siRNA Citations

OriGene产品已被全世界的科学家广泛使用，以提高他们的研究效率。 为了供您参考，我们收集了一些使用OriGene产品发表过的代表性的引用文献，将其发布在此页面上。

使用基因名称或靶标名称搜索文献

这是研究人员使用OriGene产品后最新发表的一些论文。

靶点 研究论文 杂志 产品类型 货号
The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR30003
The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ. International journal of molecular sciences siRNA SR30004
Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR30004
Impacts of Arsenic on Rad18 and Translesion Synthesis Toxicology and applied pharmacology siRNA SR30002
PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment Communications Biology siRNA SR30004
Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice Nature Communications siRNA SR30004
Cytosolic aldose metabolism contributes to progression from cirrhosis to hepatocarcinogenesis. Nature metabolism siRNA SR30004
Overexpression of the pro‐protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF / MEK signaling Molecular Oncology siRNA SR30004
Formation of the glomerular microvasculature is regulated by VEGFR-3. American journal of physiology. Renal physiology siRNA SR30004
Spinal dopaminergic D 1 and D 5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats. Brain research siRNA SR30004
FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation Scientific Reports siRNA SR30004
Spinal dopaminergic D 1 and D 5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats. Brain research siRNA SR30005
Distinct roles of the Chlamydia trachomatis effectors TarP and TmeA in the regulation of formin and Arp2/3 during entry. Journal of cell science siRNA SR30004
A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function Scientific Reports siRNA SR30002
Nanoliposome C6-Ceramide in combination with anti-CTLA4 antibody improves anti-tumor immunity in hepatocellular cancer FASEB journal : official publication of the Federation of American Societies for Experimental Biology siRNA SR30004
Maternal Exercise-Induced SOD3 Reverses the Deleterious Effects of Maternal High-Fat Diet on Offspring Metabolism Through Stabilization of H3K4me3 and Protection Against WDR82 Carbonylation. Diabetes siRNA SR30004
Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models Autophagy siRNA SR30004
Interleukin 21 Receptor Affects Adipogenesis of Human Adipose-Derived Stem/Stromal Cells Stem Cells International siRNA SR30004
Complement receptor 3 mediates Aspergillus fumigatus internalization into alveolar epithelial cells with the increase of intracellular phosphatidic acid by activating FAK Virulence siRNA SR30004
Squamous cell carcinoma subverts adjacent histologically normal epithelium to promote lateral invasion The Journal of Experimental Medicine siRNA SR30002
Occludin, caveolin‐1, and Alix form a multi‐protein complex and regulate HIV‐1 infection of brain pericytes The FASEB Journal siRNA SR30004
Modulation of Human Arylamine N -Acetyltransferase 1 Activity by Lysine Acetylation: Role of p300/CREB-Binding Protein and Sirtuins 1 and 2. Molecular pharmacology siRNA SR30004
Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer Frontiers in Oncology siRNA SR30004
Physiological roles of the GIP receptor in murine brown adipose tissue Molecular Metabolism siRNA SR30004
Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25 The Prostate siRNA SR30004
Avobenzone suppresses proliferative activity of human trophoblast cells and induces apoptosis mediated by mitochondrial disruption. Reproductive toxicology (Elmsford, N.Y.) siRNA SR30004
The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells. Chemico-biological interactions siRNA SR30002
MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncology reports siRNA SR30004
Optimization of Transfection Conditions for siRNA Screening Methods Mol. Biol. siRNA SR30004
Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1a activation Oncotarget siRNA SR30004
Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis J. Clin. Invest. siRNA SR30004
MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Oncol. Rep. siRNA SR30004
CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling PLoS ONE siRNA SR30004
HERG ???? NF-?B ?????????????? ??????? 2016 siRNA SR30004
AIM2 Inflammasome Mediates Arsenic-induced Secretion of IL-1 beta and IL-18 OncoImmunology siRNA SR30004
Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction cience Translational Medicine siRNA SR30004
MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin Oncotarget siRNA SR30004
DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. siRNA SR30003
DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. siRNA SR30004
Inhibition of adhesion, migration and of a5ß1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A J. Inorg. Biochem. siRNA SR30005
HIF1a deficiency reduces inflammation in a mouse model of proximal colon cancer Dis Model Mech siRNA SR30004
Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis. Cancer letters siRNA SR30004
Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. International journal of cancer siRNA SR30004
MiR-125a TNF receptor-associated factor 6 to inhibit osteoclastogenesis. Experimental cell research siRNA SR30004
MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells Proceedings of the National Academy of Sciences of the United States of America siRNA SR30004
The C-terminal common to group 3 POTES (CtG3P): a newly discovered nucleolar marker associated with malignant progression and metastasis American Journal of Cancer Research siRNA SR30004
Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. Journal of proteome research siRNA SR30004
The CXCL12/CXCR4 Axis Promotes Ligand-Independent Activation of the Androgen Receptor Molecular and Cellular Endocrinology siRNA SR30004
AA386476 Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy Acta Neuropathologica siRNA SR408287
ABCA1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun siRNA SR423449
ABCA1 Activation of Liver X Receptors inhibits of Hedgehog signaling, clonogenic growth,and self-renewal in multiple myeloma Mol. Cancer Ther. siRNA SR300011
ABCB10 ABCB10 depletion reduces unfolded protein response in mitochondria Biochem. Biophys. Res. Commun siRNA SR308286
ABCC1 Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1 J. Cell. Biochem. siRNA SR302963
ABCC5 MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells Biochim Biophys Acta Mol Cell Res siRNA SR306772
ABCG1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun siRNA SR418897
ABL1 The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR319232
Abl1 Abl-mediated PI3K activation regulates macrophage podosome formation. Journal of cell science siRNA SR422207
ABL2 The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR319233
Abl2 Abl-mediated PI3K activation regulates macrophage podosome formation. Journal of cell science siRNA SR421985
ACADS ACADS acts as a potential methylation biomarker associated with the proliferation and metastasis of hepatocellular carcinomas Aging (Albany NY) 2019 siRNA SR300027
ACKR3 Disease mechanism, drug-target and biomarker prediction software: Application on prostate cancer and validation bioRxiv siRNA SR311311
ACLY Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination Mol. Cell siRNA SR300035
ACP1 miR‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R Int. J. Mol. Med. siRNA SR30004
ACP1 MRP5 nitration by NO-releasing gemcitabine encapsulated in liposomes confers sensitivity in chemoresistant pancreatic adenocarcinoma cells Biochim Biophys Acta Mol Cell Res siRNA SR30004
ACP1 Osthole interacts with an ER-mitochondria axis and facilitates tumor suppression in ovarian cancer J. Cell. Physiol. siRNA SR30004
ACP1 Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats Oxid Med Cell Longev siRNA SR30004
ACP1 Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer Cells siRNA SR30004
ACP1 Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer J. Exp. Clin. Cancer Res. siRNA SR30004
ACP1 Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma Oncol Lett siRNA SR30004
ACP1 LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget siRNA SR30004
ACSL1 ACSL1 Regulates TNFα-Induced GM-CSF Production by Breast Cancer MDA-MB-231 Cells Biomolecules siRNA SR320120
ACSL1 TNF-α Induces a Pro-Inflammatory Phenotypic Shift in Monocytes through ACSL1: Relevance to Metabolic Inflammation Cell. Physiol. Biochem. siRNA SR320120
ACSL4 The positive feedback between ACSL4 expression and O-GlcNAcylation contributes to the growth and survival of hepatocellular carcinoma Aging (Albany NY) 2020 siRNA SR301523
ACSL4 Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages Carcinogenesis siRNA SR301523
Actg2 Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene siRNA SR412703
ACTR1A Crosslinking Proteomics Indicates Effects of Simvastatin on the TLR2 interactome and Reveals ACTR1A as a Novel Regulator of the TLR2 Signal Cascade bioRxiv siRNA SR306823
ADAM10 Proteolytic Processing of Neuregulin 2 Mol. Neurobiol. siRNA SR419811
ADAM10 Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse Matrix biology : journal of the International Society for Matrix Biology siRNA SR319260
ADAM10 Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse siRNA SR300066
Adam17 Combination of natural polyphenols with a precursor of NAD + and a TLR2/6 ligand lipopeptide protects mice against lethal γ radiation Journal of Advanced Research siRNA SR420467
ADAM17 CD36 promotes vasculogenic mimicry in melanoma by mediating adhesion to the extracellular matrix BMC Cancer siRNA SR321951
ADAM17 Receptor-Interacting Protein 140 Enhanced Temozolomide-Induced Cellular Apoptosis Through Regulation of E2F1 in Human Glioma Cell Lines. Neuromolecular medicine siRNA SR321951
ADAM17 PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions Nature Communications siRNA SR321951
ADAM17 Proteolytic Processing of Neuregulin 2 Mol. Neurobiol. siRNA SR420467
ADAM17 LRP1 receptor-mediated immunosuppression of α-MMC on monocytes. International immunopharmacology siRNA SR321951
ADAM17 Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A 2 and mediates its toxic activity Scientific Reports siRNA SR321951
ADAM17 Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1. Molecular and cellular endocrinology siRNA SR321951
ADAM17 Insulin promotes cell migration by regulating PSA-NCAM. Experimental cell research siRNA SR321951
ADAM17 Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6 Hormones & Cancer siRNA SR321951
ADAM17 Cytotoxicity mechanism of α-MMC in normal liver cells through LRP1 mediated endocytosis and JNK activation. Toxicology siRNA SR321951
ADAM17 Transcriptome-wide analysis of alternative RNA splicing events in Epstein-Barr virus-associated gastric carcinomas PLoS ONE siRNA SR321951
ADAM17 Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival Oncotarget siRNA SR321951
ADAM17 Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation Scientific Reports siRNA SR321951
ADAM17 The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells Journal of cellular biochemistry siRNA SR321951
ADAM17 Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor PLoS ONE siRNA SR321951
ADAM17 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma International journal of cancer siRNA SR321951
ADAM17 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nature Communications siRNA SR321951
ADAM17 Endoplasmic reticulum protein 29 (ERp29) confers radioresistance through the DNA repair gene, O 6 -methylguanine DNA-methyltransferase, in breast cancer cells Scientific Reports siRNA SR321951
ADAM17 Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism Oncotarget siRNA SR321951
ADAM17 Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures The Journal of nutritional biochemistry siRNA SR321951
ADAM17 ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling Scientific Reports siRNA SR321951
ADAM17 Acute hantavirus infection induces galectin-3-binding protein. The Journal of general virology siRNA SR321951
ADAM17 Angiopoietin-like protein 2 renders colorectal cancer cells resistant to chemotherapy by activating spleen tyrosine kinase–phosphoinositide 3-kinase-dependent anti-apoptotic signaling Cancer Science siRNA SR321951
ADAM17 Holocarboxylasesynthetase interacts physically with euchromatic histone-lysine N-methyltransferase, linking histone biotinylation with methylation events The Journal of nutritional biochemistry siRNA SR321951
ADAM17 IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1. Gynecologic oncology siRNA SR321951
ADAM17 Chemotherapy stimulates syndecan-1 shedding: A potentially negative effect of treatment that may promote tumor relapse siRNA SR304689
ADAM17 A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng PLoS ONE siRNA SR321951
ADAM17 The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest PLoS ONE siRNA SR321951
ADAM17 Regulation of RUNX2 transcription factor-DNA interactions and cell proliferation by vitamin D3 (cholecalciferol) prohormone activity. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research siRNA SR321951
ADAM19 Proteolytic Processing of Neuregulin 2 Mol. Neurobiol. siRNA SR421207
ADAM19 (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells American Journal of Physiology - Cell Physiology siRNA SR305748
ADAM9 Proteolytic Processing of Neuregulin 2 Mol. Neurobiol. siRNA SR420608
Adcy3 Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells BMC Nephrology siRNA SR422209
Adcy6 Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells BMC Nephrology siRNA SR422280
Adcy7 Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells BMC Nephrology siRNA SR422059
Adcy9 Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells BMC Nephrology siRNA SR422722
ADGRF4 G-protein coupled receptor Gpr115 (Adgrf4) is required for enamel mineralization mediated by ameloblasts J. Biol. Chem. siRNA SR419262
ADGRL1 Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release Cell Rep siRNA SR422506
Adgrl3 Involvement of the Adhesion GPCRs Latrophilins in the Regulation of Insulin Release Cell Rep siRNA SR422985
ADH5 O-Aminobenzoyl-S-nitrosoglutathione: A fluorogenic, cell permeable, pseudo-substrate for S-nitrosoglutathione reductase Free Radic. Biol. Med. siRNA SR412637
Adipor1 Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1 Am. J. Physiol. Gastrointest. Liver Physiol. siRNA SR412651
ADORA2B Sevoflurane Exerts Protective Effects in Murine Peritonitis-induced Sepsis via Hypoxia-inducible Factor 1α/Adenosine A2B Receptor Signaling Anesthesiology siRNA SR300095
AGER The AGEs/RAGE Transduction Signaling Prompts IL-8/CXCR1/2-Mediated Interaction between Cancer-Associated Fibroblasts (CAFs) and Breast Cancer Cells Cells siRNA SR319295
