNA TR312496
HDAC1 Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia J. Biol. Chem. shRNA TG312496
HDAC1 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG312496
HDAC1 Histone Deacetylase 2 Cell Autonomously Suppresses Excitatory and Enhances Inhibitory Synaptic Function in CA1 Pyramidal Neurons J. Neurosci., Apr 2013; 33: 5924 - 5929. shRNA TG312496
HDAC1 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312496
HDAC2 Precision Targeting with EZH2 and HDAC Inhibitors in Epigenetically Dysregulated Lymphomas Clin. Cancer Res. shRNA TG312495
HDAC2 LPS impairs oxygen utilization in epithelia by triggering degradation of the mitochondrial enzyme Alcat1 J. Cell. Sci. shRNA TG312495
HDAC2 HDAC2-dependent Deacetylation of MORF4L1 Enhances Its Homodimerization J. Biol. Chem., Jan 2014. shRNA TG312495
HDAC2 Histone Deacetylase 2 (HDAC2) Protein-dependent Deacetylation of Mortality Factor 4-like 1 (MORF4L1) Protein Enhances Its Homodimerization Journal of Biological Chemistry shRNA TG312495
HDAC2 Nuclear Localization of the Transcriptional Regulator MIER1a Requires Interaction with HDAC1/2 in Breast Cancer Cells PLoS ONE Dec 2013. shRNA TG312495
HDAC2 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312495
HDAC3 Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model Proc. Natl. Acad. Sci. U.S.A. shRNA TG500941
HDAC3 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312494
HDAC4 Inhibition of androgen receptor activity by histone deacetylase 4 through receptor SUMOylation Oncogene (17 January 2011) doi:10.1038/onc.2010.600 Original Article shRNA TR312493
HDAC5 HDAC5, a potential therapeutic target and prognostic biomarker, promotes proliferation, invasion and migration in human breast cancer Oncotarget shRNA TG312492
HDAC6 HDAC6 Deacetylates and Ubiquitinates MSH2 to Maintain Proper Levels of MutSa Mol. Cell shRNA TR312491
HDAC6 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR312491
HDAC6 Histone deacetylase 6 interacts with the microtubule-associated protein tau Journal of Neurochemistry. 106(5):2119-2130, September 2008 shRNA TR312491
HDAC8 Histone Deacetylase Inhibitors Stimulate Histone H3 Lysine 4 Methylation in Part Via Transcriptional Repression of Histone H3 Lysine 4 Demethylases Mol. Pharmacol., Jan 2011; 79: 197 - 206 shRNA TR304143
HECTD1 HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition Int J Oncol shRNA TF304134
HES1 Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embryonic and induced pluripotent stem cells Blood, Aug 2013; 122: 1162 - 1173. shRNA TG312478
HES1 Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR312478
HES5 Growth differentiation factor 5 is a key physiological regulator of dendrite growth during development Development. 2013 Dec;140(23):4751-62 shRNA TG312477
Hes5 Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation. Glia shRNA TG711044
HEXIM1 Identification of HEXIM1 as a Positive Regulator of p53 J. Biol. Chem., Oct 2012; 287: 36443 - 36454. shRNA TG312473
HHEX A runaway PRH/HHEX-Notch3 positive feedback loop drives cholangiocarcinoma and determines response to CDK4/6 inhibition Cancer Res. shRNA TR312464
HHEX PRH/HHex inhibits the migration of breast and prostate epithelial cells through direct transcriptional regulation of Endoglin Oncogene shRNA TG312464
HHEX DNA compaction by the higher-order assembly of PRH/Hex homeodomain protein oligomers Nucleic Acids Res., Jul 2010; 10.1093/nar/gkq659. shRNA TR312464
HHEX PRH/HHex controls cell survival through coordinate transcriptional regulation of VEGF signalling Mol. Cell. Biol., May 2010; 30: 2120 - 2134 shRNA TR312464
HHIP Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms Blood Cancer Journal 2, e87 doi:10.1038/bcj.2012.36 shRNA TR304118
HIF1A Mitochondrial ROS drive resistance to chemotherapy and immune-killing in hypoxic non-small cell lung cancer Journal of Experimental & Clinical Cancer Research : CR shRNA TL320380
HIF1A ERK regulates HIF-1α-mediated platinum resistance by directly targeting PHD2 in ovarian cancer Clin. Cancer Res. shRNA TG320380
Hif1a Secretion-mediated STAT3 activation promotes self-renewal of glioma stem-like cells during hypoxia Oncogene shRNA TR517255
HIF1A Placental growth factor silencing ameliorates liver fibrosis and angiogenesis and inhibits activation of hepatic stellate cells in a murine model of chronic liver disease J. Cell. Mol. Med. shRNA TR320380
HIF1A Hypoxic niche-mediated regeneration of hematopoiesis in the engraftment window is dominantly affected by oxygen tension in the milieu Stem Cells Dev. shRNA TF517255
HIF1A Hypoxia-Sensitive Epigenetic Regulation of an Antisense-Oriented lncRNA Controls WT1 Expression in Myeloid Leukemia Cells PLoS ONE shRNA TR320380
HIF1A Regulation of Noxa-mediated apoptosis in Helicobacter pylori-infected gastric epithelial cells FASEB J. shRNA TG320380
HIF1A A Splice Variant of the Human Ion Channel TRPM2 Modulates Neuroblastoma Tumor Growth Through HIF-1/2a J. Biol. Chem. shRNA TG320380
HIF1A The dual PI3K/mTOR inhibitor NVP-BEZ235 prevents epithelial-mesenchymal transition induced by hypoxia and TGF-β1 Eur. J. Pharmacol., Feb 2014. shRNA TG320380
HIF1A Tirapazamine Sensitizes Hepatocellular Carcinoma Cells to Topoisomerase I Inhibitors via Cooperative Modulation of Hypoxia-Inducible Factor-1a Mol. Cancer Ther. Dec 2013. shRNA TG320380
Hif1a Adenosine A(2)A receptor but not HIF-1 mediates Tyrosine hydroxylase induction in hypoxic PC12 cells. Journal of neuroscience research shRNA TR517255
HIF1A Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion British Journal of Cancer (15 December 2009) doi:10.1038/sj.bjc.6605486 Full Paper shRNA TR320380
HIF1A Role of HIF-1 and NF-B Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals J. Biol. Chem., Jul 2008; 283: 20674 - 20686 shRNA TR517255
HIP1 HIP1 mediates oncogenic transformation and cancer progression through STAT3 signalling bioRxiv shRNA TR312457
HIRA Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth Human genetics shRNA TF500962
HK2 Regulation of VDAC trafficking modulates cell death Cell Death Discov shRNA TR312415
HLA-DRA CIITA enhances HIV-1 attachment to CD4+ T cells leading to enhanced infection and cell depletion. Journal of immunology (Baltimore, Md. : 1950) shRNA TG304088
HLA-DRA CIITA Enhances HIV-1 Attachment to CD4+ T Cells Leading to Enhanced Infection and Cell Depletion J. Immunol., Dec 2010; 185: 6480 - 6488 shRNA TG304088
HMGA2 Chaperoning HMGA2 Protein Protects Stalled Replication Forks in Stem and Cancer Cells Cell Rep, Feb 2014. shRNA TR319507
HMGB1 Intracellular translocation of HMGB1 is important for Zika virus replication in Huh7 cells Scientific Reports shRNA TL316576
HMGB1 HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy Toxicol. Lett. shRNA TG316576
HMGB1 Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells Mol Med Rep shRNA TG316576
HMGB1 HMGB1 knockdown effectively inhibits the progression of rectal cancer by suppressing HMGB1 expression and promoting apoptosis of rectal cancer cells Mol Med Rep shRNA TG316576
HMGB1 Interference with HMGB1 increases the sensitivity to chemotherapy drugs by inhibiting HMGB1-mediated cell autophagy and inducing cell apoptosis Tumour Biol. shRNA TG316576
HMGB1 Soluble HMGB1 is a novel adipokine stimulating IL-6 secretion through RAGE receptor in SW872 preadipocyte cell line: contribution to chronic inflammation in fat tissue PLoS One. 2013 Sep 20;8(9):e76039 shRNA TR316576
HMGCS2 Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate J. Lipid Res., Mar 2013; 54: 592 - 601. shRNA TR312391
HMGCS2 Human HMGCS2 Regulates Mitochondrial Fatty Acid Oxidation and FGF21 Expression in HepG2 Cell Line J. Biol. Chem., Jun 2011; 286: 20423 - 20430 shRNA TR312391
HMGN2 Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem shRNA TF319505
HMOX1 Hypoxia‐induced oxidative stress promotes therapy resistance via upregulation of heme oxygenase‐1 in multiple myeloma Cancer Medicine shRNA TL312388
HMOX1 4-Hydroxyestradiol induces mammary epithelial cell transformation through Nrf2-mediated heme oxygenase-1 overexpression Oncotarget shRNA TR312388
HMOX1 The Flavonoid, Eriodictyol, Induces Long-term Protection in ARPE-19 Cells through Its Effects on Nrf2 Activation and Phase 2 Gene Expression Invest. Ophthalmol. Vis. Sci., May 2009; 50: 2398 - 2406. shRNA TR312388
Hmox2 Heme oxygenase-2 deletion impairs macrophage function: implication in wound healing FASEB J. shRNA TR514171
HNF1B Inhibition of Cell Death and Induction of G2 Arrest Accumulation in Human Ovarian Clear Cells by HNF-1ß Transcription Factor: Chemosensitivity Is Regulated by Checkpoint Kinase CHK1 Int. J. Gynecol. Cancer shRNA TG308907
HNF4A Modification in Oxidative Stress, Inflammation, and Lipoprotein Assembly in Response to Hepatocyte Nuclear Factor 4{alpha} Knockdown in Intestinal Epithelial Cells J. Biol. Chem., Dec 2010; 285: 40448 - 40460 shRNA TR320382
HNRNPC The RNA binding protein hnRNP Q modulates the utilization of exon 7 in the survival motor neuron 2 (SMN2) gene Mol. Cell. Biol., Nov 2008; 28: 6929 - 6938 shRNA TR304074
HNRNPK Anxiety-associated alternative polyadenylation of the serotonin transporter mRNA confers translational regulation by hnRNPK PNAS, Jul 2013; 110: 11624 - 11629. shRNA TG712371
HNRNPL HnRNP L is important for the expression of oncogene SRSF3 and oncogenic potential of oral squamous cell carcinoma cells Sci Rep shRNA TG312371
HNRNPL Separate cis-trans Pathways Post-transcriptionally Regulate Murine CD154 (CD40 Ligand) Expression: A NOVEL FUNCTION FOR CA REPEATS IN THE 3'-UNTRANSLATED REGION J. Biol. Chem., Sep 2008; 283: 25606 - 25616 shRNA TR312371
HNRNPM The Role of the Carcinoembryonic Antigen Receptor in Colorectal Cancer Progression Journal of Integrative Oncology shRNA TR304071
HOXA10 HOXA10 controls proliferation, migration and invasion in oral squamous cell carcinoma Int J Clin Exp Pathol shRNA TG316581
Hoxa11 Knockdown of Hoxa11 in vivo in the uterosacral ligament and uterus of mice results in altered collagen and matrix metalloproteinase activity. Biology of reproduction shRNA TL512291
HOXA11 Knockdown of Hoxa11 In Vivo in the Uterosacral Ligament and Uterus of Mice Results in Altered Collagen and Matrix Metalloproteinase Activity Biol Reprod, Jul 2012; 86: 100. shRNA TR312366
HOXA11 HoxA-11 and FOXO1A Cooperate to Regulate Decidual Prolactin Expression: Towards Inferring the Core Transcriptional Regulators of Decidual Genes PLoS ONE 4(9): e6845. doi:10.1371/journal.pone.0006845 shRNA TR312366
HOXA13 Reprogramming Antagonizes the Oncogenicity of HOXA13-Long Noncoding RNA HOTTIP Axis in Gastric Cancer Cells Stem Cells shRNA TR312365
Hoxa9 TWIST1-WDR5- Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer research shRNA TL500979
HOXA9 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. shRNA TG307647
HOXA9 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. shRNA TG500979
HOXA9 Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models Genomics Data shRNA TG307647
HOXA9 Transcriptional profiling of HOXA9-regulated genes in humanglioblastoma cell models Genomics Data shRNA TG307647
HOXA9 A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide Oncotarget shRNA TG307647
HOXA9 HOXA9 promotes homotypic and heterotypic cell interactions that facilitate ovarian cancer dissemination via its induction of P-cadherin Mol. Cancer July 2014 shRNA TG307647
HOXB5 HOXB5 promotes malignant progression in pancreatic cancer via the miR-6732 pathway Cell Cycle shRNA TR312357
HPSE Heparanase regulates the M1 polarization of renal macrophages and their crosstalk with renal epithelial tubular cells after ischemia/reperfusion injury FASEB J. shRNA TF307138
HPSE Heparanase: A Potential New Factor Involved in the Renal Epithelial Mesenchymal Transition (EMT) Induced by Ischemia/Reperfusion (I/R) Injury PLoS ONE shRNA TR307138
HPSE Everolimus-induced epithelial to mesenchymal transition in immortalized human renal proximal tubular epithelial cells: key role of heparanase J Transl Med 292 shRNA TR307138
HPSE Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells J. Biol. Chem., Jan 2012; 287: 1478 - 1488. shRNA TR307138
HPSE Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice Circulation Research:Volume 104(3)13 February 2009pp 380-387 shRNA TR307138
HRAS The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation Cell Rep shRNA TR704050
HS6ST1 Ovarian Cancer Cell Heparan Sulfate 6-O-Sulfotransferases Regulate an Angiogenic Program Induced by HB-EGF/EGF Receptor Signaling J. Biol. Chem., Feb 2014. shRNA TG312328
HSF1 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cellular signalling shRNA TR312318
HSP90B1 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cellular signalling shRNA TR312309
Hspa1a Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity Oncogene shRNA TF312308
Hspa1b Tumor-derived inducible heat-shock protein 70 (HSP70) is an essential component of anti-tumor immunity Oncogene shRNA TF312307
Hspa5 Knockdown of endoplasmic reticulum chaperone BiP leads to the death of parvocellular AVP/CRH neurons in mice. Journal of neuroendocrinology shRNA TR500881
Hspa5 Endoplasmic reticulum chaperone BiP/GRP78 knockdown leads to autophagy and cell death of arginine vasopressin neurons in mice Scientific Reports shRNA TR500881
HSPA5 The loss of glucose-regulated protein 78 (GRP78) during normal aging or from siRNA knockdown augments human alpha-synuclein (a-syn) toxicity to rat nigral neurons Neurobiol. Aging shRNA TG312303
HSPA5 The Loss of Glucose Regulated Protein 78 (GRP78) during Normal Aging or from siRNA Knockdown Augments Human Alpha-Synuclein (a-syn) Toxicity to Rat Nigral Neurons Neurobiology of Aging shRNA TG312303
Hspa8 The Molecular Chaperone Hsc70 Interacts with Tyrosine Hydroxylase to Regulate Enzyme Activity and Synaptic Vesicle Localization J Biol Chem shRNA TR501001
Hspa9 HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons Scientific Reports shRNA TL704140
Hspa9 HSPA9/Mortalin mediates axo-protection and modulates mitochondrial dynamics in neurons Scientific Reports shRNA TR704140
HSPB1 Heat shock protein 27 inhibits HMGB1 translocation by regulating CBP acetyltransferase activity and ubiquitination Mol. Immunol. shRNA TR320383
Hspb1 Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation Mucosal Immunol shRNA TG501011
HSPB1 HSP27 phosphorylation modulates TRAIL-induced activation of Src-Akt/ERK signaling through interaction with Beta-arrestin2 Cell. Signal. Dec 2013. shRNA TR320383
HSPB1 Regulation of lipopolysaccharide-induced inflammatory response by heat shock protein 27 in THP-1 cells. Cellular immunology shRNA TR320383
HSPB1 HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination. Cellular signalling shRNA TR320383
ID1 Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance glycolysis and the TCA cycle for virus replication. Cellular microbiology shRNA TG303996
ID1 CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3 Sci Rep shRNA TR511687
ID3 CCAAT/Enhancer Binding Protein β inhibits myogenic differentiation via ID3 Sci Rep shRNA TR501033
ID4 Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article shRNA TR319484
IDH2 Metabolic profiling reveals distinct metabolic alterations in different subtypes of pituitary adenomas and confers therapeutic targets J Transl Med shRNA TF702283
IDH2 Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells Int. J. Biochem. Cell Biol. shRNA TG312260
IDH3B Avian reovirus σA-modulated suppression of lactate dehydrogenase and upregulation of glutaminolysis and the mTOC1/eIF4E/HIF-1α pathway to enhance glycolysis and the TCA cycle for virus replication Cell. Microbiol. shRNA TG303995
IDO1 Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer. Cancer & metabolism shRNA TL312147
IDO1 INDOLEAMINE 2,3-DIOXYGENASE 1 (IDO1) IS UPREGULATED IN THYROID CARCINOMA AND DRIVES THE DEVELOPMENT OF AN IMMUNOSUPPRESSANT TUMOR MICROENVIRONMENT J. Clin. Endocrinol. Metab., Feb 2014. shRNA TG312147
IDUA Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores J. Cell Biol., Jun 2008; 10.1083/jcb.200712028. shRNA TR312256
IFI16 Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells PLoS Pathog. shRNA TR312254
Ifi203 Silencing of the interferon-inducible gene Ifi204/p204 induces resistance to interferon-γ-mediated cell growth arrest of tumor cells. Cytokine shRNA TL517645
IFITM1 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. shRNA TG312242
IFITM2 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. shRNA TG312241
IFITM3 Respiratory Syncytial Virus Infection is Inhibited by Interferon-Induced Transmembrane Proteins J. Gen. Virol. shRNA TG303991
IFNAR1 Exclusive Temporal Stimulation of IL-10 Expression in LPS-Stimulated Mouse Macrophages by cAMP Inducers and Type I Interferons Front Immunol shRNA TG312233
IFNAR1 Type-1 interferons contribute to oxygen glucose deprivation induced neuro-inflammation in BE(2)M17 human neuroblastoma cells J Neuroinflammation shRNA TG312233
IFNAR1 Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer's disease Neurobiol. Aging Dec 2013. shRNA TR312233
IFNAR1 Type-1 interferon signalling mediates neuro-inflammatory events in models of Alzheimer's disease Neurobiology of Aging shRNA TG312233
IFNLR1 IL28RA inhibits human epidermal keratinocyte proliferation by inhibiting cell cycle progression. Molecular biology reports shRNA TR303938
IGF1 Acute Inflammation Induces Insulin-like Growth Factor-1 to Mediate Bcl-2 and Muc5ac Expression in Airway Epithelial Cells Am. J. Respir. Cell Mol. Biol., Dec 2012; 47: 784 - 791. shRNA TG319480
IGF1 Intracellular Insulin-like Growth Factor-1 Induces Bcl-2 Expression in Airway Epithelial Cells J. Immunol., May 2012; 188: 4581 - 4589. shRNA TR319480
IGF1R Discoidin Domain Receptor 1 functionally interacts with the IGF-I system in bladder cancer Matrix Biology Plus shRNA TG320384
IGF1R Procyanidins from Cinnamomi Cortex promote proteasome-independent degradation of nuclear Nrf2 through phosphorylation of insulin-like growth factor-1 receptor in A549 cells Arch. Biochem. Biophys. shRNA TG320384
IGF1R TGFß signaling confers sorafenib resistance via induction of multiple RTKs in hepatocellular carcinoma cells Mol. Carcinog. shRNA TG320384
IGF1R Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I Thesis shRNA TG320384
IGF1R TDP-43 neurotoxicity and protein aggregation modulated by heat shock factor and insulin/IGF-1 signaling Hum. Mol. Genet., Mar 2011; 10.1093/hmg/ddr076 shRNA TR320384
IGF2BP3 IGF2BP3-mediated translation in cell protrusions promotes cell invasiveness and metastasis of pancreatic cancer Oncotarget shRNA TG312221
IGFBP2 Novel anti IGFBP2 single chain variable fragment inhibits glioma cell migration and invasion. Journal of neuro-oncology shRNA TR316590
IGFBP3 STAT-1 expression is regulated by IGFBP-3 in malignant glioma cells and is a strong predictor of poor survival in patients with glioblastoma J. Neurosurg. shRNA TF312217
Igfbp4 IGFBP-4 activates the Wnt/beta-catenin signaling pathway and induces M-CAM expression in human renal cell carcinoma. International journal of cancer shRNA TL510928
IGFBP5 Genetic Screen Identifies Insulin-like Growth Factor Binding Protein 5 as a Modulator of Tamoxifen Resistance in Breast Cancer Cancer Res., Apr 2010; 70: 3013 - 3019 shRNA TR316591
IGFBP7 Insulin-like growth factor-binding protein 7 alters the sensitivity to interferon-based anticancer therapy in hepatocellular carcinoma cells British Journal of Cancer (20 April 2010) doi:10.1038/sj.bjc.6605669 Full Paper shRNA TR312216
Igsf11 Promotion of differentiation in developing mouse cerebellar granule cells by a cell adhesion molecule BT-IgSF. Neuroscience letters shRNA TL506226
IHH Endogenously-produced Indian Hedgehog Regulates TGFß-driven Chondrogenesis of Human Bone Marrow Stromal/Stem Cells Stem Cells Dev. shRNA TG312208
IKBKB A constitutively-active IKK-complex at the axon initial segment Brain Res. shRNA TG509787
IKBKE Glucose Metabolism Reprogrammed by Overexpression of IKKe Promotes Pancreatic Tumor Growth Cancer Res shRNA TG517180
IKZF1 Regulation of Small GTPase Rab20 by Ikaros in B-Cell Acute Lymphoblastic Leukemia Int J Mol Sci shRNA TG502473
IKZF1 RAG1 high expression associated with IKZF1 dysfunction in adult B-cell acute lymphoblastic leukemia J Cancer shRNA TG502473
IKZF1 Aberrant ARID5B expression and its association with Ikaros dysfunction in acute lymphoblastic leukemia Oncogenesis shRNA TG308127
IKZF1 Ikaros regulation of the BCL6/BACH2 axis and its clinical relevance in acute lymphoblastic leukemia Oncotarget shRNA TG308127
IKZF1 Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia Sci Rep shRNA TG308127
IKZF1 Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacteylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B Cell Acute Lymphoblastic Leukemia J. Biol. Chem. shRNA TG308127
Il10 The Bile Acid Receptor GPBAR1 Regulates the M1/M2 Phenotype of Intestinal Macrophages and Activation of GPBAR1 Rescues Mice from Murine Colitis. Journal of immunology (Baltimore, Md. : 1950) shRNA TF501065
IL15RA IL15RA is required for osteoblast function and bone mineralization Bone shRNA TR501072
Il15ra Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget shRNA TG501072
IL18 TLR2 controls the development of hepatocellular carcinoma by reducing interleukin-18-mediated immunosuppression Cancer Res. shRNA TG510212
IL1A Mitogen-Activated Protein Kinase-Dependent Interleukin-1a Intracrine Signaling Is Modulated by YopP during Yersinia enterocolitica Infection Infect. Immun., Jan 2012; 80: 289 - 297. shRNA TR312183
IL1R1 Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget shRNA TG501076
IL22 Downregulation of miR‐26 promotes invasion and metastasis via targeting interleukin‐22 in cutaneous T‐cell lymphoma Cancer Science shRNA TL303948
IL33 Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity Stem Cell Reports shRNA MR203528
IL3RA Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 Leukemia shRNA TG516353
IL6 Autocrine IL-6 mediates pituitary tumor senescence Oncotarget shRNA TG709233
IL6 Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes J. Orthop. Res. shRNA TG312162
IL6 Metastatic Cells Can Escape the Proapoptotic Effects of TNF-a through Increased Autocrine IL-6/STAT3 Signaling Cancer Res., Feb 2012; 72: 865 - 875. shRNA TR312162
IL6RA Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article shRNA TR501088
IL6ST Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages Nature Immunology 12, 551-559 (24 April 2011) doi:10.1038/ni.2030 Article shRNA TR501089
ILK CCN1 induces a reversible epithelial–mesenchymal transition in gastric epithelial cells Laboratory Investigation (10 May 2010) doi:10.1038/labinvest.2010.101 Research Article shRNA TR712638
IMMT Mic60/mitofilin overexpression alters mitochondrial dynamics and attenuates vulnerability of dopaminergic cells to dopamine and rotenone Neurobiol. Dis. shRNA TR312153
IMPDH2 IMPDH2 mediate radioresistance and chemoresistance in osteosarcoma cells Eur Rev Med Pharmacol Sci shRNA TR312150
INAVA INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression Cell Biosci shRNA TR306059
ING1 Tumour suppressor ING1b maintains genomic stability upon replication stress Nucleic Acids Res., Jan 2011; 10.1093/nar/gkq1337 shRNA TR312146
Inhba In vivo induction of activin A-producing alveolar macrophages supports the progression of lung cell carcinoma Nature Communications shRNA TR516955
Inpp5d IVIG activates FcγRIIB-SHIP1-PIP3 Pathway to stabilize mast cells and suppress inflammation after ICH in mice Sci Rep shRNA TG516227
INPPL1 The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics J. Cell Biol., Aug 2010; 10.1083/jcb.201005018 shRNA TR312134
INSIG2 Insulin-induced gene 2 expression correlates with colorectal cancer metastasis and disease outcome IUBMB Life shRNA TG303915
INSR Regulación de la captación de glucosa en astrocitos por el eje insulina/IGF-I Thesis shRNA TG320387
IPMK Inositol Polyphosphate Multikinase Is a Coactivator of p53-Mediated Transcription and Cell Death Sci. Signal., Apr 2013; 6: ra22. shRNA TG303904
IPO7 Knockdown of Importin 7 Inhibits Lung Tumorigenesis in K-ras(LA1) Lung Cancer Mice Anticancer Res. shRNA TF312126
IRF6 TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate J. Cell. Physiol. shRNA TR312109
IRF7 Soluble amyloid triggers a myeloid differentiation factor 88 and interferon regulatory factor 7 dependent neuronal type-1 interferon response in vitro J Neuroinflammation shRNA TR315487
IRF7 Translational control of the innate immune response through IRF-7 Nature 452, 323 - 328 (13 Feb 2008) shRNA TR315487
Irf8 DNA methylation protects against cisplatin-induced kidney injury by regulating specific genes including interferon regulatory factor 8 Kidney international shRNA TG701093
IRF8 Interferon Regulatory Factor 8 Protects Against Cerebral Ischaemic-Reperfusion Injury J. Neurochem., Feb 2014. shRNA TG701093
IRS1 Expression levels of insulin receptor substrate-1 modulate the osteoblastic differentiation of mesenchymal stem cells and osteosarcoma cells Growth Factors, Jan 2014. shRNA TF516309
ISLR Islr regulates canonical Wnt signaling-mediated skeletal muscle regeneration by stabilizing Dishevelled-2 and preventing autophagy Nat Commun shRNA TG512833
ITGA2 CD49b inhibits osteogenic differentiation and plays an important role in osteosarcoma progression Oncotarget shRNA TG312097
ITGB1 Physical and Functional Interactions between a Glioma Cation Channel and Integrin ß1 Require a-Actinin Am. J. Physiol., Cell Physiol. shRNA TG320392
ITGB1 Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion J Natl Cancer Inst, Aug 2011; 103: 1162 - 1178. shRNA TR320392
ITGB1 Extracellular matrix-induced transforming growth factor-beta receptor signaling dynamics. Oncogene shRNA TR320392
ITGB1 Extracellular matrix-induced transforming growth factor-ß receptor signaling dynamics Oncogene (25 January 2010) doi:10.1038/onc.2009.514 Original Article shRNA TR320392
ITGB3 Estudio de los mecanismos celulares y moleculares implicados en la adhesión y migración de células de carcinoma pulmonar no microcítico inducidas por TGFß Thesis shRNA TR312082
ITGB3 Inhibition of tumor-associated avß3 integrin regulates the angiogenic switch by enhancing expression of IGFBP-4 leading to reduced melanoma growth and angiogenesis in vivo Angiogenesis shRNA TR312082
ITGB3 Combined targeting of TGF-beta1 and integrin beta3 impairs lymph node metastasis in a mouse model of non-small-cell lung cancer Mol. Cancer shRNA TR312082
ITGB6 Immunoglobulin light chains generate proinflammatory and profibrotic kidney injury The Journal of Clinical Investigation shRNA TF312078
ITPR1 IP3 receptor blockade restores autophagy and mitochondrial function in skeletal muscle fibers of dystrophic mice Biochim Biophys Acta Mol Basis Dis shRNA TR517036
ITPR1 Mitochondrial Calcium Increase Induced by RyR1 and IP3R Channel Activation After Membrane Depolarization Regulates Skeletal Muscle Metabolism Front Physiol shRNA TF517036
JAG1 Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling American Journal of Cancer Research shRNA TG312059
JAG2 Distinct Biological Roles for the Notch Ligands Jagged-1 and Jagged-2 J. Biol. Chem., Jun 2009; 284: 17766 - 17774 shRNA TR303860
Jak1 Oncogenic IL7R gain-of-function mutations in childhood T-cell acute lymphoblastic leukemia Nature genetics shRNA TG511227
JAK2 An activity-dependent determinant of synapse elimination in the mammalian brain Neuron shRNA TF320395
JUN ICBP90 Regulates MIF Expression, Glucocorticoid Sensitivity, and Apoptosis at the , MIF Immune Susceptibility Locus Arthritis & rheumatology (Hoboken, N.J.) 2021 shRNA TG320397
JUN Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget shRNA TG501139
