新冠病毒SARS-CoV-2 (2019-nCoV)

新冠病毒SARS-CoV-2 (2019-nCoV) 相关科研工具

背景

COVID-19是由新发现的冠状病毒SARS-CoV-2（以前称为2019-nCoV）引起的。它属于冠状病毒科，广泛分布于人类和其他哺乳动物中。不同于某些引起轻度呼吸道疾病的已知冠状病毒，例如hCoV-229E，OC43和HKU1； SARS-CoV，SARS-CoV-2和MERS导致严重至致命的呼吸道疾病[1]。

为什么SARS-CoV-2的传播速度更快？是什么使SARS-Cov-2致死？近期的研究表明病毒和宿主之间存在一些重要的免疫反应。这些相互作用中涉及的关键标志物包括除细胞因子外的棘突蛋白（S），核衣壳蛋白（N），血管紧张素转换酶2（ACE-2）受体，（FES上游区域）FURIN蛋白酶。

SARS-CoV-2 (2019-nCoV) S蛋白（Spike protein, S）


	SARS-CoV-2 S蛋白	SARS-CoV-2通过Spike介导与ACE2细胞受体发生相互作用进入细胞。基因序列的任何变化都会影响这种相互作用。 OriGene自主研发2019-nCoV S蛋白(Cat#： TP701119,真核表达) ,现可免费申请，助力诊断试剂及抗病毒药物的更快开发。即刻申请>>

TMPRSS2

跨膜丝氨酸蛋白酶2（TMPRSS2）

跨膜丝氨酸蛋白酶2（TMPRSS2）：这是一种丝氨酸蛋白酶，可裂解并激活病毒Spike糖蛋白，从而促进病毒与细胞膜融合。最近的一项研究表明，SARS-CoV-2既需要ACE2受体，又需要丝氨酸蛋白酶TMPRSS2来使病毒进入细胞。[2]
TMPRSS2相关产品：

SARS-CoV-2 (2019-nCoV) N蛋白（Nucleocapsid protein, N）


	SARS-CoV-2 N蛋白	核衣壳蛋白：核衣壳磷蛋白将病毒基因组包装成螺旋核衣壳，因此在病毒自组装中起着至关重要的作用。 OriGene自主研发2019-nCoV N蛋白(Cat#： TP750180)及生物素化N蛋白(Cat#： TP750180-B) ,现可免费申请，助力诊断试剂及抗病毒药物的更快开发。即刻申请>>


		SARS-CoV-2 N protein 兔多抗 CAT＃: TA890226 Western blot analysis of full length recombinant SARS-Cov-2 N protein(0.02ug, TP790189) by using anti-SARS-Cov-2 N protein antibody (TA890226). (1：2000)

ACE2受体

ACE2受体蛋白

ACE2受体：ACE2是负责介导SARS-CoV-2感染宿主细胞的受体。
ACE2相关产品：

Furin


	Furin蛋白	Furin蛋白酶：它是一种存在于许多人体器官中的蛋白酶，可识别并激活SARS-CoV-2 Spike蛋白上的特定位点，从而促进与ACE2受体的紧密结合，并可能是较高感染率的一大因素[3]。 Furin相关科研工具>>

细胞因子


	IL2信号通路	细胞因子：研究表明，疾病的严重程度与IL2，IL7，IL10，GCSF，MCP1和TNFα的浓度之间存在很强的相关性[1]。分析与细胞因子风暴有关的6种细胞因子的工具： IL2 \| IL7 \| IL10 \| GCSF \| MCP1 \| TNFα

申请活动说明：

1. 每个课题组限申请一支免费小规格。（注*同一导师或同一公司为同一课题组，同一课题组多人申请，不累计赠送。）
2. 免费规格： S蛋白（Cat# : TP701119) ：10ug； N蛋白 (Cat#： TP750180)及生物素化N蛋白(Cat#： TP750180-B) ：20ug
3. 工作人员会及时审核，审核通过后，第一时间发货。
4. 数量有限，赠完即止。
5. 本活动最终解释权归OriGene所有。

参考文献：

1.https://link.springer.com/article/10.1007/s12098-020-03263-6
2.https://www.sciencedirect.com/science/article/pii/S0092867420302294
3.https://science.sciencemag.org/content/367/6483/1260