AGER Activation of the S100A7/RAGE Pathway by IGF-1 Contributes to Angiogenesis in Breast Cancer Cancers siRNA SR319295
AGER Advanced Glycation End Products Induce Vascular Smooth Muscle Cell-Derived Foam Cell Formation and Transdifferentiate to a Macrophage-Like State Mediators Inflamm. siRNA SR319295
Ago1 Novel functional small RNAs are selectively loaded onto mammalian Ago1 Nucleic Acids Res. siRNA SR308857
AGO2 miRNA-dependent regulation of STIM1 expression in breast cancer Sci Rep siRNA SR323843
AGO2 MicroRNA therapeutics: design of single-stranded miR-216b mimics to target KRAS in pancreatic cancer cells RNA Biol siRNA SR323843
AGO2 Novel functional small RNAs are selectively loaded onto mammalian Ago1 Nucleic Acids Research siRNA SR323843
AHR The aryl hydrocarbon receptor ligand ITE inhibits cell proliferation and migration and enhances sensitivity to drug-resistance in hepatocellular carcinoma. Journal of cellular physiology siRNA SR319302
AHR IDO1‐mediated Trp‐kynurenine‐AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas Oral Science International siRNA SR319302
AHR AHR is a Zika virus host factor and a candidate target for antiviral therapy Nat. Neurosci. siRNA SR319302
AHR The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions biorxiv.org siRNA SR319302
AHR The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions bioRxiv siRNA SR319302
AHR Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells Sci Rep siRNA SR319302
AHR The aryl hydrocarbon receptor is a novel negative regulator of interleukin-17-mediated signaling and inflammation in vitro FEBS Lett. siRNA SR319302
AHR Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway Nat Commun siRNA SR300136
AIFM1 Downregulation of microRNA-425-5p suppresses cervical cancer tumorigenesis by targeting AIFM1 Exp Ther Med siRNA SR418168
AKT1 Angiotensin II-Induced Histone Deacetylase 5 Phosphorylation, Nuclear Export and Egr-1 Expression is mediated by Akt Pathway in A10 Vascular Smooth Muscle Cells American journal of physiology. Heart and circulatory physiology siRNA SR515430
AKT1 Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells PLoS ONE siRNA SR415524
AKT1 Protein kinase B mediates insulin-like growth factor 1-induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells J. Cell. Physiol. siRNA SR500756
AKT1 Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma Biomed. Pharmacother. siRNA SR300143
AKT1 Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels Front Mol Neurosci siRNA SR300143
AKT1 Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR300143
AKT1 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR300143
AKT1 Concurrent Targeting of KRAS and AKT by MiR-4689 Is a Novel Treatment Against Mutant KRAS Colorectal Cancer Mol Ther Nucleic Acids siRNA SR300143
AKT1 PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. siRNA SR300143
AKT1 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. siRNA SR300143
AKT1 Rb1 family mutation is sufficient for sarcoma initiation Nat Commun. 2013 Oct 23;4:2650 siRNA SR415524
AKT2 Akt Protein Kinase, miR-200/miR-182 Expression and Epithelial-Mesenchymal Transition Proteins in Hibernating Ground Squirrels Front Mol Neurosci siRNA SR300144
AKT2 miR-608 regulates apoptosis in human lung adenocarcinoma via regulation of AKT2 Int. J. Oncol. siRNA SR300144
AKT2 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR300144
AKT2 Curcumin Modulates MicroRNA-203–Mediated Regulation of the Src-Akt Axis in Bladder Cancer Cancer Prevention Research, Oct 2011; 4: 1698 - 1709. siRNA SR300144
AKT3 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR306727
ALDH18A1 Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 siRNA SR303932
ALDH2 ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties Oxidative Medicine and Cellular Longevity siRNA SR319314
ALK Targeting ALK in pediatric RMS does not induce antitumor activity in vivo Cancer Chemother. Pharmacol. siRNA SR300165
ALK Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma Clin. Cancer Res. siRNA SR300165
ALOX12 Arachidonate 12-Lipoxygenase and 12-Hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer J. Biol. Chem. siRNA SR300166
ALOX12E STAT-3-independent production of IL-17 by mouse innate-like αβ T cells controls ocular infection J. Exp. Med. siRNA SR41884
ALOX15 Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution Cell Rep siRNA SR300171
ANGPT1 NEAT1 promotes the repair of abdominal aortic aneurysms of endothelial progenitor cells via regulating miR-204-5p/Ang-1 American journal of translational research siRNA SR512502
ANGPT2 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. siRNA SR300199
Ano1 Arctigenin Attenuates Vascular Inflammation Induced by High Salt through TMEM16A/ESM1/VCAM-1 Pathway Biomedicines siRNA SR411408
ANO1 Knockdown of TMEM16A suppressed MAPK and inhibited cell proliferation and migration in hepatocellular carcinoma OncoTargets and therapy siRNA SR310492
ANXA2 Annexin A2 Mediates Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells MBio siRNA SR300208
APC A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell calcium siRNA SR300226
APEX1 AT101 exerts a synergetic efficacy in gastric cancer patients with 5-FU based treatment through promoting apoptosis and autophagy Oncotarget siRNA SR300230
APLP2 Amyloid precursor-like protein 2 and sortilin do not regulate the PCSK9 convertase-mediated low density lipoprotein receptor degradation but interact with each other J. Biol. Chem. siRNA SR300236
AQP3 AQP3-Dependent PI3K/Akt Modulation in Breast Cancer Cells. International journal of molecular sciences siRNA SR300258
AQP3 AQP3 Increases Intercellular Cohesion in NSCLC A549 Cell Spheroids through Exploratory Cell Protrusions International Journal of Molecular Sciences siRNA SR300258
AR c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer Oncotarget siRNA SR300264
Areg ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion JCI Insight siRNA SR406992
ARF6 EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth Nat Commun siRNA SR300275
ARG2 Mapping Metabolic Events in the Cancer Cell Cycle Reveals Arginine Catabolism in the Committed SG2M Phase Cell Rep siRNA SR319383
ARG2 Human cytomegalovirus may promote tumour progression by upregulating arginase-2 Oncotarget siRNA SR300277
ARHGDIA Renal FGF23 signaling depends on redox protein Memo1 and promotes orthovanadate-sensitive protein phosphotyrosyl phosphatase activity Journal of Cell Communication and Signaling siRNA SR300287
ARHGEF39 ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients Lab. Invest. siRNA SR313727
ARID1A Downregulation of ARID1A in gastric cancer cells: a putative protective molecular mechanism against the Harakiri-mediated apoptosis pathway Virchows Arch. siRNA SR305421
ARID1A Downregulation of ARID1A, a component of the SWI/SNF chromatin remodeling complex, in breast cancer Journal of Cancer siRNA SR305421
ARID2 Targeted next-generation sequencing for molecular diagnosis of endometriosis-associated ovarian cancer J. Mol. Med. siRNA SR316272
Arl8b α-Synuclein fibrils subvert lysosome structure and function for the propagation of protein misfolding between cells through tunneling nanotubes PLoS Biology siRNA SR404583
ARNT Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma Biomed. Pharmacother. siRNA SR300295
ARNT Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports siRNA SR300295
ARNT Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. siRNA SR300295
ARPC5L Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine Leukemia siRNA SR313117
ASAH1 Acid Ceramidase in Melanoma: Expression, Localization and Effects of Pharmacological Inhibition J. Biol. Chem. siRNA SR300310
ASNS Epigenetic silencing affects L-asparaginase sensitivity and predicts outcome in T-ALL Clin. Cancer Res. siRNA SR300319
ASNS Knockdown of asparagine synthetase (ASNS) suppresses cell proliferation and inhibits tumor growth in gastric cancer cells Scand. J. Gastroenterol. siRNA SR300319
ASS1 Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI-PEG20 treatment in CCA cell lines Oncol Lett siRNA SR300322
ASS1 Decreased argininosuccinate synthetase expression in Thai patients with cholangiocarcinoma and the effects of ADI‑PEG20 treatment in CCA cell lines Oncol Lett siRNA SR300322
ATF2 A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells siRNA SR300975
ATF4 Tetracyclines promote survival and fitness in mitochondrial disease models Nature metabolism siRNA SR319410
ATF4 GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice Exp. Neurol. siRNA SR411790
ATF5 A cytosolic surveillance mechanism activates the mitochondrial UPR Nature siRNA SR307793
ATF6 A miR-494 dependent feedback loop regulates ER stress bioRxiv siRNA SR307883
ATF6 The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes Aging (Albany NY) 2019 siRNA SR418766
ATF6 Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol. siRNA SR323457
ATF6 Alkylating agent induced NRF2 blocks endoplasmic reticulum stress-mediated apoptosis via control of glutathione pools and protein thiol homeostasis Mol. Cancer Ther. siRNA SR307883
ATF6 Endoplasmic reticulum stress mediates house dust mite-induced airway epithelial apoptosis and fibrosis Respir. Res. Dec 2013. siRNA SR418766
ATG16L1 ATG16L1 negatively regulates RICK/RIP2-mediated innate immune responses Int. Immunol. siRNA SR324356
ATG16L1 Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites IUBMB Life siRNA SR324356
ATG3 Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites IUBMB Life siRNA SR312050
ATG5 Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis Cell death & disease siRNA SR322789
ATG5 Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells Autophagy siRNA SR407903
ATG5 Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites IUBMB Life siRNA SR322789
ATG5 Countervailing, time-dependent effects on host autophagy promotes intracellular survival of leishmania J. Biol. Chem. siRNA SR306286
ATG5 Viability of primary cultured podocytes is associated with extracellular high glucose-dependent autophagy downregulation Mol. Cell. Biochem siRNA SR504857
ATG5 Reactive oxygen species are involved in insulin-dependent regulation of autophagy in primary rat podocytes Int. J. Biochem. Cell Biol. siRNA SR504857
ATG5 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy siRNA SR306286
ATG5 Antagonism of tumoral prolactin receptor promotes autophagy-related cell death Cell Rep 488-500 7 2. April 2014 siRNA SR306286
Atg5 Increased drug resistance associated with reduced glucose levels and an enhanced glycolysis phenotype Br. J. Pharmacol. siRNA SR306286
ATG7 Age-related defects in autophagy alter the secretion of paracrine factors from bone marrow mononuclear cells Aging siRNA SR427399
ATG7 Autophagy inhibition blunts PDGFRA adipose progenitors\' cell-autonomous fibrogenic response to high-fat diet Autophagy siRNA SR427399
ATG7 Acid Sphingomyelinase Inhibition Attenuates Cell Death in Mechanically-Ventilated Newborn Rat Lung Am. J. Respir. Crit. Care Med. siRNA SR507240
ATG7 Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites IUBMB Life siRNA SR323157
ATG7 Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells Biomaterials siRNA SR307159
Atg7 The Effect of Mechanical Ventilation on Lung Epithelial Cell Fate thesis siRNA SR507240
ATG9A Countervailing, time-dependent effects on host autophagy promotes intracellular survival of leishmania J. Biol. Chem. siRNA SR312320
ATM Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells J. Exp. Clin. Cancer Res. siRNA SR423623
ATM Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure Cell Cycle siRNA SR300330
ATM Apoptosis-related protein-2 triggers melanoma cell death by a mechanism including both endoplasmic reticulum stress and mitochondrial dysregulation Carcinogenesis, Aug 2011; 32: 1268 - 1278. siRNA SR300330
ATOX1 Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells Scientific Reports siRNA SR300333
Atox1 Roles of Atox1 and p53 in the trafficking of copper-64 to tumor cell nuclei: implications for cancer therapy J. Biol. Inorg. Chem., Jan 2014. siRNA SR300333
ATP13A3 ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers Am J Cancer Res siRNA SR312433
Atp1a2 Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell siRNA SR421739
ATP6AP2 Elabela Antagonizes Intrarenal Renin-Angiotensin System to Lower Blood Pressure and Protects Against Renal Injury Am. J. Physiol. Renal Physiol. siRNA SR426490
Atp6ap2 High Potassium Promotes Mutual Interaction between (Pro)Renin Receptor and the Local Renin-Angiotensin-Aldosterone System in Rat IMCD Cells Am. J. Physiol., Cell Physiol. siRNA SR411813
ATP6V0A2 Mammary epithelium-specific inactivation of V-ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer Mol Oncol siRNA SR323628
Atp6v0a2 The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-ß signaling Cell Death Dis siRNA SR420750
ATR Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells J. Exp. Clin. Cancer Res. siRNA SR423556
AXIN1 The synthetic small molecule FL3 combats intestinal tumorigenesis via Axin1-mediated inhibition of Wnt/beta-catenin signaling Cancer Res. siRNA SR305433
AXIN1 Forskolin exerts anticancer roles in non-Hodgkin's lymphomas via regulating Axin/β-catenin signaling pathway Cancer Manag Res siRNA SR305433
AXL Targeting AXL and the DNA damage response pathway as a novel therapeutic strategy in melanoma Mol. Cancer Ther. siRNA SR319445
AXL The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor Sci Signal siRNA SR300386
B3GNT3 Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells BMC Cancer siRNA SR307003
BAG3 Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis Oncotarget siRNA SR306333
BAG3 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE siRNA SR306333
BAMBI Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells Sci Rep siRNA SR308516
BBC3 Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma Neoplasia siRNA SR308982
BCAM BCAM and LAMA5 Mediate the Recognition between Tumor Cells and the Endothelium in the Metastatic Spreading of KRAS Mutant Colorectal Cancer Clin. Cancer Res. siRNA SR302744
BCL2 LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression Biomed. Pharmacother. siRNA SR300411
BCL2 LIN28B promotes the progression of colon cancer by increasing B-cell lymphoma 2 expression Biomed. Pharmacother. siRNA SR405079
BCL2 microRNA-10b Is Overexpressed and Critical for Cell Survival and Proliferation in Medulloblastoma PLoS ONE siRNA SR300411