JUN MicroRNA 10b promotes abnormal expression of the proto-oncogene c-Jun in metastatic breast cancer cells Oncotarget shRNA TR320397
Jun Co-inhibition of NF-?B and JNK is synergistic in TNF-expressing human AML J. Exp. Med. shRNA TG501139
JUN PNAS Plus: Aberrant expression of c-Jun in glioblastoma by internal ribosome entry site (IRES)-mediated translational activation PNAS, Oct 2012; 109: E2875 - E2884. shRNA TG320397
JUNB Safeguard function of PU.1 shapes the inflammatory epigenome of neutrophils Nat. Immunol. shRNA TF516091
JUNB Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget shRNA TG516091
Jund Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling Oncotarget shRNA TG501140
JUND Human T-Cell Leukemia Virus Type 1 (HTLV-1) bZIP Factor Requires Cellular Transcription Factor JunD To Upregulate HTLV-1 Antisense Transcription from the 3' Long Terminal Repeat J. Virol., Sep 2012; 86: 9070 - 9078. shRNA TG312046
JUP Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3{sigma} J. Cell Sci., Jul 2013; 126: 3031 - 3042. shRNA TG312045
JUP Molecular characterization of the tumor/metastasis suppressor activity of plakoglobin Thesis shRNA TG312045
KAT2B PCAF interacts with XBP-1S and mediates XBP-1S-dependent transcription Nucleic Acids Res., Jan 2011; 39: 429 - 439 shRNA TR310589
KAT2B Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation J. Cell Sci., Nov 2010; 123: 3718 - 3726 shRNA TR310589
Kcna1 Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals Neuron shRNA TR713329
Kcnc1 Control and Plasticity of the Presynaptic Action Potential Waveform at Small CNS Nerve Terminals Neuron shRNA TR709473
KCNH2 A microtranslatome coordinately regulates sodium and potassium currents in the human heart Elife shRNA TG320399
KCNH2 A microtranslatome coordinately regulates sodium and potassium currents in the heart bioRxiv shRNA TG320399
Kcnh6 From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion. Cell reports shRNA TL512772
KCNK1 Kir2.1 and K2P1 channels reconstitute two levels of resting membrane potential in cardiomyocytes J. Physiol. (Lond.) 2017 shRNA TF315498
KCNK1 TWIK-1 Two-Pore Domain Potassium Channels Change Ion Selectivity and Conduct Inward Leak Sodium Currents in Hypokalemia Sci. Signal., Jun 2011; 4: ra37. shRNA TR315498
KCNQ1 Synergistic Restoring Effects of Isoproterenol and Magnesium on KCNQ1-Inhibited Bradycardia Cell Models Cultured in Microelectrode Array Cardiology, Feb 2014. shRNA TR711664
KCTD5 KCTD5, a novel TRPM4‐regulatory protein required for cell migration as a new predictor for breast cancer prognosis FASEB j. shRNA TG303786
KCTD5 KCTD5 and Ubiquitin Proteasome Signaling Are Required for Helicobacter pylori Adherence Front Cell Infect Microbiol shRNA TG303786
KDM1A Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan Nature Communications shRNA TL316984
KDM1A Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription PLoS Biol. shRNA TF316984
KDM3A The Hypoxia-Inducible Epigenetic Regulators Jmjd1a and G9a Provide a Mechanistic Link between Angiogenesis and Tumor Growth Mol. Cell. Biol. July 2014 shRNA TG303857
KDM4B MicroRNA-15a Carried by Mesenchymal Stem Cell-Derived Extracellular Vesicles Inhibits the Immune Evasion of Colorectal Cancer Cells by Regulating the KDM4B/HOXC4/PD-L1 Axis Frontiers in Cell and Developmental Biology shRNA TR312052
KDM6B Folic Acid Remodels Chromatin on Hes1 and Neurog2 Promoters during Caudal Neural Tube Development J. Biol. Chem., Nov 2010; 285: 36922 - 36932 shRNA TR320873
KDR CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma Sci Rep shRNA TR320400
KDR CD146 acts as a novel receptor for netrin-1 in promoting angiogenesis and vascular development Cell Res. shRNA TG320400
KDR Autocrine VEGF signaling promotes cell proliferation and modulates the sorafenib treatment efficacy in hepatocellular carcinoma Hepatology shRNA TG320400
KHK Ketohexokinase-Dependent Metabolism of Fructose Induces Proinflammatory Mediators in Proximal Tubular Cells . Am. Soc. Nephrol., Mar 2009; 20: 545 - 553. shRNA TR311985
KHSRP KHSRP-bound small nucleolar RNAs associate with promotion of cell invasiveness and metastasis of pancreatic cancer Oncotarget shRNA TR311984
KHSRP KSRP Modulation of GAP-43 mRNA Stability Restricts Axonal Outgrowth in Embryonic Hippocampal Neurons PLoS ONE e79255 shRNA TG311984
KIF11 Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TG501174
KIF13B Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TG517925
Kif19a Production of transgenic mice by random recombination of targeted genes in female germline stem cells J Mol Cell Biol, Dec 2010; 10.1093/jmcb/mjq043 shRNA TR517467
KIF20A Aberrant KIF20A Expression Is Associated with Adverse Clinical Outcome and Promotes Tumor Progression in Prostate Cancer Dis. Markers shRNA TG311916
KIF20A KIF20A Affects the Prognosis of Bladder Cancer by Promoting the Proliferation and Metastasis of Bladder Cancer Cells Disease Markers shRNA TG311916
KIF20A KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells Neoplasia shRNA TG311916
KIF21A Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TG501180
KIF21B Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TG501181
KIF23 Aberrant KIF20A Expression Is Associated with Adverse Clinical Outcome and Promotes Tumor Progression in Prostate Cancer Disease Markers shRNA TG311914
KIF23 KIF20A-Mediated RNA Granule Transport System Promotes the Invasiveness of Pancreatic Cancer Cells Neoplasia (New York, N.Y.) shRNA TG311914
KIF3A Live-Cell Imaging Evidence for the Ciliary Transport of Rod Photoreceptor Opsin by Heterotrimeric Kinesin-2 J. Neurosci., Aug 2012; 32: 10587 - 10593. shRNA TR311911
Kif3b Molecular Motor KIF3B Acts as a Key Regulator of Dendritic Architecture in Cortical Neurons Frontiers in Cellular Neuroscience shRNA TL501182
KISS1R KISS1R signaling promotes invadopodia formation in human breast cancer cell via ß-arrestin2/ERK Cell. Signal. shRNA TR303680
KISS1R Regulation of GPR54 Signaling by GRK2 and {beta}-Arrestin Mol. Endocrinol., Oct 2009; 10.1210/me.2009-0013 shRNA TR303680
KL Klotho upregulation contributes to the neuroprotection of ligustilide against cerebral ischemic injury in mice Eur. J. Pharmacol. shRNA TG303679
KLF4 Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing Am J Cancer Res shRNA TG316853
KLF4 Putative Tumor-Suppressive Function of Krüppel-Like Factor 4 in Primary Lung Carcinoma Clin. Cancer Res., Sep 2009; 15: 5688 - 5695 shRNA TR316853
KLF5 Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer Cancers shRNA TR311886
Klf5 Role of miR-145 in cardiac myofibroblast differentiation. Journal of molecular and cellular cardiology shRNA TG509991
KLF6 Energy Restriction-mimetic Agents Induce Apoptosis in Prostate Cancer Cells in Part through Epigenetic Activation of KLF6 Tumor Suppressor Gene Expression J. Biol. Chem., Mar 2011; 286: 9968 - 9976 shRNA TR311885
KLHDC8B The Kelch Protein KLHDC8B Guards against Mitotic Errors, Centrosomal Amplification, and Chromosomal Instability J. Biol. Chem., Nov 2012; 287: 39083 - 39093. shRNA TR318087
KLHDC8B Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells PNAS, Sep 2009; 106: 14920 - 14925 shRNA TR318087
KLHL34 Epigenetic Regulation of KLHL34 Predictive of Pathologic Response to Preoperative Chemoradiation Therapy in Rectal Cancer Patients Int. J. Radiat. Oncol. Biol. Phys. shRNA TG307679
KLHL40 Kbtbd5 is regulated by MyoD and restricted to the myogenic lineage Differentiation Dec 2013. shRNA TG303840
KLK5 Kallikrein-5 Promotes Cleavage of Desmoglein-1 and Loss of Cell-Cell Cohesion in Oral Squamous Cell Carcinoma J. Biol. Chem., Mar 2011; 286: 9127 - 9135 shRNA TR311870
Kmt2a Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin shRNA TR517798
KMT2D Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan Nature Communications shRNA TL311461
KRT14 Platelet-rich plasma activates AKT signaling to promote wound healing in a mouse model of radiation-induced skin injury J Transl Med shRNA TR311838
KRT6A K16 is a further new candidate for homotypic intermediate filament protein interactions. Experimental dermatology shRNA TG311830
KRT80 SREBP1 drives KRT80-dependent cytoskeletal changes and invasive behavior in endocrine resistant ERα breast cancer bioRxiv shRNA TF307833
LAMA3 A Cdh3-β-catenin-laminin signaling axis in a subset of breast tumor leader cells control leader cell polarization and directional collective migration Developmental cell shRNA TL311804
LAMP1 Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level J. Biol. Chem., Feb 2012; 287: 4165 - 4176. shRNA TR311795
LAMP1 Visualizing Microtubule-Dependent Vasopressin Type 2 Receptor Trafficking Using a New High-Affinity Fluorescent Vasopressin Ligand Endocrinology, Oct 2011; 152: 3893 - 3904. shRNA TR311795
LAMP2 Chronic acidosis in the tumour microenvironment selects for overexpression of LAMP2 in the plasma membrane Nat Commun shRNA TR311794
LARP1 The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer Nucleic Acids Res. shRNA TF303581
LARS1 PGC-1α Regulates Cell Proliferation, Migration, and Invasion by Modulating Leucyl-tRNA Synthetase 1 Expression in Human Colorectal Cancer Cells. Cancers shRNA TG303577
LCE1H Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren\'s syndrome Cell Death Dis shRNA TG503987
Lcn2 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. shRNA TR511895
Lcn2 Mutant p53 Together with TGFß Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer Clin. Cancer Res. shRNA MR226233
LCN2 Lipocalin 2 Enhances Migration and Resistance against Cisplatin in Endometrial Carcinoma Cells PLoS ONE shRNA TG311777
LCN2 Lipocalin 2 attenuates iron-related oxidative stress and prolongs the survival of ovarian clear cell carcinoma cells by up-regulating the CD44 variant Free radical Research shRNA TG311777
LDHA Tumor-Derived Lactic Acid Contributes to the Paucity of Intratumoral ILC2s Cell Rep shRNA TG515372
Leap2 Liver-expressed antimicrobial peptide 2 elevation contributes to age-associated cognitive decline JCI Insight shRNA TR519691
LEF1 MicroRNAs Regulate Pituitary Development, and MicroRNA 26b Specifically Targets Lymphoid Enhancer Factor 1 (Lef-1), Which Modulates Pituitary Transcription Factor 1 (Pit-1) Expression J. Biol. Chem., Nov 2010; 285: 34718 - 34728 shRNA TR712526
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG303551
LEO1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR303551
LETM1 LETM1-mediated K+ and Na+ homeostasis regulates mitochondrial Ca2+ efflux Frontiers in Physiology shRNA TR311758
LGR5 FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells Biochem. Biophys. Res. Commun. shRNA TF311747
LIMK1 Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects Nature Medicine 18, 1087-1094 doi:10.1038/nm.2834 shRNA TR320403
LINC00261 LINC00261 is an epigenetically-regulated tumor suppressor that is essential for activation of the DNA damage response Cancer Res. shRNA HC137604
LINC00504 The LINC00504/Mir-4739/KLK4 Axis Facilitates Cell Proliferation and Suppresses Cell Apoptosis Through Triggering The Wnt/Β-Catenin Pathway In Triple-Negative Breast Cancer Cells Research Square shRNA TR318094
LMBRD1 LMBD1 protein participates in cell mitosis by regulating microtubule assembly The Biochemical journal shRNA TF303512
LMNA Promoter hypermethylation as a mechanism for Lamin A/C silencing in a subset of neuroblastoma cells PLoS ONE shRNA TG303510
LMO1 LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer Oncotarget shRNA TG311708
LNP1 Lunapark Is a Component of a Ubiquitin Ligase Complex Localized to the Endoplasmic Reticulum Three-way Junctions J. Biol. Chem. shRNA TR320968
LOC298795 Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation Oncotarget shRNA TL702077
LOXL2 Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane Blood, Oct 2011; 118: 3979 - 3989. shRNA TR311699
LPAR1 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells Cell. Physiol. Biochem. shRNA TR313300
LPAR1 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research shRNA TR313300
LPAR1 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog. shRNA TF712271
Lpar1 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. shRNA TG509224
LPAR2 Roles of endothelial cells in the regulation of cell motility via lysophosphatidic acid receptor-2 (LPA2) and LPA3 in osteosarcoma cells Experimental and molecular pathology shRNA TG313298
LPAR2 Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells J. Recept. Signal Transduct. Res. shRNA TG313298
LPAR2 Lysophosphatidic acid receptor-2 (LPA2)-mediated signaling enhances chemoresistance in melanoma cells treated with anticancer drugs Mol. Cell. Biochem. shRNA TG313298
LPAR2 Involvement of LPA signaling via LPA receptor-2 in the promotion of malignant properties in osteosarcoma cells Exp. Cell Res. shRNA TR313298
LPAR2 Enhanced cellular functions through induction of LPA2 by cisplatin in fibrosarcoma HT1080 cells Mol. Cell. Biochem shRNA TR313298
Lpar2 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. shRNA TG502984
Lpar3 Effects of lysophosphatidic acid (LPA) receptor-2 (LPA2) and LPA3 on the regulation of chemoresistance to anticancer drug in lung cancer cells Cell. Signal. shRNA TG517410
LPAR3 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells Cell. Physiol. Biochem. shRNA TR313295
LPAR3 Lysophosphatidic acid signaling via LPA1 and LPA3 regulates cellular functions during tumor progression in pancreatic cancer cells Experimental Cell Research shRNA TR313295
LPAR3 Different induction of LPA receptors by chemical liver carcinogens regulates cellular functions of liver epithelial WB-F344 cells Mol. Carcinog. shRNA TG710942
Lpar3 LPA signaling through LPA receptors regulates cellular functions of endothelial cells treated with anticancer drugs Mol. Cell. Biochem. shRNA TG517410
LPAR4 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells Biochem. Biophys. Res. Commun shRNA TR312652
LPAR4 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. shRNA TF312652
LPAR5 Different effects of lysophosphatidic acid receptor-2 (LPA2) and LPA5 on the regulation of chemoresistance in colon cancer cells J. Recept. Signal Transduct. Res. shRNA TG304222
LPAR5 LPA5-mediated signaling induced by endothelial cells and anticancer drug regulates cellular functions of osteosarcoma cells Experimental Cell Research shRNA TG304222
LPAR5 Modulation of chemoresistance by lysophosphatidic acid (LPA) signaling through LPA5 in melanoma cells treated with anticancer drugs Biochem. Biophys. Res. Commun. shRNA TG304222
LPAR5 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. shRNA TG304222
LPAR5 Inhibitory effects of lysophosphatidic acid receptor-5 on cellular functions of sarcoma cells Growth Factors shRNA TG304222
LPAR5 Lysophosphatidic acid receptor-5 negatively regulates cell motile and invasive activities of human sarcoma cell lines Mol. Cell. Biochem. March 2014 shRNA TG304222
Lpar5 Lysophosphatidic acid receptor-5 negatively regulates cellular responses in mouse fibroblast 3T3 cells Biochem. Biophys. Res. Commun. shRNA TG304222
LPAR6 Lysophosphatidic acid (LPA) signaling via LPA4 and LPA6 negatively regulates cell motile activities of colon cancer cells Biochem. Biophys. Res. Commun shRNA TR310642
LPAR6 Diverse effects of LPA4, LPA5 and LPA6 on the activation of tumor progression in pancreatic cancer cells Biochem. Biophys. Res. Commun. shRNA TF310642
Lpcat1 Acyl-CoA:Lysophosphatidylcholine Acyltransferase I (Lpcat1) Catalyzes Histone Protein O -Palmitoylation to Regulate mRNA Synthesis The Journal of Biological Chemistry shRNA TL704171
LRP10 Anti-Argonaute RIP-Chip shows that miRNA transfections alter global patterns of mRNA recruitment to microribonucleoprotein complexes RNA shRNA TL311681
LRP6 Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis Research Square shRNA TG509944
LRP6 RASSF10 suppresses lung cancer proliferation and invasion by decreasing the level of phosphorylated LRP6 Mol. Carcinog. shRNA TG311676
Lrrfip1 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway. Nature immunology shRNA TL514790
LRRFIP1 The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a ß-catenin-dependent pathway Nature Immunology 11, 487-494 (9 May 2010) doi:10.1038/ni.1876 Article shRNA TR311663
LRRK1 Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression The Journal of Biological Chemistry shRNA TR200242
LSP1 Lymphocyte-Specific Protein-1 Controls Sorafenib Sensitivity and Hepatocellular Proliferation through Extracellular Signal-Regulated Kinase 1/2 Activation The American Journal of Pathology shRNA TG702934
LSP1 Leukocyte specific protein-1: A novel regulator of hepatocellular proliferation and migration deleted in human HCC Hepatology shRNA TG702934
LSR LSR promotes epithelial ovarian cancer cell survival under energy stress through the LKB1-AMPK pathway Biochemical and Biophysical Research Communications shRNA TG303412
LTA Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation Cytokine shRNA TR316607
LTA4H Resveratrol, a Red Wine Polyphenol, Suppresses Pancreatic Cancer by Inhibiting Leukotriene A4 Hydrolase Cancer Res., Dec 2010; 70: 9755 - 9764 shRNA TR311651
LTA4H [6]-Gingerol Suppresses Colon Cancer Growth by Targeting Leukotriene A4 Hydrolase Cancer Res., Jul 2009; 69: 5584 - 5591 shRNA TR311651
LTC4S Maresin conjugates in tissue regeneration biosynthesis enzymes in human macrophages Proc. Natl. Acad. Sci. U.S.A. shRNA TR319192
LY6E LY6E Restricts the Entry of Human Coronaviruses, including the currently pandemic SARS-CoV-2 bioRxiv shRNA TR311641
Lypla1 Palmitoylation couples insulin hypersecretion with β cell failure in diabetes. Cell metabolism shRNA TL709612
MAD2L1 Phosphoinositide 3-kinase ß regulates chromosome segregation in mitosis Mol. Biol. Cell, Dec 2012; 23: 4526 - 4542. shRNA TG311623
MAFA Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-{alpha} Gene Expression in Pancreatic Islet Endocrine Cells J. Biol. Chem., Jan 2011; 286: 1025 - 1036 shRNA TR303385
Mafa Calcineurin/Nuclear Factor of Activated T Cells and MAPK Signaling Induce TNF-? Gene Expression in Pancreatic Islet Endocrine Cells The Journal of Biological Chemistry shRNA TG508549
MAFF Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell Rep shRNA TF501290
Mageb16 Depletion of Mageb16 induces differentiation of pluripotent stem cells predominantly into mesodermal derivatives Sci Rep shRNA TG321071
MAP1LC3B Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG503902
MAP2K1 Cyclin-dependent kinase 5 contributes to endoplasmic reticulum stress induced podocyte apoptosis via promoting MEKK1 phosphorylation at Ser280 in diabetic nephropathy Cell. Signal shRNA TR502589
MAP2K3 The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling J Biol Chem. 2005 Dec 23;280(51):42097-105. shRNA TR320491
MAP3K8 Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction Cancer Res., Oct 2009; 69: 8043 - 8049 shRNA TR512220
MAP4K4 HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells Cell Death Dis shRNA TG320615
MAPK1 p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis Aging (Albany NY) 2019 shRNA TG502598
Mapk10 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. shRNA TR502599
MAPK14 p38 MAPK mediates epithelial-mesenchymal transition by regulating p38IP and Snail in head and neck squamous cell carcinoma Oral Oncology shRNA TG320309
Mapk8 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. shRNA TR511480
Mapk8 Plumbagin induces apoptosis in lymphoma cells via oxidative stress mediated glutathionylation and inhibition of mitogen-activated protein kinase phosphatases (MKP1/2) Cancer Lett. shRNA TR511480
Mapk9 Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. shRNA TR502601
MAPKAPK2 MAPKAP kinase 2-mediated phosphorylation of HspA1L protects male germ cells from heat stress-induced apoptosis Cell Stress Chaperones shRNA TF512620
MAPKAPK2 Phosphorylation of the RNA-binding protein Dazl by MAPKAP kinase 2 regulates spermatogenesis Mol. Biol. Cell shRNA TR320609
MAPKAPK5 The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells Cancers shRNA TL320583
MAPRE2 EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion FASEB J. shRNA TF311571
MAPRE3 EB1- and EB2-dependent anterograde trafficking of TRPM4 regulates focal adhesion turnover and cell invasion FASEB J. shRNA TF311570
MAPT Glucocorticoids activate a synapse weakening pathway culminating in tau phosphorylation in the hippocampus Pharmacol. Res. shRNA TG710015
MAPT Tau Phosphorylation at Serine 396 Residue Is Required for Hippocampal LTD J. Neurosci. shRNA TG710015
Marcks Myristoylated Alanine-Rich protein Kinase C Substrate (MARCKS) expression modulates the metastatic phenotype in human and murine colon carcinoma in vitro and in vivo. Cancer letters shRNA TR512267
MBD4 Epigenetic silencing of RNF144A expression in breast cancer cells through promoter hypermethylation and MBD4 Cancer Med shRNA TG311558
MBD4 CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor Oncogene shRNA TG311558
MBD4 Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. International journal of oncology shRNA TG311558
Mbtps2 MBTPS2 exacerbates albuminuria in streptozotocin-induced type I diabetic nephropathy by promoting endoplasmic reticulum stress-mediated renal damage. Archives of physiology and biochemistry shRNA TL508125
MCAM CD146 is a novel marker for highly tumorigenic cells and a potential therapeutic target in malignant rhabdoid tumor Oncogene shRNA TG311550
MCL1 ER Stress-Mediated Upregulation of miR-29a Enhances Sensitivity to Neuronal Apoptosis Eur. J. Neurosci. shRNA TG303313
MCL1 Dinaciclib, a CDK inhibitor promotes proteasomal degradation of Mcl-1 and enhances ABT-737 mediated cell death in malignant human glioma cell lines J. Pharmacol. Exp. Ther. shRNA TR303313
MCL1 Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis Apoptosis shRNA TG303313
MCL1 Survivin Inhibitor YM-155 Sensitizes Tumor Necrosis Factor– Related Apoptosis-Inducing Ligand-Resistant Glioma Cells to Apoptosis through Mcl-1 Downregulation and by Engaging the Mitochondrial Death Pathway J. Pharmacol. Exp. Ther., Aug 2013; 346: 201 - 210. shRNA TG303313
MCL1 YM-155 Potentiates the Effect of ABT-737 in Malignant Human Glioma Cells via Survivin and Mcl-1 Downregulation in an EGFR-Dependent Context Mol. Cancer Ther., Mar 2013; 12: 326 - 338. shRNA TG303313
MCL1 Inhibition of NF-{kappa}B Signaling by Quinacrine Is Cytotoxic to Human Colon Carcinoma Cell Lines and Is Synergistic in Combination with Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) or Oxaliplatin J. Biol. Chem., Jun 2010; 285: 19162 - 19172 shRNA TR303313
MCOLN1 Defective Autophagosome Trafficking Contributes to Impaired Autophagic Flux in Coronary Arterial Myocytes Lacking CD38 Gene Cardiovasc. Res., Jan 2014. shRNA TR303307
MCOLN2 Zinc Dyshomeostasis Is Linked with the Loss of Mucolipidosis IV-associated TRPML1 Ion Channel J. Biol. Chem., Nov 2010; 285: 34304 - 34308 shRNA TR303306
MCU Molecular tuning of the axonal mitochondrial Ca2+ uniporter ensures metabolic flexibility of neurotransmission bioRxiv shRNA TR704979
MDK Quantitative Analysis of Human Pluripotency and Neural Specification by In-Depth (Phospho)Proteomic Profiling Stem Cell Reports shRNA TG319183
MDM2 Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma Oncol. Res. shRNA TG311529
MDM2 Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters shRNA TR311529
MDM2 FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage Oncogene shRNA TG311529
MDM2 EMILIN1–a4/a9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation J. Cell Biol., Oct 2011; 195: 131 - 145. shRNA TR311529
MECOM Stem cell-like transcriptional reprogramming mediates metastatic resistance to mTOR inhibition Oncogene shRNA TG313148
MECOM Identifying a Potential Molecular Therapeutic Target for MLL-AF9 Leukemia Thesis shRNA TG313148
MEF2C Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell Rep shRNA TF511428
Meg3 Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity Elife shRNA TG501330
MEG3 Crosstalk between Meg3 and miR-1297 regulates growth of testicular germ cell tumor through PTEN/PI3K/AKT pathway Am J Transl Res shRNA TG320132
MEN1 miR-29b Modulates Intestinal Epithelium Homeostasis by Repressing Menin Translation Biochem. J. shRNA TG501333
MEOX1 Mesoderm/mesenchyme homeobox gene l promotes vascular smooth muscle cell phenotypic modulation and vascular remodeling Int. J. Cardiol.2017 shRNA TG311507
MET FOXO1 Suppression is a Determinant of Acquired Lapatinib-Resistance in HER2-Positive Gastric Cancer Cells Through MET Upregulation Cancer Res Treat shRNA TG320418
MET Induction of tumor initiation is dependent on CD44s in c-Met(+) hepatocellular carcinoma BMC Cancer shRNA TG320418
MET Induction of tumor initiation is dependent on CD44s in c-Met+ hepatocellular carcinoma BMC Cancer shRNA TG320418
Metrnl Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. Journal of advanced research shRNA TL702232
MFGE8 Endometrial MFG-E8 regulates TGF-ß induced EMT promoting trophoblast invasion and implantation Reproduction shRNA TR311492
Mfn2 Mitofusin 2 Integrates Mitochondrial Network Remodelling, Mitophagy and Renewal of Respiratory Chain Proteins in Neurons after Oxygen and Glucose Deprivation. Molecular neurobiology shRNA TL712567
MGMT O(6)-Methylguanine-DNA Methyltransferase Is a Novel Negative Effector of Invasion in Glioblastoma Multiforme Mol. Cancer Ther., Nov 2012; 11: 2440 - 2450. shRNA TG316615
MGP Inhibitor of DNA binding-4 promotes angiogenesis and growth of glioblastoma multiforme by elevating matrix GLA levels Oncogene (10 May 2010) doi:10.1038/onc.2010.147 Original Article shRNA TR311480
Mical1 Podocyte Shape Regulation by Semaphorin 3A and MICAL-1 Methods in molecular biology (Clifton, N.J.) shRNA TG506165
MICAL1 Podocyte Shape Regulation by Semaphorin 3A and MICAL-1 Methods Mol. Biol. shRNA TF506165
Micu2 Functional roles of MICU1 and MICU2 in mitochondrial Ca(2+) uptake. Biochimica et biophysica acta shRNA TL712808
MIF UHRF1 regulates the transcriptional repressor HBP1 through MIF in T acute lymphoblastic leukemia Oncology reports shRNA TR319111
MIF Macrophage Migration Inhibitory Factor Regulates Akt Signaling in Hypoxic Culture to Modulate Senescence of Human Mesenchymal Stem Cells Stem Cells Dev. shRNA TR319111
MITF Microphthalmia transcription factor expression contributes to bone marrow failure in Fanconi anemia J. Clin. Invest. shRNA TG514672
MKRN2 Ubiquitous Expression of MAKORIN-2 in Normal and Malignant Hematopoietic Cells and Its Growth Promoting Activity PLoS ONE shRNA TG311466
MLLT11 Involvement of AF1q/MLLT11 in the progression of ovarian cancer Oncotarget shRNA TF319110
MMP1 Matrix Metalloproteinase-1 (MMP1) Upregulation through Promoter Hypomethylation Enhances Tamoxifen Resistance in Breast Cancer Cancers shRNA TL311450
MMP1 Activation of EGFR/p38/HIF-1a is pivotal for angiogenesis and tumorigenesis of malignantly transformed cells induced by hexavalent chromium J. Biol. Chem. shRNA TG311450
MMP13 Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 Tumour Biol. shRNA TG311446
Mmp14 MT1-MMP silencing by an shRNA-armed glioma-targeted conditionally replicative adenovirus (CRAd) improves its anti-glioma efficacy in vitro and in vivo. Cancer letters shRNA TF510301
MMP9 MMP-9 Reinforces Radiation-Induced Delayed Invasion and Metastasis of Surviving Neuroblastoma Cells Through Second-Signaling Positive Feedback With NFkB Via Both ERK and IKK Activation Research Square shRNA TF311436
MMS19 IOP1 Protein Is an External Component of the Human Cytosolic Iron-Sulfur Cluster Assembly (CIA) Machinery and Functions in the MMS19 Protein-dependent CIA Pathway J. Biol. Chem., Jun 2013; 288: 16680 - 16689. shRNA TG303224
MORC2 MORC2 regulates DNA damage response through a PARP1-dependent pathway Nucleic Acids Research shRNA TG311427