蛋白

Molecule	SKU	Species	Host	Description
Spike	TP701119	SARS-CoV-2	HEK293	Fusion protein of S-M, C-His tag
S-RBD	TP701124	SARS-CoV-2	HEK293	SARS-CoV-2 Spike-RBD Protein (Arg319~Phe541), C-Mouse FC tag
S-RBD	TP701122	SARS-CoV-2	HEK293	SARS-CoV-2 Spike-RBD Protein (Asn331~Val524), C-HIS tag
Nucleocapsid	TP701121	SARS-CoV-2	HEK293	Nucleocapsid Protein, C-HIS tag
Nucleocapsid	TP701121-B	SARS-CoV-2	HEK293	Biotinylated N-protein, C-HIS and site-specific Biotinylation on the C-AVIplus tag
Nucleocapsid	TP790189	SARS-CoV-2	HEK293	Nucleocapsid Protein, C-Myc/DDK tag
Nucleocapsid	TP750180	SARS-CoV-2	E. coli	Nucleocapsid Protein, N-HIS tag
Nucleocapsid	TP750180-B	SARS-CoV-2	E. coli	Biotinylated N-protein, N-HIS and site-specific Biotinylation on the C-AVIplus tag
ACE2	TP701115	Human	HEK293	Recombinant protein of human ACE2, C-FC tag
ACE2	TP720353	Human	HEK293	Recombinant protein of human ACE2, C-His tag
BSG	TP303894	Human	HEK293T	Recombinant protein of human BSG, transcript variant 2, C-MYC/DDK tag
BSG	TP319418	Human	HEK293T	Recombinant protein of human BSG, transcript variant 4, C-MYC/DDK tag
BSG	TP319464	Human	HEK293T	Recombinant protein of human BSG, transcript variant 1, C-MYC/DDK tag
BSG	TP503655	Mouse	HEK293T	Recombinant protein of Mouse Bsg, C-MYC/DDK tag
BSG	TP720365	Human	HEK293	Recombinant protein of human BSG, transcript variant 2,N-His tag

抗体

Molecule	SKU	Reactivity	Applications	Description
Nucleocapsid	TA890226	SARS-CoV-2	ELISA, ICC, IHC, WB	SARS-CoV-2 N Protein Rabbit PAb
Nucleocapsid	TA190323	SARS-CoV-2	ELISA, WB, ICC	SARS-CoV-2 N protein Human mAb
Nucleocapsid	TA190324	SARS-CoV-2	ELISA, WB	SARS-CoV-2 N protein Human mAb
Nucleocapsid	TA355143	SARS-CoV-2	ELISA, IHC, WB	SARS-CoV-2 N protein mouse mAb
S-RBD	TA190325	SARS-CoV-2	ELISA	SARS-CoV-2 Spike protein RBD Human mAb
ACE2	CF803841	Hu	IHC, WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb, clone OTI4D2 (formerly 4D2)
ACE2	CF803842	Hu	WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb, clone OTI1D2 (formerly 1D2)
ACE2	CF803844	Hu	IHC, WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb, clone OTI4C5 (formerly 4C5)
ACE2	CF803845	Hu	IHC, WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb,clone OTI2G7
ACE2	CF803906	Hu	IHC, WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb, clone OTI1D6 (formerly 1D6)
ACE2	CF804152	Hu	IHC, WB	Carrier-free (BSA/glycerol-free) ACE2 mouse mAb, clone OTI1G4 (formerly 1G4)
ACE2	TA803841	Hu	IHC, WB	ACE2 mouse mAb, clone OTI4D2 (formerly 4D2)
ACE2	TA803842	Hu	WB	ACE2 mouse mAb, clone OTI1D2 (formerly 1D2)
ACE2	TA803844	Hu	IHC, WB	Purified ACE2 mouse mAb, clone OTI4C5 (formerly 4C5)
ACE2	TA803845	Hu	IHC, WB	ACE2 mouse mAb,clone OTI2G7
ACE2	TA803906	Hu	IHC, WB	Purified ACE2 mouse mAb, clone OTI1D6 (formerly 1D6)
ACE2	TA804152	Hu	IHC, WB	ACE2 mouse mAb, clone OTI1G4 (formerly 1G4)
BSG	CF501160	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI5E1 (formerly 5E1)
BSG	CF501161	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI3E9 (formerly 3E9)
BSG	CF501162	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI4E11 (formerly 4E11)
BSG	CF501163	Hu	FC, IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI3H1 (formerly 3H1)
BSG	CF501164	Hu, Mky, Rt, Dog	FC, IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI9H5 (formerly 9H5)
BSG	CF501165	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI7A7 (formerly 7A7)
BSG	CF501189	Hu, Mky, Rt, Dog	FC, IF, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI10E10 (formerly 10E10)
BSG	CF501190	Hu	FC, IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI5D8 (formerly 5D8)
BSG	CF501191	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI3E5 (formerly 3E5)
BSG	CF501212	Hu	FC, IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI4E4 (formerly 4E4)
BSG	CF501248	Hu	IF, IHC, WB	Carrier-free (BSA/glycerol-free) BSG mouse mAb, clone OTI4D3 (formerly 4D3)
BSG	TA501160	Hu	IF, IHC, WB	Anti-BSG (CD147) mouse mAb, clone OTI5E1 (formerly 5E1)
BSG	TA501161	Hu	IF, IHC, WB	Anti-BSG (CD147) mouse mAb, clone OTI3E9 (formerly 3E9)
BSG	TA501162	Hu	IF, IHC, WB	BSG (CD147) mouse mAb, clone OTI4E11 (formerly 4E11)
BSG	TA501163	Hu	FC, IF, IHC, WB	BSG (CD147) mouse mAb, clone OTI3H1 (formerly 3H1)
BSG	TA501164	Hu, Mky, Rt, Dog	FC, IF, IHC, WB	Anti-BSG (CD147) mouse mAb, clone OTI9H5 (formerly 9H5)
BSG	TA501165	Hu	IF, IHC, WB	BSG (CD147) mouse mAb, clone OTI7A7 (formerly 7A7)
BSG	TA501188	Hu	FC, IF, WB	Anti-BSG (CD147) mouse mAb, clone OTI9B10 (formerly 9B10)
BSG	TA501189	Hu, Mky, Rt, Dog	FC, IF, WB	BSG (CD147) mouse mAb, clone OTI10E10 (formerly 10E10)
BSG	TA501190	Hu	FC, IF, IHC, WB	Anti-BSG (CD147) mouse mAb, clone OTI5D8 (formerly 5D8)
BSG	TA501248	Hu	IF, IHC, WB	Anti-BSG (CD147) mouse mAb, clone OTI4D3 (formerly 4D3)
BSG	TA590317	Hu, Mky, Rt	ELISA, IHC, WB	Rabbit Polyclonal CD147 Antibody

