Bile Acid Receptor (NR1H4) Human shRNA Plasmid Kit (Locus ID 9971)
CAT#: TG320627
NR1H4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 2 publications. |
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Specifications
Product Data | |
Product Name | Bile Acid Receptor (NR1H4) Human shRNA Plasmid Kit (Locus ID 9971) |
Locus ID | 9971 |
UniProt ID | Q96RI1 |
Synonyms | BAR; FXR; HRR-1; HRR1; PFIC5; RIP14 |
Vector | pGFP-V-RS |
Format | Retroviral plasmids |
Kit Components | NR1H4 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 9971). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
RefSeq | NM_001206977, NM_001206978, NM_001206979, NM_001206992, NM_001206993, NM_005123, NR_135146, NM_005123.1, NM_005123.2, NM_005123.3, NM_001206978.1, NM_001206977.1, NM_001206979.1, NM_001206992.1, NM_001206993.1, BC035654, BC071778, BC130573, BC144183, BC144184, BC144187, NM_005123.4, NM_001206977.2, NM_001206993.2, NM_001206992.2, NM_001206978.2, NM_001206979.2 |
Summary | This gene encodes a ligand-activated transcription factor that shares structural features in common with nuclear hormone receptor family members. This protein functions as a receptor for bile acids, and when bound to bile acids, binds to DNA and regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2016] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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Farnesoid X receptor as marker of osteotropism of breast cancers through its role in the osteomimetism of tumor cells
,Absil, L;Journé, F;Larsimont, D;Body, JJ;Tafforeau, L;Nonclercq, D;,
BMC Cancer
,PubMed ID 32650752
[NR1H4]
|
Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling
,Cipriani, S;Renga, B;D'Amore, C;Simonetti, M;De Tursi, AA;Carino, A;Monti, MC;Sepe, V;Zampella, A;Fiorucci, S;,
PLoS ONE
,PubMed ID 26177448
[NR1H4]
|
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