MPG Germ-line variants of human N-methylpurine DNA glycosylase show impaired DNA repair activity and facilitate 1,N6 ethenoadenine induced mutations J. Biol. Chem. shRNA TR311419
MSH2 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis shRNA TR311383
MSH3 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis shRNA TR311382
MSH6 Der Einfluss des Mismatch Reparaturfaktors hMSH2 auf distinkte Reparaturwege der DNA Doppelstrangbruch Reparatur thesis shRNA TR311380
MSI1 Upregulation of musashi1 increases malignancy of hepatocellular carcinoma via the Wnt/β-catenin signaling pathway and predicts a poor prognosis BMC Gastroenterol shRNA TG311379
MSI1 The RNA-binding protein Musashi 1 stabilizes the onco tachykinin 1 mRNA in breast cancer cells to promote cell growth FASEB J. shRNA TF311379
MSI2 Transcriptome-wide analysis uncovers the targets of the RNA-binding protein MSI2 and effects of MSI2's RNA-binding activity on IL-6 signaling J. Biol. Chem. shRNA TF303128
MSLN Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation Carcinogenesis, Jul 2011; 32: 1013 - 1024. shRNA TR311377
msr1 Expression of scavenger receptor-AI promotes alternative activation of murine macrophages to limit hepatic inflammation and fibrosis Hepatology shRNA TR515183
MSRA Methionine sulfoxide reductase A down-regulation in human breast cancer cells results in a more aggressive phenotype PNAS, Oct 2010; 107: 18628 - 18633 shRNA TR316620
MST1 MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells Int J Mol Sci shRNA TF514455
Mstn Myostatin induces DNA damage in skeletal muscle of streptozotocin-induced type 1 diabetic mice J. Biol. Chem., Jan 2014. shRNA TG512805
MT2A Development of an Integrated Genomic Classifier for a Novel Agent in Colorectal Cancer: Approach to Individualized Therapy in Early Development Clin. Cancer Res., Jun 2010; 16: 3193 - 3204 shRNA TR319082
MTA1 Mechanism of TRIM25 mediated ubiquitination of metastasis associated protein (MTA) 1 in normal liver cells Exp. Cell Res. shRNA TR311372
mTOR Inactivation of the mTORC1-Eukaryotic Translation Initiation Factor 4E Pathway Alters Stress Granule Formation Mol. Cell. Biol., Jun 2013; 33: 2285 - 2301. shRNA TG320364
MUC1 An intrinsic purine metabolite AICAR blocks lung tumour growth by targeting oncoprotein mucin 1 British Journal of Cancer shRNA TL316625
MUC1 MUC1 protein induces urokinase-type plasminogen activator (uPA) by forming a complex with NF-?B p65 transcription factor and binding to the uPA promoter, leading to enhanced invasiveness of cancer cells J. Biol. Chem. shRNA TG316625
MUS81 Phosphorylation By CK2 Regulates MUS81/EME1 In Mitosis And After Replication Stress bioRxiv shRNA TR303095
MYB MYB is a novel regulator of pancreatic tumour growth and metastasis Br. J. Cancer shRNA TG311329
MYB Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53 Mol. Cell. Biol., Aug 2010; 30: 3981 - 3993 shRNA TR311329
MYC The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal Adenocarcinoma bioRxiv shRNA TF311323
MYC c-Myc Dependent Cell Competition in Human Cancer Cells J. Cell. Biochem shRNA TF311323
Myc GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism J. Immunol. shRNA TR509322
MYC Novel IL-21 signaling pathway up-regulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas Blood, Jan 2010; 115: 570 - 580 shRNA TR311323
MYC Regulation of reactive oxygen species homeostasis by peroxiredoxins and c-Myc J. Biol. Chem., Dec 2008; 10.1074/jbc.M807564200. shRNA TR311323
Myct1 Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc J. Biol. Chem., Mar 2009; 284: 6520 - 6529. shRNA TR513832
MYD88 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TG311320
MYD88 Deubiquitinase CYLD acts as a negative regulator for bacterium NTHi-induced inflammation by suppressing K63-linked ubiquitination of MyD88 Proc. Natl. Acad. Sci. U.S.A. shRNA TG311320
MYH9 Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation bioRxiv shRNA TF311309
MYH9 Proteomics Analysis of the Non-Muscle Myosin Heavy Chain IIa-Enriched Actin-Myosin Complex Reveals Multiple Functions within the Podocyte PLoS ONE shRNA TF311309
MYO5A Myosin Va is Required for the Transport of Fragile X Mental Retardation Protein (FMRP) Granules shRNA TR311295
MYO5A Myosin Va Is Required for P Body but Not Stress Granule Formation J. Biol. Chem., Apr 2011; 286: 11519 - 11528 shRNA TR311295
MYOD1 Repression of ESR1 transcription by MYOD potentiates letrozole-resistance in ERα-positive breast cancer cells Biochem. Biophys. Res. Commun. shRNA TR311289
MYOF Myoferlin-Mediated Lysosomal Exocytosis Regulates Cytotoxicity by Phagocytes J. Immunol. shRNA TR518387
Myt1 Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming Stem Cell Reports shRNA TG501427
MZF1 Phosphorylation-dependent stabilization of MZF1 upregulates N-cadherin expression during protein kinase CK2-mediated epithelial-mesenchymal transition Oncogenesis shRNA TG303059
MZF1 Myeloid Zinc Finger 1 (MZF-1) Regulates Expression of the CCN2/CTGF and CCN3/NOV Genes in the Hematopoietic Compartment J. Cell. Physiol. shRNA TG303059
MZF1 The glyceraldehyde 3-phosphate dehydrogenase gene (GAPDH) is regulated by myeloid zinc finger 1 (MZF-1) and is induced by calcitriol Biochem. Biophys. Res. Commun. July 2014 shRNA TR303059
NACC1 NAC-1, a potential stem cell pluripotency factor, contributes to paclitaxel resistance in ovarian cancer through inactivating Gadd45 pathway Oncogene 28, 1941-1948 (23 March 2009) shRNA TR306354
NANOG The allosteric glycogen synthase kinase-3 inhibitor NP12 limits myocardial remodeling and promotes angiogenesis in an acute myocardial infarction model J. Biol. Chem. shRNA TF303039
NANOG CD133(+) cancer stem cells promoted by VEGF accelerate the recurrence of hepatocellular carcinoma Sci Rep shRNA TR303039
NANOG Overexpression of NANOG in Gestational Trophoblastic Diseases: Effect on Apoptosis, Cell Invasion, and Clinical Outcome Am. J. Pathol., Oct 2008; 173: 1165 - 1172 shRNA TR303039
NAT10 MORC2 regulates DNA damage response through a PARP1-dependent pathway Nucleic Acids Research shRNA TG303028
NBPF1 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer shRNA TR307077
NBPF14 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer shRNA TR303019
NBPF9 NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest BMC Cancer shRNA TR311258
NBR1 The p38-activated ER stress-ATF6α axis mediates cellular senescence FASEB J. shRNA TG311256
NCF1 Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. Free radical biology & medicine shRNA TR311251
NCF2 Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. Free radical biology & medicine shRNA TR311250
NCKAP1 PTEN dephosphorylates Abi1 to promote epithelial morphogenesis J. Cell Biol. shRNA TF510899
NCOA1 MicroRNA-223-3p inhibits human bladder cancer cell migration and invasion Tumour Biol shRNA TG320589
NCOA2 Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog shRNA TR311243
NCOA3 Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog shRNA TR320577
NDRG3 Lactate Promotes Synthetic Phenotype in Vascular Smooth Muscle Cells Circ. Res. shRNA TG303004
NDRG4 NDRG4 promoter hypermethylation is a mechanistic biomarker associated with metastatic progression in breast cancer patients NPJ Breast Cancer shRNA TG303003
NdufA10 Cardiolipin promotes electron transport between ubiquinone and complex I to rescue PINK1 deficiency J. Cell Biol shRNA TR311229
NDUFA13 Repression of GRIM19 expression potentiates cisplatin chemoresistance in advanced bladder cancer cells via disrupting ubiquitination-mediated Bcl-xL degradation Cancer Chemother. Pharmacol. shRNA TR503841
Nedd4l Mutations in the HECT domain of NEDD4L lead to AKT-mTOR pathway deregulation and cause periventricular nodular heterotopia Nat. Genet. shRNA TG505433
Negative Control Serum-borne lipids amplify TLR-activated inflammatory responses J. Leukoc. Biol. shRNA TR30013
Negative Control A β-arrestin-2-dependent mechanism of GPR52 signalling in frontal cortical neurons ACS Chem Neurosci shRNA TR30013
Negative Control Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling Biochim Biophys Acta Mol Cell Biol Lipids shRNA TR30021
Negative Control ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes Front Oncol shRNA TR30021
Negative Control Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema Cell shRNA TR30021
negative Control Mechanism of miR-222 and miR-126 regulation and its role in asbestos-induced malignancy Int. J. Biochem. Cell Biol. shRNA TR30012
Negative Control Pbrm1 Steers Mesenchymal Stromal Cell Osteolineage Differentiation by Integrating PBAF-Dependent Chromatin Remodeling and BMP/TGF-β Signaling Cell Rep shRNA TR30021
negative Control Acid/bile exposure triggers TRAIL-mediated apoptosis in esophageal cancer cells by suppressing the decoy receptors and c-FLIPR The International Journal of Biochemistry & Cell Biology shRNA TR30012
Negative Control Hippocampal GABA-inhibitory circuitry regulates despair-like behavior in mice bioRxiv shRNA TR30013
Negative Control Opposite Control of Excitatory and Inhibitory Synapse Formation by Slitrk2 and Slitrk5 on Dopamine Neurons Modulates Hyperactivity Behavior Cell Rep shRNA TR30021
Negative Control Acute knockdown of Depdc5 leads to synaptic defects in mTOR-related epileptogenesis Neurobiol. Dis. shRNA TR30021
Negative Control The RNA-Binding Ubiquitin Ligase MEX3A Affects Glioblastoma Tumorigenesis by Inducing Ubiquitylation and Degradation of RIG-I Cancers (Basel) 2020 shRNA TR30021
Negative Control Interference with SMO increases chemotherapy drug sensitivity of A2780/DDP cells by inhibiting the Hh/Gli signaling pathway J. Cell. Biochem. shRNA TR30021
Negative Control Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells bioRxiv shRNA TR30013
Negative Control TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance Cell Rep shRNA TR30015
Negative Control Long Noncoding RNA (lncRNA) Maternally Expressed Gene 3 (MEG3) Participates in Chronic Obstructive Pulmonary Disease through Regulating Human Pulmonary Microvascular Endothelial Cell Apoptosis Med Sci Monit shRNA TR30021
Negative Control miR-181c Activates Mitochondrial Calcium Uptake by Regulating MICU1 in the Heart J Am Heart Assoc shRNA TR30021
Negative Control The future of plant biotechnology in a globalized and environmentally endangered world Genet. Mol. Biol. shRNA TR30021
Negative Control Mechanism associated with aberrant lncRNA MEG3 expression in gestational diabetes mellitus Exp Ther Med shRNA TR30021
Negative Control RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells Heliyon shRNA TR30013
Negative Control Nitrate uptake and metabolism in human skeletal muscle cell cultures Nitric Oxide shRNA TR30021
Negative Control Bovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway Vet. Res. shRNA TR30013
Negative Control Cdc20 and molecular chaperone CCT2 and CCT5 are required for the Muscovy duck reovirus p10.8-induced cell cycle arrest and apoptosis Veterinary Microbiology shRNA TR30013
Negative Control EK7 Regulates NLRP3 Inflammasome Activation and Neuroinflammation Post-traumatic Brain Injury Front Mol Neurosci shRNA TR30021
Negative Control Prolactin promotes fibrosis and pancreatic cancer progression Cancer Res. shRNA TR30021
Negative Control Early growth response 1 regulates hematopoietic support and proliferation in human primary bone marrow stromal cells Haematologica shRNA TR30021
Negative Control BCDIN3D regulates tRNAHis 3' fragment processing PLoS Genet. shRNA TR30012
Negative Control HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding Molecular Cell shRNA TR30021
Negative Control Rudhira/BCAS3 couples microtubules and intermediate filaments to promote cell migration for angiogenic remodeling Mol. Biol. Cell shRNA TR30015
Negative Control SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib Cancers (Basel) 2019 shRNA TR30012
Negative Control SORLA regulates endosomal trafficking and oncogenic fitness of HER2 Nat Commun shRNA TR30021
Negative Control c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer Mol Oncol shRNA TR30012
Negative Control Antagonistic interactions between osterix and pyrophosphate during cementum formation Bone shRNA TR30013
Negative Control Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ Sci Rep shRNA TR30021
Negative Control miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma Nat Metab shRNA TR30021
Negative Control Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation Mol. Cell. Biol. shRNA TR30015
Negative Control p38 MAPK activation through B7-H3-mediated DUSP10 repression promotes chemoresistance Sci Rep shRNA TR30003
Negative Control Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2 Kidney International shRNA TR30021
Negative Control Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program Nucleic Acids Res. shRNA TR30021
Negative Control A critical role for the nuclear protein Akirin2 in the formation of mammalian muscle in vivo Genesis shRNA TR30015
Negative Control The CNTNAP2-CASK complex modulates GluA1 subcellular distribution in interneurons Neurosci. Lett. shRNA TR30015
Negative Control The Genetic Basis of Transcriptional and Spatial Heterogeneity of Squamous Features in Pancreatic Ductal Adenocarcinoma bioRxiv shRNA TR30015
Negative Control Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells Pharm. Res. shRNA TR30012
Negative Control TFAP2C- and p63-Dependent Networks Sequentially Rearrange Chromatin Landscapes to Drive Human Epidermal Lineage Commitment Cell Stem Cell shRNA TR30021
Negative Control DKK3 knockdown confers negative effects on the malignant potency of head and neck squamous cell carcinoma cells via the PI3K/Akt and MAPK signaling pathways Int. J. Oncol. shRNA TR30021
Negative Control Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TR30013
Negative Control Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma J. Neurooncol. shRNA TR30021
Negative Control Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1 PLoS Pathog. shRNA TR30021
Negative Control Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1 Cell Death Dis shRNA TR30021
Negative Control Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma Sci Rep shRNA TR30013
Negative Control WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma Theranostics shRNA TR30012
Negative Control BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells Mol Ther Nucleic Acids shRNA TR30015
Negative Control Involvement of an orphan transporter, SLC22A18, in cell growth and drug resistance of human breast cancer MCF7 cells J Pharm Sci shRNA TR30012
Negative Control Epigenetically regulated PAX6 drives cancer cells toward a stem-like state via GLI-SOX2 signaling axis in lung adenocarcinoma Oncogene shRNA TR30021
Negative Control CNTNAP2 stabilizes interneuron dendritic arbors through CASK Mol. Psychiatry shRNA TR30013
Negative Control SORLA-driven endosomal trafficking regulates the oncogenic fitness of HER2 bioRxiv shRNA TR30021
Negative Control Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation Mol. Carcinog. shRNA TR30013
Negative Control Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell shRNA TR30015
Negative Control Epigenetic modifiers promote mitochondrial biogenesis and oxidative metabolism leading to enhanced differentiation of neuroprogenitor cells Cell Death Dis shRNA TR30015
Negative Control Knockdown of ZEB1 suppressed the formation of vasculogenic mimicry and epithelial-mesenchymal transition in the human breast cancer cell line MDA-MB-231 Mol Med Rep shRNA TR30021
Negative Control Reduced N-Type Ca2+Channels in Atrioventricular Ganglion Neurons Are Involved in Ventricular Arrhythmogenesis J Am Heart Assoc shRNA TR30021
Negative Control Sphingosine 1-phosphate regulates proliferation, cell cycle and apoptosis of hepatocellular carcinoma cells via syndecan-1 Prog. Biophys. Mol. Biol.2017 shRNA TR30021
Negative Control Astrocytes promote progression of breast cancer metastases to the brain via a KISS1-mediated autophagy Autophagy shRNA TR30013
Negative Control Innate sensing of influenza A virus hemagglutinin glycoproteins by the host endoplasmic reticulum (ER) stress pathway triggers a potent antiviral response via ER-associated protein degradation J. Virol. shRNA TR30021
Negative Control Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease Aging Cell shRNA TR30013
Negative Control An E2F1/MiR-17-92 Negative Feedback Loop mediates proliferation of Mouse Palatal Mesenchymal Cells Sci Rep shRNA TR30013
Negative Control RBM10 promotes transformation-associated processes in small cell lung cancer and is directly regulated by RBM5 PLoS ONE shRNA TR30003
Negative Control Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas J. Clin. Invest shRNA TR30013
Negative Control Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination Nat Commun shRNA TR30021
Negative Control Hyperglycemia-induced Changes in ZIP7 and ZnT7 Expression Cause Zn(2+) Release from the Sarco(endo)plasmic Reticulum and Mediate ER-stress in the Heart Diabetes shRNA TR30033
Negative Control PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature shRNA TR30013
Negative Control Delaying histone deacetylase response to injury accelerates conversion into repair Schwann cells and nerve regeneration Nat Commun shRNA TR30021
Negative Control Inhibiting the cytoplasmic location of HMGB1 reverses cisplatin resistance in human cervical cancer cells Mol Med Rep shRNA TR30013
Negative Control DNA damage response defect in Williams‑Beuren syndrome INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE shRNA TR30013
Negative control Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation EMBO J. shRNA TR30015
Negative Control Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin Cancer Lett shRNA TR30015
negative control Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Dec 2011; 10.1093/nar/gkr1260. shRNA
NEIL1 Cockayne syndrome group B protein stimulates repair of formamidopyrimidines by NEIL1 DNA glycosylase J. Biol. Chem., Jan 2009; 10.1074/jbc.M807006200. shRNA TR307276
NEK3 Identification of NEK3 Threonine 165 as a Novel Regulatory Phosphorylation Site that Modulates Focal Adhesion Remodeling Necessary for Breast Cancer Cell Migration J. Biol. Chem. shRNA TF320430
NES Identification and Cytoprotective Function of a Novel Nestin Isoform, Nes-S, in Dorsal Root Ganglia Neurons J. Biol. Chem., Mar 2013; 288: 8391 - 8404. shRNA TR311207
Neurod1 MiR-30a-5p and miR-153-3p regulate LPS-induced neuroinflammatory response and neuronal apoptosis by targeting NeuroD1 BMB Reports shRNA TL710234
NF2 Expression of P2X7 Receptor Increases In Vivo Tumor Growth Cancer Res., Jun 2012; 72: 2957 - 2969. shRNA TR316639
NFATC1 TRPC6 channel activation promotes neonatal glomerular mesangial cell apoptosis via calcineurin/NFAT and FasL/Fas signaling pathways Sci Rep shRNA TG302973
NFATC2 NFATC2 Modulates Radiation Sensitivity in Dermal Fibroblasts From Patients With Severe Side Effects of Radiotherapy Frontiers in Oncology shRNA TF311198
NFATC2 An actionable axis linking NFATc2 to EZH2 controls the EMT-like program of melanoma cells Oncogene shRNA TF311198
Nfatc2 Transcriptional regulation of SPROUTY 2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 Leukemia shRNA TG516359
NFATC2 NFATc2 is an intrinsic regulator of melanoma dedifferentiation Oncogene shRNA TF311198
NFATC2 NFAT Targets Signaling Molecules to Gene Promoters in Pancreatic ß Cells Mol. Endocrinol. shRNA TG516359
NFATC2 CD3-T Cell Receptor Co-stimulation through SLAMF3 and SLAMF6 Receptors Enhances RORt Recruitment to the IL17A Promoter in Human T Lymphocytes J. Biol. Chem., Nov 2012; 287: 38168 - 38177. shRNA TG311198
NFE2L2 Effect of the Nrf2-ARE signaling pathway on biological characteristics and sensitivity to sunitinib in renal cell carcinoma Oncol Lett shRNA TG311194
NFE2L2 Oxidative stress-elicited YY1 potentiates antioxidative response via enhancement of NRF2-driven transcriptional activity: A potential neuronal defensive mechanism against ischemia/reperfusion cerebral injury Biomed. Pharmacother. shRNA TR515053
NFE2L2 Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane Toxicol. Appl. Pharmacol. shRNA TG311194
NFE2L2 Nuclear factor erythroid 2-related factor 2 enhances carcinogenesis by suppressing apoptosis and promoting autophagy in nickel-transformed cells J. Biol. Chem shRNA TG311194
NFE2L2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TG311194
Nfe2l2 1,4-Naphthoquinone, a pro-oxidant, ameliorated radiation induced gastro-intestinal injury through perturbation of cellular redox and activation of Nrf2 pathway Drug Discov Ther shRNA TF515053
NFE2L2 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. shRNA TG311194
NFE2L2 ROS/Autophagy/Nrf2 Pathway Mediated Low-Dose Radiation Induced Radio-Resistance in Human Lung Adenocarcinoma A549 Cell Int. J. Biol. Sci. shRNA TG311194
NFKB1 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TR318700
NFKB1 Leptin pro-angiogenic signature in breast cancer is linked to IL-1 signalling British Journal of Cancer 104, 128-137 (7 December 2010) doi:10.1038/sj.bjc.6606013 Full Pape shRNA TR516641
NIT1 A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/ß-catenin signalling pathway Cell Discovery shRNA TG311168
NKD2 Naked2 Acts as a Cargo Recognition and Targeting Protein to Ensure Proper Delivery and Fusion of TGF-{alpha}-containing Exocytic Vesicles at the Lower Lateral Membrane of Polarized MDCK Cells Mol Biol Cell. 2007 Aug;18(8):3081-93. shRNA TR302950
NKX2-5 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR311165
Nlgn2 Cell-type-specific role for nucleus accumbens neuroligin-2 in depression and stress susceptibility Proceedings of the National Academy of Sciences of the United States of America shRNA TG516880
NLK Nemo-like Kinase Drives Foxp3 Stability and Is Critical for Maintenance of Immune Tolerance by Regulatory T Cells Cell Rep shRNA TF501483
NLRP1 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing apoptosis in metastatic melanoma Oncogene shRNA TG303052
NLRP3 Contribution of cathepsin B-dependent Nlrp3 inflammasome activation to nicotine-induced endothelial barrier dysfunction Eur. J. Pharmacol. shRNA TG510752
NLRP3 Procyanidin B2 protects rats from paraquat-induced acute lung injury by inhibiting NLRP3 inflammasome activation Immunobiology shRNA TR510752
NLRP3 Enhancement of endothelial permeability by free fatty acid through lysosomal cathepsin B-mediated Nlrp3 inflammasome activation Oncotarget shRNA TG510752
NLRP3 Involvement of the P2X7-NLRP3 axis in leukemic cell proliferation and death Sci Rep shRNA TG305382
Nlrp3 Inhibition of Hyperhomocysteinemia-Induced Inflammasome Activation and Glomerular Sclerosis by NLRP3 Gene Deletion Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology shRNA TG510752
NLRP3 Instigation of endothelial Nlrp3 inflammasome by adipokine visfatin promotes inter-endothelial junction disruption: role of HMGB1 J. Cell. Mol. Med. shRNA TG510752
NLRP3 Gene silencing of NLRP3 protects against the sepsis-induced hyper -bileacidemia in a rat model Clin. Exp. Immunol. shRNA TG305382
NLRP3 Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1ß Secretion J. Virol., Dec 2011; 85: 13019 - 13026. shRNA TR305382
NLRP3 Francisella tularensis Reveals a Disparity between Human and Mouse NLRP3 Inflammasome Activation J. Biol. Chem., Nov 2011; 286: 39033 - 39042. shRNA TR305382
NLRX1 Nlrx1 regulates neuronal cell death Mol Brain shRNA TG515304
NME2 Promoter-proximal transcription factor binding is transcriptionally active when coupled with nucleosome repositioning in immediate vicinity Nucleic Acids Res. July 2014 shRNA TR311160
NMRK2 SNARE-dependent interaction of Src, EGF receptor and β1 integrin regulates invadopodium formation and tumour cell invasion J. Cell. Sci., Feb 2014. shRNA TF315677
NMS Decreased LIN28B in preeclampsia impairs human trophoblast differentiation and migration FASEB J. shRNA TG311156
Nod1 Cdx2 Expression and Intestinal Metaplasia Induced by H. pylori Infection of Gastric Cells Is Regulated by NOD1-Mediated Innate Immune Responses Cancer research shRNA TL511305
NOD1 Cdx2 expression and intestinal metaplasia induced by H. pylori infection of gastric cells is regulated by NOD1-mediated innate immune responses Cancer Res. shRNA TG511305
NODAL Cancer-associated fibroblasts promote PD-L1 expression in mice cancer cells via secreting CXCL5 Int. J. Cancer shRNA TG501492
NODAL Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo Am J Cancer Res shRNA TG501492
NODAL Nodal promotes the generation of M2-like macrophages and downregulates the expression of IL-12 Eur J Immunol. 2013 Oct 1. shRNA TG302929
NOLC1 Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex J. Biol. Chem., Aug 2011; 286: 27867 - 27871. shRNA TR311147
Non-effective 29-mer Scrambled shRNA The role of the ATPase inhibitor factor 1 (IF1) in cancer cells adaptation to hypoxia and anoxia Biochimica et Biophysica Acta (BBA) - Bioenergetics shRNA TR30013
Non-effective Control Evaluation of tryptophan-aspartic acid repeat-containing protein 34 as a novel tumor-suppressor molecule in human oral cancer Biochem. Biophys. Res. Commun. shRNA TR30012
Non-Effective GFP RhoC regulates actin remodeling to form phagosomes during FcγR-mediated phagocytosis J. Cell. Sci.2017 shRNA TR30008
NONO p54nrb/NONO Regulates cAMP-dependent Glucocorticoid Production by Modulating Phosphodiesterase mRNA Splicing and Degradation Mol. Cell. Biol. shRNA TG311143
NOS1 Sarcolemmal loss of active nNOS (Nos1) is an oxidative stress-dependent, early event driving disuse atrophy J. Pathol. shRNA TG711710
Nos1ap Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice. Science advances shRNA TL511126
NOS2 Inducible nitric oxide synthase (NOS2) knockout mice as a model of trichotillomania PeerJ shRNA TR709254
Nos2 Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype Nat. Immunol. shRNA TR512302
NOS2 Apoptotic Programs Are Determined during Lineage Commitment of CD4+ T Effectors: Selective Regulation of T Effector-Memory Apoptosis by Inducible Nitric Oxide Synthase J. Immunol., Jan 2013; 190: 97 - 105. shRNA TG512302
Notch1 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife shRNA TG513589
NOTCH1 Directed Differentiation of Patient-Specific Induced Pluripotent Stem Cells Identifies the Transcriptional Repression and Epigenetic Modification of NKX2-5, HAND1, and NOTCH1 in Hypoplastic Left Heart Syndrome PLoS ONE July 2014 shRNA TR302916
NOTCH2 NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells Oncol. Rep. shRNA TR302915
NOTCH2 Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo Mol Med Rep shRNA TG302915
Notch2 Short hairpin RNA targeting Notch2 inhibits U87 human glioma cell proliferation by inducing cell cycle arrest and apoptosis in vitro and in vivo Molecular Medicine Reports shRNA TL711020
Notch3 Notch3 is necessary for neuronal differentiation and maturation in the adult spinal cord J. Cell. Mol. Med. shRNA TR515445
NOVA1 Obatoclax interacts synergistically with the irreversible proteasome inhibitor carfilzomib in GC- and ABC- DLBCL cells in vitro and in vivo Molecular cancer therapeutics shRNA TF311136
NOX1 Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis. Free radical biology & medicine shRNA TG311135
NOX1 Nox1 promotes colon cancer cell metastasis via activation of the ADAM17 pathway Eur Rev Med Pharmacol Sci shRNA TF311135
Nox1 NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine shRNA TL514988
NOX1 NADPH oxidase 1-dependent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small cell lung cancer. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine shRNA TL311135
NOX3 Targeting tyrosine kinase inhibitor resistant non-small-cell lung cancer by inducing EGFR degradation via methionine 790 oxidation Antioxid. Redox Signal. shRNA TG302912