克隆

SKU	Accn	Description
VC102555	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 nucleocapsid phosphoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724397
VC102556	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 surface glycoprotein extracellular domain [Severe acute respiratory syndrome coronavirus 2], YP_009724390
VC102557	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724390
VC102558	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF3a protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724391
VC102559	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 Membrane Glycoprotein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724393
VC102560	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF6 protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724394
VC102561	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF7a protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724395
VC102562	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF8 protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724396
VC102563	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 Nucleocapsid Phosphoprotein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724397
VC102564	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF10 protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009725255
VC102565	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 Envelop Protein [Severe acute respiratory syndrome coronavirus 2], codon optimized for human cell expression, YP_009724392
VC102566	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724390
VC102567	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF3a protein [Severe acute respiratory syndrome coronavirus 2], YP_009724391
VC102568	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 Membrane Glycoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724393
VC102569	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF6 protein [Severe acute respiratory syndrome coronavirus 2], YP_009724394
VC102571	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF8 protein [Severe acute respiratory syndrome coronavirus 2], YP_009724396
VC102572	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF10 protein [Severe acute respiratory syndrome coronavirus 2], YP_009725255
VC102573	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 Envelop Protein [Severe acute respiratory syndrome coronavirus 2], YP_009724392
VC102577	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP7 [Severe acute respiratory syndrome coronavirus 2], YP_009725303.1
VC102578	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP8 [Severe acute respiratory syndrome coronavirus 2], YP_009725304.1
VC102579	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP9 [Severe acute respiratory syndrome coronavirus 2], YP_009725305.1
VC202557	NC_045512	Native cDNA clone for SARS-CoV-2 surface glycoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724390
VC202558	NC_045512	Native cDNA clone for SARS-CoV-2 ORF3a protein [Severe acute respiratory syndrome coronavirus 2], YP_009724391
VC202559	NC_045512	Native cDNA clone for SARS-CoV-2 Membrane Glycoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724393
VC202560	NC_045512	Native cDNA clone for SARS-CoV-2 ORF6 protein [Severe acute respiratory syndrome coronavirus 2], YP_009724394
VC202561	NC_045512	Native cDNA clone for SARS-CoV-2 ORF7a protein [Severe acute respiratory syndrome coronavirus 2], YP_009724395
VC202562	NC_045512	Native cDNA clone for SARS-CoV-2 ORF8 protein [Severe acute respiratory syndrome coronavirus 2], YP_009724396
VC202563	NC_045512	Native cDNA clone for SARS-CoV-2 Nucleocapsid Phosphoprotein [Severe acute respiratory syndrome coronavirus 2], YP_009724397
VC202564	NC_045512	Native cDNA clone for SARS-CoV-2 ORF10 protein [Severe acute respiratory syndrome coronavirus 2], YP_009725255
VC202565	NC_045512	Native cDNA clone for SARS-CoV-2 Envelop Protein [Severe acute respiratory syndrome coronavirus 2], YP_009724392
VC102570	NC_045512	Myc-DDK-tagged ORF clone for SARS-CoV-2 ORF7a protein [Severe acute respiratory syndrome coronavirus 2], YP_009724395
VC102574	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP4 [Severe acute respiratory syndrome coronavirus 2], YP_009725300.1
VC102575	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP5 [Severe acute respiratory syndrome coronavirus 2], YP_009725301.1
VC102576	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP6 [Severe acute respiratory syndrome coronavirus 2], YP_009725302.1
VC102580	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP10 [Severe acute respiratory syndrome coronavirus 2], YP_009725306.1
VC102581	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 NSP14 [Severe acute respiratory syndrome coronavirus 2], YP_009725309.1
VC102582	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 ORF3a [Severe acute respiratory syndrome coronavirus 2], YP_009724391.1
VC102583	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 M protein [Severe acute respiratory syndrome coronavirus 2], YP_009724393.1
VC102584	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 ORF9b [Severe acute respiratory syndrome coronavirus 2], YP_009724397.2
VC102585	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 ORF9c [Severe acute respiratory syndrome coronavirus 2], YP_009724397.2
VC102586	NC_045512	mRFP-tagged ORF clone for SARS-CoV-2 ORF10 [Severe acute respiratory syndrome coronavirus 2], YP_009725255.1

