BCL2 Human shRNA Plasmid Kit (Locus ID 596)
CAT#: TR316461
BCL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector, 5µg of each construct provided
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CNY 4,790.00
货期*
现货
规格
Cited in 2 publications. |
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经常一起买 (2)
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Specifications
Product Data | |
Product Name | BCL2 Human shRNA Plasmid Kit (Locus ID 596) |
Locus ID | 596 |
UniProt ID | P10415 |
Synonyms | Bcl-2; PPP1R50 |
Vector | pRS |
Format | Retroviral plasmids |
Kit Components | BCL2 - Human, 4 unique 29mer shRNA constructs in retroviral untagged vector(Gene ID = 596). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRS Vector, TR30012, included for free. |
RefSeq | BC027258, NM_000633, NM_000657, NM_000633.1, NM_000633.2, NM_000657.1, NM_000657.2, BC027258.1, NM_000657.3, NM_000633.3 |
Summary | This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (2)
The use of this RNAi has been cited in the following citations: |
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Blocking Bcl-2 resolves IL-13-mediated mucous cell hyperplasia in a Bik-dependent manner
,Chand, HS;Mebratu, YA;Kuehl, PJ;Tesfaigzi, Y;,
J. Allergy Clin. Immunol.
,PubMed ID 28784260
[BCL2]
|
Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in BclxL silenced glioma cell lines
,Jane, EP;Premkumar, DR;Sutera, PA;Cavaleri, JM;Pollack, IF;,
Molecular carcinogenesis
,PubMed ID 27805285
[BCL2]
|
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