NOX4 Guidelines for the Detection of NADPH Oxidases by Immunoblot and RT-qPCR Methods in molecular biology (Clifton, N.J.) shRNA TG302911
NOXA1 Obatoclax Interacts Synergistically with the Irreversible Proteasome Inhibitor Carfilzomib in GC- and ABC-DLBCL Cells In Vitro and In Vivo Mol. Cancer Ther., May 2012; 11: 1122 - 1132. shRNA TR311134
NP100005 NRP-1 expression is strongly associated with the progression of pituitary adenomas Oncol. Rep. shRNA TR30019
NP100041 Retinoic acid synergizes ATO-mediated cytotoxicity by precluding Nrf2 activity in AML cells Br. J. Cancer July 2014 shRNA TR20003
Npr3 NPR3 protects cardiomyocytes from apoptosis through inhibition of cytosolic BRCA1 and TNF-a Cell Cycle shRNA TR709485
Nprl3 DEPDC5 and NPRL3 modulate cell size, filopodial outgrowth, and localization of mTOR in neural progenitor cells and neurons Neurobiol. Dis. shRNA TG501301
NQO2 Control of stability of cyclin D1 by quinone reductase 2 in CWR22Rv1 prostate cancer cells Carcinogenesis, Mar 2012; 33: 670 - 677. shRNA TR311108
Nr1h3 Regulation of Insulin Resistance and Adiponectin Signaling in Adipose Tissue by Liver X Receptor Activation Highlights a Cross-Talk with PPAR? PLoS ONE shRNA TG502381
NR1H4 Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells BMC Cancer shRNA TG320627
NR1H4 Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling PLoS ONE shRNA TG320627
NR1I2 Effects of silenced PAR-2 on cell proliferation, invasion and metastasis of esophageal cancer Oncology Letters shRNA TG320596
NR1I2 Pregnane X Receptor As a Therapeutic Target to Inhibit Androgen Activity Endocrinology, Oct 2010; 10.1210/en.2010-0708 shRNA TR320596
NR2F2 Oncogenic KRAS signaling activates mTORC1 through COUP-TFII-mediated lactate production EMBO Rep. shRNA TR320548
NR4A1 Dendrogenin A drives LXR to trigger lethal autophagy in cancers Nat Commun shRNA TG514239
NR4A1 Chymase Mediates Injury and Mitochondrial Damage in Cardiomyocytes during Acute Ischemia/Reperfusion in the Dog PLoS ONE e94732 9 4. April 2014 shRNA TG320381
NR4A3 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell Rep shRNA TF501493
Nr4a3 Dendrogenin A drives LXR to trigger lethal autophagy in cancers Nat Commun shRNA TF501493
NR5A1 cAMP-stimulated transcription of DGK{theta} requires steroidogenic factor 1 and sterol regulatory element binding protein 1 J. Lipid Res., Aug 2013; 54: 2121 - 2132. shRNA TG311103
NRAS The X-Linked Intellectual Disability Gene Zdhhc9 Is Essential for Dendrite Outgrowth and Inhibitory Synapse Formation Cell Rep shRNA TR712458
NRF1 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TR311098
NRIP1 New Target Genes in Endometrial Tumors Show a Role for the Estrogen-Receptor Pathway in Microsatellite Unstable Cancers Hum. Mutat. shRNA TG311094
NRP1 Sema3a-Nrp1 Signaling Mediates Fast-Twitch Myofiber Specificity of Tw2+ Cells Dev. Cell shRNA TG513573
NRP1 Neuropilin1 is an important niche component and exerts context-dependent effects on hematopoietic stem cells Stem Cells Dev. shRNA TR513573
NRP1 NRP-1 expression is strongly associated with the progression of pituitary adenomas Oncol. Rep. shRNA TR311093
NRP1 The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR311093
Nsd2 The Histone Methyltransferase MMSET Regulates Class Switch Recombination J. Immunol., Jan 2013; 190: 756 - 763. shRNA TF517851
NSUN5 RNA cytosine methyltransferase NSUN5 promotes protein synthesis and tumorigenic phenotypes in glioblastoma. Molecular oncology shRNA TL302876
Nt5e Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis PNAS, Jan 2010; 107: 1547 - 1552 shRNA TR515992
Ntf4 PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise Cell metabolism shRNA TF709774
NTRK1 Safrole oxide induces human umbilical vein endothelial cell transdifferentiation to 5-hydroxytryptaminergic neuron-like cells through tropomyosin receptor kinase A/cyclooxygenase 2/nuclear factor-kappa B/interleukin 8 signaling. The international journal of biochemistry & cell biology shRNA TR320435
NTRK1 Effect of Brain- and Tumor-Derived Connective Tissue Growth Factor on Glioma Invasion J Natl Cancer Inst, Aug 2011; 103: 1162 - 1178. shRNA TR320435
Ntrk2 BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization J. Pathol. shRNA TR510739
NTRK2 TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma Oncogene (18 January 2010) doi:10.1038/onc.2009.486 Original Article shRNA TR320436
NUCB2 Nucleobindin-2 is a positive regulator for insulin-stimulated glucose transporter 4 translocation in fenofibrate treated E11 podocytes [Rapid Communication] Endocr. J. shRNA TR502933
Nucb2 Nucleobindin-2 Is a Positive Modulator of EGF-Dependent Signals Leading to Enhancement of Cell Growth and Suppression of Adipocyte Differentiation Endocrinology, Jul 2012; 153: 3308 - 3319. shRNA TR502933
Nudt1 MTH1 favors mesothelioma progression and mediates paracrine rescue of bystander endothelium from oxidative damage JCI Insight shRNA TL501390
NUMA1 The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair Nucleic Acids Res. shRNA TR311065
NUMB NUMB and NUMBL differences in gene regulation Oncotarget shRNA TR311064
NUMB The cargo protein MAP17 (PDZK1IP1) regulates the cancer stem cell pool activating the Notch pathway by abducting NUMB Clin. Cancer Res shRNA TR311064
Numb Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy Oncotarget shRNA TR311064
NUMB Uric acid crystal could inhibit Numb-induced URAT1 lysosome degradation in uric acid nephropathy J. Physiol. Biochem. shRNA TR311064
NUMBL NUMB and NUMBL differences in gene regulation Oncotarget shRNA TR311063
NumbL Numb-like (NumbL) downregulation increases tumorigenicity, cancer stem cell-like properties and resistance to chemotherapy Oncotarget shRNA TR311063
ODAM ODAM inhibits RhoA-dependent invasion in breast cancer Cell Biochem. Funct. shRNA TG307066
OGA Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation J. Biol. Chem. shRNA TG315637
OGT The essential role of YAP O-GlcNAcylation in high-glucose-stimulated liver tumorigenesis Nat Commun shRNA TG302811
OGT Epithelial mesenchymal transition induces aberrant glycosylation through hexosamine biosynthetic pathway activation J. Biol. Chem. shRNA TG302811
OLR1 Lectin-like oxidized LDL receptor-1 expresses in mouse bone marrow-derived mesenchymal stem cells and stimulates their proliferation. Experimental cell research shRNA TL311028
OMA1 Depletion of mitochondrial protease OMA1 alters proliferative properties and promotes metastatic growth of breast cancer cells Sci Rep shRNA TR302802
OMA1 OMA1 mediates OPA1 proteolysis and mitochondrial fragmentation in experimental models of ischemic kidney injury Am. J. Physiol. Renal Physiol. . March 2014 shRNA TR302802
OR51E1 Ectopically expressed olfactory receptors OR51E1 and OR51E2 suppress proliferation and promote cell death in a prostate cancer cell line The Journal of biological chemistry shRNA TR302775
ORAI1 Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line Cancer Cell Int. shRNA TF301009
ORAI1 Molecular mechanisms of spontaneous and directed mast cell motility J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. shRNA TG301009
ORAI1 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR301009
Orai1 Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line J. Immunol., Feb 2008; 180: 2233 - 2239. shRNA TR301009
ORAI2 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR301008
ORAI3 Arachidonic acid-induced Ca2+entry and migration in a neuroendocrine cancer cell line Cancer Cell Int. shRNA TF307587
ORAI3 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR307587
OSBPL2 Oxysterol-related-binding-protein related Protein-2 (ORP2) regulates cortisol biosynthesis and cholesterol homeostasis Mol. Cell. Endocrinol. shRNA TG310662
OSBPL9 Odd-skipped related 1 is a novel tumour suppressor gene and a potential prognostic biomarker in gastric cancer The Journal of Pathology shRNA TG302749
OSR1 Odd-skipped related 1 is a novel tumor suppressor gene and a potential prognostic biomarker in gastric cancer J. Pathol. shRNA TG302745
P4HB Inhibition of prolyl 4-hydroxylase, beta polypeptide (P4HB) attenuates temozolomide resistance in malignant glioma via the endoplasmic reticulum stress response (ERSR) pathways Neuro Oncology, May 2013; 15: 562 - 577. shRNA TR310639
P4HB Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure Blood, Aug 2010; 116: 993 - 1001 shRNA TR310639
PABPC4 The Cytoplasmic poly(A) Binding Protein, PABPC4, Serves a Critical Role in Erythroid Differentiation Mol. Cell. Biol., Jan 2014. shRNA TG510913
Padi4 Citrullination regulates pluripotency and histone H1 binding to chromatin Nature, Feb 2014. shRNA TF501611
PAF1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG302706
PAF1 A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR302706
PAK1 Modulation of store-operated calcium entry and nascent adhesion by p21-activated kinase 1 Exp. Mol. Med. shRNA TF320442
PAK1 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep shRNA TG501572
PAK1 P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion J. Biol. Chem., Feb 2013; 288: 3025 - 3035. shRNA TG320442
PAK2 Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells Cancers (Basel) 2019 shRNA TF506650
PAK4 p21-Activated kinase 4 promotes prostate cancer progression through CREB Oncogene doi:10.1038/onc.2012.255 shRNA TR320637
PAK4 p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients PNAS, Oct 2010; 107: 18622 - 18627 shRNA TR320637
PAK6 P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor ß Expression and Enhanced Matrix Metalloproteinase 9 Secretion J. Biol. Chem., Feb 2013; 288: 3025 - 3035. shRNA TF320717
PALB2 PALB2 Functionally Connects the Breast Cancer Susceptibility Proteins BRCA1 and BRCA2 Mol. Cancer Res., Jul 2009; 7: 1110 - 1118. shRNA TR307284
Pam16 Magmas, a Gene Newly Identified as Overexpressed in Human and Mouse ACTH-Secreting Pituitary Adenomas, Protects Pituitary Cells from Apoptotic Stimuli Endocrinology, Oct 2010; 151: 4635 - 4642 shRNA TR513987
PANX1 High PANX1 Expression Leads to Neutrophil Recruitment and the Formation of a High Adenosine Immunosuppressive Tumor Microenvironment in Basal-like Breast Cancer Cancers shRNA TF302694
PANX1 Pannexin 1 binds β-catenin to modulate melanoma cell growth and metabolism The Journal of biological chemistry shRNA TR302694
PANX1 Pannexin 1 binds β-catenin to modulate melanoma cell growth and metabolism The Journal of Biological Chemistry shRNA TL302694
PANX1 Inhibition of Pannexin 1 Reduces the Tumorigenic Properties of Human Melanoma Cells Cancers (Basel) 2019 shRNA TR302694
PANX1 Loss of Pannexin 1 Attenuates Melanoma Progression by Reversion to a Melanocytic Phenotype J. Biol. Chem., Aug 2012; 287: 29184 - 29193. shRNA TR302694
PANX1 The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes J. Biol. Chem., Jul 2009; 284: 18143 - 18151 shRNA TR302694
PANX3 Pannexin 3 regulates skin development via Epiprofin Scientific Reports shRNA TG302692
PANX3 Characterization and Function of the~ 70 kDa Immunoreactive Species of Pannexin3 in Rhabdomyosarcomas Thesis shRNA TF302692
Panx3 Pannexin 1 and Pannexin 3 Channels Regulate Skeletal Muscle Myoblast Proliferation and Differentiation J. Biol. Chem. shRNA TF302692
PARD3 Elevated expression of Par3 promotes prostate cancer metastasis by forming a Par3/aPKC/KIBRA complex and inactivating the hippo pathway J. Exp. Clin. Cancer Res. shRNA TR302678
Parp1 Poly(ADP-ribose) Polymerase 1 Mediates Rab5 Inactivation after DNA Damage International Journal of Molecular Sciences shRNA TL509117
PARP1 Poly(ADP-ribose) polymerase 1 is necessary for coactivating hypoxia-inducible factor-1-dependent gene expression by Epstein-Barr virus latent membrane protein 1 PLoS Pathog. shRNA TR315488
PARP1 The Rheumatoid Arthritis Risk Variant CCR6DNP Regulates CCR6 via PARP-1 PLoS Genet. shRNA TG315488
PARP1 Poly(ADP-ribose) Contributes to an Association between Poly(ADP-ribose) Polymerase-1 and Xeroderma Pigmentosum Complementation Group A in Nucleotide Excision Repair J. Biol. Chem., Nov 2012; 287: 39824 - 39833. shRNA TG315488
PARP1 Thrombomodulin Is Silenced in Malignant Mesothelioma by a Poly(ADP-ribose) Polymerase-1-mediated Epigenetic Mechanism J. Biol. Chem., Jun 2011; 286: 19478 - 19488 shRNA TR315488
PARP1 Notch/HES1-mediated PARP1 activation: a cell type–specific mechanism for tumor suppression Blood, Mar 2011; 117: 2891 - 2900 shRNA TR315488
ParvB Expression of parvin-ß is a prognostic factor for patients with urothelial cell carcinoma of the upper urinary tract British Journal of Cancer 103, 852-860 (24 August 2010) doi:10.1038/sj.bjc.6605835 Full Paper shRNA TR310602
PATE4 shRNA mediated ablation of prostate and testis expressed (Pate) messenger RNA results in impaired sperm function and fertility Andrology shRNA TG707288
PAX5 PAX5 is the transcriptional activator of mucolipin-2 (MCOLN2) gene Gene shRNA TG302663
PAX6 Pax6 Regulates the Expression of Dkk3 in Murine and Human Cell Lines, and Altered Responses to Wnt Signaling Are Shown in FlpIn-3T3 Cells Stably Expressing Either the Pax6 or the Pax6(5a) Isoform PLoS ONE July 2014 shRNA TG310597
Pbx3 PBX3 is an important cofactor of HOXA9 in leukemogenesis Blood, Feb 2013; 121: 1422 - 1431. shRNA TG310590
PCBP1 PolyC-binding proteins enhance expression of the CDK2 cell cycle regulatory protein via alternative splicing Nucleic Acids Res. shRNA TG310588
PCBP1 PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer cell shRNA TG310588
Pcdh17 PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death Signal Transduction and Targeted Therapy shRNA TL705847
PCDH7 PCDH7 interacts with GluN1 and regulates dendritic spine morphology and synaptic function Sci Rep shRNA TR700521
PCLO Kinesin Family of Proteins Kif11 and Kif21B Act as Inhibitory Constraints of Excitatory Synaptic Transmission Through Distinct Mechanisms Sci Rep shRNA TF502633
pCMVENTRY Kinesin KIF4A transports integrin ß1 in developing axons of cortical neurons Mol. Cell. Neurosci. shRNA TR30013
PCMVMIR Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells Nature July 2014 shRNA TR30021
PCSK5 Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF310565
PCSK7 Furin Is the Major Proprotein Convertase Required for KISS1-to-Kisspeptin Processing PLoS ONE, Jan 2014. shRNA TF310564
PCSK9 ß-Estradiol Results in a PCSK9-Dependent Increase in LDLR Levels in Human Hepatic HuH7 Cells FEBS J. shRNA TG302581
PCTM1 The MicroRNA 15a/16–1 Cluster Down-regulates Protein Repair Isoaspartyl Methyltransferase in Hepatoma Cells: IMPLICATIONS FOR APOPTOSIS REGULATION J. Biol. Chem., Dec 2011; 286: 43690 - 43700. shRNA
PDCD4 Expression of TRPM8 in human reactive lymphoid tissues and mature B-cell neoplasms Oncol Lett shRNA TG302573
PDCD4 Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression Anat Rec (Hoboken) 2018 shRNA TG302573
PDCD4 MicroRNA-429 sensitizes pancreatic cancer cells to gemcitabine through regulation of PDCD4 Am J Transl Res shRNA TG302573
PDCD6 ALG2 Influences T cell apoptosis by regulating FASLG intracellular transportation Biochem. J. shRNA TG310558
PDCD6 Apoptosis-linked gene 2 promotes breast cancer growth and metastasis by regulating the cytoskeleton Oncotarget shRNA TG310558
PDCD6 Structural and Functional Study of Apoptosis-linked Gene-2/Heme-binding Protein 2 Interactions in HIV-1 Production J. Biol. Chem. shRNA TR310558
PDGFRA PDGFRa Regulates Follicular Cell Differentiation Driving Treatment Resistance and Disease Recurrence in Papillary Thyroid Cancer EBioMedicine shRNA TR310535
PDGFRA Culture dimensionality influences the resistance of glioblastoma stem-like cells to multikinase inhibitors Mol. Cancer Ther. April 2014 shRNA TR310535
PDGFRB Primary breast cancer cell culture yields intra-tumor heterogeneous subpopulations expressing exclusive patterns of receptor tyrosine kinases BMC Cancer shRNA TG310534
PDIA2 Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum The EMBO Journal 29, 4185-4197 (5 November 2010) doi:10.1038/emboj.2010.273 Article shRNA TR310528
PDK1 Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions Cell Rep shRNA TR517458
PDK1 HMGB1 Is Phosphorylated by Classical Protein Kinase C and Is Secreted by a Calcium-Dependent Mechanism J. Immunol., May 2009; 182: 5800 - 5809. shRNA TR320448
PDK1 Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors Cancer Res., Apr 2008; 68: 2820 - 2830 shRNA TR320448
PDK2 Retinoic acid-related orphan receptor alpha reprograms glucose metabolism in glutamine-deficient hepatoma cells Hepatology shRNA TR320449
PDK4 Identification of ERR alpha as a specific partner of PGC-1 alpha for the activation of PDK4 gene expression in muscle FEBS J., Apr 2006; 273: 1669-1680. shRNA TR320451
Per1 Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. Journal of neurochemistry shRNA TL501619
Per1 Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK J. Neurochem. shRNA TG501619
PERP PERP, a p53 pro-apoptotic target, mediates apoptotic cell death in renal ischemia Am J Physiol Renal Physiol, Jan 2009; 10.1152/ajprenal.90438.2008. shRNA TR302542
PEX5 A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS Nature Cell Biology doi:10.1038/ncb2822 shRNA TG310491
Pfkfb3 Differential role of neuronal glucose and PFKFB3 in memory formation during development. Glia shRNA TL712366
PFKFB3 A ROLE FOR PFKFB3/IPFK2 IN OVERNUTRITION-ASSOCIATED ADIPOSE TISSUE AND INTESTINE INFLAMMATORY RESPONSES AND INSULIN RESISTANCE Thesis shRNA TR517196
PFKFB3 Disruption of Inducible 6-Phosphofructo-2-kinase Ameliorates Diet-induced Adiposity but Exacerbates Systemic Insulin Resistance and Adipose Tissue Inflammatory Response J. Biol. Chem., Feb 2010; 285: 3713 - 3721 shRNA TR517196
PGAM2 Oxidative stress activates SIRT2 to deacetylate and stimulate phosphoglycerate mutase Cancer Res. shRNA TG310477
Pgam5 A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy Redox Biology shRNA TR702898
Pgap2 Glycosylphosphatidylinositol biosynthesis and remodeling are required for neural tube closure, heart development, and cranial neural crest cell survival eLife shRNA TL507043
pGFP-C-shLenti Whole-transcriptome microarray analysis reveals regulation of Rab4 by RBM5 in neurons Neuroscience shRNA TR30021
PHF1 Polycomb Group Protein PHF1 Regulates p53-dependent Cell Growth Arrest and Apoptosis J. Biol. Chem., Jan 2013; 288: 529 - 539. shRNA TG302514
PHLPP1 Oncogenic suppression of PHLPP1 in human melanoma. Oncogene shRNA TL302501
PI3K Nuclear but not cytosolic phosphoinositide 3-kinase beta has an essential function in cell survival Mol. Cell. Biol., Mar 2011; 10.1128/MCB.01313-10 shRNA
PIEZO1 Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis Channels shRNA TF313084
PIEZO2 A critical role for Piezo2 channels in the mechanotransduction of mouse proprioceptive neurons Sci Rep shRNA TR509519
PIK3C2A Grainyhead 1 acts as a drug-inducible conserved transcriptional regulator linked to insulin signaling and lifespan Nature Communications shRNA TL310432
Pik3c3 Simultaneous Inhibition of BCR-ABL1 Tyrosine Kinase and PAK1/2 Serine/Threonine Kinase Exerts Synergistic Effect against Chronic Myeloid Leukemia Cells Cancers shRNA TF506698
Pik3c3 Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife shRNA TG506698
PIK3C3 pp60c-Src Phosphorylates and Activates Vacuolar Protein Sorting 34 to Mediate Cellular Transformation Cancer Res., Jul 2010; 70: 5974 - 5983 shRNA TR310429
Pik3ca Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG501641
PIK3CB Nuclear phosphoinositide 3-kinase ß controls double-strand break DNA repair PNAS, Apr 2010; 107: 7491 - 7496 shRNA TR310427
Pik3cb Specific function of phosphoinositide 3-kinase beta in the control of DNA replication Proceedings of the National Academy of Sciences of the United States of America shRNA TF711892
PIK3CB Specific function of phosphoinositide 3-kinase beta in the control of DNA replication PNAS, May 2009; 106: 7525 - 7530. shRNA TR310427
Pik3r1 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Nov 2012; 10.1093/nar/gks1095. shRNA TG509680
PIK3R1 p85ß phosphoinositide 3-kinase subunit regulates tumor progression PNAS, Jun 2012; 10.1073/pnas.1118138109. shRNA TR307821
PIM1 miR24-2 accelerates progression of liver cancer cells by activating Pim1 through tri-methylation of Histone H3 on the ninth lysine J. Cell. Mol. Med. shRNA TF315503
PIM1 HistoneH3 demethylase JMJD2A promotes growth of liver cancer cells through up-regulating miR372 Oncotarget shRNA TG315503
PINK1 Clearance of damaged mitochondria via mitophagy is important to the protective effect of ischemic preconditioning in kidneys Autophagy shRNA TR705269
PINK1 Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy J. Neurochem. shRNA TR320728
PINK1 Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission J. Biol. Chem., May 2009; 284: 13843 - 13855. shRNA TR320728
Pip5k1b DNA damage causes rapid accumulation of phosphoinositides for ATR signaling Nat Commun shRNA TF517012
Pip5k1b Acute and Temporal Expression of Tumor Necrosis Factor (TNF)-α-stimulated Gene 6 Product, TSG6, in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successful Transplantation into Muscle Tissue The Journal of Biological Chemistry shRNA TF517012
PITX1 Downregulated PITX1 Modulated by MiR-19a-3p Promotes Cell Malignancy and Predicts a Poor Prognosis of Gastric Cancer by Affecting Transcriptionally Activated PDCD5 Cell. Physiol. Biochem. shRNA TG310405
PIWIL2 Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis Oncotarget shRNA TG302470
PKM Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein Viruses shRNA TG302462
Pkm Functional polarization of tumour-associated macrophages by tumour-derived lactic acid Nature July 2014 shRNA TG511241
Pla2g6 H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells Antioxid. Redox Signal. shRNA TG700671
Pla2g6 Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development FASEB J, Jun 2010; 10.1096/fj.10-161356 shRNA TR515018
plasmid Oxygen-coupled redox regulation of the skeletal muscle ryanodine receptor-Ca2+ release channel by NADPH oxidase 4 PNAS, Sep 2011; 108: 16098 - 16103. shRNA
PLCG1 CCR7/CCL21 Migration on Fibronectin Is Mediated by Phospholipase C{gamma}1 and ERK1/2 in Primary T Lymphocytes J. Biol. Chem., Dec 2010; 285: 38781 - 38787 shRNA TF302445
Pld1 Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors Cell Reports shRNA TF711124
Pld2 Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors Cell Reports shRNA TF711696
PLD2 Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment Oncogene shRNA TR511484
Pld3 Rare coding variants in Phospholipase D3 (PLD3) confer risk for Alzheimer's disease Nature shRNA TL501676
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013. shRNA TG310364
PLD3 Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease Nature Dec 2013. shRNA TG501676
PLK1 PLK1 inhibition downregulates polycomb group protein BMI1 via modulation of the miR-200c/141 cluster J. Biol. Chem. shRNA TG320457
PLK1 PLK1 Inhibitors Synergistically Potentiate HDAC Inhibitor Lethality in Imatinib Mesylate–Sensitive or –Resistant BCR/ABL+ Leukemia Cells In Vitro and In Vivo Clin. Cancer Res., Jan 2013; 19: 404 - 414. shRNA TG320457
PLK1 Centrosomal Protein 55 (Cep55) Stability Is Negatively Regulated by p53 Protein through Polo-like Kinase 1 (Plk1) J. Biol. Chem., Feb 2012; 287: 4376 - 4385. shRNA TR320457
PLOD3 Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression Mol. Cell. Probes shRNA TR310350
PLPP3 Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development Cardiovasc. Res. shRNA TG302357
Plpp6 Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes Drug Metab. Dispos. shRNA TR703334
PLXNA1 The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR302406
Pmaip1 Noxa/HSP27 complex delays degradation of ubiquitylated IkBα in airway epithelial cells to reduce pulmonary inflammation Mucosal Immunol shRNA TR512752
PMAIP1 NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5 Int. J. Oncol. shRNA TR318983
Pnpla8 H2O2-activated mitochondrial phospholipase iPLA2? prevents lipotoxic oxidative stress in synergy with UCP2, amplifies signaling via G-protein-coupled receptor GPR40, and regulates insulin secretion in pancreatic ß-cells Antioxid. Redox Signal. shRNA TG706565
PODXL High Podocalyxin levels promote cell viability partially through up-regulation of Annexin A2 Biochem. Biophys. Res. Commun. shRNA TG310316
PODXL Methylation of an intronic region regulates miR-199a in testicular tumor malignancy Oncogene (7 March 2011) doi:10.1038/onc.2011.60 Original Article shRNA TR310316
Pofut1 Secretory expression of mammalian NOTCH tandem epidermal growth factor-like repeats based on increased O-glycosylation. Analytical biochemistry shRNA TG506022
POLD3 Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney Am J Physiol Renal Physiol, Dec 2012; 303: F1629 - F1640. shRNA TG310310
PON1 Paraoxonase-1 (PON1) induces metastatic potential and apoptosis escape via its antioxidative function in lung cancer cells Oncotarget shRNA TR310286
Positive Control An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation DNA Res shRNA TR30002
POU1F1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. shRNA TG310279
POU2F1 Epigenetic events involved in OCT1-dependent impaired response of hepatocellular carcinoma to sorafenib Br. J. Pharmacol. shRNA TF310277
POU2F1 Role of SUMO activating enzyme in cancer stem cell maintenance and self-renewal Nature Communications shRNA TL310277
POU2F3 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus The Journal of Clinical Investigation shRNA TG310275
POU5F1 OCT4 accelerates tumorigenesis through activating JAK/STAT signaling in ovarian cancer side population cells Cancer Manag Res shRNA TR310267
POU5F1 MiR-145 regulates cancer stem-like properties and epithelial-to-mesenchymal transition in lung adenocarcinoma-initiating cells Tumour Biol. shRNA TF310267
POU5F1 OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation Cell Death Dis, Jan 2014. shRNA TG310267
PPARD Exercise Training-Induced PPARβ Increases PGC-1α Protein Stability and Improves Insulin-Induced Glucose Uptake in Rodent Muscles Nutrients shRNA TG501712
PPARD PPARβ Is Essential for Maintaining Normal Levels of PGC-1α and Mitochondria and for the Increase in Muscle Mitochondria Induced by Exercise Cell Metab. shRNA TF709733
PPARD Changes in PPARδ expression in a rat model of stress-induced depression Clin. Exp. Pharmacol. Physiol shRNA TR709733
Ppard Serine Carboxypeptidase SCPEP1 and Cathepsin A Play Complementary Roles in Regulation of Vasoconstriction via Inactivation of Endothelin-1 PLoS Genetics shRNA TF501712
Pparg Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF510219
PPARG Lack of epithelial PPARγ causes cystic adenomatoid malformations in mouse fetal lung Biochem. Biophys. Res. Commun. shRNA TG510219
PPARG Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP Proc. Natl. Acad. Sci. U.S.A. shRNA TG320459
PPARG TGFß can stimulate the p(38)/ß-catenin/PPAR? signaling pathway to promote the EMT, invasion and migration of non-small cell lung cancer (H460 cells) Clin. Exp. Metastasis shRNA TR320459
PPARGC1A PPRC1, but not PGC-1α, levels directly correlate with expression of mitochondrial proteins in human dermal fibroblasts Genet. Mol. Biol. shRNA TG310260
PPARGC1A Genome-wide analyses of transcription factors and co-regulators across seven cohorts identified reduced PPARGC1A expression as a driver of prostate cancer progression bioRxiv shRNA TG310260
PPARGC1A Nicotinamide Pathway-Dependent Sirt1 Activation Restores Calcium Homeostasis to Achieve Neuroprotection in Spinocerebellar Ataxia Type 7 Neuron shRNA TG310260
PPARGC1A c-MYB- and PGC1a-dependent metabolic switch induced by MYBBP1A loss in renal cancer Mol Oncol shRNA TR310260