BCL2 Platelet-Derived Growth Factor Primes Cancer-Associated Fibroblasts For Apoptosis J. Biol. Chem. siRNA SR300411
BCL2L1 Malignant pleural mesothelioma co-opts BCL-XL and autophagy to escape apoptosis Cell death & disease siRNA SR319459
BCL3 MicroRNA-19b inhibits proliferation of gastric cancer cells by targeting B-cell CLL/lymphoma 3 Oncol. Rep. siRNA SR300415
BCL9 BCL9 Upregulation in Adrenocortical Carcinoma: A Novel Wnt/β-Catenin Activating Event Driving Adrenocortical Malignancy J. Am. Coll. Surg. siRNA SR300418
BCL9L Single-walled carbon nanotubes functionalized with aptamer and piperazine-polyethylenimine derivative for targeted siRNA delivery into breast cancer cells Int J Pharm siRNA SR316986
BDNF Enhanced BDNF Actions Following Acute Hypoxia Facilitate HIF-1α-Dependent Upregulation of Cav3-T-Type Ca2+ Channels in Rat Cardiomyocytes Membranes siRNA SR510549
BDNF The acetylation of cyclin-dependent kinase 5 at lysine 33 regulates kinase activity and neurite length in hippocampal neurons Sci Rep siRNA SR510549
BECN1 ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis Journal of experimental & clinical cancer research : CR siRNA SR322490
BECN1 Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis Oncol Lett siRNA SR322490
BECN1 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep siRNA SR322490
BECN1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy siRNA SR305711
BECN1 GX15-070 (Obatoclax) Induces Apoptosis and Inhibits Cathepsin D- and L–Mediated Autophagosomal Lysis in Antiestrogen-Resistant Breast Cancer Cells Mol. Cancer Ther., Apr 2013; 12: 448 - 459. siRNA SR305711
BHLHE40 BHLHE40, a third transcription factor required for insulin induction of SREBP-1c mRNA in rodent liver Elife siRNA SR515541
BHLHE41 Phospho-?Np63?/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure Cell Cycle siRNA SR312407
BID BID-dependent release of mitochondrial SMAC dampens XIAP-mediated immunity against Shigella EMBO J. July 2014 siRNA SR300435
BIN1 Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane Commun Biol siRNA SR511599
BIRC3 IL-1β induces up-regulation of BIRC3, a gene involved in chemoresistance to doxorubicin in breast cancer cells Cancer Lett siRNA SR319355
BIRC3 NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival Cell Death Differ. siRNA SR300232
Blvra Bliverdin reductase-A improves neurological function in a germinal matrix hemorrhage rat model Neurobiol. Dis. siRNA SR512469
Braf Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia Oncotarget siRNA SR420296
BRAF The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy siRNA SR300470
BRCA1 Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats J. Biomed. Sci. siRNA SR512467
BRCA2 A Functional Analysis of the Unclassified Pro2767Ser BRCA2 Variant Reveals Its Potential Pathogenicity that Acts by Hampering DNA Binding and Homology-Mediated DNA Repair Cancers (Basel) 2019 siRNA SR423642
BRD2 H2A. Z. 1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs Cell Reports siRNA SR419051
BRD4 H2A. Z. 1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs Cell Reports siRNA SR422790
BRMS1 MicroRNA-423 enhances the invasiveness of hepatocellular carcinoma via regulation of BRMS1 Am J Transl Res siRNA SC207572
BTG3 MicroRNA-519c-3p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting BTG3 Biomed. Pharmacother. siRNA SR307479
BTRC Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells Oncogenesis siRNA SR305917
C21ORF91 Inherited duplications of PPP2R3B promote naevi and melanoma via a novel C21orf91-driven proliferative phenotype bioRxiv siRNA SR310041
C3 C3a Increases VEGF and Decreases PEDF mRNA Levels in Human Retinal Pigment Epithelial Cells BioMed Research International siRNA SR300499
C3AR1 Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells Inflamm. Res. siRNA SR300500
C87436 NF-κB-Dependent Upregulation of (Pro)Renin Receptor Mediates High NaCl-Induced Apoptosis in Mouse Inner Medullary Collecting Duct Cells Am. J. Physiol., Cell Physiol. siRNA SR41760
CA12 Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Sci Rep siRNA SR300539
CA9 Blocking HIF signaling via novel inhibitors of CA9 and APE1/Ref-1 dramatically affects pancreatic cancer cell survival Sci Rep siRNA SR319527
CACNA2D3 CACNA2D3 Enhances the Chemosensitivity of Esophageal Squamous Cell Carcinoma to Cisplatin via Inducing Ca2+-Mediated Apoptosis and Suppressing PI3K/Akt Pathways Front Oncol siRNA SR310953
CACNA2D3 Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma. International journal of cancer siRNA SR310953
CADM1 MicroRNA-155-3p promotes breast cancer progression through down-regulating CADM1 Onco Targets Ther siRNA SR308445
CALR Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo Int J Mol Sci siRNA SR300567
Calr Aberrant Calreticulin Expression in Articular Cartilage of Dio2 Deficient Mice PLoS ONE siRNA SR413808
CAMK1D Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action Proc. Natl. Acad. Sci. U.S.A. siRNA SR412965
CAMK2A CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFβ and BMP through SMAD signaling Osteoarthr. Cartil. siRNA SR319547
Camk2a Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat Stroke siRNA SR500835
CANX N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding Elife siRNA SR417891
CANX N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding Elife siRNA SR319552
CAPN1 Neuroprotective effect of paeoniflorin on okadaic acid-induced tau hyperphosphorylation via calpain/Akt/GSK-3β pathway in SH-SY5Y cells Brain Res. siRNA SR300578
CAPN2 Targeting Cellular Calcium Homeostasis to Prevent Cytokine-Mediated Beta Cell Death Sci Rep siRNA SR300579
CARD9 Caspase recruitment domain family member 9 expression is a promising biomarker in esophageal squamous cell carcinoma Ann Gastroenterol Surg siRNA SR311981
CARD9 The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein PLoS one siRNA SR311981
Casp8 Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 Cell Rep siRNA SR415523
CAV1 Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5) Autophagy siRNA SR404266
CAV1 Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes FASEB J siRNA SR319567
CAV1 Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis Oncotarget siRNA SR319567
CAV1 Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR319567
CAV1 CD47 and Nox1 Mediate Dynamic Fluid-Phase Macropinocytosis of Native LDL Antioxid. Redox Signal siRNA SR404266
Cav1 Caveolin-1 regulates the expression of tight junction proteins during hyperoxia-induced pulmonary epithelial barrier breakdown Respiratory Research siRNA SR404266
CAV1 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. siRNA SR300603
CAVIN2 CAVIN2 is frequently silenced by CpG methylation and sensitizes lung cancer cells to paclitaxel and 5-FU. Epigenomics siRNA SR305524
CBX4 CBX4-mediated SUMO modification regulates BMI1 recruitment at sites of DNA damage Nucleic Acids Res., Jul 2012; 40: 5497 - 5510. siRNA SR305603
CCDC117 Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation Sci Rep siRNA SR325856
CCDC85B CCDC85B promotes non-small cell lung cancer cell proliferation and invasion Mol. Carcinog. siRNA SR307524
Ccl2 ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation Cellular and Molecular Life Sciences siRNA SR403037
Ccl5 ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation Cellular and Molecular Life Sciences siRNA SR400775
Ccl7 ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation Cellular and Molecular Life Sciences siRNA SR400957
CCN2 Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism Sci Rep siRNA SR301057
CCN2 KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Oncotarget siRNA SR301057
Ccn4 WNT1-inducible signaling protein-1 mediates TGF-β1-induced renal fibrosis in tubular epithelial cells and unilateral ureteral obstruction mouse models via autophagy J. Cell. Physiol. siRNA SR509133
CCN4 Macrophage-derived IL-10 mediates mucosal repair by epithelial WISP-1 signaling J. Clin. Invest. siRNA SR305836
CCNA2 The p53/miRNAs/Ccna2 pathway serves as a novel regulator of cellular senescence: Complement of the canonical p53/p21 pathway Aging Cell siRNA SR414006
CCNA2 CCNA2 facilitates epithelial-to-mesenchymal transition via the integrin αvβ3 signaling in NSCLC Int J Clin Exp Patho siRNA SR300626
CCNB1IP1 CCNB1 Expedites the Progression of Cervical Squamous Cell Carcinoma via the Regulation by FOXM1 OncoTargets and therapy siRNA SR311714
CCND1 Hypoxia-inducible factor-1 promotes cancer progression through activating AKT/Cyclin D1 signaling pathway in osteosarcoma Biomed. Pharmacother. siRNA SR300410
CCND1 Mig-6 is down-regulated in HCC and inhibits the proliferation of HCC cells via the P-ERK/Cyclin D1 pathway Exp. Mol. Pathol. siRNA SR300410
CCNG2 MicroRNA-340 promotes the tumor growth of human gastric cancer by inhibiting cyclin G2. Oncology reports siRNA SR300634
CCNP The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration Sci Rep siRNA SR312715
CD14 LPS and IL-1 differentially activate mouse and human astrocytes: Role of CD14 Glia siRNA SR412356
CD163 The New Role of CD163 in the Differentiation of Bone Marrow Stromal Cells into Vascular Endothelial-Like Cells Stem Cells International siRNA SR506300
CD24 CD24 expression is a marker for predicting clinical outcome and regulates the epithelial-mesenchymal transition in ovarian cancer via both the Akt and ERK pathways Oncol. Rep. siRNA SR319178
CD274 MiR-570 inhibited the cell proliferation and invasion through directly targeting B7-H1 in hepatocellular carcinoma Tumour Biol. siRNA SR309223
CD276 Hepatocellular carcinomas promote tumor-associated macrophage M2-polarization via increased B7-H3 expression Oncol. Rep. siRNA SR312921
CD2BP2 TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells Nucleic Acids Research siRNA SR307065
CD2BP2 TEG-1 CD2BP2 controls miRNA levels by regulating miRISC stability in C. elegans and human cells Nucleic Acids Res. siRNA SR307065
CD36 CD36 Promotes Vasculogenic Mimicry in Melanoma by Mediating Adhesion to the Extracellular Matrix Research Square siRNA SR319610
CD36 CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies Cell Rep siRNA SR319610
CD36 Oxidized LDL activated eosinophil polarize macrophage phenotype from M2 to M1 through activation of CD36 scavenger receptor Atherosclerosis siRNA SR300671
CD36 Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake J. Biol. Chem. siRNA SR300671
CD38 CD38 Mediates Angiotensin II-induced Intracellular Ca(2+) Release in Rat Pulmonary Arterial Smooth Muscle Cells Am. J. Respir. Cell Mol. Biol. July 2014 siRNA SR509476
CD44 iTRAQ‑based proteomic analysis of the interaction of A549 human lung epithelial cells with Aspergillus fumigatus conidia Mol Med Rep siRNA SR319622
CD44 Glioblastoma-secreted soluble CD44 activates tau pathology in the brain Exp. Mol. Med. siRNA SR417715
CD46 Complement receptor CD46 co-stimulates optimal human CD8+ T cell effector function via fatty acid metabolism Nat Commun siRNA SR302841
CD46 Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses Immunity siRNA SR302841
CD46 Intracellular sensing of complement C3 activates cell autonomous immunity Science siRNA SR302841
CD47 Identification of Schlafen-11 as a Target of CD47 Signaling That Regulates Sensitivity to Ionizing Radiation and Topoisomerase Inhibitors Front Oncol siRNA SR319623
CD55 Intracellular sensing of complement C3 activates cell autonomous immunity Science siRNA SR301131
CD74 Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells Cancer Sci. siRNA SR319632
CD9 Role of dendritic cell-mediated immune response in oral homeostasis: A new mechanism of osteonecrosis of the jaw FASEB J. siRNA SR406173
CD9 Quantitatively mapping the assembly pattern of EpCAM on cell membranes with peptide probes Anal. Chem. siRNA SR319596
CDA Chemotherapy-induced CDA expression renders resistant non-small cell lung cancer cells sensitive to 5\'-deoxy-5-fluorocytidine (5\'-DFCR) Journal of experimental & clinical cancer research : CR siRNA SR300700
CDC25B Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25B Sci Rep siRNA SR417180
CDC42 Cholesterol Efflux-Independent Modification of Lipid Rafts by AIBP (Apolipoprotein A-I Binding Protein) Arterioscler. Thromb. Vasc. Biol. siRNA SR319646
CDC42 Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy Cells siRNA SR319646
CDC42 Glucose insult elicits hyperactivation of cancer stem cells through miR-424-cdc42-prdm14 signalling axis Br. J. Cancer siRNA SR319646
CDC42 MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes Nat Commun siRNA SR300714
CDCP1 Gene Therapy for Neuropathic Pain through siRNA-IRF5 Gene Delivery with Homing Peptides to Microglia Mol Ther Nucleic Acids siRNA SR420521
CDH13 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR300727
CDH2 Persistent N-cadherin Expression Induced by Extended Epidermal Growth Factor Exposure Regulates Multicellular Aggregate Compaction and Sensitivity to Cisplatin Med chem S siRNA SR300716
CDK1 Laryngeal squamous cell carcinoma cell lines show high tolerance for siRNA-mediated CDK1 knockdown American journal of cancer research siRNA SR319639
CDK14 MiR-1202 suppresses hepatocellular carcinoma cells migration and invasion by targeting cyclin dependent kinase 14 Biomed. Pharmacother. siRNA SR303472
CDK4 MicroRNA-195 inhibits epithelial-mesenchymal transition via downregulating CDK4 in bladder cancer Int J Clin Exp Pathol siRNA SR319663
CDK4 Dual ALK and CDK4/6 Inhibition Demonstrates Synergy against Neuroblastoma Clin. Cancer Res. siRNA SR319663
CDK5 Phosphorylation of Pit-1 by Cyclin-Dependent Kinase 5 at Serine 126 is Associated with Cell Proliferation and Poor Prognosis in Prolactinomas Research Square siRNA SR507441
CDK5 Phosphorylation of kinase insert domain receptor by cyclin-dependent kinase 5 at serine 229 is associated with invasive behavior and poor prognosis in prolactin pituitary adenomas Oncotarget siRNA SR507441
CDKN1A Modulation of calcium signaling pathway by hepatitis C virus core protein stimulates NLRP3 inflammasome activation PLoS Pathog. siRNA SR403488
CDKN1A T-cell intracellular antigens function as tumor suppressor genes Cell Death Dis siRNA SR300740
CDKN1C High Dosage Lithium Treatment Induces DNA Damage and p57Kip2 Decrease Int J Mol Sci siRNA SR300742
Cdkn2a The impact of senescence on muscle wasting in chronic kidney disease Journal of Cachexia, Sarcopenia and Muscle siRNA SR403922
CDKN2A USP22 deubiquitinates CD274 to suppress anti-cancer immunity Cancer Immunol Res siRNA SR300743
CEACAM1 CEACAM1 regulates the IL-6 mediated fever response to LPS through the RP105 receptor in murine monocytes bioRxiv siRNA SR414805