qPCR

SKU	locus_id	Description
HP234774	43740578	qSTAR qPCR primer pairs against SARS-CoV-2 (COVID-19) RdRp gene
HP234775	43740575	qSTAR qPCR primer pairs against SARS-CoV-2 (COVID-19) Nucleocapsid Phosphoprotein (N protein) gene
HP234776	43740568	qSTAR qPCR primer pairs against SARS-CoV-2 (COVID-19) surface glycoprotein (S protein) gene
HK212669	43740578	qPCR primer pairs and template standards against SARS-CoV-2 (COVID-19) RdRp gene
HK212670	43740575	qPCR primer pairs and template standards against SARS-CoV-2 (COVID-19) Nucleocapsid Phosphoprotein (N protein) gene
HK212671	43740568	qPCR primer pairs and template standards against SARS-CoV-2 (COVID-19) surface glycoprotein (S protein) gene

ELISA试剂盒

Molecule	SKU	Reactivtiy	Description
Nucleocapsid	EA200001	Human	Indirect ELISA kit of Detection for SARS-CoV-2 Nucleocapsid Protein Human IgG Antibodies
RBD+M	EA200002	Human	Indirect ELISA kit of Detection for SARS-CoV-2 RBD+M Protein Human IgG Antibodies
ACE2	EA100641	Human	Sandwich ELISA kit of Quantitative Detection for Human ACE2
ACE2	EA100696	Mouse	Sandwich ELISA kit of Quantitative Detection for Mouse ACE2
Furin	EA100575	Human	Sandwich ELISA kit of Quantitative Detection for Human Furin

客户使用反馈1：

货号： TP701119
产品： S-M融合蛋白, C-His标签
应用：SARS-COV-2 IgM/IgG抗体检测卡（胶体金法）
使用反馈：标准品样本，灵敏度1ppm；阴性血清样本，无假阳，共测试10例。

客户使用反馈2：

货号： TP750180-B
产品： 生物素化N蛋白
应用：抗原特异性淋巴细胞检测
使用反馈：灵敏度，特异性未与其他产品比较，检测结果尚可。

客户使用反馈3：

货号： TP701119
产品： S-M融合蛋白, C-His标签
应用：新冠病毒的合成多肽的阻断剂
使用反馈：样本灵敏度很好，与官方给出的对照实验类似。