PPARGC1A PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis Nat. Cell Biol. shRNA TG310260
Ppif Cyclophilin D-induced mitochondrial impairment confers axonal injury after intracerebral hemorrhage in mice Neural Regeneration Research shRNA TL713307
PPP1R12A Downregulation of MYPT1 increases tumor resistance in ovarian cancer by targeting the Hippo pathway and increasing the stemness Mol. Cancer shRNA TR310238
PPP2CA Restoration of PPP2CA expression reverses epithelial-to-mesenchymal transition and suppresses prostate tumour growth and metastasis in an orthotopic mouse model Br. J. Cancer shRNA TG310229
PPP2R1A Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors Mod. Pathol. shRNA TR310227
PPP4R2 PATZ1 induces PP4R2 to form a negative feedback loop on IKK/NF-κB signaling in lung cancer Oncotarget shRNA TF302311
PRB1 Transcriptional Activation by pRB and Its Coordination with SWI/SNF Recruitment Cancer Res., Nov 2010; 70: 8282 - 8287 shRNA TR310199
PRDX1 Peroxiredoxin 1 protein interacts with influenza virus ribonucleoproteins and is required for efficient virus replication Vaccine shRNA TG302287
PRDX1 Dithiol-based Compounds Maintain Expression of Antioxidant Protein Peroxiredoxin 1 That Counteracts Toxicity of Mutant Huntingtin J. Biol. Chem., Jun 2012; 287: 22717 - 22729. shRNA TR302287
PRDX2 Silencing peroxiredoxin-2 sensitizes human colorectal cancer cells to ionizing radiation and oxaliplatin Cancer Lett shRNA TR310194
PRDX5 Peroxiredoxin 5 is involved in cancer cell invasion and tumor growth of oral squamous cell carcinoma. Oral diseases shRNA TL310192
PRDX5 Regulation of Reactive Oxygen Species Homeostasis by Peroxiredoxins and c-Myc J. Biol. Chem., Mar 2009; 284: 6520 - 6529. shRNA TR503057
PRDX6 Peroxiredoxin 6 (Prdx6) supports NADPH oxidase1 (Nox1)-based superoxide generation and cell migration Free Radic. Biol. Med. shRNA TR310191
pRFP-C-RS Triclosan Impairs Hippocampal Synaptic Plasticity and Spatial Memory in Male Rats Front Mol Neurosci shRNA TR30014
PRKAA1 DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide Eur. J. Pharmacol. shRNA TG320461
PRKAA1 Regulation of inositol 1,4,5-trisphosphate-induced Ca2+ release from the endoplasmic reticulum by AMP-activated kinase modulators Cell Calcium shRNA TG320461
PRKAA1 Folate Metabolism Regulates Oligodendrocyte Survival and Differentiation by Modulating AMPKα Activity Sci Rep shRNA TR505729
PRKAA1 Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression Clin Exp Metastasis. 2013 Oct 5 shRNA TG505729
PRKAA2 AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation J. Cell. Sci. shRNA TG320462
PRKAA2 Identification of a novel AMPK-PEA15 axis in the anoikis-resistant growth of mammary cells Breast Cancer Res. shRNA TF320462
PRKAA2 AMPK protects proximal tubular cells from stress-induced apoptosis by an ATP-independent mechanism: potential role of Akt activation Am J Physiol Renal Physiol, Dec 2011; 301: F1177 - F1192. shRNA TR320462
PRKAB1 Reduced expression of AMPK-ß1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer Mol. Cancer shRNA TG315591
Prkca Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nat Commun shRNA TG501653
PRKCA Caveolin-1 promotes resistance to chemotherapy-induced apoptosis in Ewing's sarcoma cells by modulating PKC{ALPHA} phosphorylation shRNA TR320466
PRKCA PCPH/ENTPD5 Expression Confers to Prostate Cancer Cells Resistance against Cisplatin-Induced Apoptosis through Protein Kinase C–Mediated Bcl-2 Stabilization Cancer Res., Jan 2009; 69: 102 - 110. shRNA TR320466
PRKCD Protein Kinase C Delta restrains growth in ACTH-secreting pituitary adenoma cells Mol. Cell. Endocrinol. shRNA TG513052
PRKCD Distinct ICD substrate modifications selectively regulate ectodomain cleavage of NRG1 or CD44 Mol. Cell. Biol. shRNA TG320468
PRKCD Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 Cell. Signal. shRNA TR320468
PRKCD PKCd maintains phenotypes of tumor initiating cells through cytokine-mediated autocrine loop with positive feedback Oncogene shRNA TG320468
PRKCD Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy J. Cell. Physiol. shRNA TG513052
PRKCD miR-26a Plays an Important Role in Cell Cycle Regulation in ACTH-Secreting Pituitary Adenomas by Modulating Protein Kinase C Endocrinology, May 2013; 154: 1690 - 1700. shRNA TG320468
PRKCD Sprouty2 Interacts with Protein Kinase C and Disrupts Phosphorylation of Protein Kinase D1 J. Biol. Chem., Jul 2009; 284: 19623 - 19636 shRNA TR320468
PRKCD Connexin43 Potentiates Osteoblast Responsiveness to Fibroblast Growth Factor 2 via a Protein Kinase C-Delta/Runx2–dependent Mechanism Mol. Biol. Cell, Jun 2009; 20: 2697 - 2708 shRNA TR320468
PRKCD PCPH/ENTPD5 Expression Enhances the Invasiveness of Human Prostate Cancer Cells by a Protein Kinase C{delta} Dependent Mechanism Cancer Res. 2007 Nov 15;67(22):10859-68 shRNA TR320468
PRKCE Adenosine A1 receptor activation modulates human equilibrative nucleoside transporter 1 (hENT1) activity via PKC-mediated phosphorylation of serine-281 Cell. Signal. shRNA TR320469
PRKCI PRKCI negatively regulates autophagy via PIK3CA/AKT-MTOR signaling Biochem. Biophys. Res. Commun. shRNA TR320472
PRKCI Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota Cancer Res. 2008; 68(18): p. 7403-7408 shRNA TR320472
PRKCQ Suppression of protein kinase C theta contributes to enhanced myogenesis In vitro via IRS1 and ERK1/2 phosphorylation BMC Cell Biol. 2013 Sep 21;14:39. shRNA TG501657
PRKCZ Identification of a Small Molecule with Synthetic Lethality for K-Ras and Protein Kinase C Iota Cancer Res. 2008; 68(18): p. 7403-7408 shRNA TR320477
PRKDC DNA-PKcs controls calcineurin mediated IL-2 production in T lymphocytes PLoS ONE shRNA TR320478
PRKN Parkin Protects Against Misfolded SOD1 Toxicity by Promoting Its Aggresome Formation and Autophagic Clearance Mol. Neurobiol. shRNA TG310609
PRMT5 Protein Arginine Methyltransferase 5 (PRMT5) Signaling Suppresses Protein Kinase C- and p38-dependent Signaling and Keratinocyte Differentiation J. Biol. Chem., Mar 2012; 287: 7313 - 7323. shRNA TR310167
PROM1 Ultrasound-targeted microbubble destruction-mediated downregulation of CD133 inhibits epithelial-mesenchymal transition, stemness and migratory ability of liver cancer stem cells Oncol. Rep. shRNA TG310163
PRPF39 Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation Journal of Virology shRNA TL302262
pRS Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters shRNA TR20003
PRS Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection J. Exp. Med., Aug 2011; 208: 1823 - 1834. shRNA
pRS The Elk-1 and Serum Response Factor Binding Sites in the Major Immediate-Early Promoter of the Human Cytomegalovirus are Required for Efficient Viral Replication in Quiescent Cells and Compensate for Inactivation of the NF-{kappa}B Sites in Proliferating Cells J. Virol., May 2010; 84: 4481 - 4493 shRNA
pRS vector HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer Nature (13 December 2009) doi:10.1038/nature08697 Letter shRNA
pRS vector Heparanase Alters Arterial Structure, Mechanics, and Repair Following Endovascular Stenting in Mice Circ. Res., Dec 2008; 10.1161/CIRCRESAHA.108.180695. shRNA
pRS vector Tumor Suppressor Activity of CCAAT/Enhancer Binding Protein {alpha} Is Epigenetically Down-regulated in Head and Neck Squamous Cell Carcinoma Cancer Res. 2007 May 15;67(10):4657-64. shRNA
PS100001 Funktionelle Charakterisierung des putativen Tumorsuppressors Epithelial Membrane Protein 3 Thesis shRNA TR30007
PS100001 CD109 plays a role in osteoclastogenesis PLoS ONE Apr2013 shRNA TR30013
PS100027 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Mol. Cell. Biol. shRNA TR30013
PSIP1 High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells Cell. Physiol. Biochem. shRNA TR505629
PSME3 The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells Nat Commun shRNA TG302223
PSME3 REGγ potentiates TGF-β/Smad signal dependent epithelial-mesenchymal transition in thyroid cancer cells Cell. Signal. shRNA TG302223
PSME3 REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway Cell Death Differ. shRNA TG302223
PSME3 REGγ deficiency suppresses tumor progression via stabilizing CK1ε in renal cell carcinoma Cell Death Dis shRNA TG302223
PSME3 REGγ controls Hippo signaling and reciprocal NF-κB-YAP regulation to promote colon cancer Clin. Cancer Res. shRNA TR501768
PSME3 REG? is critical for skin carcinogenesis by modulating the Wnt/ß-catenin pathway Nat Commun shRNA TG302223
PSME3 PA28 is a novel corepressor of HTLV-1 replication and controls viral latency Blood, Jan 2013; 121: 791 - 800. shRNA TG302223
PSTPIP1 PSTPIP1 inhibition of TCR signalling depends on its SH3 domain FEBS J. July 2014 shRNA TF310088
PTAFR Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. shRNA TR310087
PTAFR Platelet-activating factor receptor-mediated PI3K/AKT activation contributes to the malignant development of esophageal squamous cell carcinoma Oncogene shRNA TR310087
PTBP1 Integrated analysis of a compendium of RNA-Seq datasets for splicing factors bioRxiv shRNA TG501773
PTEN PTEN is a predictive biomarker of trastuzumab resistance and prognostic factor in HER2-overexpressing gastroesophageal adenocarcinoma Scientific Reports shRNA TL320498
PTEN F-box and leucine-rich repeat protein 5 promotes colon cancer progression by modulating PTEN/PI3K/AKT signaling pathway Biomed. Pharmacother. shRNA TG320498
PTEN Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a Mol. Cancer shRNA TG320498
PTEN Long noncoding RNA MEG3 suppresses liver cancer cells growth through inhibiting β-catenin by activating PKM2 and inactivating PTEN Cell Death Dis shRNA TG320498
PTEN Sensitivity of PTEN deficient non-small cell lung cancer to ionising radiation through inhibition of ataxia terangiectasia related 3 kinase (ATR) Cancer Research shRNA TG320498
PTEN Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG320498
PTEN Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent Am J Clin Exp Urol shRNA TR320498
PTEN RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res. shRNA TG320498
PTEN Atorvastatin overcomes gefitinib resistance in KRAS mutant human non-small cell lung carcinoma cells Cell Death Dis. 2013 Sep 26;4:e814. doi: 10.1038/cddis.2013.312. shRNA TR320498
PTEN Short hairpin RNA against PTEN enhances regenerative growth of corticospinal tract axons after spinal cord injury J Neurosci. 2013 Sep 25;33(39):15350-61 shRNA TR320498
PTEN Cooperation of protease-activated receptor 1 and integrin a?ß5 in thrombin-mediated lung cancer cell invasion Oncol. Rep. shRNA TG320498
PTEN MicroRNA-21 Is a Downstream Effector of AKT That Mediates Its Antiapoptotic Effects via Suppression of Fas Ligand J. Biol. Chem., Jun 2010; 285: 20281 - 20290 shRNA TR320498
PTEN Immunosuppressive Cyclosporin A Activates AKT in Keratinocytes through PTEN Suppression: IMPLICATIONS IN SKIN CARCINOGENESIS J. Biol. Chem., Apr 2010; 285: 11369 - 11377 shRNA TR320498
PTGER2 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. shRNA TG310080
PTGER4 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. shRNA TG310079
PTGER4 Prostaglandin E receptor EP4 is a therapeutic target in breast cancer cells with stem-like properties Breast Cancer Res. Treat. shRNA TR310079
PTGES Allergin-1 Immunoreceptor Suppresses House Dust Mite-Induced Allergic Airway Inflammation J. Immunol. shRNA TG503457
PTGES Resistance of melanoma to immune checkpoint inhibitors is overcome by targeting the sphingosine kinase-1 Nat Commun shRNA TG318942
PTGR1 Leukotriene B4 BLT Receptor Signaling Regulates the Level and Stability of Cyclooxygenase-2 (COX-2) mRNA through Restricted Activation of Ras/Raf/ERK/p42 AUF1 Pathway J. Biol. Chem., Jul 2010; 285: 23568 - 23580. shRNA TR311650
PTGS2 Analysis of the in vitro and in vivo effects of Photodynamic Therapy on Prostate Cancer by using new photosensitizers, protoporphyrin IX-polyamine derivatives Biochim. Biophys. Acta shRNA TR310074
PTGS2 Identification and validation of COX-2 as a co-target for overcoming cetuximab resistance in colorectal cancer cells Oncotarget shRNA TG310074
PTGS2 IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs Oncotarget shRNA TG310074
PTGS2 Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections Nat. Med. shRNA TG310074
PTGS2 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. shRNA TG501784
PTGS2 Premetastatic soil and prevention of breast cancer brain metastasis Neuro Oncology, Jul 2013; 15: 891 - 903. shRNA TG310074
PTK2 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep shRNA TG514293
Ptk2b α 1 -Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca 2+ channel Ca V 1.2 activity and long-term potentiation in rodents eLife shRNA TL710108
PTK2B The Human Ion Channel TRPM2 Modulates Neuroblastoma Cell Survival and Mitochondrial Function through Pyk2, CREB, and MCU Activation Am. J. Physiol., Cell Physiol. shRNA TG320352
Ptk2b Sustained Gq-Protein Signaling Disrupts Striatal Circuits via JNK J. Neurosci. shRNA TR501788
PTK7 Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis J. Biol. Chem. July 2014 shRNA TF200451
PTP4A3 PRL-3 activates mTORC1 in Cancer Progression Sci Rep shRNA TR320652
Ptpn12 Macrophage Fusion Is Controlled by the Cytoplasmic Protein Tyrosine Phosphatase PTP-PEST/PTPN12 Mol. Cell. Biol., Jun 2013; 33: 2458 - 2469. shRNA TG310066
Ptpn13 The serologically defined colon cancer antigen-3 interacts with the protein tyrosine phosphatase PTPN13 and is involved in the regulation of cytokinesis. Oncogene shRNA TL510136
PTPN21 BMX negatively regulates BAK function thereby increasing apoptotic resistance to chemotherapeutic drugs Cancer Res. shRNA TR310062
PTPN5 Tyrosine dephosphorylation is required for Bak activation in apoptosis The EMBO Journal (19 October 2010) doi:10.1038/emboj.2010.244 Article shRNA TR310058
PTPN6 SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma Neoplasia July 2014 shRNA TG310057
PTPRH Tyrosine dephosphorylation is required for Bak activation in apoptosis The EMBO Journal shRNA TR310053
PTPRJ Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases J. Biol. Chem., Aug 2009; 284: 22048 - 22058 shRNA TR310052
PTRH2 Downregulation of Bit1 expression promotes growth, anoikis resistance, and transformation of immortalized human bronchial epithelial cells via Erk activation-dependent suppression of E-cadherin Biochem. Biophys. Res. Commun.2017 shRNA TR302190
PTRH2 The Anoikis Effector Bit1 Inhibits EMT through Attenuation of TLE1-Mediated Repression of E-Cadherin in Lung Cancer Cells PLoS ONE shRNA TR302190
PTTG1 Pituitary tumor-transforming gene 1 regulates invasion of prostate cancer cells through MMP13 Tumour Biol. shRNA TG310042
PTTG1 PTTG1 Oncogene Promotes Tumor Malignancy via Epithelial to Mesenchymal Transition and Expansion of Cancer Stem Cell Population J. Biol. Chem., Jun 2012; 287: 19516 - 19527. shRNA TR310042
PUM2 Translational Regulation of Acetylcholinesterase by the RNA-binding Protein Pumilio-2 at the Neuromuscular Synapse J. Biol. Chem., Oct 2011; 286: 36492 - 36499. shRNA TR302189
PWP1 PWP1 Promotes the Malignant Phenotypes of Lung Cancer Cells by Interacting with DVL2 and Merlin Onco Targets Ther shRNA TR310031
PYCARD Activation of inflammasomes in podocyte injury of mice on the high fat diet: Effects of ASC gene deletion and silencing Biochim. Biophys. Acta, Feb 2014. shRNA TR310027
Pygo2 Overexpression of Pygopus-2 is required for canonical Wnt activation in human lung cancer Oncol Lett, Dec 2013. shRNA TF317702
QPRT The Endogenous Tryptophan Metabolite and NAD+ Precursor Quinolinic Acid Confers Resistance of Gliomas to Oxidative Stress Cancer Res., Jun 2013; 73: 3225 - 3234. shRNA TG310018
QSOX1 Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis Int J Mol Sci shRNA TG310017
QSOX1 Quiescin Sulfhydryl Oxidase 1 (QSOX1) Secreted by Lung Cancer Cells Promotes Cancer Metastasis Preprints shRNA TG515942
RAB10 Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med shRNA TG302162
RAB11A Membrane depolarization activates BK channels through ROCK-mediated β1 subunit surface trafficking to limit vasoconstriction Sci Signal shRNA TR711274
RAB11A Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction Am. J. Physiol., Cell Physiol. shRNA TG310015
Rab31 INVESTIGATIONS ON RAB31'S ROLE IN EGFR TRAFFICKING AND NEURAL PROGENITOR CELL DIFFERENTIATION TOWARDS ASTROGLIA Thesis shRNA TF509046
Rab31 Engagement of the Small GTPase Rab31 and its Effector, Early Endosome Antigen 1, is Important for Trafficking of Ligand-bound Epidermal Growth Factor Receptor from Early to Late Endosome J. Biol. Chem. shRNA TF509046
RAB4A Angiotensin II stimulates internalization and degradation of arterial myocyte plasma membrane BK channels to induce vasoconstriction Am. J. Physiol., Cell Physiol. shRNA TG309988
RAB7A Rab7 Regulates CDH1 Endocytosis, Circular Dorsal Ruffles Genesis and Thyroglobulin Internalization in a Thyroid Cell Line J. Cell. Physiol. shRNA TR710925
RAB7A Bovine Ephemeral Fever Virus Uses a Clathrin-Mediated and Dynamin 2-Dependent Endocytosis Pathway That Requires Rab5 and Rab7 as Well as Microtubules J. Virol., Dec 2012; 86: 13653 - 13661. shRNA TG309983
RAB7A Large Putative PEST-like Sequence Motif at the Carboxyl Tail of Human Calcium Receptor Directs Lysosomal Degradation and Regulates Cell Surface Receptor Level J. Biol. Chem., Feb 2012; 287: 4165 - 4176. shRNA TR309983
RAB8B Tuba activates Cdc42 during neuronal polarization downstream of the small GTPase Rab8a bioRxiv shRNA TG713207
Rac1 CXCL12-induced rescue of cortical dendritic spines and cognitive flexibility eLife shRNA TL712781
RAC2 Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors Blood, May 2012; 119: 4253 - 4263. shRNA TR318935
RAC3 Role of RAC3 coactivator in the adipocyte differentiation Cell Death Discov shRNA TG510528
RACK1 NPY1-36 and PYY1-36 activate cardiac fibroblasts: an effect enhanced by genetic hypertension and inhibition of dipeptidyl peptidase 4 Am. J. Physiol. Heart Circ. Physiol. shRNA TR312717
RAD17 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR302133
RAD54L BLM helicase stimulates the ATPase and chromatin-remodeling activities of RAD54 J. Cell Sci., Aug 2009; 10.1242/jcs.051813 shRNA TR309964
RAD9A Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery Hum. Mol. Genet., Oct 2010; 10.1093/hmg/ddq451 shRNA TR309962
Raf1 Crosstalk between autophagy and apoptosis in the regulation of paclitaxel-induced cell death in v-Ha-ras-transformed fibroblasts. Molecular and cellular biochemistry shRNA TR516793
RALA Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. shRNA TR309957
RALa Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 shRNA TR309957
RALa ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR309957
RALB Nodal signals via ß-arrestins and RalGTPases to regulate trophoblast invasion Cell. Signal. shRNA TR309956
RALb Dual regulation of lysophosphatidic acid (LPA1) receptor signalling by Ral and GRK Cellular Signalling, Volume 21, Issue 7, July 2009, Pages 1207-1217 shRNA TR309956
RALb ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells Mol. Cancer Res., Jul 2009; 7: 1064 - 1077 shRNA TR309956
RAMP1 Calcitonin Gene-Related Peptide Rescues Proximity Associations of Its Receptor Components Calcitonin Receptor-Like-Receptor and Receptor Activity Modifying Protein1 in Rat Uterine Artery Smooth Muscle Cells Exposed to Tumor Necrosis Factor-Alpha Biol. Reprod. shRNA TR711449
RANBP2 Cdk1 Activates Pre-mitotic Nuclear Envelope Dynein Recruitment and Apical Nuclear Migration in Neural Stem Cells Dev. Cell shRNA TG309949
Rap1gds1 Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis. Stem cell research shRNA TL506858
Rap1gds1 Microgravity simulation activates Cdc42 via Rap1GDS1 to promote vascular branch morphogenesis during vasculogenesis Stem Cell Res2017 shRNA TG506858
RAPGEF3 Pancreatic ß-Cell Response to Increased Metabolic Demand and to Pharmacologic Secretagogues Requires EPAC2A Diabetes, Aug 2013; 62: 2796 - 2807. shRNA TR512817
RASGRF1 Running title: RasGRF and cocaine pdfs.semanticscholar.org shRNA TR302103
RASGRF2 Running title: RasGRF and cocaine pdfs.semanticscholar.org shRNA TR309928
RASSF1 The RASSF1A Tumor Suppressor Binds the RasGAP DAB2IP and Modulates RAS Activation in Lung Cancer Cancers shRNA TG307696
RASSF1 The RASSF1A Tumor Suppressor Regulates XPA-Mediated DNA repair Mol. Cell. Biol. shRNA TR307696
RASSF10 RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer Cell. Physiol. Biochem shRNA TR320923
RASSF10 Ras association domain family member 10 suppresses gastric cancer growth by cooperating with GSTP1 to regulate JNK/c-Jun/AP-1 pathway Oncogene shRNA TG320923
RASSF5 NORE1A Tumor Suppressor Candidate Modulates p21CIP1 via p53 Cancer Res., Jun 2009; 69: 4629 - 4637. shRNA TR302093
Rbfox3 Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development J. Cell Biol., Feb 2013; 200: 443 - 458. shRNA TR502927
RBL1 p107-Dependent recruitment of SWI/SNF to the alkaline phosphatase promoter during osteoblast differentiation Bone shRNA TF509105
RBM25 A novel splicing factor RBM25 modulates Bcl-x pre-mRNA 5' splice site selection Mol. Cell. Biol. published 28 July 2008, 10.1128/MCB.00560-08 shRNA TR302072
RBM5 Decreased RNA-binding motif 5 expression is associated with tumor progression in gastric cancer Tumour Biol shRNA TR309910
RBPJ Notch Inhibition Enhances Cardiac Reprogramming by Increasing MEF2C Transcriptional Activity Stem Cell Reports shRNA MR226108
Rbpj Notch1 regulated autophagy controls survival and suppressor activity of activated murine T-regulatory cells Elife shRNA TG512813
RBPJ Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a ?-secretase inhibitor, in a preclinical colorectal explant model British Journal of Cancer doi:10.1038/bjc.2013.361 shRNA TF302060
RCAN1 Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4 Cancer Lett. shRNA TR304903
Rcan1 Pyrrolidine dithiocarbamate (PDTC) inhibits inflammatory signaling via expression of regulator of calcineurin activity 1 (RCAN1): Anti-inflammatory mechanism of PDTC through RCAN1 induction Biochem. Pharmacol. shRNA TR511392
RCAN1 RCAN1-4 is a thyroid cancer growth and metastasis suppressor JCI Insight shRNA TR304903
RCAN1 Pituitary adenylate cyclase-activating polypeptide (PACAP) targets Down syndrome candidate region 1 (DSCR1/RCAN1) to control neuronal differentiation J. Biol. Chem. shRNA TG713231
RCAN1 APP facilitates the RCAN1-mediated apoptosis by downregulating PSMA5 and PSMB7 Neurobiology of Aging shRNA TF304903
RCAN1 The Regulator of Calcineurin 1 (RCAN1/DSCR1) Activates the cAMP Response Element-binding Protein (CREB) Pathway J. Biol. Chem., Oct 2011; 286: 37841 - 37848. shRNA TR511392
REC8 REC8 inhibits EMT by downregulating EGR1 in gastric cancer cells Oncol. Rep. shRNA TG309883
REC8 REC8 functions as a tumor suppressor and is epigenetically downregulated in gastric cancer, especially in EBV-positive subtype Oncogene shRNA TG309883
Rec8 The role of meiotic cohesin REC8 in chromosome segregation in gamma irradiation-induced endopolyploid tumour cells. Experimental cell research shRNA TL509475
RECQL4 Human RecQL4 Helicase Plays Critical Roles in Prostate Carcinogenesis Cancer Res., Nov 2010; 70: 9207 - 9217 shRNA TR309882
REG1A REG{gamma} deficiency promotes premature aging via the casein kinase 1 pathway PNAS, Jul 2013; 110: 11005 - 11010. shRNA TG309878
REG4 REG{gamma} modulates p53 activity by regulating its cellular localization J. Cell Sci., Dec 2010; 123: 4076 - 4084 shRNA TR302039
RELA Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons Molecular and Cellular Neuroscience shRNA TG713753
RELA NF-?B regulates neuronal ankyrin-G via a negative feedback loop Sci Rep shRNA TR516660
RELA COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma Oncotarget shRNA TR302038
RELA Tumours with elevated levels of the Notch and Wnt pathways exhibit efficacy to PF-03084014, a γ -secretase inhibitor, in a preclinical colorectal explant model British Journal of Cancer shRNA TF302038
RELA Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-{kappa}B Signaling Pathway Mol. Cancer Ther., Jan 2011; 10: 198 - 208 shRNA TR302038
RELA Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis Physiol Genomics, Nov 2010; 42A: 259 - 266 shRNA TR302038
RFC1 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG501877
RFC2 DNA damage response defect in Williams-Beuren syndrome Int. J. Mol. Med. shRNA TG309864
RFC2 PLA2G16 represents a switch between entry and clearance of Picornaviridae Nature shRNA TG309864
RFC2 DNA damage response defect in Williams‑Beuren syndrome INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE shRNA TG309864
RFC4 Phosphoinositide 3-kinase beta controls replication factor C assembly and function Nucleic Acids Res., Jan 2013; 41: 855 - 868. shRNA TG505746
RFX1 RFX-1-dependent activation of SHP-1 inhibits STAT3 signaling in hepatocellular carcinoma cells Carcinogenesis shRNA TG309857
RFX1 SC-2001 Overcomes STAT3-mediated Sorafenib Resistance through RFX-1/SHP-1 Activation in Hepatocellular Carcinoma Neoplasia July 2014 shRNA TR309857
RGCC Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR315657
RGS4 Decreased levels of RGS4 in the paraventricular nucleus facilitate GABAergic inhibition during the acute stress response Biochem. Biophys. Res. Commun. shRNA TG510988
RGS4 Breast Cancer Migration and Invasion Depend on Proteasome Degradation of Regulator of G-Protein Signaling 4 Cancer Res., Jul 2009; 69: 5743 - 5751. shRNA TR309833
RHBDD1 Intramembrane protease RHBDL4 interacts with erlin complex to target unstable soluble proteins for degradation bioRxiv shRNA TR302010
RHBDF1 Human rhomboid family-1 modulates clathrin coated vesicle-dependent pro-transforming growth factor α membrane trafficking to promote breast cancer progression EBioMedicine shRNA TR302009
RHBDF1 Human Rhomboid Family-1 (RHBDF1) Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1a in Breast Cancer Cancer Res. shRNA TF302009
RHOA Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin Biochemical and Biophysical Research Communications shRNA TG309823
RHOA S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle J. Physiol. (Lond.) 2020 shRNA TG309823
RHOC Cooperation of G12/13 and Gi proteins via lysophosphatidic acid receptor-2 (LPA2) signaling enhances cancer cell survival to cisplatin Biochemical and Biophysical Research Communications shRNA TG302002
RHOQ GTP Hydrolysis of TC10 Promotes Neurite Outgrowth through Exocytic Fusion of Rab11- and L1-Containing Vesicles by Releasing Exocyst Component Exo70 PLoS ONE e79689 shRNA TF309817
RHOT1 Miro1 regulates intercellular mitochondrial transport & enhances mesenchymal stem cell rescue efficacy EMBO J., Feb 2014. shRNA TG309816
RHOU The Transforming Rho Family GTPase Wrch-1 Disrupts Epithelial Cell Tight Junctions and Epithelial Morphogenesis Mol. Cell. Biol., Feb 2009; 29: 1035 - 1049. shRNA TR307205
RICTOR Potential Role of mTORC2 as a Therapeutic Target in Clear Cell Carcinoma of the Ovary Mol. Cancer Ther., Jul 2013; 12: 1367 - 1377. shRNA TG307650
Rif1 A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Molecular cell shRNA TF502862
RIOX2 Paradoxical roles of mineral dust induced gene on cell proliferation and migration/invasion PLoS ONE, Feb 2014. shRNA TF317654
RIPK1 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy shRNA TG320591
RIPK1 RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res. shRNA TG320591
RMDN3 Effectiveness of EGFR/HER2-targeted drugs is influenced by the downstream interaction shifts of PTPIP51 in HER2-amplified breast cancer cells Oncogenesis shRNA TG304606
RNASEK A Subtle Alternative Splicing Event Gives Rise to a Widely Expressed Human RNase k Isoform PLoS ONE shRNA TR318608