CEBPB Inhibition of estrogen related receptor α blocks liver steatosis and steatohepatitis and attenuates triglyceride biosynthesis The American journal of pathology siRNA SR408590
CEBPB WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice EBioMedicine siRNA SR408590
CENPA Human Centromeres Produce Chromosome-Specific and Array-Specific Alpha Satellite Transcripts that Are Complexed with CENP-A and CENP-C Dev. Cell siRNA SR300765
CERK Ceramide Kinase Regulates TNF-α-induced Immune Responses in Human Monocytic Cells Research Square siRNA SR312120
CFL1 Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. siRNA SR300775
Cflar Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4 Cell Rep siRNA SR400039
CHADL Novel Small Leucine-Rich Protein Chondroadherin-like (CHADL) is Expressed in Cartilage and Modulates Chondrocyte Differentiation J. Biol. Chem. siRNA SR419797
CHD4 CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells International journal of molecular sciences siRNA SR300792
CHDH Mapping choline metabolites in normal and transformed cells Metabolomics : Official journal of the Metabolomic Society siRNA SR310700
CHI3L1 A Natural CHI3L1-Targeting Compound, Ebractenoid F, Inhibits Lung Cancer Cell Growth and Migration and Induces Apoptosis by Blocking CHI3L1/AKT Signals. Molecules (Basel, Switzerland) siRNA SR319700
CHI3L1 Inhibition of Chitinase-3-like-1 by K284-6111 Reduces Atopic Skin Inflammation via Repressing Lactoferrin Immune Network siRNA SR319700
CHI3L1 Chitinase 3 like 1 (CHI3L1) is a regulator of smooth muscle cell physiology and atherosclerotic lesion stability Cardiovascular research siRNA SR319700
CHI3L1 Chitinase-3-like-1 deficiency attenuates ethanol-induced liver injury by inhibition of sterol regulatory element binding protein 1-dependent triglyceride synthesis Metab. Clin. Exp. siRNA SR319700
CHI3L1 Suppression of metastasis through inhibition of chitinase 3-like 1 expression by miR-125a-3p-mediated up-regulation of USF1 Theranostics siRNA SR319700
Chil1 Atherosclerosis is exacerbated by chitinase-3-like-1 in amyloid precursor protein transgenic mice Theranostics siRNA SR412856
CHMP2B CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. siRNA SR308637
CHOP Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts Reproduction siRNA SR301166
CIAO2B Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation Sci Rep siRNA SR309893
CIITA Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart FASEB J. siRNA SR302895
CITED2 Electrochemical evaluation of sarcomeric a-actinin in embryoid bodies after gene silencing using an LSI-based amperometric sensor array Anal. Methods . April 2014 siRNA SR307027
CLASP1 Centrosome-declustering drugs mediate a two-pronged attack on interphase and mitosis in supercentrosomal cancer cells Cell Death Dis siRNA SR308193
CLEC4E Macrophage inducible C-type lectin (Mincle) recognizes glycosylated surface (S)-layer of the periodontal pathogen Tannerella forsythia PLoS ONE siRNA SR308788
CLIC1 Chloride intracellular channel 1 (CLIC1) contributes to modulation of cyclic AMP-activated whole-cell chloride currents in human bronchial epithelial cells Physiol Rep siRNA SR300854
CLK1 Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules Journal of Cellular and Molecular Medicine siRNA SR300856
Clk2 Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules Journal of Cellular and Molecular Medicine siRNA SR416008
Clk4 Induction of beige‐like adipocyte markers and functions in 3T3‐L1 cells by Clk1 and PKCβII inhibitory molecules Journal of Cellular and Molecular Medicine siRNA SR408785
CLN5 Knockdown of CLN5 inhibits the tumorigenic properties of glioblastoma cells via the Akt/mTOR signaling pathway Oncology letters siRNA SR300861
CLPP ClpP regulates breast cancer cell proliferation, invasion and apoptosis by modulating the Src/PI3K/Akt signaling pathway PeerJ siRNA SR305388
CLTC Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane Commun Biol siRNA SR507164
CLTC Anti-MET VHH pool overcomes MET-targeted cancer therapeutic resistance Mol. Cancer Ther. siRNA SR300867
CLTC Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. siRNA SR300867
CLTC Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. siRNA SR300867
CLU Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin Sci Rep siRNA SR300853
CNOT2 CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells Cancer Lett. siRNA SR303204
Coasy Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection Mol. Cell siRNA SR417447
COL11A1 Activation of TWIST1 by COL11A1 promotes chemoresistance and inhibits apoptosis in ovarian cancer cells by modulating NF-κB-mediated IKKβ expression Int. J. Cancer siRNA SR300918
COL11A1 COL11A1 promotes tumor progression and predicts poor clinical outcome in ovarian cancer Oncogene doi:10.1038/onc.2013.307 siRNA SR300918
COL5A2 High expression of COL5A2, a member of COL5 family, indicates the poor survival and facilitate cell migration in gastric cancer Bioscience reports siRNA SR300907
COL6A6 Cancer-Associated Fibroblast Subgroups Showing Differential Promoting Effect on HNSCC Progression Cancers siRNA SR315141
COMMD1 Copper metabolism domain-containing 1 represses the mediators involved in the terminal effector pathways of human labour and delivery Mol. Hum. Reprod. siRNA SR315744
COMT Suppressor effect of catechol-O-methyltransferase gene in prostate cancer PLoS ONE siRNA SR319770
control siRNA Low Dose Ultraviolet B Irradiation Increases Hyaluronan Synthesis in Epidermal Keratinocytes via Sequential Induction of Hyaluronan Synthases Has1–3 Mediated by p38 and Ca2+/Calmodulin-dependent Protein Kinase II (CaMKII) Signaling J. Biol. Chem., Jun 2013; 288: 17999 - 18012. siRNA SR30004
CONTROL VECTOR iTRAQ‑based proteomic analysis of the interaction of A549 human lung epithelial cells with Aspergillus fumigatus conidia Mol Med Rep siRNA SR30004
COPB2 Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration Med. Sci. Monit. siRNA SR306142
COPB2 COPB2 promotes cell proliferation and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma cells Biomed. Pharmacother. siRNA SR306142
COX5A Serine-70 phosphorylated Bcl-2 prevents oxidative stress-induced DNA damage by modulating the mitochondrial redox metabolism Nucleic Acids Research siRNA SR306213
CPEB2 Tumor suppressor role of cytoplasmic polyadenylation element binding protein 2 (CPEB2) in human mammary epithelial cells BMC Cancer siRNA SR315168
CREB3 Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells Can. J. Physiol. Pharmacol. siRNA SR500635
CREB3 STIM-1 and ORAI-1 Channel Mediate Angiotensin-II-Induced Expression of Egr-1 in Vascular Smooth Muscle Cells J. Cell. Physiol siRNA SR500635
CREM The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis Pediatr Rheumatol Online J siRNA SR300979
CRKL Copy number gains of the putative CRKL oncogene in laryngeal squamous cell carcinoma result in strong nuclear expression of the protein and influence cell proliferation and migration Sci Rep siRNA SR300987
CRKL Escherichia coli virulence protein NleH1 interaction with the v-crk sarcoma virus CT10 oncogene-Like protein (CRKL) governs NleH1 inhibition of the ribosomal protein S3 (RPS3)/NF-kappaB pathway J Biol Chem. 2013 Oct 21 siRNA SR300987
CSA Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR300835
CSB Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR301453
CSF1R Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling Am J Cancer Res siRNA SR301013
CSMD1 Analysis of head and neck carcinoma progression reveals novel and relevant stage-specific changes associated with immortalisation and malignancy Sci Rep siRNA SR312062
CSMD3 Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference bioRxiv siRNA SR314432
CSNK1A1 Casein kinase 1α mediates degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus J. Virol. siRNA SR319812
CSTF2 Alternative polyadenylation factors link cell cycle to migration Genome Biol. siRNA SR301049
CSTF2 CstF-64 supports pluripotency and regulates cell cycle progression in embryonic stem cells through histone 3' end processing Nucleic Acids Res. siRNA SR301049
CSTF3 The structural basis of CstF-77 modulation of cleavage and polyadenylation through stimulation of CstF-64 activity Nucleic Acids Res. siRNA SR301050
CT55 Cancer/Testis Antigen 55 is required for cancer cell proliferation and mitochondrial DNA maintenance. Mitochondrion siRNA SR310386
CTCF DNA Methylation Profiling in Human Huntington's Disease Brain Hum. Mol. Genet. siRNA SR307273
CTCF Identification of CTCF as a master regulator of the clustered protocadherin genes Nucleic Acids Res., Apr 2012; 40: 3378 - 3391. siRNA SR307273
CTNNA3 Copy Number Variations in CTNNA3 and RBFOX1 Associate with Pediatric Food Allergy J. Immunol. siRNA SR309217
CTNNB1 1,25(OH)2D3 inhibits osteogenic differentiation through activating β‑catenin signaling via downregulating bone morphogenetic protein 2 Mol Med Rep siRNA SR500644
CTNNB1 Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/β-catenin signaling pathway Biomedicine & Pharmacotherapy siRNA SR319832
CTNNB1 CHI3L1 results in poor outcome of ovarian cancer by promoting properties of stem-like cells Endocr. Relat. Cancer siRNA SR319832
CTNNB1 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. siRNA SR301063
CTNNB1 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR301063
CTNNB1 Altered Protease-Activated Receptor-1 Expression and Signaling in a Malignant Pleural Mesothelioma Cell Line, NCI-H28, with Homozygous Deletion of the ß-Catenin Gene PLoS ONE siRNA SR301063
CTNNBIP1 The Alteration of CTNNBIP1 in Lung Cancer Int J Mol Sci siRNA SR311306
CTNNBL1 Spliceosome-associated factor catenin b-like 1 accelerates ovarian cancer progression by inducing expression and nuclear accumulation of yes-associated protein Int J Clin Exp Med siRNA SR311144
CTRL A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells siRNA SR301068
CTTN Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection Mol. Cell siRNA SR427044
Cttn Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice J. Cereb. Blood Flow Metab. siRNA SR416350
CTTN PDCD10 (CCM3) regulates brain endothelial barrier integrity in cerebral cavernous malformation type 3: role of CCM3-ERK1/2-cortactin cross-talk Acta Neuropathol. siRNA SR301402
CUL1 TRIM26 Negatively Regulates Interferon-ß Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3 PLoS Pathog. siRNA SR305540
CUL3 WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 Sci Rep siRNA SR419963
CUL4A Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE siRNA SR305537
CUTC Silencing of Human CutC Gene (hCutC) Induces Apoptosis in HepG2 Cells Biol Trace Elem Res siRNA SR309512
Cx3cl1 Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction Nature Communications siRNA SR426672
CXCL9 CXCL9 promotes the progression of diffuse large B-cell lymphoma through up-regulating β-catenin Biomed. Pharmacother. siRNA SR302901
CXCR3 The Synthetic Dipeptide Pidotimod Shows a Chemokine-Like Activity through CXC Chemokine Receptor 3 (CXCR3) Int J Mol Sci siRNA SR301896
CXCR4 Disease mechanism, drug-target and biomarker prediction software: Application on prostate cancer and validation bioRxiv siRNA SR322283
CXCR4 CXCL12/CXCR4 Axis Activation Mediates Prostate Myofibroblast Phenoconversion through Non-Canonical EGFR/MEK/ERK Signaling PLoS ONE siRNA SR322283
Cy-3-labeled control siRNA cAMP-responsive Element Modulator a (CREMa) Suppresses IL-17F Protein Expression in T Lymphocytes from Patients with Systemic Lupus Erythematosus (SLE) J. Biol. Chem., Feb 2012; 287: 4715 - 4725. siRNA
CYBB Nox2-mediated PI3K and Cofilin Activation Confers Alternate Redox Control of Macrophage Pinocytosis Antioxid. Redox Signal. siRNA SR301088
CYCS Apoptosome-dependent myotube formation involves activation of caspase-3 in differentiating myoblasts Cell Death Dis siRNA SR401266
CYP1A1 Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells. Gene siRNA SR301093
CYP1A1 Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway Nat Commun siRNA SR301093
Cyp1a1 LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR? ligand synthesis Nat Commun siRNA SR416691
Cyp1b1 LRH-1 mediates anti-inflammatory and antifungal phenotype of IL-13-activated macrophages through the PPAR? ligand synthesis Nat Commun siRNA SR417055
CYP1B1 7,12-Dimethylbenzanthracene induces apoptosis in RL95-2 human endometrial cancer cells: ligand-selective activation of cytochrome P450 1B1. Toxicology and applied pharmacology siRNA SR301095
CYP27A1 Mitochondrial cytochrome P450 1B1 is involved in pregnenolone synthesis in human brain cells The Journal of Biological Chemistry siRNA SR301124
CYP2J2 CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes Sci Rep siRNA SR301109
CYP2J2 CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity Drug Metab. Dispos. siRNA SR301109
CYP7A1 Simvastatin promotes NPC1-mediated free cholesterol efflux from lysosomes through CYP7A1/LXRa signalling pathway in oxLDL-loaded macrophages J. Cell. Mol. Med. siRNA SR319873
CYSLTR1 1,4-dihydroxy quininib attenuates growth of colorectal cancer cells and xenografts and regulates the TIE-2 signaling pathway in patient tumours Oncotarget siRNA SR307365
CYSLTR1 1,4-dihydroxy Quininib Attenuates Growth of Colorectal Cancer Cells and Xenografts and Regulates the TIE-2 Signaling Pathway in Patient Tumours bioRxiv siRNA SR035004
DAAM1 Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity–signaling pathway Molecular Biology of the Cell siRNA SR307929
DAB2 Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane Commun Biol siRNA SR505444
DCC Netrin-1 Preserves Blood-Brain Barrier Integrity Through Deleted in Colorectal Cancer/Focal Adhesion Kinase/RhoA Signaling Pathway Following Subarachnoid Hemorrhage in Rats J Am Heart Assoc siRNA SR502160
DCLK1 Doublecortin-Like Kinase 1 (DCLK1) Is a Novel NOTCH Pathway Signaling Regulator in Head and Neck Squamous Cell Carcinoma Frontiers in Oncology siRNA SR306088
DDB1 The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation Nat Commun siRNA SR301160
DDIT3 Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer J. Exp. Clin. Cancer Res. siRNA SR319903
DDIT3 Increased sensitivity to apoptosis upon endoplasmic reticulum stress-induced activation of the unfolded protein response in chemotherapy-resistant malignant pleural mesothelioma Br. J. Cancer siRNA SR319903
DDIT3 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE siRNA SR301166
DDR1 The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR319533
