Map1lc3b Mouse shRNA Plasmid (Locus ID 67443)
CAT#: TG503902
Map1lc3b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 2 publications. |
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经常一起买 (1)
Specifications
Product Data | |
Product Name | Map1lc3b Mouse shRNA Plasmid (Locus ID 67443) |
Locus ID | 67443 |
UniProt ID | Q9CQV6 |
Synonyms | 1010001C15Rik; Atg8; LC3b; Map1lc3 |
Vector | pGFP-V-RS |
Format | Retroviral plasmids |
Kit Components | Map1lc3b - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 67443). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free. |
RefSeq | BC068180, BC110308, NM_026160, NM_026160.1, NM_026160.2, NM_026160.3, BC028812, BC086774, NM_001364358, NM_026160.5 |
Summary | Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Promotes primary ciliogenesis by removing OFD1 from centriolar satellites via the autophagic pathway.[UniProtKB/Swiss-Prot Function] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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Avian Reovirus Protein p17 Functions as a Nucleoporin Tpr Suppressor Leading to Activation of p53, p21 and PTEN and Inactivation of PI3K/AKT/mTOR and ERK Signaling Pathways
,Huang, WR;Chiu, HC;Liao, TL;Chuang, KP;Shih, WL;Liu, HJ;,
PLoS ONE
,PubMed ID 26244501
[MAP1LC3B]
|
Clearance of the mutant androgen receptor in motoneuronal models of spinal and bulbar muscular atrophy
,null,
Neurobiology of Aging
,PubMed ID 23810450
[Map1lc3b]
|
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