RNF8 Identification of RNF8 as a Ubiquitin Ligase Involved in Targeting the p12 Subunit of DNA Polymerase for Degradation in Response to DNA Damage J. Biol. Chem., Feb 2013; 288: 2941 - 2950. shRNA TG309783
RNH1 Genomic Analysis of Chemo-Resistance to HDAC inhibitor in Gastric Cancer cells Thesis Jul 2014 shRNA TG309781
RNH1 RNH1 regulation of reactive oxygen species contributes to histone deacetylase inhibitor resistance in gastric cancer cells Oncogene doi:10.1038/onc.2013.104 shRNA TG309781
ROCK1 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG309775
ROR2 Ror2, a developmentally regulated kinase, promotes tumor growth potential in renal cell carcinoma Oncogene (18 May 2009) doi:10.1038/onc.2009.116 Original Article shRNA TR320439
RORA Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting Beta-catenin and AKT signaling but frequently methylated in common carcinomas Cell Mol Life Sci. 2013 Oct 25 shRNA TR320515
RPA1 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR309767
RPS6KA1 Caveolin-1 promotes Ewing sarcoma metastasis regulating MMP-9 expression through MAPK/ERK pathway Oncotarget shRNA TR320517
RPS6KA3 Phosphorylation of RSK2 at Tyr529 by FGFR2-p38 enhances human mammary epithelial cells migration Biochim. Biophys. Acta July 2014 shRNA TG320519
Rps6ka4 miR-93 regulates Msk2-mediated chromatin remodelling in diabetic nephropathy Nat Commun shRNA TR503222
Rps6ka5 Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes Epigenetics Chromatin shRNA TR504795
RPS6KB1 Constitutive GLI1 expression in chondrosarcoma is regulated by major vault protein via mTOR/S6K1 signaling cascade Cell death and differentiation shRNA TF320520
Rps6kb1 S6K directly phosphorylates IRS-1 on Ser270 to promote insulin resistance in response to TNF-alpha signaling through IKK2 J. Biol. Chem. published 24 October 2008, 10.1074/jbc.M806480200 shRNA TR504743
RSU1 Role of PINCH and Its Partner Tumor Suppressor Rsu-1 in Regulating Liver Size and Tumorigenesis PLoS One. 2013 Sep 18;8(9):e74625 shRNA RG203334
Runx1 Neural EGFL like 1 as a potential pro-chondrogenic, anti-inflammatory dual-functional disease-modifying osteoarthritis drug Biomaterials shRNA TL500282
RUNX1 MiR-18a increased the permeability of BTB via RUNX1 mediated down-regulation of ZO-1, occludin and claudin-5 Cell. Signal. shRNA TG309685
Runx2 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF510502
Runx2 Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling The American Journal of Pathology shRNA TF510502
Runx2 Nfatc1 Is a Functional Transcriptional Factor Mediating Nell-1-Induced Runx3 Upregulation in Chondrocytes International Journal of Molecular Sciences shRNA TF510502
RUNX2 RUNX2 in subtype specific breast cancer and mammary gland differentiation Dis Model Mech shRNA TG309683
RUNX3 IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. JCI insight shRNA TL309682
RUNX3 The cell-surface 5′-nucleotidase CD73 defines a functional T memory cell subset that declines with age Cell reports shRNA TL309682
Runx3 Neural EGFL-Like 1 Regulates Cartilage Maturation through Runt-Related Transcription Factor 3–Mediated Indian Hedgehog Signaling The American Journal of Pathology shRNA TG500285
Rxra Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation PLoS Genet. shRNA TG501955
Rxrb Retinoid-X-Receptors (a/ß) in Melanocytes Modulate Innate Immune Responses and Differentially Regulate Cell Survival following UV Irradiation PLoS Genet. shRNA TF501956
S100A4 S100A4 is activated by RhoA and catalyzes the polymerization of non-muscle myosin, adhesion complex assembly and contraction in airway smooth muscle J. Physiol. (Lond.) 2020 shRNA TG309668
S100a8 Hypoxia-Induced S100A8 Expression Activates Microglial Inflammation and Promotes Neuronal Apoptosis International Journal of Molecular Sciences shRNA TL712179
S100B S100B Promotes Glioma Growth through Chemoattraction of Myeloid-Derived Macrophages Clin. Cancer Res., Jul 2013; 19: 3764 - 3775. shRNA TG309665
S1PR1 Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways Blood, Aug 2008; 112: 1129 - 1138. shRNA TR313301
S1PR3 Sphingosine-1-phosphate promotes lymphangiogenesis by stimulating S1P1/Gi/PLC/Ca2+ signaling pathways Blood, Jun 2008; 10.1182/blood-2007-11-125203. shRNA TR313299
SAR1A Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med shRNA TG301838
SATB1 SATB1 Knockdown Inhibits Proliferation and Invasion and Decreases Chemoradiation Resistance in Nasopharyngeal Carcinoma Cells by Reversing EMT and Suppressing MMP-9 Int J Med Sci. shRNA TG309643
SATB1 Silencing SATB1 influences cell invasion, migration, proliferation, and drug resistance in nasopharyngeal carcinoma Int J Clin Exp Pathol shRNA TG309643
SATB2 Role of miR-31 and SATB2 in arsenic-induced malignant BEAS-2B cell transformation Mol. Carcinog. shRNA TG301833
SATB2 Molecular Mechanisms of Malignant Transformation by Low Dose Cadmium in Normal Human Bronchial Epithelial Cells PLoS ONE shRNA TG301833
SATB2 SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells Toxicol. Appl. Pharmacol. shRNA TG301833
SAV1 Salvador Protein Is a Tumor Suppressor Effector of RASSF1A with Hippo Pathway-independent Functions J. Biol. Chem., May 2011; 286: 18483 - 18491 shRNA TR301832
SCARB1 Chlamydia trachomatis utilizes the mammalian CLA1 lipid transporter to acquire host phosphatidylcholine essential for growth Cell. Microbiol. shRNA TG309633
SCG3 Carboxypeptidase E and Secretogranin III coordinately facilitate efficient sorting of pro-opiomelanocortin to the regulated secretory pathway in AtT20 cells Molecular Endocrinology Dec2015 shRNA TR516044
SCIMP SCIMP, a Transmembrane Adaptor Protein Involved in Major Histocompatibility Complex Class II Signaling Mol. Cell. Biol., Nov 2011; 31: 4550 - 4562. shRNA
SCPEP1 Serine carboxypeptidase SCPEP1 and Cathepsin A play complementary roles in regulation of vasoconstriction via inactivation of endothelin-1 PLoS Genet. shRNA TF505007
Scrambled Control Proteasome dysfunction under compromised redox metabolism dictates liver injury in NASH through ASK1/PPARγ binodal complementary modules Redox biology shRNA TR30013
Scrambled Control Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism International Journal of Molecular Sciences shRNA TR30012
Scrambled Control NLR family pyrin domain containing 3 (NLRP3) and caspase 1 (CASP1) modulation by intracellular Cl- concentration Immunology shRNA TR30013
Scrambled Control Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein Viruses shRNA TR30013
Scrambled Control Engineered exosomes delivering specific tumor-suppressive RNAi attenuate oral cancer progression Scientific reports shRNA TR30012
Scrambled Control Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs Cells shRNA TR30013
Scrambled Control Cell dynamics in Hertwig\'s epithelial root sheath are regulated by β-catenin activity during tooth root development Journal of cellular physiology shRNA TR30013
Scrambled Control Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress-induced senescence in cultured skeletal muscle cells J Cell Physiol shRNA TR30013
Scrambled Control USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway Proc Natl Acad Sci U S A shRNA TR30015
Scrambled Control Matrin-3 plays an important role in cell cycle and apoptosis for survival in malignant melanoma J. Dermatol. Sci. shRNA TR30021
Scrambled Control TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance SSRN Journal shRNA TR30015
Scrambled Control Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction Nat Commun shRNA TR30015
Scrambled Control Imbalance of a KLF4-miR-7 auto-regulatory feedback loop promotes prostate cancer cell growth by impairing microRNA processing Am J Cancer Res shRNA TR30013
Scrambled Control Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience Genome Med shRNA TR30013
Scrambled shRNA Targeting Tyro3 ameliorates a model of PGRN-mutant FTLD-TDP via tau-mediated synaptic pathology Nat Commun shRNA TR30012
Scrambled shRNA Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory Antioxid. Redox Signal. shRNA TR30013
scrambled shRNA Calcium release mediated by redox-sensitive RyR2 channels has a central role in hippocampal structural plasticity and spatial memory Antioxid. Redox Signal. shRNA TR30015
SCRT2 Scratch2 Modulates Neurogenesis and Cell Migration Through Antagonism of bHLH Proteins in the Developing Neocortex Cereb Cortex, Nov 2012; 10.1093/cercor/bhs356. shRNA TG307416
SDC2 Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK PLoS ONE, Feb 2014. shRNA TR309597
SDC3 Binding of Y-P30 to Syndecan 2/3 Regulates the Nuclear Localization of CASK PLoS ONE, Feb 2014. shRNA TR309596
SDC4 Myoblast Migration and Directional Persistence Affected by Syndecan-4-Mediated Tiam-1 Expression and Distribution Int J Mol Sci shRNA TR513122
SDC4 Syndecan-4 influences mammalian myoblast proliferation by modulating myostatin signalling and G1/S transition FEBS Lett. shRNA TR513122
Sdcbp Syntenin controls migration, growth, proliferation, and cell cycle progression in cancer cells Frontiers in Pharmacology shRNA TG512166
SDHA Complex I and II are required for normal mitochondrial Ca2+ homeostasis Mitochondrion shRNA TR315539
SELENOP Selenoprotein P neutralizes lipopolysaccharide and participates in hepatic cell endoplasmic reticulum stress response FEBS Lett shRNA TR309547
SEMA6D The Plexin-A1 Receptor Activates Vascular Endothelial Growth Factor-Receptor 2 and Nuclear Factor-B to Mediate Survival and Anchorage-Independent Growth of Malignant Mesothelioma Cells Cancer Res., Feb 2009; 69: 1485 - 1493 shRNA TR301776
SENP3 Increased SUMO-2/3-ylation mediated by SENP3 degradation is protective against cadmium-induced caspase 3-dependent cytotoxicity J Toxicol Sci shRNA TG505363
SENP3 Protective effect of SENP3-mediated SUMOylation against cadmium toxicity J Toxicol Sci shRNA TG701864
Senp5 Synaptic localization of the SUMOylation-regulating protease SENP5 in the adult mouse brain. The Journal of comparative neurology shRNA TL508307
SENP7 Novel SUMO-Protease SENP7S Regulates ß-catenin Signaling and Mammary Epithelial Cell Transformation Sci Rep shRNA TR301771
Septin2 Septins promote macropinosome maturation and traffic to the lysosome by facilitating membrane fusion J. Cell Biol. shRNA TG515794
Septin5 Mapping axon initial segment structure and function by multiplexed proximity biotinylation Nature Communications shRNA TL501695
Septin6 Mapping axon initial segment structure and function by multiplexed proximity biotinylation Nature Communications shRNA TL509453
Serpina1 Endothelial-mesenchymal transition in atherosclerotic lesion calcification Atherosclerosis shRNA TR710718
Serpinb2 Depletion of ID3 enhances mesenchymal stem cells therapy by targeting BMP4 in Sjögren’s syndrome Cell Death & Disease shRNA TL710486
SERPINB2 PNAS Plus: TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2 PNAS, Jan 2012; 109: E177 - E186. shRNA TR309533
SERPINB9 Anti-Apoptotic Gene Delivery with cyclo-(d-Trp-Tyr) Peptide Nanotube via Eye Drop Following Corneal Epithelial Debridement Pharmaceutics shRNA TF309527
SERPINE1 Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease Aging Cell shRNA TF709263
SESN2 HGK-sestrin 2 signaling-mediated autophagy contributes to antitumor efficacy of Tanshinone IIA in human osteosarcoma cells Cell Death Dis shRNA TG301755
SETD7 SET9-Mediated Regulation of TGF-ß Signaling Links Protein Methylation to Pulmonary Fibrosis Cell Rep shRNA TG301748
SETMAR Metnase mediates chromosome decatenation in acute leukemia cells Blood, May 2009; 10.1182/blood-2008-08-175760 shRNA TR309513
Sf1 DNA damage causes rapid accumulation of phosphoinositides for ATR signaling Nat Commun shRNA TF516038
SFRP5 Secreted frizzled-related protein 5 protects against oxidative stress-induced apoptosis in human aortic endothelial cells via downregulation of Bax J. Biochem. Mol. Toxicol. shRNA TR309497
SFXN4 Complementary anti-cancer pathways triggered by inhibition of sideroflexin 4 in ovarian cancer Scientific Reports shRNA TL301736
SGK1 p38MAPK/SGK1 signaling regulates macrophage polarization in experimental autoimmune encephalomyelitis Aging (Albany NY) 2019 shRNA TG502013
Sgms1 The suppression of ghrelin signaling mitigates age-associated thermogenic impairment Aging (Albany NY) shRNA TG506246
SGTA Tumor suppressor REIC/Dkk‑3 and its interacting protein SGTA inhibit glucocorticoid receptor to nuclear transport Exp Ther Med shRNA TG309472
sh-Luc(in vivo application) RNA interference-mediated in vivo silencing of FasL as a strategy for the enhancement of DNA vaccine potency Human Gene Therapy. August 2008, 19(8): 763-773 shRNA
SH3BGRL SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane J. Exp. Clin. Cancer Res. shRNA TG309466
SH3BGRL SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia Leuk. Lymphoma shRNA TG309466
SH3GL2 SH3BGRL confers innate drug resistance in breast cancer by stabilizing HER2 activation on cell membrane Journal of Experimental & Clinical Cancer Research : CR shRNA TG309461
SH3GL2 SH3BGRL as a novel prognostic biomarker is down-regulated in acute myeloid leukemia. Leukemia & lymphoma shRNA TG309461
SH3GL2 Dual-faced SH3BGRL: oncogenic in mice, tumor suppressive in humans Oncogene shRNA TG309461
shank3 SHANK3 mutations identified in autism lead to modification of dendritic spine morphology via an actin-dependent mechanism Molecular Psychiatry (24 May 2011) doi:10.1038/mp.2011.57 Original Article shRNA TR320871
shRNA Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells J. Leukoc. Biol., Jun 2011; 89: 935 - 944 shRNA
shRNA GPR103b Functions in the Peripheral Regulation of Adipogenesis Mol. Endocrinol., Aug 2010; 24: 1615 - 1625 shRNA
shRNA A New Type of Membrane Raft-Like Microdomains and Their Possible Involvement in TCR Signaling J. Immunol., Apr 2010; 184: 3689 - 3696 shRNA
shRNA TRAF6 distinctively mediates MyD88- and IRAK-1-induced activation of NF-B J. Leukoc. Biol., Mar 2008; 83: 702 - 707 shRNA
SIGLECE Siglec-E Is Up-Regulated and Phosphorylated Following Lipopolysaccharide Stimulation in Order to Limit TLR-Driven Cytokine Production J. Immunol., Dec 2009; 183: 7703 - 7709 shRNA TR512042
SIGMAR1 SKF-10047, a prototype Sigma-1 receptor agonist, augmented the membrane trafficking and uptake activity of the serotonin transporter and its C-terminus-deleted mutant via a Sigma-1 receptor-independent mechanism J. Pharmacol. Sci. shRNA TG311012
SIGMAR1 Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP 3 -Evoked Ca 2+ Signals through Sigma-1 Receptors Cell Reports shRNA TF311012
Sigmar1 Cocaine Inhibits Store-Operated Ca 2+ Entry in Brain Microvascular Endothelial Cells: Critical Role for Sigma-1 Receptors The Biochemical journal shRNA TF711128
SIGMAR1 Loss of function of the ALS protein SigR1 leads to ER pathology associated with defective autophagy and lipid raft disturbances Cell Death Dis shRNA TF311012
SIGMAR1 Altered localization, abnormal modification and loss of function of Sigma receptor-1 in amyotrophic lateral sclerosis Hum. Mol. Genet., Apr 2013; 22: 1581 - 1600. shRNA TG311012
SIRT1 Long noncoding RNA HULC accelerates liver cancer by inhibiting PTEN via autophagy cooperation to miR15a Mol. Cancer shRNA TG309433
SIRT1 Chronic sun exposure is associated with distinct histone acetylation changes in human skin Br. J. Dermatol.2017 shRNA TG309433
SIRT1 SIRT1 promotes metastasis of human osteosarcoma cells Oncotarget shRNA TG309433
SIRT2 Targeting SIRT2 Sensitizes Melanoma Cells to Cisplatin via an EGFR-Dependent Mechanism International Journal of Molecular Sciences shRNA TR301692
SIRT2 SIRT2 Contributes to the Resistance of Melanoma Cells to the Multikinase Inhibitor Dasatinib Cancers (Basel) 2019 shRNA TR301692
SIRT2 Sirt2 Regulates Radiation-Induced Injury Radiat. Res. shRNA TG301692
Sirt2 SIRT2 Interacts with β-catenin to Inhibit Wnt Signaling Output in Response to Radiation-Induced Stress Molecular cancer research : MCR shRNA TL503462
SIRT3 GATA3 ameliorates melanocyte injuries in vitiligo through SIRT3-mediated HMGB1 deacetylation. The Journal of dermatology shRNA TG309432
SIRT3 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells Oncogene shRNA TR309432
SIRT3 Sirtuin 3 silencing improves oxaliplatin efficacy through acetylation of MnSOD in colon cancer. Journal of cellular physiology shRNA TR309432
SIRT3 Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells bioRxiv shRNA TR309432
SIRT3 Sirtuin 3 silencing impairs mitochondrial biogenesis and metabolism in colon cancer cells Am. J. Physiol., Cell Physiol. shRNA TR309432
SIRT7 SIRT7 promotes genome integrity and modulates non-homologous end joining DNA repair EMBO J. shRNA TR301690
SIX1 HPV16-transformed human keratinocytes depend on SIX1 expression for proliferation and HPV E6/E7 gene expression Virology shRNA TG309429
SKP2 Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma Sci Rep shRNA TG301684
SLAMF1 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response J. Clin. Invest. shRNA TG309422
SLC16A1 Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. Cell reports shRNA TL309405
SLC16A1 Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer Cell Rep shRNA TR309405
SLC17A5 From the Cover: Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane PNAS, Aug 2012; 109: 13434 - 13439. shRNA TR309394
SLC17A5 Sialin (SLC17A5) functions as a nitrate transporter in the plasma membrane PNAS, Jul 2012; 10.1073/pnas.1116633109. shRNA TR309394
SLC1A3 Insulin Regulates Astrocytic Glucose Handling Through Cooperation With IGF-I Diabetes shRNA TR515328
SLC22A18 Knockdown of Orphan Transporter SLC22A18 Impairs Lipid Metabolism and Increases Invasiveness of HepG2 Cells Pharm. Res. shRNA TR309377
SLC22A18 Involvement of an orphan transporter, SLC22A18, in cell growth and drug resistance of human breast cancer MCF7 cells J Pharm Sci shRNA TR309377
Slc22a2 The organic cation transporter 2 regulates dopamine D1 receptor signaling at the Golgi apparatus eLife shRNA TL517269
SLC25A1 SLC25A1, or CIC, is a novel transcriptional target of mutant p53 and a negative tumor prognostic marker Oncotarget shRNA TG316728
SLC25A1 The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis Oncotarget shRNA TG316728
SLC26A9 Effects of Wood Smoke Constituents on Mucin Gene Expression in Mice and Human Airway Epithelial Cells and on Nasal Epithelia of Subjects with a Susceptibility Gene Variant in Tp53 Environmental Health Perspectives shRNA TR301620
SLC29A1 SLC29A1 (ENT1) polymorphisms and outcome of complete remission in acute myeloid leukemia Cancer Chemother. Pharmacol. shRNA TG309346
SLC2A4 GLUT4 Mobilization Supports Energetic Demands of Active Synapses Neuron shRNA TR709372
Slc30a8 Down-Regulation of ZnT8 Expression in INS-1 Rat Pancreatic Beta Cells Reduces Insulin Content and Glucose-Inducible Insulin Secretion PLoS ONE 4(5):e5679, 2009 shRNA TR708553
SLC35A2 Aberrant Expression of Solute Carrier Family 35 Member A2 Correlates With Tumor Progression in Breast Cancer In Vivo shRNA TL309328
SLC36A4 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell shRNA TG507107
SLC39A12 Role of zinc transporter ZIP12 in susceptibility-weighted brain magnetic resonance imaging (MRI) phenotypes and mitochondrial function FASEB J. shRNA TF508163
SLC39A12 Neurulation and neurite extension require the zinc transporter ZIP12 (slc39a12) PNAS, Jun 2013; 110: 9903 - 9908. shRNA TG301572
SLC39A4 ZIP4 Regulates Pancreatic Cancer Cell Growth by Activating IL-6/STAT3 Pathway through Zinc Finger Transcription Factor CREB Clin. Cancer Res., Mar 2010; 16: 1423 - 1430 shRNA TR317306
SLC39A4 Down-regulation of ZIP4 by RNA Interference Inhibits Pancreatic Cancer Growth and Increases the Survival of Nude Mice with Pancreatic Cancer Xenografts Clin. Cancer Res., Oct 2009; 15: 5993 - 6001 shRNA TR317306
Slc6a15 Reduced Slc6a15 in Nucleus Accumbens D2-Neurons Underlies Stress Susceptibility The Journal of Neuroscience shRNA TG505662
SLC7A8 Tumor-Repopulating Cells Induce PD-1 Expression in CD8+T Cells by Transferring Kynurenine and AhR Activation Cancer Cell shRNA TG502853
SLC9A3R1 Extracellular anti-angiogenic proteins augment an endosomal protein trafficking pathway to reach mitochondria and execute apoptosis in HUVECs Cell Death Differ. shRNA TF316855
SLC9A3R1 NHERF1 Regulates Parathyroid Hormone Receptor Desensitization: Interference with ß-Arrestin Binding Mol. Pharmacol., May 2009; 75: 1189 - 1197. shRNA TR316855
SLC9A3R1 NHERF1 Regulates Parathyroid Hormone Receptor Desensitization; Interference with -arrestin Binding Mol. Pharmacol., Feb 2009; 10.1124/mol.108.054486. shRNA TR316855
SLC9A3R1 NHERF1 regulates parathyroid hormone receptor membrane retention without affecting recycling J Biol Chem. 2007 Dec 14;282(50):36214-22. shRNA TR316855
SLC9A3R2 Convergent Signaling Pathways Regulate Parathyroid Hormone and Fibroblast Growth Factor-23 Action on NPT2A-mediated Phosphate Transport J. Biol. Chem. shRNA TR309271
SLC9A3R2 Na/H Exchanger Regulatory Factors Control Parathyroid Hormone Receptor Signaling by Facilitating Differential Activation of G{alpha} Protein Subunits J. Biol. Chem., Aug 2010; 285: 26976 - 26986 shRNA TR309271
SLK SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation J. Cell Biol. shRNA TG320620
SMAD2 Suppression of canonical TGF-β signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis Journal of molecular and cellular cardiology shRNA TR509694
Smad2 Adult cardiac stem cells are multipotent and robustly myogenic: c-kit expression is necessary but not sufficient for their identification Cell Death and Differentiation shRNA TL710211
SMAD2 The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner J. Biol. Chem. April 2014 shRNA TG309255
Smad2 Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR309255
Smad3 Response gene to complement 32 interacts with Smad3 to promote epithelial-mesenchymal transition of human renal tubular cells Am J Physiol Cell Physiol, Jun 2011; 300: C1415 - C1421 shRNA TR309254
SMAD4 Protein kinase CK2 activation is required for transforming growth factor β-induced epithelial-mesenchymal transition Mol Oncol shRNA TR309253
SMAD4 Loss of Trefoil Factor 2 From Pancreatic Duct Glands Promotes Formation of Intraductal Papillary Mucinous Neoplasms in Mice Gastroenterology shRNA TG309253
SMAD4 The transcription factor GLI1 interacts with SMAD proteins to modulate TGFß-induced gene expression in a PCAF-dependent manner J. Biol. Chem. April 2014 shRNA TG309253
Smad7 microRNA-181a has a critical role in ovarian cancer progression through the regulation of the epithelial-mesenchymal transition Nat Commun, Jan 2014. shRNA TG320409
SMARCE1 SWI/SNF Regulates the Cellular Response to Hypoxia J. Biol. Chem., Feb 2009; 284: 4123 - 4131 shRNA TR309242
SMG1 Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. shRNA TR318864
SMN1 iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases JCI Insight shRNA TR301496
Smo Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. PLoS biology shRNA TG510788
SMO Sonic hedgehog induces response of commissural axons to Semaphorin repulsion during midline crossing Nature Neuroscience (29 November 2009) shRNA TR309234
SMPDL3B Rituximab Targets Podocytes in Recurrent Focal Segmental Glomerulosclerosis Science Translational Medicine, Jun 2011; 3: 85ra46 shRNA TR309229
Smurf1 Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages. Nature communications shRNA TL505101
SNAI1 CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells International journal of molecular sciences shRNA TR309226
SNAI1 Inflammatory mediators drive metastasis and drug resistance in head and neck squamous cell carcinoma Laryngoscope shRNA TG309226
SNAI1 BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3ß Signaling Pathway Cancer Res., Mar 2012; 72: 1579 - 1587. shRNA TR309226
SNAI1 Role of {Delta}Np63{gamma} in Epithelial to Mesenchymal Transition J. Biol. Chem., Feb 2011; 286: 3915 - 3924 shRNA TG309226
SNAI1 Proinflammatory Mediators Upregulate Snail in Head and Neck Squamous Cell Carcinoma Clin. Cancer Res., Oct 2009; 15: 6018 - 6027 shRNA TR309226
SNAI2 MicroRNA-124 suppresses Slug-mediated lung cancer metastasis Eur Rev Med Pharmacol Sci shRNA TR309225
SNAP25 The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses J. Neurosci., May 2013; 33: 9169 - 9175. shRNA TF711123
SNX27 Actin-Sorting Nexin 27-Retromer Complex Mediates Rapid Parathyroid Hormone Receptor Recycling J. Biol. Chem. shRNA TF301468
SOCS3 Human ß-defensin-2 enhances IFN-{gamma} and IL-10 production and suppresses IL-17 production in T cells J. Leukoc. Biol., Jun 2011; 89: 935 - 944 shRNA TR316847
SOD2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TG309190
SOD2 Different roles of ROS and Nrf2 in Cr(VI)-induced inflammatory responses in normal and Cr(VI)-transformed cells Toxicol. Appl. Pharmacol. shRNA TR309190
SOD2 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. shRNA TG309190
SOD2 Mitochondrial superoxide dismutase has a pro-tumorigenic role in ovarian clear cell carcinoma Cancer Res. shRNA TG309190
SOD2 Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development J. Biol. Chem. shRNA TG309190
Sort1 Sortilin regulates sorting and secretion of Sonic hedgehog J. Cell. Sci. shRNA TR502101
SORT1 Sortilin regulates progranulin action in castration-resistant prostate cancer cells Endocrinology shRNA TG309180
SOX2 Efficient extravasation of tumor-repopulating cells depends on cell deformability Sci Rep shRNA TG515613
SOX2 Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming Stem Cell Reports shRNA TG515613
SOX2 SOX2 expression in the developing, adult, as well as, diseased prostate Prostate Cancer Prostatic Dis. shRNA TR309173
Sox2 Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression Nat Commun shRNA TG515613
SOX4 SOX4 interacts with EZH2 and HDAC3 to suppress microRNA-31 in invasive esophageal cancer cells Mol. Cancer shRNA TF315513
SOX4 Down-regulated SOX4 expression suppresses cell proliferation, metastasis and induces apoptosis in Xuanwei female lung cancer patients J. Cell. Biochem. shRNA TG315513
SOX4 The early retinal progenitor-expressed gene Sox11 regulates the timing of the differentiation of retinal cells Development, Feb 2013; 140: 740 - 750. shRNA TF315513
Sox9 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF511411
SOX9 Oncogenicity of the Developmental Transcription Factor Sox9 Cancer Res., Mar 2012; 72: 1301 - 1315. shRNA TR309170
SP1 The Specificity Protein Factor Sp1 Mediates Transcriptional Regulation of P2X7 Receptors in the Nervous System J. Biol. Chem., Dec 2012; 287: 44628 - 44644. shRNA TF502115
Sp7 Mapping Distinct Bone Marrow Niche Populations and Their Differentiation Paths Cell reports shRNA TF514041
SP7 Antagonistic interactions between osterix and pyrophosphate during cementum formation Bone shRNA TG514041
SPAG11A Transgenesis and active immunization mediated reduction of sperm associated antigen 11A mRNA and protein levels affect fecundity in the rat Theriogenology shRNA TG713093
SPARCL1 Methylation of SPARCL1 Is Associated with Oncologic Outcome of Advanced Upper Urinary Tract Urothelial Carcinoma Int J Mol Sci shRNA TG309157
SPC24 SPC24 promotes osteosarcoma progression by increasing EGFR/MAPK signaling Oncotarget shRNA TG301421
SPC24 SPC24 is critical for anaplastic thyroid cancer progression Oncotarget shRNA TR301421
Sphk1 Sphingosine Kinase 1 expression in peritoneal macrophages is required for colon carcinogenesis Carcinogenesis shRNA TF512690
SPHK1 Comprehensive gene and microRNA expression profiling reveals a role for miRNAs in the oncogenic roles of SphK1 in papillary thyroid cancer J. Cancer Res. Clin. Oncol shRNA TR301413
Sphk1 Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway Journal of immunology (Baltimore, Md. : 1950) shRNA TL512690
Sphk1 Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway Journal of immunology (Baltimore, Md. : 1950) shRNA TF512690