DEPTOR Cell cycle genes are downregulated after adipogenic triggering in human adipose tissue-derived stem cells by regulation of mRNA abundance Sci Rep siRNA SR312133
DHCR24 Dhcr24 activates the PI3K/Akt/HKII pathway and protects against dilated cardiomyopathy in mice Anim Models Exp Med siRNA SR416496
DHFR DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide Eur. J. Pharmacol. siRNA SR301197
DHFR Towards Identifying Novel Modulators and Targets for Alzheimer's Disease Therapy Thesis siRNA SR301197
DICER1 Identification of PTBP1 responsible for caspase dependent YRNA cleavage bioRxiv siRNA SR323577
DKK1 A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells Pharmacology siRNA SR323463
DKK3 A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis BMC Cancer siRNA SR308986
DLG1 SAP97 blocks the RXR ER retention signal of NMDA receptor subunit GluN1-3 through its SH3 domain Biochim. Biophys. Acta siRNA SR301211
DLGAP5 Hepatoma upregulated protein expression is involved in the pathogenesis of human breast carcinogenesis Oncol Lett siRNA SR306548
DLK1 LncRNA LINC01315 silencing modulates cancer stem cell properties and epithelial-to-mesenchymal transition in colorectal cancer via miR-484/DLK1 axis. Cell cycle (Georgetown, Tex.) siRNA SR305789
DLK1 The adaptor SASH1 acts through NOTCH1 and its inhibitor DLK1 in a 3D model of lumenogenesis involving CEACAM1 Exp. Cell Res. siRNA SR305789
DLL1 Delta-like 1-mediated cis-inhibition of Jagged1/2 signalling inhibits differentiation of human epidermal cells in culture Sci Rep siRNA SR509346
DMPK The pyrazolyl-urea GeGe3 inhibits tumor angiogenesis and reveals dystrophia myotonica protein kinase (DMPK)1 as a novel angiogenesis target Oncotarget siRNA SR301227
DNAJC10 IRE1 prevents endoplasmic reticulum membrane permeabilization and cell death under pathological conditions Sci Signal siRNA SR512297
DNM1L Dynamin-related protein 1 mediates low glucose-induced endothelial dysfunction in human arterioles Am. J. Physiol. Heart Circ. Physiol siRNA SR306774
DNM2 Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane Commun Biol siRNA SR501378
DNM2 Dynamin controls extracellular level of Awd/Nme1 metastasis suppressor protein Naunyn Schmiedebergs Arch. Pharmacol. siRNA SR301243
DNMT1 DAXX Suppresses Tumor-Initiating Cells in Estrogen Receptor-positive Breast Cancer following endocrine therapy Cancer Res. siRNA SR301244
DNMT1 LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation EBioMedicine siRNA SR301244
DNMT1 The DNA methyl-transferase protein DNMT1 enhances tumor-promoting properties of breast stromal fibroblasts Oncotarget siRNA SR301244
DNMT3A Cyclic AMP Response Element Modulator-α Suppresses PD-1 Expression and Promotes Effector CD4+ T Cells in Psoriasis Journal of immunology (Baltimore, Md. : 1950) 2021 siRNA SR319937
DNMT3A Prognostic significance of DNMT3A alterations in Middle Eastern papillary thyroid carcinoma European Journal of Cancer siRNA SR319937
DNMT3A LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation EBioMedicine siRNA SR319937
DNMT3A Hypoxia-induced endothelial-mesenchymal transition is associated with RASAL1 promoter hypermethylation in human coronary endothelial cells FEBS Lett. siRNA SR301246
DNMT3a cAMP responsive element modulator (CREM)a mediates chromatin remodeling of CD8 during the generation of CD3+CD4-CD8- T cells J. Biol. Chem. Dec 2013. siRNA SR301246
DNMT3a cAMP response element modulator a controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus PNAS, Oct 2012; 109: 16606 - 16611. siRNA SR301246
DNMT3B LncRNA HOTAIR epigenetically suppresses miR-122 expression in hepatocellular carcinoma via DNA methylation EBioMedicine siRNA SR301247
Drd1 Spinal dopaminergic D 1 and D 5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats. Brain research siRNA SR502135
DRD2 Tumor suppressor DRD2 facilitates M1 macrophages and restricts NF-κB signaling to trigger pyroptosis in breast cancer Theranostics siRNA SR319948
Drd5 Spinal dopaminergic D 1 and D 5 receptors contribute to reserpine-induced fibromyalgia-like pain in rats. Brain research siRNA SR502866
DROSHA Identification of PTBP1 responsible for caspase dependent YRNA cleavage bioRxiv siRNA SR309202
DROSHA Novel functional small RNAs are selectively loaded onto mammalian Ago1 Nucleic Acids Res. siRNA SR309202
DSC3 Desmocollin 3 has a tumor suppressive activity through inhibition of AKT pathway in colorectal cancer Exp. Cell Res. siRNA SR301278
DSC3 The p53 target gene desmocollin 3 acts as a novel tumor suppressor through inhibiting EGFR/ERK pathway in human lung cancer Carcinogenesis, Dec 2012; 33: 2326 - 2333. siRNA SR421036
DSG2 Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome Oncotarget siRNA SR301282
DSG2 A non-canonical role for desmoglein-2 in endothelial cells: implications for neoangiogenesis Angiogenesis siRNA SR301282
DSP Desmoplakin acts as a tumor suppressor by inhibition of the Wnt/ß-catenin signaling pathway in human lung cancer Carcinogenesis, Oct 2012; 33: 1863 - 1870. siRNA SR301285
DTNA Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle J. Mol. Endocrinol. siRNA SR419093
DUSP1 Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors J. Immunol. siRNA SR301295
DUSP16 Angiotensin II induces connective tissue growth factor expression in human hepatic stellate cells by a transforming growth factor β-independent mechanism Sci Rep siRNA SR312968
DUSP4 Modulation of p38 kinase by DUSP4 Is important in regulating cardiovascular function under oxidative stress Free Radic. Biol. Med. siRNA SR508955
DUSP4 Redox Activation of DUSP4 by N-Acetyl Cysteine Protects Endothelial Cells from Cd(2+)-Induced Apoptosis Free Radic. Biol. Med. siRNA SR508955
DVL1 DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage J Neuroinflammation siRNA SR419232
DYRK1A REST Regulates DYRK1A Transcription in a Negative Feedback Loop J. Biol. Chem., Mar 2011; 286: 10755 - 10763 siRNA SR301308
E2F1 E2F1 activates MFN2 expression by binding to the promoter and decreases mitochondrial fission and mitophagy in HeLa cells FEBS J. siRNA SR301310
EDA Ectodysplasin-A mRNA in exosomes released from activated hepatic stellate cells stimulates macrophage response. Experimental cell research siRNA SR301325
EGFR Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics siRNA SR418750
EGFR EGFR activity addiction facilitates anti-ERBB based combination treatment of squamous bladder cancer Oncogene siRNA SR320009
EGFR Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo Biomaterials siRNA SR320009
EGFR Small Molecules Identified from a Quantitative Drug Combinational Screen Resensitize Cisplatin's Response in Drug-Resistant Ovarian Cancer Cells Transl Oncol siRNA SR301357
EGFR MiR-615 inhibits cell proliferation, migration and invasion by targeting EGFR in human glioblastoma Biochem. Biophys. Res. Commun. siRNA SR320009
EGFR Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer Oncotarget siRNA SR301357
EGFR Celecoxib-erlotinib combination delays growth and inhibits angiogenesis in EGFR-mutated lung cancer Am J Cancer Res siRNA SR301357
EGR1 c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR320010
EGR1 FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR320010
EIF2A GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice Exp. Neurol. siRNA SR415709
EIF2A Distinctive subcellular inhibition of cytokine-induced SRC by salubrinal and fluid flow PLoS ONE siRNA SR313291
EIF2AK2 Knockdown of HIP1 expression promotes ligand‑induced endocytosis of EGFR in HeLa cells Oncol. Rep. siRNA SR303767
EIF2AK2 AIM2 Inflammasome Mediates Arsenic-induced Secretion of IL-1 beta and IL-18 OncoImmunology siRNA SR303767
EIF2AK3 MicroRNA-494 Regulates Endoplasmic Reticulum Stress in Endothelial Cells Frontiers in Cell and Developmental Biology siRNA SR306267
EIF2AK3 A miR-494 dependent feedback loop regulates ER stress bioRxiv siRNA SR306267
EIF2AK3 HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer Oncogenesis siRNA SR306267
EIF2AK3 Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol. siRNA SR306267
Eif2ak3 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget siRNA SR422112
EIF2AK3 Ectopic ATP Synthase Blockade Suppresses Lung Adenocarcinoma Growth by Activating the Unfolded Protein Response Cancer Res., Sep 2012; 72: 4696 - 4706. siRNA SR306267
EIF2AK4 Oxidative Stress Triggers Selective tRNA Retrograde Transport in Human Cells during the Integrated Stress Response Cell Rep siRNA SR318498
EIF3B EIF3B silencing inhibits cell proliferation via regulating EGFR/ERK pathway in lung adenocarcinoma Int J Clin Exp Patho siRNA SR305696
EIF4E Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS -mutant lung cancer Journal of Experimental & Clinical Cancer Research : CR siRNA SR320018
EIF4E HSP90/AXL/eIF4E-regulated unfolded protein response as an acquired vulnerability in drug-resistant KRAS-mutant lung cancer Oncogenesis siRNA SR320018
Eif4g2 The thyroid hormone increases bulk histones expression by enhancing translational efficiency Mol. Endocrinol. siRNA SR421103
ELF1 Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells Sci Rep siRNA SR301385
ELK3 LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1α stability J. Invest. Dermatol. siRNA SR301391
ELK3 LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1α stability J. Invest. Dermatol. siRNA SR413593
ELOVL5 Polyunsaturated fatty acid elongation and desaturation in activated human T cells: ELOVL5 is the key elongase J. Lipid Res. siRNA SR311827
EMD Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus Nat Commun siRNA SR301395
EP300 Stat3 promotes IL-10 expression in lupus T cells through trans-activation and chromatin remodeling Proc. Natl. Acad. Sci. U.S.A. siRNA SR301414
EPAS1 Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports siRNA SR301415
EPAS1 Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. siRNA SR301415
EPG5 The Vici syndrome protein EPG5 regulates intracellular nucleic acid trafficking linking autophagy to innate and adaptive immunity Autophagy siRNA SR311692
EPRS EPRS is a critical mTORC1-S6K1 effector that influences adiposity in mice Nature siRNA SR422951
ERBB2 HER2 Impedes MLK3 Kinase Activity to Support Breast Cancer Cell Survival J. Biol. Chem. siRNA SR301443
ERBB2 A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene siRNA SR301443
ERBB3 ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism siRNA SR320065
ERBB3 Human Papillomavirus Regulates HER3 Expression in Head and Neck Cancer: Implications for Targeted HER3 Therapy in HPV+ Patients Clin. Cancer Res. siRNA SR320065
ERBB3 A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene siRNA SR301444
ERBB4 EGFR Ligands Differentially Stabilize Receptor Dimers to Specify Signaling Kinetics Cell siRNA SR320066
ERBB4 Receptor tyrosine kinase ERBB4 mediates acquired resistance to ERBB2 inhibitors in breast cancer cells Cell Cycle siRNA SR301445
ERCC6 ROS-induced R loops trigger a transcription-coupled but BRCA1/2-independent homologous recombination pathway through CSB Nat Commun siRNA SR320072
ERN1 A miR-494 dependent feedback loop regulates ER stress bioRxiv siRNA SR320074
ERN1 Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol. siRNA SR320074
Ern1 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget siRNA SR421536
ERN1 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer siRNA SR301457
ERO1A Endoplasmic Reticulum Oxidase 1α is Critical for Collagen Secretion from and Membrane Type 1-Matrix Metalloproteinase levels in Hepatic Stellate Cells J. Biol. Chem. siRNA SR309340
ERRFI1 Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation EMBO Rep. siRNA SR310045
ESR1 Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation Laboratory investigation; a journal of technical methods and pathology siRNA SR301461
ESR1 Estrogenic and anti-inflammatory effects of pseudoprotodioscin in atherosclerosis-prone mice: Insights into endothelial cells and perivascular adipose tissues Eur. J. Pharmacol. siRNA SR418015
ESR1 Estrogenic and anti-inflammatory effects of pseudoprotodioscin in atherosclerosis-prone mice: Insights into endothelial cells and perivascular adipose tissues Eur. J. Pharmacol. siRNA SR301461
ESR1 Hypoxia-induced secretion stimulates breast cancer stem cell regulatory signalling pathways Mol Oncol siRNA SR301461
ESR1 Aminophenols increase proliferation of thyroid tumor cells by inducing the transcription factor activity of estrogen receptor α Biomed. Pharmacother. siRNA SR418015
ESR1 Six1 promotes colorectal cancer growth and metastasis by stimulating angiogenesis and recruiting tumor-associated macrophages Carcinogenesis siRNA SR301461
ESR1 Transcription factor activity of estrogen receptor a activation upon nonylphenol or bisphenol A treatment enhances the in vitro proliferation, invasion, and migration of neuroblastoma cells Onco Targets Ther siRNA SR301461
ESR1 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer siRNA SR301461
ESR1 Estrogen regulation of anti-apoptotic bcl-2 family member mcl-1 expression in breast cancer cells PLoS ONE siRNA SR301461
ESR1 Oestrogen induced downregulation of TFPI expression is mediated by ERa Thrombosis Research . April 2014 siRNA SR301461
ESR2 GPER1 promotes estrogen receptor negative breast cancer cell migration and invasion via non-genomic activation of c-Src/NF-κB/focal adhesion kinase cascade Journal of Bio-X Research siRNA SR301462
ESRRA Repression of the transcriptional activity of ERRα with sequence-specific DNA-binding polyamides Med Chem Res siRNA SR414015
ETS1 ANGPTL2 increases bone metastasis of breast cancer cells through enhancing CXCR4 signaling Sci Rep siRNA SR301470
ETS2 Membrane-bound β-catenin degradation is enhanced by ETS2-mediated Siah1 induction in Helicobacter pylori-infected gastric cancer cells Oncogenesis siRNA SR301471
ETS2 ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 Biochem. J. siRNA SR301471
EXOSC10 Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis Cell Rep siRNA SR420984
EXOSC5 Chromatin Dynamics and the RNA Exosome Function in Concert to Regulate Transcriptional Homeostasis Cell Rep siRNA SR406507
EXTL3 REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway Communications biology siRNA SR421199
EZH2 Flow-dependent epigenetic regulation of IGFBP5 expression by H3K27me3 contributes to endothelial anti-inflammatory effects Theranostics siRNA SR320099
EZH2 MiR-101 Targets the EZH2/Wnt/ß-Catenin the Pathway to Promote the Osteogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells Sci Rep siRNA SR301494
EZH2 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR301494
