NF-kB p65 (RELA) Human shRNA Plasmid Kit (Locus ID 5970)
CAT#: TR302038
RELA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 4 publications. |
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经常一起买 (2)
Specifications
Product Data | |
Product Name | NF-kB p65 (RELA) Human shRNA Plasmid Kit (Locus ID 5970) |
Locus ID | 5970 |
UniProt ID | Q04206 |
Synonyms | CMCU; NFKB3; p65 |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | RELA - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 5970). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | NM_001145138, NM_001243984, NM_001243985, NM_021975, NM_021975.1, NM_021975.2, NM_021975.3, NM_001145138.1, NM_001243984.1, NM_001243985.1, BC033522, BC011603, BC014095, BC069248, BC110830, BM916512, NM_001243984.2, NM_021975.4, NM_001145138.2 |
Summary | NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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Human Norovirus Induces Aquaporin 1 Production by Activating NF-κB Signaling Pathway
,null,
Viruses
,PubMed ID 35458572
[RELA]
|
COMMD7 is correlated with a novel NF-?B positive feedback loop in hepatocellular carcinoma
,Zheng, L;Deng, CL;Wang, L;Huang, XB;You, N;Tang, YC;Wu, K;Liang, P;Mi, N;Li, J;,
Oncotarget
,PubMed ID 27129158
[RELA]
|
Bortezomib Sensitizes Malignant Human Glioma Cells to TRAIL, Mediated by Inhibition of the NF-{kappa}B Signaling Pathway
,Esther P. Jane, Daniel R. Premkumar, and Ian F. Pollack,
Mol. Cancer Ther., Jan 2011; 10: 198 - 208
[RELA]
|
Angiotensin II-regulated transcription regulatory genes in adrenal steroidogenesis
,Damian G. Romero, Elise P. Gomez-Sanchez, and Celso E. Gomez-Sanchez,
Physiol Genomics, Nov 2010; 42A: 259 - 266
[RELA]
|
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