Sphk1 Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway J. Immunol., Oct 2012; 189: 3421 - 3429. shRNA TG301413
Sphk2 Inducible IL-33 expression by mast cells is regulated by a calcium-dependent pathway Journal of immunology (Baltimore, Md. : 1950) shRNA TL701575
Sphk2 Inducible IL-33 Expression by Mast Cells Is Regulated by a Calcium-Dependent Pathway J. Immunol., Oct 2012; 189: 3421 - 3429. shRNA TG301412
Sphkap Neuronal ER-plasma membrane junctions couple excitation to Ca 2+ -activated PKA signaling Nature Communications shRNA TL708390
Spi1 Alzheimer\'s-associated PU.1 expression levels regulate microglial inflammatory response Neurobiology of disease shRNA TG502008
Spi1 A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease Nat. Neurosci. shRNA TG502008
SPI1 A common haplotype lowers SPI1 (PU. 1) expression in myeloid cells and delays age at onset for Alzheimer's disease bioRxiv shRNA TG502008
SPI1 Repression of primitive erythroid program is critical for the initiation of multi-lineage hematopoiesis in mouse development J. Cell. Physiol. shRNA TG502008
SPP1 Identification of a Biphasic Role for Genistein in the Regulation of Prostate Cancer Growth and Metastasis Cancer Res., Apr 2009; 69: 3695 - 3703. shRNA TR309135
SPRY2 Regulation of vascular signalling by nuclear Sprouty2 in fetal lung epithelial cells: Implications for co-ordinated airway and vascular branching in lung development Comp. Biochem. Physiol. B, Biochem. Mol. Biol. shRNA TR309130
SPRY2 Transcriptional regulation of SPROUTY2 by MYB influences myeloid cell proliferation and stem cell properties by enhancing responsiveness to IL-3 Leukemia shRNA TG515588
Spry4 Suppression of Sproutys Has a Therapeutic Effect for a Mouse Model of Ischemia by Enhancing Angiogenesis PLoS ONE. 2009; 4(5): e5467 shRNA TR509780
SPTAN1 α-Fodrin is required for the organization of functional microtubules during mitosis Cell Cycle shRNA TR309127
SPTBN1 Transcriptional Regulation of STAT3 by SPTBN1 and SMAD3 in HCC Through cAMP-Response Element-Binding Proteins ATF3 and CREB2* Carcinogenesis shRNA TR301396
SQSTM1 Enhanced Sensitivity to NVP-BEZ235 by Inhibition of p62/SQSTM1 in Human Bladder Cancer KoTCC-1 Cells Both In Vitro and In Vivo In Vivo shRNA TR309121
SQSTM1 Roles of ROS, Nrf2, and autophagy in cadmium-carcinogenesis and its prevention by sulforaphane Toxicol. Appl. Pharmacol. shRNA TG309121
SQSTM1 Anti-oncogenic and oncogenic properties of Nrf2 in arsenic-induced carcinogenesis J. Biol. Chem. shRNA TG309121
SR30004 Liver Molecular Mechanisms Involved in Type 2 Diabetes: An Investigation Using Roux-en Y Gastric Bypass as a Human Model of Diabetes Remission Thesis July 2014 shRNA TR30015
SRC Lusianthridin Targeting of Lung Cancer Stem Cells via Src-STAT3 Suppression Phytomedicine shRNA TR320529
SRC Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog shRNA TR320529
SRC alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 shRNA TG320529
SRC TR3 Modulates Platinum Resistance in Ovarian Cancer Cancer Res., Aug 2013; 73: 4758 - 4769. shRNA TG320529
SREBF1 Myostatin induces insulin resistance via Cblb-mediated degradation of IRS1 in response to high calorie diet intake J. Biol. Chem., Jan 2014. shRNA TG514167
SREBF1 Activation of Androgen Receptor, Lipogenesis, and Oxidative Stress Converged by SREBP-1 Is Responsible for Regulating Growth and Progression of Prostate Cancer Cells Mol. Cancer Res., Jan 2012; 10: 133 - 142. shRNA TR309117
SREBF1 Androgen Receptor Survival Signaling Is Blocked by Anti-ß2-microglobulin Monoclonal Antibody via a MAPK/Lipogenic Pathway in Human Prostate Cancer Cells J. Biol. Chem., Mar 2010; 285: 7947 - 7956 shRNA TR309117
Srebf2 Lung tumors with distinct p53 mutations respond similarly to p53 targeted therapy but exhibit genotype-specific statin sensitivity Genes & Development shRNA TG510683
SRRT ARS2 is required for retinal progenitor cell S-phase progression and Müller glial cell fate specification Biochem. Cell Biol. shRNA TG514443
SRRT Mutagenesis of ARS2 Domains to Assess Possible Roles in Cell Cycle Progression, MicroRNA and Replication-dependent Histone mRNA Biogenesis Mol. Cell. Biol. shRNA TG514443
SRSF1 Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-arginine-rich Protein ASF/SF2 J. Cell. Biochem. shRNA TR309496
SRSF5 SRSF5 Regulates the Expression of BQ323636.1 to Modulate Tamoxifen Resistance in ER-Positive Breast Cancer. Cancers shRNA TL309487
St6galnac4 Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche Cancer Discov shRNA TG502032
STARD4 Stable reduction of STARD4 alters cholesterol regulation and lipid homeostasis Biochim Biophys Acta Mol Cell Biol Lipids shRNA TG301353
STARD4 STARD4 abundance regulates sterol transport and sensing Mol. Biol. Cell, Nov 2011; 22: 4004 - 4015. shRNA TR506047
STAT1 STAT1‑HDAC4 signaling induces epithelial‑mesenchymal transition and sphere formation of cancer cells overexpressing the oncogene, CUG2 Oncol. Rep. shRNA TG301349
STAT1 Isocitrate dehydrogenase mutations suppress STAT1 and CD8+ T cell accumulation in gliomas J. Clin. Invest shRNA TG502153
STAT1 STAT1 drives tumor progression in serous papillary endometrial cancer Cancer Res. shRNA TG301349
STAT1 A switch from hBrm to Brg1 at IFN?-activated sequences mediates the activation of human genes Cell Research 20, 1345-1360 (16 November 2010) doi:10.1038/cr.2010.155 Original Article shRNA
STAT1 Stat1 mediates an auto-regulation of hsp90beta gene in heat shock response. Cellular signalling shRNA TR301349
Stat3 Targeted inhibition of STAT3 induces immunogenic cell death of hepatocellular carcinoma cells via glycolysis Molecular Oncology shRNA TF502154
STAT3 ß-cell mass restoration by α7-nicotinic acetylcholine receptor activation J. Biol. Chem. shRNA TG709368
STAT3 GLI3 knockdown decreases stemness, cell proliferation and invasion in oral squamous cell carcinoma Int. J. Oncol. shRNA TG301348
STAT3 Regulation of endometrial cell proliferation by estrogen-induced BDNF signaling pathway Gynecol. Endocrinol shRNA TR301348
STAT3 Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism Sci Rep shRNA TR301348
STAT3 Rig-G is a growth inhibitory factor of lung cancer cells that suppresses STAT3 and NF-κB Oncotarget shRNA TR301348
STAT3 Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling Oncotarget shRNA TR301348
STAT3 Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. shRNA TR301348
STAT3 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. shRNA TF301348
Stim1 Activity-dependent endoplasmic reticulum Ca 2+ uptake depends on Kv2.1-mediated endoplasmic reticulum/plasma membrane junctions to promote synaptic transmission Proceedings of the National Academy of Sciences of the United States of America shRNA TR707032
STIM1 Role of STIM2 and Orai proteins in regulating TRPC1 channel activity upon calcium store depletion Cell calcium shRNA TG309049
STIM1 Axonal Endoplasmic Reticulum Ca(2+) Content Controls Release Probability in CNS Nerve Terminals Neuron shRNA TR707032
STIM1 Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation Immunity, Inflammation and Disease shRNA TF502160
STIM1 STIM1 and STIM2 Proteins Differently Regulate Endogenous Store-operated Channels in HEK293 Cells J. Biol. Chem. shRNA TR309049
STIM1 JBC Papers in Press. Published on December 22, 2014 as Manuscript M114. 601856 The Journal of Biological Chemistry shRNA TR309049
STIM1 Amplified lipid rafts of malignant cells constitute a target for inhibition of aberrantly active NFAT and melanoma tumor growth by the aminobisphosphonate zoledronic acid Carcinogenesis shRNA TG309049
STIM1 Molecular mechanisms of spontaneous and directed mast cell motility J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. shRNA TG309049
STIM1 Lipid rafts couple store-operated Ca2+ entry to constitutive activation of PKB/Akt in a Ca2+/calmodulin-, Src- and PP2A-mediated pathway and promote melanoma tumor growth Carcinogenesis, Feb 2012; 10.1093/carcin/bgs021. shRNA TR309049
Stim1 Mitochondria depletion abolishes agonist-induced Ca2+ plateau in airway smooth muscle cells - potential role of H2O2 Am J Physiol Lung Cell Mol Physiol, Nov 2009; 10.1152/ajplung.00134.2009 shRNA TR707032
STIM1 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR309049
STIM1 Store-operated cyclic AMP signalling mediated by STIM1 Nature Cell Biology 11, 433-442 (15 March 2009) shRNA TR309049
STIM1 Canonical Transient Receptor Potential 5 Channel in Conjunction with Orai1 and STIM1 Allows Sr2+ Entry, Optimal Influx of Ca2+, and Degranulation in a Rat Mast Cell Line J. Immunol., Feb 2008; 180: 2233 - 2239. shRNA TR309049
STIP1 Stress-induced phosphoprotein 1 promotes pancreatic cancer progression through activation of the FAK/AKT/MMP signaling axis. Pathology, research and practice shRNA TL309048
STK11 Latrepirdine is a potent activator of AMP-activated protein kinase and reduces neuronal excitability Transl Psychiatry. 2013 Oct 22;3:e317 shRNA TG706613
STMN2 The landscape of multiscale transcriptomic networks and key regulators in Parkinson\'s disease Nat Commun shRNA TF511127
STRIP2 STRIP2 is indispensable for the onset of embryonic stem cell differentiation olecular Therapy: Methods & Clinical Developmen shRNA TR508344
Strip2 Fam40b is required for lineage commitment of murine embryonic stem cells Cell Death Dis July 2014 shRNA TR508344
STUB1 Hsp90 inhibition renders iNOS aggregation and the clearance of iNOS aggregates by proteasomes requires SPSB2 Free Radic. Biol. Med. shRNA TG316909
STUB1 A Critical Role for CHIP in the Aggresome Pathway Mol. Cell. Biol., Jan 2009; 29: 116 - 128. shRNA TR316909
SUMO1 Adenosine Signaling Mediates SUMO-1 Modification of IB during Hypoxia and Reoxygenation J. Biol. Chem., May 2009; 284: 13686 - 13695. shRNA TR316774
SUN1 Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell shRNA TF300647
SUN2 Fluorescence Fluctuation Spectroscopy Reveals Differential SUN Protein Oligomerization In Living Cells Mol. Biol. Cell shRNA TF300646
SUOX Suppressor of Ty homolog-5, a novel tumor-specific human telomerase reverse transcriptase promoter-binding protein and activator in colon cancer cells Oncotarget shRNA TG309008
SUPT5H A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Oct 2012; 209: 2099 - 2111. shRNA TG309005
SUPT5H A role for the RNA pol II–associated PAF complex in AID-induced immune diversification J. Exp. Med., Sep 2012; 10.1084/jem.20112145. shRNA TR309005
Sv2c Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinsons disease bioRxiv shRNA TR711401
Svbp Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.) shRNA TL517601
SYK Fc?-receptor IIa-mediated Src Signaling Pathway is Essential for the Antibody-Dependent Enhancement of Ebola Virus Infection PLoS Pathog shRNA TR320543
SYK The Spleen Tyrosine Kinase (syk) Regulates Alzheimer's Aß Production and Tau Hyperphosphorylation J. Biol. Chem. shRNA TG320543
Syngr3 Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau. Neuron shRNA TL502195
SYNGR3 Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau Neuron shRNA TF705557
TACSTD2 Trop2 enhances invasion of thyroid cancer by inducing MMP2 through ERK and JNK pathways BMC Cancer shRNA TR308966
TAGLN2 Oncogenic transgelin-2 is differentially regulated in isocitrate dehydrogenase wild-type vs. mutant gliomas Oncotarget shRNA TG316819
TAP1 Cellular and Molecular Requirements for the Selection of In Vitro–Generated CD8 T Cells Reveal a Role for Notch J. Immunol., Aug 2013; 191: 1704 - 1715. shRNA TG308949
TAS2R14 Potential role of the bitter taste receptor T2R14 in the prolonged survival and enhanced chemoresponsiveness induced by apigenin International Journal of Oncology shRNA TL301238
TAS2R14 Activation of airway epithelial bitter taste receptors by Pseudomonas aeruginosa quinolones modulates calcium, cyclic-AMP, and nitric oxide signaling J. Biol. Chem. shRNA TR301238
TBC1D23 Homozygous Truncating Variants in TBC1D23 Cause Pontocerebellar Hypoplasia and Alter Cortical Development Am. J. Hum. Genet. shRNA TR503947
TBC1D9 Delivery of Functional Anti-miR-9 by Mesenchymal Stem Cell-derived Exosomes to Glioblastoma Multiforme Cells Conferred Chemosensitivity Mol Ther Nucleic Acids. 2013 Oct 1;2:e126 shRNA TF308932
Tcf3 Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular cell shRNA TL510854
TCF3 Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular cell shRNA TL308904
Tcf4 ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis Genes & Development shRNA TG502233
TDG Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. International journal of oncology shRNA TG316755
TDP1 Expression Of TDP-43 C-terminal fragments in vitro recapitulates pathological features of TDP-43 proteinopathies J. Biol. Chem., Jan 2009; 10.1074/jbc.M809462200. shRNA TR308891
TEAD2 Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular cell shRNA TL308887
Tead2 Transcription factors TEAD2 and E2A globally repress acetyl-CoA synthesis to promote tumorigenesis. Molecular cell shRNA TR502250
TERF2 DNA damage-induced phosphorylation of TRF2 is required for the fast pathway of DNA double-strand break repair Mol. Cell. Biol., Jul 2009; 29: 3597 - 3604 shRNA TR308880
TESK1 Tesk1 Interacts with Spry2 to Abrogate Its Inhibition of ERK Phosphorylation Downstream of Receptor Tyrosine Kinase Signaling J. Biol. Chem., Jan 2008; 283: 1679 - 1691. shRNA TR308879
TET2 TET2 Protects against oxLDL-Induced HUVEC Dysfunction by Upregulating the CSE/H2S System Front Pharmacol shRNA TG303734
Tet2 Ten-Eleven Translocation-2 (Tet2) Is Involved in Myogenic Differentiation of Skeletal Myoblast Cells in Vitro Sci Rep shRNA TR513547
TFAM Knockdown of TFAM in Tumor Cells Retarded Autophagic Flux through Regulating p53 Acetylation and PISD Expression Cancers (Basel) 2020 shRNA TG316756
TFAM Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway J. Cell. Mol. Med. shRNA TG502265
TFAM Cyclooxygenase-2-Mediated Up-Regulation of Mitochondrial Transcription Factor A Mitigates the Radio-Sensitivity of Cancer Cells Int J Mol Sci shRNA TG502265
TFAM HuR stabilizes TFAM mRNA in an ATM/p38-dependent manner in ionizing irradiated cancer cells Cancer Sci. shRNA TR316756
TFAM Mitochondrial transcription factor A regulated ionizing radiation-induced mitochondrial biogenesis in human lung adenocarcinoma A549 cells J Radiat Res, May 2013; 10.1093/jrr/rrt046. shRNA TR316756
TFEB Mitochondrial Translocation of TFEB Regulates Complex I and Inflammation SSRN Electronic Journal shRNA TF308867
TFEB Curcumin Analogue C1 Promotes Hex and Gal Recruitment to the Plasma Membrane via mTORC1-Independent TFEB Activation Int J Mol Sci shRNA TR308867
TFEB Oncogenic H-Ras Up-Regulates Acid β-Hexosaminidase by a Mechanism Dependent on the Autophagy Regulator TFEB PLOS ONE, Feb 2014. shRNA TR308867
TGFB1 Mesenchymal stem cells enhance tumorigenic properties of human glioblastoma through independent cell-cell communication mechanisms Oncotarget shRNA TG308855
TGFB1 TGF Beta1 Expression Correlates with Survival and Tumor Aggressiveness of Prostate Cancer Ann. Surg. Oncol. shRNA TG308855
TGFB1 TGF-ß1 mediates the radiation response of prostate cancer J. Mol. Med. shRNA TG308855
TGFB1 Altered mineralization of human osteoarthritic osteoblasts is attributable to abnormal type I collagen production Arthritis & Rheumatism Volume 60 Issue 5, Pages 1438 - 1450 shRNA TR308855
TGFBR1 Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells J. Biol. Chem. shRNA TR709395
TGFBR1 The role of Alk-1 and Alk-5 in the mechanosensing of chondrocytes Cell. Mol. Biol. Lett. shRNA TG709395
TGFBR2 Periostin promotes liver fibrogenesis by activating lysyl oxidase in hepatic stellate cells J. Biol. Chem. shRNA TR711255
Tgfbr2 TGF-ß Signaling Regulates Cementum Formation through Osterix Expression Sci Rep shRNA TR516186
Tgfbr2 Metastatic tumor evolution and organoid modeling implicate TGFBR2 as a cancer driver in diffuse gastric cancer Genome Biology shRNA TG516186
tGFP The RNA-binding protein LARP1 is a post-transcriptional regulator of survival and tumorigenesis in ovarian cancer Nucleic Acids Res. shRNA TR30016
THOC2 THOC2 expression and its impact on 5-fluorouracil resistance in glioblastoma multiforme American Journal of Cancer Research shRNA TL301111
Thrap3 Thrap3 promotes R-loop resolution via interaction with methylated DDX5 Experimental & Molecular Medicine shRNA TL701343
TIAM1 Regulation of Stat5 by FAK and PAK1 in Oncogenic FLT3- and KIT-Driven Leukemogenesis Cell Rep shRNA TG511327
TIMP1 Regulation of soluble vascular endothelial growth factor receptor 1 secretion from human endothelial cells by tissue inhibitor of metalloproteinase 1 Molecular Human Reproduction, doi:10.1093/molehr/gap053 shRNA TR308814
TIMP3 Mesenchymal Stem Cells Regulate Blood-Brain Barrier Integrity Through TIMP3 Release After Traumatic Brain Injury Science Translational Medicine, Nov 2012; 4: 161ra150. shRNA TR308813
Tissue Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution Methods in Cell Biology shRNA TR30007
Tle1 Transducin-like Enhancer of Split-1 (TLE1) Combines with Forkhead Box Protein G1 (FoxG1) to Promote Neuronal Survival J. Biol. Chem., Apr 2012; 287: 14749 - 14759. shRNA TG511107
TLE5 Repression of HNF1a-mediated transcription by amino-terminal enhancer of split (AES) Biochem. Biophys. Res. Commun. shRNA TR306804
TLE5 Amino-terminal Enhancer of Split (AES) Interacts with the Oncoprotein NUP98-HOXA9 and Enhances Its Transforming Ability J. Biol. Chem., Nov 2011; 286: 38989 - 39001. shRNA TR306804
TLK1 The TLK1–MK5 Axis Regulates Motility, Invasion, and Metastasis of Prostate Cancer Cells Cancers shRNA TL320623
TLK1 DNA damage response and repair data with pharmacological modulators of Tousled Data in Brief shRNA TG320623
TLR2 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TR320553
TLR4 Atractylenolide-I Suppresses Tumorigenesis of Breast Cancer by Inhibiting Toll-Like Receptor 4-Mediated Nuclear Factor-κB Signaling Pathway Frontiers in pharmacology shRNA TG320555
TLR4 Atractylenolide-I suppresses tumorigenesis of breast cancer by inhibiting toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway Research Square shRNA TG320555
TLR4 Cathelicidin-mediated lipopolysaccharide signaling via intracellular TLR4 in colonic epithelial cells evokes CXCL8 production Gut Microbes shRNA TG320555
TLR4 Cathelicidin senses enteric pathogen Salmonella typhimurium/LPS for colonic chemokine generation: a new innate immune role for a host defense peptide bioRxiv shRNA TG320555
TLR4 Resveratrol alleviates lysophosphatidylcholine-induced damage and inflammation in vascular endothelial cells Mol Med Rep shRNA TG320555
TLR4 HSV-2 Increases TLR4-Dependent Phosphorylated IRFs and IFN-ß Induction in Cervical Epithelial Cells PLoS ONE e94806 9 4. April 2014 shRNA TG320555
TLR4 TLR4-MyD88/Mal-NF-kB Axis Is Involved in Infection of HSV-2 in Human Cervical Epithelial Cells PLoS ONE e80327 shRNA TG320555
TLR5 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TR308792
TLR7 Toll-Like Receptor 7 Mediates Inflammation Resolution and Inhibition of Angiogenesis in Non-Small Cell Lung Cancer Cancers shRNA TG301078
TLR9 Plasmodium falciparum Histidine-Rich Protein II Compromises Brain Endothelial Barriers and May Promote Cerebral Malaria Pathogenesis MBio shRNA TR301076
TM4SF5 Interaction of tetraspan(in) TM4SF5 with CD44 promotes self-renewal and circulating capacities of hepatocarcinoma cells Hepatology shRNA TG308787
TMEM106A Transmembrane protein 106A is silenced by promoter region hypermethylation and suppresses gastric cancer growth by inducing apoptosis J. Cell. Mol. Med. shRNA TF301042
Tmem106b Lysosome size, motility and stress response regulated by Fronto-Temporal Dementia modifier TMEM106B Molecular and cellular neurosciences shRNA TL504639
Tmem126a Novel transmembrane protein 126A (TMEM126A) Couples with CD137L Reverse Signals in Myeloid cells Cellular signalling shRNA TL503575
TMEM127 Germline mutations in TMEM127 confer susceptibility to pheochromocytoma Nature Genetics 42, 229-233 (14 February 2010) doi:10.1038/ng.533 Letter shRNA TR301024
Tmem184a Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1 The Journal of Biological Chemistry shRNA TL702927
Tmem184a Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin The Journal of Biological Chemistry shRNA TL702927
TMEM184A Heparin decreases in TNFa;-induced endothelial stress responses require transmembrane protein 184A and induction of dual specificity phosphatase-1 J. Biol. Chem. shRNA TG702927
TMEM88 Transmembrane protein 88 (TMEM88) promoter hypomethylation is associated with platinum resistance in ovarian cancer Gynecol. Oncol. shRNA TR318781
Tmod2 Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development. Biochemical and biophysical research communications shRNA TL711420
TMOD2 Down-regulated in renal cell carcinoma 1 (DRR1) regulates axon outgrowth during hippocampal neuron development Biochemical and biophysical research communications shRNA TG711420
TNF Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation Cytokine shRNA TR318768
TNF Transmembrane TNF-alpha promotes chemoresistance in breast cancer cells Oncogene shRNA TG318768
TNF Targeting Transmembrane TNF-a Suppresses Breast Cancer Growth Cancer Res., Jul 2013; 73: 4061 - 4074. shRNA TG318768
Tnfaip2 Protective effect of the tunneling nanotube-TNFAIP2/M-sec system on podocyte autophagy in diabetic nephropathy Autophagy shRNA TL513846
TNFAIP3 Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR320557
TNFAIP6 Acute and Temporal Expression of TNF-a-stimulated Gene 6 Product,TSG-6,in Mesenchymal Stem Cells Creates Microenvironments Required for Their Successul Transplantation into the Muscle Tissue J. Biol. Chem. shRNA TF517014
TNFRSF10C Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR308740
TNFRSF10D Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR308739
TNFRSF11B Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR308738
TNFRSF1B WISP1, a Pro-mitogenic, Pro-survival Factor, Mediates Tumor Necrosis Factor- (TNF-)-stimulated Cardiac Fibroblast Proliferation but Inhibits TNF--induced Cardiomyocyte Death J. Biol. Chem., May 2009; 284: 14414 - 14427 shRNA TR308733
TNFSF10 Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR308728
TNFSF10 CCN1 sensitizes esophageal cancer cells to TRAIL-mediated apoptosis Exp. Cell Res. shRNA TR308728
TNIK Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK J. Pharmacol. Exp. Ther. shRNA TF320665
TNK2 ACK1 promotes hepatocellular carcinoma progression via downregulating WWOX and activating AKT signaling Int. J. Oncol. shRNA TR320634
TNKS1BP1 Endothelial p130cas confers resistance to anti-angiogenesis therapy Cell reports shRNA TL300907
TNMD Effects of X-chromosome Tenomodulin Genetic Variants on Obesity in a Children's Cohort and Implications of the Gene in Adipocyte Metabolism Sci Rep shRNA TR300905
TNPO3 Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection Biosci. Biotechnol. Biochem. shRNA TG315644
TOP2B(GFP vector) Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements Nature Genetics (4 July 2010) doi:10.1038/ng.613 Article shRNA
TOPBP1 ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical Stress Cell July 2014 shRNA TR308695
TOX MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation Sci Adv shRNA TG507539
TOX3 TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex J. Cell Sci., Jan 2011; 124: 252 - 260 shRNA TR300899
TP53 COUP-TFII Overexpression Inhibits Cell Proliferation and Invasion via Increased Expression of p53 and PTEN and Decreased Akt Phosphorylation in Human Colorectal Cancer SNU-C4 Cells Anticancer Res. shRNA TG320558
TP53 TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background Front Oncol shRNA TR320558
TP53 p53-Dependent and -Independent Responses of Cells Challenged by Photosensitization Photochem. Photobiol. shRNA TG320558
TP53 p53 is essential for embelin-induced apoptosis in p53-wildtype prostate cancer cells Int J Clin Exp Med shRNA TR320558
TP53 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG320558
TP53 Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma Neoplasia shRNA TR320558
TP53 Oncomorphic TP53 Mutations in Gynecologic Cancers Lose the Normal Protein: Protein Interactions with the microRNA Microprocessing Complex Journal of Cancer Therapy April 2014 shRNA TR320558
TP53 Oncomorphic Tp53 mutations in advanced serous ovarian carcinomas Thesis shRNA TF320558
TP53 Gene Expression Profiles Resulting from Stable Loss of p53 Mirrors Its Role in Tissue Differentiation PLOS ONE e82494 shRNA TG320558
TP53 Deacetylation of p53 induces autophagy by suppressing Bmf expression J. Cell Biol., Apr 2013; 201: 427 - 437. shRNA TG320558
TP53 Downregulation of SMG-1 in HPV-Positive Head and Neck Squamous Cell Carcinoma Due to Promoter Hypermethylation Correlates with Improved Survival Clin. Cancer Res., Mar 2012; 18: 1257 - 1267. shRNA TR320558
TP53BP1 Heterozygous PALB2 c.1592delT mutation channels DNA double-strand break repair into error-prone pathways in breast cancer patients Oncogene shRNA TR308691
TP53BP1 MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection Nature shRNA TF308691
TP53BP1 MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection Nature shRNA TR308691
TP63 TGFß3 Regulates Periderm Removal through ?Np63 in the Developing Palate J. Cell. Physiol. shRNA TR308688
TP63 OCT4 as a target of miR-34a stimulates p63 but inhibits p53 to promote human cell transformation Cell Death Dis, Jan 2014. shRNA TG308688
TP73 The p53 family member p73 modulates the pro-proliferative role of IGFBP3 in short children born SGA Mol. Biol. Cell shRNA TR308689
Tpcn2 VEGF-induced neoangiogenesis is mediated by NAADP and two-pore channel-2-dependent Ca2+ signaling Proc. Natl. Acad. Sci. U.S.A. shRNA TR300883
TPK1 TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer Pathol. Res. Pract. shRNA TG300880
Tpp2 A High-Content Screen Identifies TPP1 and Aurora B as Regulators of Axonal Mitochondrial Transport Cell reports shRNA TL711260
TPR Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TG308677
TR20003 Circadian Modulation of 8-Oxoguanine DNA Damage Repair Sci Rep shRNA TR20003
TR20003 Feed forward reciprocal activation of PAFR and STAT3 regulates epithelial-mesenchymal transition in non-small cell lung cancer Cancer Res. shRNA TR20003
TR20003 Actin-Modulating Protein Cofilin Is Involved in the Formation of Measles Virus Ribonucleoprotein Complex at the Perinuclear Region J. Virol. shRNA TR20003
TR20003 SLC9A3R1 stimulates autophagy via BECN1 stabilization in breast cancer cells Autophagy shRNA TR20003
TR20003 STX13 regulates cargo delivery from recycling endosomes during melanosome biogenesis J. Cell. Sci. shRNA TR20003
TR20003 TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine shRNA TR20003
TR20003 Different states of integrin LFA-1 aggregation are controlled through its association with tetraspanin CD9 Biochim. Biophys. Acta shRNA TR20003
TR20003 Redox signalling to nuclear regulatory proteins by reactive oxygen species contributes to oestrogen-induced growth of breast cancer cells Br. J. Cancer shRNA TR20003
TR20003 Characterisation of mesothelioma-initiating cells and their susceptibility to anti-cancer agents PLoS ONE shRNA TR20003
TR20003 Involvement of aldehyde dehydrogenase 1A2 in the regulation of cancer stem cell properties in neuroblastoma Int. J. Oncol. shRNA TR20003
TR20003 STING agonists induce an innate antiviral immune response against hepatitis B virus Antimicrob. Agents Chemother. shRNA TR20003
TR30002 Aberrant glycosylation promotes lung cancer metastasis through adhesion to galectins in the metastatic niche Cancer Discov shRNA TR30002
TR30003 A novel miR-371a-5p-mediated pathway, leading to BAG3 upregulation in cardiomyocytes in response to epinephrine, is lost in Takotsubo cardiomyopathy Cell Death Dis shRNA TR30003