EZH2 VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. siRNA SR301494
F2R Tetracyclines promote survival and fitness in mitochondrial disease models Nature metabolism siRNA SR301496
FAM111A Nascent chromatin capture proteomics determines chromatin dynamics during DNA replication and identifies unknown fork components Nat. Cell Biol., Feb 2014. siRNA SR311883
FAM114A2 Genetic association of primary non-response to Anti-TNFα therapy in patients with Inflammatory Bowel Disease medRxiv siRNA SR307384
FAM20C Fam20C‐mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis FASEB j. siRNA SR511577
FAM20C Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia Bone July 2014 siRNA SR511577
FBXO6 Fbxo6 confers drug-sensitization to cisplatin via inhibiting the activation of Chk1 in non-small cell lung cancer FEBS Lett. siRNA SR308802
FBXW7 Role of integrin-linked kinase in regulating the protein stability of the MUC1-C oncoprotein in pancreatic cancer cells Oncogenesis siRNA SR310654
Fbxw7 MicroRNA-27b exerts an oncogenic function by targeting Fbxw7 in human hepatocellular carcinoma Tumour Biol. siRNA SR310654
FCGR2A CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms J. Immunol., May 2013; 190: 5267 - 5278. siRNA SR301549
FCGR3A CD163 and IgG Codefend against Cytotoxic Hemoglobin via Autocrine and Paracrine Mechanisms J. Immunol., May 2013; 190: 5267 - 5278. siRNA SR301551
FGF1 MiR-205-5p suppresses angiogenesis in gastric cancer by downregulating the expression of VEGFA and FGF1 Experimental Cell Research siRNA SR301569
FGF1 INAVA promotes aggressiveness of papillary thyroid cancer by upregulating MMP9 expression Cell Biosci siRNA SR301569
FGF5 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry siRNA SR301573
FGFR1 Synergistic effects of FGFR1 and PLK1 inhibitors target a metabolic liability in KRAS ‐mutant cancer EMBO Molecular Medicine siRNA SR320159
FGFR1 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry siRNA SR301583
FGFR1 miR-296 inhibits proliferation and induces apoptosis by targeting FGFR1 in human hepatocellular carcinoma FEBS Lett. siRNA SR301583
Fgfr3 Fibroblast growth factor 18 alleviates stress-induced pathological cardiac hypertrophy in male mice Nature Communications siRNA SR513507
FGFR3 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR301584
FGFR4 A Hippo and Fibroblast Growth Factor Receptor Autocrine Pathway in Cholangiocarcinoma Journal of Biological Chemistry siRNA SR301587
FKBP1A FKBP12: A partner of Snx10 required for vesicular trafficking in osteoclasts J. Cell. Biochem. siRNA SR425778
FLNA Filamin A (FLNA) modulates chemosensitivity to docetaxel in triple-negative breast cancer through the MAPK/ERK pathway Tumour Biol. siRNA SR301624
Flot1 Trogocytic molting of T cell microvilli upregulates T cell receptor surface expression and promotes clonal expansion Nature Communications siRNA SR414173
FLOT1 Flotillins in the intercalated disc are potential modulators of cardiac excitability J. Mol. Cell. Cardiol. siRNA SR514199
FLOT1 Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. siRNA SR306899
FLOT2 Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells Biochem. Biophys. Res. Commun. siRNA SR301627
FLT1 Adipose Stromal Cell Contact with Endothelial Cells Results in Loss of Complementary Vasculogenic Activity Mediated by Induction of Activin A Stem Cells siRNA SR301628
FLT3 Molecular characterization and prognostic significance of FLT3 in CML progression. Leukemia research siRNA SR301629
FLT4 Formation of the glomerular microvasculature is regulated by VEGFR-3. American journal of physiology. Renal physiology siRNA SR301631
Fluorescent-labeled Control Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells Autophagy siRNA SR30002
Fluorescent-labeled Control A human minisatellite hosts an alternative transcription start site for NPRL3 driving its expression in a repeat number-dependent manner Hum. Mutat. siRNA SR30002
Fluorescent-labeled Control Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells Biochim Biophys Acta Gene Regul Mech siRNA SR30002
Fluorescent-labeled Control SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma Cancer Gene Ther. siRNA SR30002
Fluorescent-labeled Control Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry Cells siRNA SR30002
FN1 Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors Cancer Sci. siRNA SR301640
FOLR1 Anti-Folate Receptor alpha-directed Antibody Therapies Restrict the Growth of Triple Negative Breast Cancer Clin. Cancer Res. siRNA SR301644
FOS EB2 promotes hepatocellular carcinoma proliferation and metastasis via MAPK/ERK pathway by modulating microtubule dynamics Clinical science (London, England : 1979) 2021 siRNA SR301647
FOS Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE siRNA SR301647
FOSL1 Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1 Gastroenterology siRNA SR322327
FOSL2 Oncogenic properties of the antisense lncRNA COMET in BRAF- and RET-driven papillary thyroid carcinomas Cancer Res. siRNA SR301649
Foxa1 FOXA1 is a transcriptional activator of Odf2/Cenexin and regulates primary ciliation Scientific Reports siRNA SR415184
FOXC1 Shear stimulation of FOXC1 and FOXC2 differentially regulates cytoskeletal activity during lymphatic valve maturation Elife siRNA SR320173
FOXC1 FOXC1 plays a crucial role in the growth of pancreatic cancer Oncogenesis siRNA SR301606
FOXM1 Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury Heliyon siRNA SR503608
FOXM1 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep siRNA SR301615
FOXM1 Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer J. Pathol. siRNA SR301615
FOXO1 c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR320177
FOXO1 FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR320177
FOXO1 A novel FOXO1-mediated dedifferentiation blocking role for DKK3 in adrenocortical carcinogenesis BMC Cancer siRNA SR301618
FOXO1 Cutting Edge: Differential Regulation of PTEN by TCR, Akt, and FoxO1 Controls CD4+ T Cell Fate Decisions J. Immunol. siRNA SR418715
FOXO3 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep siRNA SR301619
FOXO3 The inhibition of activated hepatic stellate cells proliferation by arctigenin through G0/G1 phase cell cycle arrest: Persistent p27(Kip1) induction by interfering with PI3K/Akt/FOXO3a signaling pathway Eur. J. Pharmacol. siRNA SR301619
FOXO4 WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 Sci Rep siRNA SR416251
FSCN1 The retinoic acid-metabolizing enzyme CYP26A1 upregulates fascin and promotes the malignant behavior of breast carcinoma cells Oncol. Rep. siRNA SR304498
FSHR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR301661
FSTL1 Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats Stroke siRNA SR307656
FSTL3 Follistatin-like 3, an activin A binding protein, is involved in early pregnancy loss Biomedicine & Pharmacotherapy siRNA SR306954
FSTL3 Involvement of follistatin-like 3 in preeclampsia Biochemical and Biophysical Research Communications siRNA SR306954
FTH1 cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool Elife siRNA SR301663
FTH1 cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool bioRxiv siRNA SR301663
FTO Smooth muscle cell FTO regulates contractile function. American journal of physiology. Heart and circulatory physiology siRNA SR324951
FTO N6-Adenosine Methylation in MiRNAs PLoS ONE siRNA SR312322
FURIN Extracellular processing of lysyl oxidase-like 2 and its effect on amine oxidase activity Biochemistry siRNA SR303336
FURIN PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity J. Biol. Chem. siRNA SR303336
FURIN The effects of cytokines on spontaneous hepatitis B surface antigen seroconversion in chronic hepatitis B virus infection J. Immunol. siRNA SR303336
FUT3 alpha3/4 Fucosyltransferase 3-Dependent Synthesis of Sialyl Lewis A on CD44 Variant Containing Exon 6 Mediates Polymorphonuclear Leukocyte Detachment from Intestinal Epithelium during Transepithelial Migration J Immunol. 2013 Nov 1;191(9):4804-17 siRNA SR301673
FXN Acute frataxin knockdown in induced pluripotent stem cell-derived cardiomyocytes activates a type I interferon response Disease Models & Mechanisms siRNA SR320201
FXN Ferroptosis as a novel therapeutic target for Friedreich's ataxia J. Pharmacol. Exp. Ther. siRNA SR320201
FXN Identification of p38 MAPK as a novel therapeutic target for Friedreich's ataxia Sci Rep siRNA SR405405
FYB1 The adapter proteins ADAP and Nck cooperate in T cell adhesion Mol. Immunol. 72-79 60 1. April 2014 siRNA SR301681
FZD1 Wnt pathway in atypical teratoid rhabdoid tumors Neuro-oncology siRNA SR305440
FZD4 MicroRNA-101 inhibits cell migration and invasion in bladder cancer via targeting FZD4 Exp Ther Med SiRNA SR305441
FZD7 Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/β-catenin signal pathway in hepatocellular carcinoma Cell Death Dis siRNA SR305443
Fzd7 Frizzled Gene Expression and Negative Regulation of Canonical WNT-ß?-catenin Signaling in Mouse F9 Teratocarcinoma Cells Biochemistry and Cell Biology siRNA SR417570
FZR1 USP22 deubiquitinates CD274 to suppress anti-cancer immunity Cancer Immunol Res siRNA SR324108
G3BP1 A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer iScience siRNA SR306845
G3BP1 N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis Nat. Struct. Mol. Biol. siRNA SR306845
G6PD Regulation of AMPK-related glycolipid metabolism imbalances redox homeostasis and inhibits anchorage independent growth in human breast cancer cells Redox Biol siRNA SR301686
G6pdx G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea J. Neurosci. siRNA SR416484
GAB1 Macrophage Stimulating Protein (MSP) Preserves Blood Brain Barrier Integrity After Intracerebral Hemorrhage Through RON Dependent GAB1/Src/β-catenin Pathway Activation in a Mouse Model J. Neurochem. siRNA SR419225
GABPA Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR301693
GALNT3 Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells BMC Cancer siRNA SR301729
GALR1 Coordinated Targeting of Galanin Receptors on Cholangiocytes and Hepatic Stellate Cells Ameliorates Liver Fibrosis in Multidrug Resistance Protein 2 Knockout Mice Am. J. Pathol. siRNA SR411760
GAPDH Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell siRNA SR301734
GAPDH Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301734
GARS HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease Brain siRNA SR419603
GATA3 MiR-205 Promotes the Viability, Migration, and Tube Formation of Cervical Cancer Cells In Vitro by Targeting GATA3 Cancer biotherapy & radiopharmaceuticals siRNA SR320264
GATA3 Differential expression and function of the endogenous lactate receptor, GPR81, in ER��-positive/HER2-positive epithelial vs. post-EMT triple-negative mesenchymal breast cancer cells JCMT siRNA SR320264
GATA3 TOX expression and role in CTCL J Eur Acad Dermatol Venereol siRNA SR320264
GATA4 The zinc finger protein GATA4 induces MET and cellular senescence through the NF-κB pathway in hepatocellular carcinoma J. Gastroenterol. Hepatol. siRNA SR301745
GBA Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301748
GCGR The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice Mol Metab siRNA SR415672
GCLC Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis Carcinogenesis siRNA SR301815
GCLC Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake J. Biol. Chem. siRNA SR301815
GCNT1 Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma Oncotarget siRNA SR320274
GCNT1 Aberrant O-glycosylation modulates aggressiveness in neuroblastoma Oncotarget siRNA SR301767
GDF11 Reduced expression of growth differentiation factor 11 promoted the progression of chronic obstructive pulmonary disease by activating the AKT signaling pathway Biomed. Pharmacother. siRNA SR413495
GDF15 Prostate cancer promotes a vicious cycle of bone metastasis progression through inducing osteocytes to secrete GDF15 that stimulates prostate cancer growth and invasion Oncogene siRNA SR408860
GDF9 Insulin-like 3 induced rat preantral follicular growth is mediated by growth differentiation factor 9 Endocrinology. 2013 Oct 29. siRNA SR505007
GDNF Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. siRNA SR301778
GEMIN4 Gemin4 functions as a coregulator of the mineralocorticoid receptor J. Mol. Endocrinol. siRNA SR309405
GFRA1 Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action Proc. Natl. Acad. Sci. U.S.A. siRNA SR415185
GFUS Oncogenic potential of TSTA3 in breast cancer and its regulation by the tumor suppressors miR-125a-5p and miR-125b Tumour Biol. siRNA SR304956
GHR Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo Cancers siRNA SR301794
GHR Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma Cancers (Basel) 2019 siRNA SR301794
GHR TITLE: Growth hormone receptor (GHR) knockdown sensitizes human melanoma cells to chemotherapy by attenuating expression of ABC drug efflux pumps researchgate.net siRNA SR301794
GHR Targeting growth hormone receptor in human melanoma cells attenuates tumor progression and epithelial mesenchymal transition via suppression of multiple oncogenic pathways Oncotarget siRNA SR301794
GIPR Physiological roles of the GIP receptor in murine brown adipose tissue Mol Metab siRNA SR406328
GIPR TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. siRNA SR406328
GJA1 Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage Biochim Biophys Acta Mol Cell Res siRNA SR320291
GJA1 Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes Glia siRNA SR412884
GJA1 Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function Front Immunol siRNA SR412884
Gja1 Cannabinoids prevent the amyloid ß-induced activation of astroglial hemichannels: A neuroprotective mechanism Glia siRNA SR412884
GJA1 Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival Glia siRNA SR412884
GJA1 Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels Glia. 2013 Dec;61(12):2023-37 siRNA SR512943
GJB6 HIV-tat alters Connexin43 expression and trafficking in human astrocytes: role in NeuroAIDS J Neuroinflammation siRNA SR307369
GLA Drug delivery using polyhistidine peptide-modified liposomes that target endogenous lysosome Biochem. Biophys. Res. Commun. siRNA SR320297
GLA Establishing 3-nitrotyrosine as a biomarker for the vasculopathy of Fabry disease Kidney Int., Jan 2014. siRNA SR301812
GLI1 Driver mutations in USP8 wild type Cushing's disease Neuro-oncology siRNA SR421553
GLI1 Gli1 inhibition suppressed cell growth and cell cycle progression and induced apoptosis as well as autophagy depending on ERK1/2 activity in human chondrosarcoma cells Cell Death Dis, Jan 2014. siRNA SR301820
GLI2 Placental sonic hedgehog pathway regulates foetal growth via insulin-like growth factor axis in preeclampsia. The Journal of clinical endocrinology and metabolism siRNA SR301821
GLP1R Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats Neuropharmacology siRNA SR415041
GLP1R TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. siRNA SR415041
GLP1R Metformin ameliorates lipotoxicity-induced mesangial cell apoptosis partly via upregulation of Glucagon like peptide-1 receptor (GLP-1R) Arch. Biochem. Biophys. siRNA SR510491
Gls Inhibition of glutaminase 1-mediated glutaminolysis improves pathological cardiac remodeling. American journal of physiology. Heart and circulatory physiology siRNA SR500238
GLS MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer siRNA SR301829
GNA11 A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling Sci Signal siRNA SR301839
GNA11 Allosteric Modulation of the Calcium-Sensing Receptor Rectifies Signaling Abnormalities Associated with G-protein alpha-11 Mutations causing Hypercalcemic and Hypocalcemic Disorders J. Biol. Chem. siRNA SR301839
GNAT3 Activation of the sweet taste receptor, T1R3, by the artificial sweetener sucralose regulates the pulmonary endothelium Am. J. Physiol. Lung Cell Mol. Physiol. siRNA SR411970
GPBAR1 TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of Caspase-8/NLRP3 after middle cerebral artery occlusion in rats Research Square siRNA SR315770
GPBAR1 Activation of TGR5 protects blood brain barrier via the BRCA1/Sirt1 pathway after middle cerebral artery occlusion in rats J. Biomed. Sci. siRNA SR510164
Gpbar1 TGR5 suppresses high glucose-induced upregulation of fibronectin and transforming growth factor-ß1 in rat glomerular mesangial cells by inhibiting RhoA/ROCK signaling Endocrine siRNA SR510164
GPER1 The GPER1/SPOP axis mediates ubiquitination-dependent degradation of ERα to inhibit the growth of breast cancer induced by oestrogen Cancer Lett siRNA SR320365
GPER1 GPER1 promotes estrogen receptor negative breast cancer cell migration and invasion via non-genomic activation of c-Src/NF-κB/focal adhesion kinase cascade Journal of Bio-X Research siRNA SR301912
Gper1 The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells. Chemico-biological interactions siRNA SR412671
Gper1 Estrogen stimulated migration and invasion of estrogen receptor-negative breast cancer cells involves an ezrin-dependent crosstalk between G protein-coupled receptor 30 and estrogen receptor beta signaling. Steroids siRNA SR412671
GPNMB Single-walled carbon-nanohorns improve biocompatibility over nanotubes by triggering less protein-initiated pyroptosis and apoptosis in macrophages Nat Commun siRNA SR417607
GPR151 Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology Nat Commun siRNA SR413989
GPRC5B The orphan receptor GPRC5B modulates inflammatory and fibrotic pathways in cardiac fibroblasts and mice hearts Biochem. Biophys. Res. Commun. siRNA SR507482
GPX1 Expression of glutathione peroxidase 1 in the spheno-occipital synchondrosis and its role in ROS-induced apoptosis Eur J Orthod siRNA SR405153
GRIK2 GRIK2 has a role in the maintenance of urothelial carcinoma stem-like cells, and its expression is associated with poorer prognosis Oncotarget siRNA SR301950
GSC Bone Morphogenetic Protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction J. Cell. Biochem. siRNA SR315497
GSDMD Gasdermin D protects against noninfectious liver injury by regulating apoptosis and necroptosis Cell Death Dis siRNA SR415714
Gsk3b GSK-3ß/NFAT Signaling Is Involved in Testosterone-Induced Cardiac Myocyte Hypertrophy PLoS ONE siRNA SR506287
GSR Pyrrolidine dithiocarbamate reverses Bcl-xL-mediated apoptotic resistance to doxorubicin by inducing paraptosis Carcinogenesis siRNA SR301982
GSTCD Defining a role for lung function associated gene GSTCD in cell homeostasis Respir. Res. siRNA SR312613
GSTM1 Autophagy activation contributes to glutathione transferase Mu 1-mediated chemoresistance in hepatocellular carcinoma Oncol Lett siRNA SR301988
GSTM1 Autophagy activation contributes to glutathione transferase Mu 1‑mediated chemoresistance in hepatocellular carcinoma Oncol Lett siRNA SR301988
GSTO1 Mechanistic evaluation and transcriptional signature of a glutathione S-transferase omega 1 inhibitor Nat Commun siRNA SR306263
GTF2IRD1 Autophagy inhibition blunts PDGFRA adipose progenitors\' cell-autonomous fibrogenic response to high-fat diet Autophagy siRNA SR421858
GUK1 Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Nature communications siRNA SR501698
H1-2 Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem siRNA SR302039
H19 The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b. Science signaling siRNA SR402967
H19 MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells Oncotarget siRNA SR319206
H19 CD90+ liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA Mol. Cancer siRNA SR319206
H2AZ1 H2A.Z regulates tumorigenesis, metastasis and sensitivity to cisplatin in intrahepatic cholangiocarcinoma Int. J. Oncol. siRNA SR302047
HADHA Association of HADHA with human RNA silencing machinery Biochem. Biophys. Res. Commun. siRNA SR302056
HAVCR2 Hepatitis A virus cellular receptor 2 (HAVCR2) is decreased with viral infection and regulates pro-labour mediators OA Am. J. Reprod. Immunol. siRNA SR313697
Hbegf ADAM17-mediated EGFR ligand shedding directs macrophage-promoted cancer cell invasion JCI Insight siRNA SR405442
HBP1 HBP1 promoter methylation augments the oncogenic ß-catenin to correlate with prognosis in NSCLC J. Cell. Mol. Med. siRNA SR308913
HCAR2 Butyrate attenuates lipolysis in adipocytes co-cultured with macrophages through non-prostaglandin E2-mediated and prostaglandin E2-mediated pathways Lipids Health Dis siRNA SR412150
Hcar2 Anti-inflammatory effects of BHBA in both in vivo and in vitro Parkinson¿s disease models are mediated by GPR109A-dependent mechanisms J Neuroinflammation siRNA SR509630
HCAR3 Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3 PLoS Genet. siRNA SR305839
Hcfc1 Insulin receptor associates with promoters genome-wide and regulates gene expression Cell siRNA SR423371
HCFC1 Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression Cell siRNA SR302076
Hck Abl-mediated PI3K activation regulates macrophage podosome formation. Journal of cell science siRNA SR416688
HCLS1 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. siRNA SR302078
HDAC1 CaMKII exacerbates heart failure progression by activating class I HDACs J. Mol. Cell. Cardiol. siRNA SR505395
HDAC1 Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells Biochim Biophys Acta Gene Regul Mech siRNA SR505395
HDAC1 Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia The Journal of Biological Chemistry siRNA SR320458
HDAC3 CaMKII exacerbates heart failure progression by activating class I HDACs J. Mol. Cell. Cardiol. siRNA SR505399
HDAC3 Acetylation of CCAR2 establishes a BET/BRD9 acetyl switch in response to combined deacetylase and bromodomain inhibition Cancer Res. siRNA SR505399
HDAC3 Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon Clin Epigenetics siRNA SR305837
HDAC6 Histone deacetylase 6 promotes insulin resistance via deacetylating phosphatase and tensin homolog (PTEN) in ovarian OVCAR-3 cells International Journal of Clinical and Experimental Pathology siRNA HP209063
HDAC7 HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients Oncogene siRNA SR309850
HELLS HELLS and PRDM9 form a pioneer complex to open chromatin at meiotic recombination hot spots Genes & Development siRNA SR302088
HELLS HELLS and PRDM9 form a Pioneer Complex to Open Chromatin at Meiotic Recombination Hotspots bioRxiv siRNA SR302088
HES1 Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice J. Neurochem.2017 siRNA SR408110
HES3 Hes3 regulates cell number in cultures from glioblastoma multiforme with stem cell characteristics Scientific Reports siRNA SR318208
HIF1A Enhanced BDNF Actions Following Acute Hypoxia Facilitate HIF-1α-Dependent Upregulation of Cav3-T-Type Ca2+ Channels in Rat Cardiomyocytes Membranes siRNA SR320469
HIF1A Arylamine N-acetyltransferase 1 regulates expression of matrix metalloproteinase 9 in cancer cells: role of HIF1-α Mol. Pharmacol. siRNA SR320469
HIF1A LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1α stability J. Invest. Dermatol. siRNA SR320469
HIF1A LRG1 promotes keratinocyte migration and wound repair through regulation of HIF-1α stability J. Invest. Dermatol. siRNA SR420554
HIF1A Energy stress-induced lncRNA HAND2-AS1 represses HIF1α-mediated energy metabolism and inhibits osteosarcoma progression American journal of Cancer Research siRNA SR320469
HIF1A Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts Oncotarget siRNA SR320469
HIF1A Global metabolic profiling identifies a pivotal role of proline and hydroxyproline metabolism in supporting hypoxic response in hepatocellular carcinoma Clin. Cancer Res.2017 siRNA SR302102
HIF1A Bone marrow adipocytes promote the warburg phenotype in metastatic prostate tumors via HIF-1a activation Oncotarget siRNA SR302102
HIF1A SOX2 Promotes the Epithelial to Mesenchymal Transition of Esophageal Squamous Cells by Modulating Slug Expression through the Activation of STAT3/HIF-a Signaling Int J Mol Sci siRNA SR302102
HIF1A Hypoxia Inducible Regulation of Placental BOK Expression Biochem. J. siRNA SR302102
HIF1A VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. siRNA SR302102
HIF3A A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin Cell. Mol. Life Sci. siRNA SR312024
HIGD1B HIGD‑1B inhibits hypoxia‑induced mitochondrial fragmentation by regulating OPA1 cleavage in cardiomyocytes Molecular medicine reports siRNA SR324184
HJV The functional role of hemojuvelin in acute ischemic stroke J. Cereb. Blood Flow Metab. siRNA SR315661
HK2 A Quantitative Tissue-Specific Landscape of Protein Redox Regulation during Aging Cell siRNA SR421182
HMCN1 Hemicentin 1 influences podocyte dynamic changes in glomerular diseases Am. J. Physiol. Renal Physiol. siRNA SR313256
HMGA2 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR305363
HMGB1 High mobility group box-B1 (HMGB1) mediates the hypoxia-induced mesenchymal transition of osteoblast cells via activating ERK/JNK signaling Cell Biol. Int. siRNA SR302140
HMGB1 Correlation of HMGB1 expression to progression and poor prognosis of adenocarcinoma and squamous cell/adenosquamous carcinoma of gallbladder Am J Transl Res siRNA SR302140
HMGB1-PS2 Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats Neurotherapeutics siRNA SR506455
HMGB3 Regulation of HMGB3 by antitumor miR-205-5p inhibits cancer cell aggressiveness and is involved in prostate cancer pathogenesis J. Hum. Genet. siRNA SR302142
HMGCS1 The mevalonate precursor enzyme HMGCS1 is a novel marker and key mediator of cancer stem cell enrichment in luminal and basal models of breast cancer PLoS ONE siRNA SR302147
HMGN2 HMGN2 Inducibly Binds a Novel Transactivation Domain in Nuclear PRLr to Coordinate Stat5a-Mediated Transcription Mol. Endocrinol., Sep 2011; 25: 1550 - 1564. siRNA SR302144
HNRNPA1 TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs J. Immunol. siRNA SR410579
HNRNPA1 Regulation of oncogenic KRAS signaling via a novel KRAS-integrin-linked kinase-hnRNPA1 regulatory loop in human pancreatic cancer cells Oncogene siRNA SR302164
HNRNPD AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 Oncogenesis siRNA SR320518
HNRNPD AUF1 positively controls angiogenesis through mRNA stabilization-dependent up-regulation of HIF-1α and VEGF-A in human osteosarcoma Oncotarget siRNA SR320518
HNRNPD Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development Nat Commun siRNA SR302168
HNRNPK RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia Nat Commun siRNA SR302173
HNRNPK Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43 Hum. Mol. Genet. siRNA SR302173
HNRNPL hnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon Biochem. Biophys. Res. Commun. siRNA SR302174
HNRNPL TCR Signal Strength Regulates Akt Substrate Specificity To Induce Alternate Murine Th and T Regulatory Cell Differentiation Programs J. Immunol. siRNA SR417288
HNRNPL Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis Nucleic Acids Res. siRNA SR302174
HNRNPM Heterogeneous nuclear ribonucleoprotein M promotes the progression of breast cancer by regulating the axin/β-catenin signaling pathway Biomedicine & Pharmacotherapy siRNA SR303072
HOPX HOPX is methylated and exerts tumour suppressive function through Ras-induced senescence in human lung cancer J. Pathol. siRNA SR313554
HOXA1 Overexpressed lncRNA ROR Promotes the Biological Characteristics of ox-LDL-Induced HUVECs via the let-7b-5p/HOXA1 Axis in Atherosclerosis Frontiers in Cardiovascular Medicine siRNA SR302178
HOXA10 MicroRNA-544a Regulates Migration and Invasion in Colorectal Cancer Cells via Regulation of Homeobox A10. Digestive diseases and sciences siRNA SR302186
HOXA5 Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells Biochim Biophys Acta Mol Basis Dis siRNA SR407749
HOXB13 Targeting the BRD4-HOXB13 Co-regulated Transcriptional Networks with Bromodomain-Kinase Inhibitors to Suppress Metastatic Castration-Resistant Prostate Cancer Mol. Cancer Ther. siRNA SR307118
HOXD10 The roles of HOXD10 in the development and progression of head and neck squamous cell carcinoma (HNSCC) Br. J. Cancer July 2014 siRNA SR302213
HP Effect of haptoglobin on the treatment of chronic hepatitis B with interferon Exp Ther Med siRNA SR302217
HPGD ?-3 polyunsaturated fatty acids upregulate 15-PGDH expression in cholangiocarcinoma cells by inhibiting miR-26a/b expression Cancer Res. siRNA SR302220
HPRT Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells Elife siRNA SR30003
HPRT1 CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes Sci Rep siRNA SR302223
HPRT1 CYP2J2 expression in adult ventricular myocytes protects against external and drug induced ROS toxicity Drug Metab. Dispos. siRNA SR302223
HRAS EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC Cancer Discov siRNA SR302226
Hrnr Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity Nature Communications siRNA SR427596
HSF1 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE siRNA SR302246
HSP90AA1 Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry Cells siRNA SR302262
HSP90AB1 Impact of Heat Shock Protein 90 Inhibition on the Proteomic Profile of Lung Adenocarcinoma as Measured by Two-Dimensional Electrophoresis Coupled with Mass Spectrometry Cells siRNA SR302264