TR30003 TNF Apoptosis Protection Fraction (TAPF) prevents apoptosis induced by TNF, but not by Fas or TRAIL, via NF-?B-induced increase in cFLIP Cytokine shRNA TR30003
TR30007 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. shRNA TR30007
TR30007 Effect of Co-transfection of Anti-myostatin shRNA Constructs in Caprine Fetal Fibroblast Cells Anim. Biotechnol. shRNA TR30007
TR30007 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response J. Clin. Invest. shRNA TR30007
TR30007 Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways PLoS ONE shRNA TR30007
TR30007 Effects of Ezrin and Heat Shock Protein 70 on Apoptosis and Proliferation of Human Osteosarcoma Cells Orthop Surg shRNA TR30007
TR30007 Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation Sci Rep shRNA TR30007
TR30007 Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain Methods in Cell Biology shRNA TR30007
TR30007 Construction of DKK1-siRNA eukaryotic expression vectors and the therapeutic effect on osteoporotic rats Chinese Journal of Osteoporosis shRNA TR30007
TR30007 Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection Biosci. Biotechnol. Biochem. shRNA TR30007
TR30007 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. shRNA TR30007
TR30007 Biologic Roles of Estrogen Receptor-ß and Insulin-Like Growth Factor-2 in Triple-Negative Breast Cancer BioMed Research International shRNA TR30007
TR30007 PDLIM5 mediates PKCe translocation in PMA-induced growth cone collapse Cell. Signal. shRNA TR30007
TR30007 Memory and PTPIP51 - A new protein in hippocampus and cerebellum Mol. Cell. Neurosci. shRNA TR30007
TR30012 Role of Phosphatidic Acid Phosphatase Domain Containing 2 (PPAPDC2) In Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes Drug Metab. Dispos. shRNA TR30012
TR30012 Forkhead box protein A1 is a prognostic predictor and promotes tumor growth of gastric cancer Onco Targets Ther shRNA TR30012
TR30012 Signaling mechanisms coupled to CXCL12/CXCR4-mediated cellular proliferation are PTEN-dependent Am J Clin Exp Urol shRNA TR30012
TR30012 STING agonists induce an innate antiviral immune response against hepatitis B virus Antimicrob. Agents Chemother. shRNA TR30012
TR30012 a-Actinin-4 Is Required for Amoeboid-type Invasiveness ofMelanoma Cells* JOURNAL OF BIOLOGICAL CHEMISTRY shRNA TR30012
TR30012 AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells Biochem. Pharmacol. July 2014 shRNA TR20003
TR30013 SATB2 expression increased anchorage-independent growth and cell migration in human bronchial epithelial cells Toxicol. Appl. Pharmacol. shRNA TR30013
TR30013 SLAMF1 regulation of chemotaxis and autophagy determines CLL patient response J. Clin. Invest. shRNA TR30013
TR30013 A novel role for the tumour suppressor Nitrilase1 modulating the Wnt/ß-catenin signalling pathway Cell Discovery shRNA TR30013
TR30013 Endogenous Nodal promotes melanoma undergoing epithelial-mesenchymal transition via Snail and Slug in vitro and in vivo Am J Cancer Res shRNA TR30013
TR30013 Activation of peroxisome proliferator-activated receptor a stimulates ADAM10-mediated proteolysis of APP Proc. Natl. Acad. Sci. U.S.A. shRNA TR30013
TR30013 Knockdown of the host cellular protein transportin 3 attenuates prototype foamy virus infection Biosci. Biotechnol. Biochem. shRNA TR30013
TR30013 Cell entry of bovine ephemeral fever virus requires activation of Src-JNK-AP1 and PI3K-Akt-NF?B pathways as well as Cox-2-mediated PGE2 /EP receptor signaling to enhance clathrin-mediated virus endocytosis Cell. Microbiol. shRNA TR30013
TR30013 Sphingomyelin Synthase 1 Regulates Neuro-2a Cell Proliferation and Cell Cycle Progression Through Modulation of p27 Expression and Akt Signaling Mol. Neurobiol. shRNA TR30007
TR30014 Imaging of motor-dependent transport in neuronal and nonneuronal cells at high spatial and temporal resolution Methods in Cell Biology shRNA TR30014
TR30014 Cellular and subcellular imaging of motor protein-based behavior in embryonic rat brain Methods in Cell Biology shRNA TR30014
TR30014 The vesicular nucleotide transporter (VNUT) is involved in the extracellular ATP effect on neuronal differentiation Purinergic Signal. shRNA TR30014
TR30014 Dual Expression of shAkt1 and Pdcd4 Suppresses Lung Tumorigenesis in K-rasLA1 Mice Anticancer Res. shRNA TR30014
TR30014 S100 Calcium-Binding Protein A6 Promotes Epithelial-Mesenchymal Transition through ß-Catenin in Pancreatic Cancer Cell Line PLoS ONE shRNA TR30014
TR30014 ADAM8 as a drug target in pancreatic cancer Nat Commun shRNA TR30014
TR30014 RNA-Processing Protein TDP-43 Regulates FOXO-Dependent Protein Quality Control in Stress Response PLoS Genet. shRNA TR30014
TR30015 Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription PLoS Biol. shRNA TR30015
TR30018 HO-1/CO system and embryonic stem cell differentiation and maturation into cardiomyocytes Antioxid. Redox Signal. shRNA TR30018
TR30018 The Novel Gene CRNDE Encodes a Nuclear Peptide (CRNDEP) Which Is Overexpressed in Highly Proliferating Tissues PLoS ONE shRNA TR30018
TR30018 p38 MAPK down-regulates fibulin 3 expression through methylation of gene regulatory sequences. Role in migration and invasion J. Biol. Chem. shRNA TR30018
TR30021 Targeting the MLL complex in castration-resistant prostate cancer Nat. Med. shRNA TR30021
TR30023 Protein composition and movements of membrane swellings associated with primary cilia Cell. Mol. Life Sci. shRNA TR30023
TR30032 Dendrosomatic Sonic Hedgehog Signaling in Hippocampal Neurons Regulates Axon Elongation J. Neurosci. shRNA TR30032
TR313235 HuD interacts with survival motor neuron protein and can rescue spinal muscular atrophy-like neuronal defects Hum. Mol. Genet., Feb 2011; 20: 553 - 579 shRNA
TRADD Esophageal cancer cells convert the death signal from TRAIL into a stimulus for survival during acid/bile exposure Digestive and Liver Disease shRNA TR320590
Transfection Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers, FGF22 and FGF7 J. Cell. Sci. shRNA TR30014
TRIL Toll-like Receptor 3 (TLR3) Signaling Requires TLR4 Interactor with Leucine-rich Repeats (TRIL) J. Biol. Chem., Nov 2011; 286: 38795 - 38804. shRNA TR315701
TRIM28 Expression of tripartite motif-containing protein 28 in primary breast carcinoma predicts metastasis and is involved in the stemness, chemoresistance, and tumor growth Tumour Biol. shRNA TG502285
TRIM28 Exonuclease-1 interacts with the transcriptional co-repressor KAP1 Matters shRNA TR320633
Trim32 TRIM32 overexpression improves chemoresistance through regulation of mitochondrial function in non-small-cell lung cancers OncoTargets and therapy shRNA TL701612
TRIM39 TRIM39 is a MOAP-1-binding protein that stabilizes MOAP-1 through inhibition of its poly-ubiquitination process Experimental Cell Research Volume 315, Issue 7, 15 April 2009, Pages 1313-1325 shRNA TR300845
TRIM72 Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair JCI Insight shRNA TG517706
TRIM8 TRIM8 Blunts the Pro-proliferative Action of ΔNp63α in a p53 Wild-Type Background Front Oncol shRNA TR300821
TRIM8 TRIM8 restores p53 tumour suppressor function by blunting N-MYC activity in chemo-resistant tumours Mol. Cancer shRNA TR300821
TRIM8 TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma Oncotarget shRNA TR300821
TRIP10 Collective membrane dynamics emerging from curvature-dependent spatial coupling bioRxiv shRNA TG712260
Trp53 Maternal Obesity Programs Senescence Signaling and Glucose Metabolism in Osteo-Progenitors From Rat and Human. Endocrinology shRNA TG500002
TRPC1 Molecular mechanisms of spontaneous and directed mast cell motility J. Leukoc. Biol., Nov 2012; 92: 1029 - 1041. shRNA TG308629
TRPC1 Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells J. Immunol., Nov 2009; 183: 6478 - 6488 shRNA TR308629
TRPC1 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR308629
TRPC3 ACTIVITY-DEPENDENT RELEASE OF ENDOGENOUS BDNF FROM MOSSY FIBERS EVOKES A TRPC3 CURRENT AND Ca2+ ELEVATIONS IN CA3 PYRAMIDAL NEURONS J Neurophysiol, May 2010; 103: 2846 - 2856 shRNA TR308628
TRPC3 Ca2+ Waves Initiate Antigen-Stimulated Ca2+ Responses in Mast Cells J. Immunol., Nov 2009; 183: 6478 - 6488 shRNA TR308628
TRPC4 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR300814
Trpc5 Functional interplay between ganglioside GM1 and cross-linking galectin-1 induces axon-like neuritogenesis via integrin-based signaling and TRPC5-dependent Ca(2+) influx J. Neurochem. shRNA TR509727
TRPC5 Cross-Linking of GM1 Ganglioside by Galectin-1 Mediates Regulatory T Cell Activity Involving TRPC5 Channel Activation: Possible Role in Suppressing Experimental Autoimmune Encephalomyelitis J. Immunol., Apr 2009; 182: 4036 - 4045. shRNA TR308627
TRPC6 TRPC6 Channels Are Required for Proliferation, Migration and Invasion of Breast Cancer Cell Lines by Modulation of Orai1 and Orai3 Surface Exposure Cancers (Basel) 2018 shRNA TR308626
TRPC6 Hyperforin/HP-β-Cyclodextrin Enhances Mechanosensitive Ca(2+) Signaling in HaCaT Keratinocytes and in Atopic Skin Ex Vivo Which Accelerates Wound Healing Biomed Res Int shRNA TF308626
TRPC6 Mechanosensitive ATP release from hemichannels and Ca2+ influx through TRPC6 accelerate wound closure in keratinocytes J. Cell. Sci. shRNA TF308626
Trpc6 HYPERFORIN MODULATES DENDRITIC SPINE MORPHOLOGY IN HIPPOCAMPAL PYRAMIDAL NEURONS BY ACTIVATING Ca 2+ -PERMEABLE TRPC6 CHANNELS Hippocampus shRNA TG711962
TRPC6 Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration FASEB J, Apr 2009; 10.1096/fj.09-131128. shRNA TR308626
TRPM2 TRPM2 contributes to LPC-induced intracellular Ca(2+) influx and microglial activation Biochem. Biophys. Res. Commun shRNA TR515108
TRPM2 The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting Leukemia July 2014 shRNA TG308624
TRPM4 TRPM4 Is a Novel Component of the Adhesome Required for Focal Adhesion Disassembly, Migration and Contractility PLoS ONE shRNA TF504191
TRPM7 Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function Mol. Neurobiol. shRNA TR320704
TRPM7 Cholesterol-induced activation of TRPM7 regulate cell proliferation, migration, and viability of human prostate cells Biochim. Biophys. Acta. April 2014 shRNA TR320704
TRPM7 Increase in Serum Ca2+/Mg2+ Ratio Promotes Proliferation of Prostate Cancer Cells by Activating TRPM7 Channels J. Biol. Chem., Jan 2013; 288: 255 - 263. shRNA TG516988
TSC22D1 Transforming Growth Factor-ß–Stimulated Clone-22 Is an Androgen-Regulated Gene That Enhances Apoptosis in Prostate Cancer following Insulin-Like Growth Factor-I Receptor Inhibition Clin. Cancer Res., Dec 2009; 15: 7634 - 7641 shRNA TR300799
TSPAN8 Tetraspanin 8 is a novel regulator of ILK-driven β1 integrin adhesion and signaling in invasive melanoma cells Oncotarget shRNA TR308597
TSPAN8 Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts Oncotarget shRNA TR308597
TT200002 AICAR induces Nrf2 activation by an AMPK-independent mechanism in hepatocarcinoma cells Biochem. Pharmacol. July 2014 shRNA TR30012
TTK Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores J. Cell Biol., Jun 2008; 181: 893 - 901 shRNA TR320563
TTLL6 Amyloid-Beta oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin EMBO J. 2013 Nov 13;32(22):2920-37. shRNA TG300748
TUBB3 ßIII-Tubulin Is a Multifunctional Protein Involved in Drug Sensitivity and Tumorigenesis in Non–Small Cell Lung Cancer Cancer Res., Jun 2010; 70: 4995 - 5003 shRNA TR308568
TULP1 Tubby-like protein 1 (Tulp1) is a target of microRNA-134 and is down-regulated in experimental epilepsy Int J Physiol Pathophysiol Pharmacol shRNA TR308561
TWIST1 Overcoming acquired resistance of gefitinib in lung cancer cells without T790M by AZD9291 or Twist1 knockdown in vitro and in vivo Arch. Toxicol. shRNA TF308556
TWIST1 A83-01 inhibits TGF-β-induced upregulation of Wnt3 and epithelial to mesenchymal transition in HER2-overexpressing breast cancer cells Breast Cancer Res. Treat shRNA TF308556
Txndc5 Endoplasmic Reticulum Protein ERp46 in Renal Cell Carcinoma PLoS ONE shRNA TG505718
Txnip Astrocytes require insulin-like growth factor I to protect neurons against oxidative injury FJan000Research, Jan 2014. shRNA TG503152
TXNRD1 Perturbation of redox balance after thioredoxin reductase deficiency interrupts autophagy-lysosomal degradation pathway and enhances cell death in nutritionally stressed SH-SY5Y cells Free Radic. Biol. Med. shRNA TR300712
Ube2e1 Regulation of canonical Wnt signalling by the ciliopathy protein MKS1 and the E2 ubiquitin-conjugating enzyme UBE2E1 eLife shRNA TR502364
UBE2I Modulation of host cell SUMOylation facilitates efficient development of Plasmodium berghei and Toxoplasma gondii Cell. Microbiol shRNA TG300697
UBE3A Interaction of HPV E6 oncoproteins with specific proteasomal subunits Virology. 2013 Nov;446(1-2):389-96. doi: 10.1016 shRNA TG308522
Ube3a Impairment of TrkB-PSD-95 Signaling in Angelman Syndrome PLoS Biology shRNA TL502369
UBE4B Regulation of Protein Quality Control by UBE4B and LSD1 through p53-Mediated Transcription PLoS Biol. shRNA TF308519
UBE4B Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression Molecular Genetics and Metabolism Reports shRNA TF308519
UBIAD1 Mitochondrial damage and cholesterol storage in human hepatocellular carcinoma cells with silencing of UBIAD1 gene expression Molecular Genetics and Metabolism Reports shRNA TF308518
UBR1 Phosphorylation Impacts N-End Rule Degradation of the Proteolytically Activated Form of BMX Kinase JBC shRNA TG300681
UBR2 Phosphorylation Impacts N-End Rule Degradation of the Proteolytically Activated Form of BMX Kinase JBC shRNA TF300680
UBXN4 Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets Mol. Biol. Cell, Mar 2012; 23: 800 - 810. shRNA TR308513
UCHL1 NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's Disease Hum. Mol. Genet. shRNA TF710038
UCHL1 Expression and Functional Studies of Ubiquitin C-Terminal Hydrolase L1 Regulated Genes PLoS ONE 4(8): e6764 (2009) shRNA TR316775
UGDH Loss of exogenous androgen dependence by prostate tumor cells is associated with elevated glucuronidation potential Horm Cancer shRNA TG308504
UGT8 Microbubble-based enhancement of radiation effect: Role of cell membrane ceramide metabolism PLoS ONE shRNA TG308493
UHMK1 Genome-wide association study in East Asians suggests UHMK1 as a novel bone mineral density susceptibility gene Bone shRNA TR320754
UHRF1 Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus J. Clin. Invest. shRNA TG308492
UNC13B CAPS and Munc13 utilize distinct PIP2-linked mechanisms to promote vesicle exocytosis Mol. Biol. Cell Dec 2013. shRNA TG710861
Unc93b1 Antioxidative properties of paraoxonase 2 in intestinal epithelial cells Am J Physiol Gastrointest Liver Physiol, Sep 2012; 303: G623 - G634. shRNA TR515293
UPF1 UPF1 silenced cellular model systems for screening of read-through agents active on β039 thalassemia point mutation BMC Biotechnol. shRNA TR308482
UPF1 Modulation of nonsense mediated decay by rapamycin Nucleic Acids Res. shRNA TR308482
UPF1 A luciferase reporter assay to investigate the differential selenium-dependent stability of selenoprotein mRNAs. The Journal of nutritional biochemistry shRNA TR308482
USP17L2 The Deubiquitinating Enzyme USP17 Is Highly Expressed in Tumor Biopsies, Is Cell Cycle Regulated, and Is Required for G1-S Progression Cancer Res., Apr 2010; 70: 3329 - 3339 shRNA TR307933
USP17L9P The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility Nature Communications 2, 259 (29 March 2011) doi:10.1038/ncomms1243 Article shRNA TR321147
USP17L9P The Deubiquitinating Enzyme USP17 Blocks N-Ras Membrane Trafficking and Activation but Leaves K-Ras Unaffected J. Biol. Chem., Apr 2010; 285: 12028 - 12036 shRNA TR321147
USP19 USP19 Enhances MMP2/MMP9-Mediated Tumorigenesis in Gastric Cancer OncoTargets and therapy shRNA TR308463
Usp21 Systematic survey of deubiquitinase localization identifies USP21 as a regulator of centrosome- and microtubule-associated functions Mol. Biol. Cell, Mar 2012; 23: 1095 - 1103. shRNA TR708469
USP4 Ubiquitin-specific protease 4 is an endogenous negative regulator of metabolic dysfunctions in nonalcoholic fatty liver disease Hepatology shRNA TG502380
USP7 Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation The Journal of Biological Chemistry shRNA TL308454
USP7 USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway Proc Natl Acad Sci U S A shRNA TF308454
USP7 HSCARG, a novel regulator of H2A ubiquitination by downregulating PRC1 ubiquitin E3 ligase activity, is essential for cell proliferation Nucleic Acids Res. April 2014 shRNA TR308454
USP8 USP8 Deubiquitinates SHANK3 to Control Synapse Density and SHANK3 Activity-dependent Protein Levels J. Neurosci. shRNA TG705081
USP9X TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance SSRN Journal shRNA TF510959
USP9X TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance Cell Rep shRNA TF510959
UXT Depletion of UXT, a novel TSG101 interaction protein, leads to enhanced CEP55 attenuation through lysosome degradation Biochemical and biophysical research communications shRNA TF308443
VAMP2 The SNARE Proteins SNAP25 and Synaptobrevin Are Involved in Endocytosis at Hippocampal Synapses J. Neurosci., May 2013; 33: 9169 - 9175. shRNA TF709295
VAMP3 The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse J. Cell. Sci. shRNA TR308442
VAMP3 The small GTPase Rab8 interacts with VAMP-3 to regulate the delivery of recycling TCRs to the immune synapse J. Cell. Sci. shRNA TR515358
VAMP3 Regulated delivery of molecular cargo to invasive tumour-derived microvesicles Nat Commun shRNA TF308442
various knockdown plasmids NF-B regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes Nucleic Acids Res., Jan 2012; 40: 181 - 195. shRNA
Vash1 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.) shRNA TL511800
Vash2 Vasohibins/SVBP are tubulin carboxypeptidases (TCPs) that regulate neuron differentiation. Science (New York, N.Y.) shRNA TL506751
Vav2 Transcription factor CUX1 is required for intestinal epithelial wound healing and targets the VAV2-RAC1 Signalling complex. Biochimica et biophysica acta. Molecular cell research shRNA TL705141
VCAN Versican regulates metastasis of epithelial ovarian carcinoma cells and spheroids J Ovarian Res July 2014 shRNA TG313695
Vdr The mechanisms of skeletal muscle atrophy in response to transient knockdown of the vitamin D receptor in vivo The Journal of Physiology shRNA TL709870
VDR RNAi-mediated knockdown of VDR surprisingly suppresses cell growth in Jurkat T and U87-MG cells Heliyon shRNA TG320568
VDR Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance Mol Nutr Food Res shRNA TG513148
VDR Intestinal epithelial vitamin D receptor deletion leads to defective autophagy in colitis Gut July 2014 shRNA TG320568
Vegfa Fluid Flow-induced Soluble Vascular Endothelial Growth Factor Isoforms Regulate Actin Adaptation in Osteoblasts J. Biol. Chem., Oct 2010; 285: 30931 - 30941 shRNA TR510369
VENTX VentX trans-Activates p53 and p16ink4a to Regulate Cellular Senescence J. Biol. Chem., Apr 2011; 286: 12693 - 12701 shRNA
VENTX VentX, a Novel Lymphoid-Enhancing Factor/T-Cell Factor–Associated Transcription Repressor, Is a Putative Tumor Suppressor Cancer Res., Jan 2010; 70: 202 - 211 shRNA TR317112
VHL Oncotropic H-1 parvovirus infection degrades HIF-1a protein in human pancreatic cancer cells independently of VHL and RACK1 Int. J. Oncol. shRNA TR300577
VPS13A A conserved function in phosphatidylinositol metabolism for Mammalian vps13 family proteins PLoS ONE shRNA TF704233
Vps35 Microglial beclin 1 regulates retromer trafficking and phagocytosis and is impaired in Alzheimer’s disease Neuron shRNA TL503494
WDR5 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. shRNA TG300500
WDR5 TWIST1-WDR5-Hottip regulates Hoxa9 chromatin to facilitate prostate cancer metastasis Cancer Res. shRNA TG513026
WDR5 WDR5 high expression and its effect on tumorigenesis in leukemia Oncotarget shRNA TG300500
WDR82 Bone morphogenetic protein 4 reduces global H3K4me3 to inhibit proliferation and promote differentiation of human neural stem cells bioRxiv shRNA TG301034
WEE1 Whole-Genome Expression Microarray Combined with Machine Learning to Identify Prognostic Biomarkers for High-Grade Glioma J. Mol. Neurosci. shRNA TF320571
WFDC2 Human Epididymis Secretory Protein 4 (HE4) Compromises Cytotoxic Mononuclear Cells via Inducing Dual Specificity Phosphatase 6 Front Pharmacol shRNA TR318721
WFDC2 HE4 sabotages cytotoxic mononuclear cells via inducing dual specificity phosphatase 6 secretion Gynecologic Oncology shRNA TR318721
WFDC2 HE4 suppresses the expression of osteopontin in mononuclear cells and compromises their cytotoxicity against ovarian cancer cells Clin. Exp. Immunol. shRNA TR318721
WIF1 Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 Int. J. Cancer shRNA TG513512
Wnk1 WNK1-regulated inhibitory phosphorylation of the KCC2 cotransporter maintains the depolarizing action of GABA in immature neurons. Science signaling shRNA TL712155
WNK3 With-No-Lysine Kinase 3 (WNK3) stimulates glioma invasion by regulating cell volume Am J Physiol Cell Physiol, Nov 2011; 301: C1150 - C1160. shRNA TR320730
WNT3A Triptolide inhibits Wnt signaling in NSCLC through upregulation of multiple Wnt inhibitory factors via epigenetic modifications to Histone H3 Int. J. Cancer shRNA TG300447
Wnt3a Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/ß-catenin pathway Neuro Oncology, Jul 2013; 10.1093/neuonc/not104. shRNA TG300447
WNT4 Context dependent non canonical WNT signaling mediates activation of fibroblasts by transforming growth factor-ß Exp. Cell Res. shRNA TG300446
WNT5A Activation of Wnt5A signaling is required for CXC chemokine ligand 12–mediated T-cell migration Blood, Aug 2009; 114: 1366 - 1373 shRNA TR320572
WNT5A Activation of Wnt5A signaling is required for CXCL12-mediated T-cell migration Blood, Jun 2009; 10.1182/blood-2008-08-175869 shRNA TR320572
WNT5B Identification of Predictive Markers of Response to the MEK1/2 Inhibitor Selumetinib (AZD6244) in K-ras–Mutated Colorectal Cancer Mol. Cancer Ther., Dec 2010; 9: 3351 - 3362 shRNA TR300445
WNT6 WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma Theranostics shRNA TR308360
WRN CDK1 phosphorylates WRN at collapsed replication forks Nat Commun shRNA TR308355
WRN Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress Nucleic Acids Res. shRNA TF308355
WRNIP1 Checkpoint Defects Elicit a WRNIP1-Mediated Response to Counteract R-Loop-Associated Genomic Instability Cancers (Basel) 2020 shRNA TR300444
WRNIP1 Checkpoint defects require WRNIP1 to counteract R-loop-associated genomic instability bioRxiv shRNA TR300444
WT1 Wilms' tumor 1 (Wt1) regulates pleural mesothelial cell plasticity and transition into myofibroblasts in idiopathic pulmonary fibrosis FASEB J. shRNA TG300442
Wwp2 DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells Stem Cell Reports shRNA TG516592
WWTR1 Screening with a novel cell-based assay for TAZ activators identifies a compound that enhances myogenesis in C2C12 cells and facilitates muscle repair in the muscle injury model Mol. Cell. Biol., Feb 2014. shRNA TF505533
XIAP MicroRNA-212 inhibits the proliferation, migration and invasion of renal cell carcinoma by targeting X-linked inhibitor of apoptosis protein (XIAP) Oncotarget shRNA TG314473
XKR5 XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation Oncogenesis shRNA TG300427
XPA Downregulated XPA promotes carcinogenesis of bladder cancer via impairment of DNA repair Tumour Biol shRNA TR308346
XPC The Xpc gene markedly affects cell survival in mouse bone marrow Mutagenesis, Jul 2009; 24: 309 - 316. shRNA TR308345
XRCC3 WRN controls formation of extrachromosomal telomeric circles and is required for TRF2B-mediated telomere shortening Mol. Cell. Biol., Mar 2008; 28: 1892 - 1904. shRNA TR510156
XRCC5 Dual Functions of the Homeoprotein DLX4 in Modulating Responsiveness of Tumor Cells to Topoisomerase II-Targeting Drugs Cancer Res., Jan 2013; 73: 1000 - 1010. shRNA TG300421
YAP1 Naringin protects endothelial cells from apoptosis and inflammation by regulating the Hippo-YAP Pathway Biosci. Rep. shRNA TR308332
YAP1 YAP1 plays a key role of the conversion of normal fibroblasts into cancer-associated fibroblasts that contribute to prostate cancer progression J. Exp. Clin. Cancer Res. shRNA TG502437
YBX1 Silencing Y-box binding protein-1 inhibits triple-negative breast cancer cell invasiveness via regulation of MMP1 and beta-catenin expression Cancer Lett. shRNA TG308329
YWHAB Infection of Prions and Treatment of PrP106-126 Alter the Endogenous Status of Protein 14-3-3 and Trigger the Mitochondrial Apoptosis Possibly via Activating Bax Pathway Mol Neurobiol. 2013 Oct 18 shRNA TG300398
Yy1 An integrated transcriptomics-guided genome-wide promoter analysis and next-generation proteomics approach to mine factor(s) regulating cellular differentiation DNA Res shRNA TR713377
ZBTB10 MicroRNA-27a Indirectly Regulates Estrogen Receptor {alpha} Expression and Hormone Responsiveness in MCF-7 Breast Cancer Cells Endocrinology, Jun 2010; 151: 2462 - 2473 shRNA TR300388
Zbtb16 Striatal ZBTB16 Is Associated With Cognitive Deficits in Alzheimer Disease Mice International Neurourology Journal shRNA TL507125
ZDHHC18 DHHC protein family targets different subsets of glioma stem cells in specific niches J. Exp. Clin. Cancer Res. shRNA TF307371
Zdhhc3 Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons The Journal of Biological Chemistry shRNA TL703601
Zdhhc3 Brain insulin resistance impairs hippocampal synaptic plasticity and memory by increasing GluA1 palmitoylation through FoxO3a Nat Commun shRNA TG504254
ZDHHC8 Palmitoylation of cdc42 Promotes Spine Stabilization and Rescues Spine Density Deficit in a Mouse Model of 22q11.2 Deletion Syndrome Cereb. Cortex shRNA TF308290
Zeb1 Elafin Reverses Intestinal Fibrosis by Inhibiting Cathepsin S-Mediated Protease-Activated Receptor 2 Cellular and Molecular Gastroenterology and Hepatology shRNA TL513177
ZEB1 CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells International journal of molecular sciences shRNA TR301174
Zeb1 CXCR2+ MDSCs promote breast cancer progression by inducing EMT and activated T cell exhaustion Oncotarget shRNA TG513177
ZEB1 Ginkgolide B Inhibits Human Bladder Cancer Cell Migration and Invasion Through MicroRNA-223-3p Cell. Physiol. Biochem. shRNA TR301174
ZEB2 miR-637 Prevents Glioblastoma Progression by Interrupting ZEB2/WNT/β-catenin Cascades. Cellular and molecular neurobiology shRNA TG308288
ZEB2 miR-637 prevents glioblastoma progression by interrupting ZEB2/WNT/β-catenin cascades Research Square shRNA TG308288
Zfp423 Zfp423 Regulates Skeletal Muscle Regeneration and Proliferation Molecular and Cellular Biology shRNA TL711983
Zfp521 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Molecular and Cellular Biology shRNA TL705963
Zfp521 Direct Transcriptional Repression of Zfp423 by Zfp521 Mediates a Bone Morphogenic Protein-Dependent Osteoblast versus Adipocyte Lineage Commitment Switch Mol. Cell. Biol. shRNA TG506694
Zfpm2 ZEB1 sensitizes lung adenocarcinoma to metastasis suppression by PI3K antagonism J. Clin. Invest. April 2014 shRNA TG512097
ZNF567 RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy Autophagy shRNA TG300130
ZNF567 RIP1 Kinase Is an Oncogenic Driver in Melanoma Cancer Res. shRNA TG300130
ZSCAN4 ZSCAN4 facilitates chromatin remodeling and promotes the cancer stem cell phenotype Oncogene shRNA TF300013
ZSCAN5A A Modified Adenovirus Vector-Mediated Antibody Screening Method Identifies EphA2 as a Cancer Target Transl Oncol shRNA TR300012
ZSCAN5A The Transcriptional Activity of Osterix Requires the Recruitment of Sp1 to the Osteocalcin Proximal Promoter Bone shRNA TR300012