HSPA1A Cypate-Conjugated Porous Upconversion Nanocomposites for Programmed Delivery of Heat Shock Protein 70 Small Interfering RNA for Gene Silencing and Photothermal Ablation Advanced Functional materials siRNA SR302251
HSPA1B The Anti-Inflammatory Effects of the Small Molecule Pifithrin-µ on BV2 Microglia Dev. Neurosci. siRNA SR418598
HSPA4 Proteomic analysis reveals heat shock protein 70 has a key role in polycythemia Vera Mol. Cancer 142 siRNA SR302255
HSPA5 The endoplasmic reticulum stress induced by tunicamycin affects the viability and autophagy activity of chondrocytes J. Clin. Lab. Anal. siRNA SR418749
Hspa5 Unfolded protein response signaling impacts macrophage polarity to modulate breast cancer cell clearance and melanoma immune checkpoint therapy responsiveness Oncotarget siRNA SR418749
HSPA5 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer siRNA SR302256
HSPA6 Withaferin A Induces Cell Death Selectively in Androgen-Independent Prostate Cancer Cells but Not in Normal Fibroblast Cells PLoS ONE siRNA SR302257
HSPA8 DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway Nat. Cell Biol siRNA SR302258
HSPA9 Mitochondrial autophagosomes as a mechanism of drug resistance in breast carcinoma Ultrastruct Pathol siRNA SR302259
HSPB6 Reversing Acute Kidney Injury Using Pulsed Focused Ultrasound and MSC Therapy: A Role for HSP-Mediated PI3K/AKT Signaling Mol Ther Methods Clin Dev siRNA SR403606
HSPD1 Lysine biotinylation and methionine oxidation in the heat shock protein HSP60 synergize in the elimination of reactive oxygen species in human cell cultures The Journal of Nutritional Biochemistry, Jan 2014. siRNA SR302265
HTRA1 The genomic landscape of schwannoma Nat. Genet. siRNA SR303800
HTT Fluorescence Imaging of Huntingtin mRNA Knockdown Bioconjug. Chem. siRNA SR302082
ICOSLG Loss of human ICOSL results in combined immunodeficiency J. Exp. Med. siRNA SR308174
ID1 Transcription factor ID1 is involved in decidualization of stromal cells: Implications in preeclampsia. Pregnancy hypertension siRNA SR320592
ID1 Transcription factor ID1 is involved in decidualization of stromal cells: Implications in preeclampsia Pregnancy Hypertens siRNA SR302300
ID1 Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells Elife siRNA SR403015
ID2 Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells Elife siRNA SR402424
ID3 Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells Elife siRNA SR401838
ID4 Id4 promotes the elimination of the pro-activation factor Ascl1 to maintain quiescence of adult hippocampal stem cells Elife siRNA SR403601
Idh1 G6pd Deficiency Does Not Affect the Cytosolic Glutathione or Thioredoxin Antioxidant Defense in Mouse Cochlea J. Neurosci. siRNA SR413740
IDH1 IDH1 regulates phospholipid metabolism in developing astrocytes Neurosci. Lett. siRNA SR302305
IDH2 Loss of IDH2 Accelerates Age-related Hearing Loss in Male Mice Sci Rep siRNA SR414742
IDO1 IDO1‐mediated Trp‐kynurenine‐AhR signal activation induces stemness and tumor dormancy in oral squamous cell carcinomas Oral Science International siRNA SR320671
IER5 Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription Radiat Oncol siRNA SR309669
IFITM1 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol siRNA SR305589
IFITM2 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol siRNA SR307202
IFITM3 Interferon-Induced Transmembrane Protein 3 Inhibits Hantaan Virus Infection, and Its Single Nucleotide Polymorphism rs12252 Influences the Severity of Hemorrhagic Fever with Renal Syndrome Front Immunol siRNA SR323108
IFNAR1 IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection Sci Adv siRNA SR302334
Ifnb1 Activation of dopamine D1 receptor decreased NLRP3-mediated inflammation in intracerebral hemorrhage mice J Neuroinflammation siRNA SR510605
IGF1R Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res siRNA SR302344
IGF1R Targeting insulin-like growth factor 1 receptor inhibits pancreatic cancer growth and metastasis PLoS ONE siRNA SR302344
IKBKE Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy Autophagy siRNA SR306417
IKBKE Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection J. Immunol. siRNA SR306417
IKBKE Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 J. Med. Chem. siRNA SR306417
IL17C IL-17C has a pathogenic role in kidney ischemia/reperfusion Injury Kidney International siRNA SR309026
IL17RA Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment Cell. Physiol. Biochem. siRNA SR308461
IL17RC Interleukin-17 Stimulates STAT3-Mediated Endothelial Cell Activation for Neutrophil Recruitment Cell. Physiol. Biochem. siRNA SR313678
IL17RE IL-17C has a pathogenic role in kidney ischemia/reperfusion Injury Kidney International siRNA SR315146
IL1A Comparative Proteomic Analysis of Nuclear and Cytoplasmic Compartments in Human Cardiac Progenitor Cells. Functional Evaluation of IL1A and IMP3 Research Square siRNA SR320632
IL1A Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology siRNA SR302364
IL1A Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology siRNA SR407748
IL1B Prostate tumor cell-derived IL-1β induces an inflammatory phenotype in bone marrow adipocytes and reduces sensitivity to docetaxel via lipolysis-dependent mechanisms Mol. Cancer Res. siRNA SR302365
Il1b Cancer cell-derived IL-1a induces CCL22 and the recruitment of regulatory T cells OncoImmunology siRNA SR407717
Il1f6 Novel amphiphilic lipid augments the co-delivery of erlotinib and IL36 siRNA into the skin for psoriasis treatment J Control Release siRNA SR403515
IL33 Interleukin-33 predicts poor prognosis and promotes ovarian cancer cell growth and metastasis through regulating ERK and JNK signaling pathways Mol Oncol siRNA SR314047
IL37 IL-37 Attenuates Lung Fibrosis by Inducing Autophagy and Regulating TGF-β1 Production in Mice. Journal of immunology (Baltimore, Md. : 1950) siRNA SR309020
IL6 Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance PLoS ONE siRNA SR302379
IL6R Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance PLoS ONE siRNA SR302380
IL6ST Interleukin 6 is increased in preclinical HNSCC models of acquired cetuximab resistance, but is not required for maintenance of resistance PLoS ONE siRNA SR320647
IL6ST Discovery of a Novel Orally Active Small-Molecule gp130 Inhibitor for the Treatment of Ovarian Cancer Mol. Cancer Ther., Jun 2013; 12: 937 - 949. siRNA SR302381
IMP3 Comparative Proteomic Analysis of Nuclear and Cytoplasmic Compartments in Human Cardiac Progenitor Cells. Functional Evaluation of IL1A and IMP3 Research Square siRNA SR310633
ING4 MicroRNA‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells Mol Med Report siRNA SR309575
INHBA Hypoxia-induced activin A diminishes endothelial cell vasculogenic activity J. Cell. Mol. Med. siRNA SR302421
INHBB Cigarette Smoking Impairs Adipose Stromal Cell Vasculogenic Activity and Abrogates Potency to Ameliorate Ischemia Stem Cells siRNA SR302422
INPP4B INPP4B inhibits cell proliferation, invasion and chemoresistance in human hepatocellular carcinoma Onco Targets Ther siRNA SR305819
Inpp5f Multiphasic dynamics of phosphatidylinositol 4-phosphate during phagocytosis Molecular Biology of the Cell siRNA SR422169
INSR Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res siRNA SR302436
IPCEF1 HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. siRNA SR308675
IRAK3 Transduction of Functionally Contrasting Signals by Two Mycobacterial PPE Proteins Downstream of TLR2 Receptors J. Immunol. siRNA SR307690
IRAK3 Glucocorticoids suppress inflammation via the upregulation of negative regulator IRAK-M Nat Commun siRNA SR307690
IRF3 Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway Biomedicines siRNA SR320690
IRF3 MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress Cells siRNA SR320690
IRF3 The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways Int J Mol Sci siRNA SR320690
IRF3 TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation Int J Mol Sci siRNA SR320690
IRF3 The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation J. Immunol. siRNA SR320690
IRF5 Repetitive Intermittent Hyperglycemia Drives the M1 Polarization and Inflammatory Responses in THP-1 Macrophages Through the Mechanism Involving the TLR4-IRF5 Pathway Cells siRNA SR320692
IRF7 Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance Carcinogenesis siRNA SR302451
IRF9 c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR307030
IRF9 PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats J. Cereb. Blood Flow Metab. siRNA SR509139
IRF9 FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR307030
IRS2 Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE siRNA SR305694
IRX3 The homeobox factor Irx3 maintains adipogenic identity Metab. Clin. Exp. siRNA SR312392
ITGA3 Higher Integrin Alpha 3 Beta1 Expression in Papillary Thyroid Cancer Is Associated with Worst Outcome Cancers siRNA SR320700
ITGA5 Inhibition of adhesion, migration and of a5ß1 integrin in the HCT-116 colorectal cancer cells treated with the ruthenium drug NAMI-A J. Inorg. Biochem. siRNA SR302461
ITGAV Self-Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase-Cleavable Linker Adv. Sci. siRNA SR302468
ITGAV Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res siRNA SR302468
ITGB1 Hematopoietic-to-mesenchymal transition of adipose tissue macrophages is regulated by integrin β1 and fabricated fibrin matrices Adipocyte siRNA SR420242
ITGB1 MMP-2 and MMP-9 expression induced by porphyromonas gingivalis in gingival epithelial cell was influenced by integrinß1 expression Chin J Clinicians siRNA SR302470
ITGB3 FSTL1 enhances chemoresistance and maintains stemness in breast cancer cells via integrin β3/Wnt signaling under miR-137 regulation Cancer Biol. Ther. siRNA SR302472
ITGB3 Integrin beta3 regulates clonality and fate of smooth muscle-derived atherosclerotic plaque cells Nat Commun siRNA SR427515
ITGB3 HOXD3 Plays a Critical Role in Breast Cancer Stemness and Drug Resistance Cell. Physiol. Biochem. siRNA SR302472
ITGB4 Erratum: A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer iScience siRNA SR302473
ITGB4 A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer iScience siRNA SR302473
ITGB4 A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis bioRxiv siRNA SR302473
ITPKB miR-132 loss de-represses ITPKB and aggravates amyloid and TAU pathology in Alzheimer's brain EMBO Mol Med siRNA SR302488
JAG1 Osteosarcoma cell-intrinsic colony stimulating factor-1 receptor functions to promote tumor cell metastasis through JAG1 signaling Am J Cancer Res siRNA SR300128
JMJD6 Demethylase JMJD6 as a new regulator of interferon signaling: effects of HCV and ethanol metabolism Cellular and Molecular Gastroenterology and Hepatology siRNA SR308094
JUN c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR320728
JUN FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR320728
JUN A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells siRNA SR302499
Kalrn Kalirin, a GEF for Rac1, plays an important role in FSTL-1-mediated glucose uptake in skeletal muscle cells Cellular Signalling siRNA SR505738
KAT2A Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay Mol. Carcinog. siRNA SR301765
KAT5 KAT5 promotes invasion and metastasis through C-MYC stabilization in ATC Endocr. Relat. Cancer siRNA SR415850
KCNAB2 Physiological role of Kvβ2 (AKR6) in murine skeletal muscle growth and regulation Acta Physiol (Oxf) 2018 siRNA SR412390
KCNH2 HERG ???? NF-?B ?????????????? ??????? 2016 siRNA SR302526
KCNJ2 Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease J. Immunol. siRNA SR302528
KCNN4 SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer Cell Calcium siRNA SR320777
KCNN4 KCa3.1 channel inhibition leads to an ICAM-1 dependent increase of cell-cell adhesion between A549 lung cancer and HMEC-1 endothelial cells Oncotarget siRNA SR302550
KCNN4 KCa3.1 as an Effective Target for Inhibition of Growth and Progression of Intrahepatic Cholangiocarcinoma J Cancer siRNA SR302550
Kcnn4 Inhibition of vascular calcification by block of intermediate conductance calcium-activated potassium channels with TRAM-34 Pharmacol. Res. siRNA SR414096
KCNT2 Oxytocin can regulate myometrial smooth muscle excitability by inhibiting the Na± activated K± channel, Slo2.1 J. Physiol. (Lond.) 2018 siRNA SR317593
KCTD11 KCTD11 inhibits growth and metastasis of hepatocellular carcinoma through activating Hippo signaling Oncotarget siRNA SR315580
KDM5A Comparison of Histone H3K4me3 between IVF and ICSI Technologies and between Boy and Girl Offspring International Journal of Molecular Sciences siRNA SR304002
KDM5B Geometric regulation of histone state directs melanoma reprogramming Commun Biol siRNA SR427794
KDM5B Geometric regulation of histone state directs melanoma reprogramming bioRxiv siRNA SR422988
KDM5B Melanoma topology reveals a stem-like phenotype that promotes angiogenesis Sci Adv siRNA SR427794
KDR VEGF/VEGFR-2 upregulates EZH2 expression in lung adenocarcinoma cells and EZH2 depletion enhances the response to platinum-based and VEGFR-2-targeted therapy Clin. Cancer Res. siRNA SR302557
KDR Increased VEGFR-2 Gene Copy Is Associated with Chemoresistance and Shorter Survival in Patients with Non–Small-Cell Lung Carcinoma Who Receive Adjuvant Chemotherapy Cancer Res., Aug 2011; 71: 5512 - 5521. siRNA SR302557
KEAP1 Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis Cell Death & Disease siRNA SR322898
KHDRBS1 Differential regulation of a placental Sam68 and sFlt-1 gene pathway and the relevance to maternal vitamin D sufficiency Pregnancy Hypertension siRNA SR307267
KIF22 KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation Sci Signal siRNA SR302592
KIF26B Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity signaling pathway Mol. Biol. Cell siRNA SR310475
KIT Cycloartenyl Ferulate Inhibits Paraquat-Induced Apoptosis in HK-2 Cells With the Involvement of ABCC1. Journal of cellular biochemistry siRNA SR302578
KIZ PLK1 promotes epithelial-mesenchymal transition and metastasis of gastric carcinoma cells Am J Transl Res siRNA SR310998
KL Role of Klotho in migration and proliferation of human dermal microvascular endothelial cells Microvasc. Res. siRNA SR306202
KLF15 Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection Viruses siRNA SR413764
KLF15 Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action Proc. Natl. Acad. Sci. U.S.A. siRNA SR413764
Klf2 Nanoliposome C6-Ceramide in combination with anti-CTLA4 antibody improves anti-tumor immunity in hepatocellular cancer FASEB journal : official publication of the Federation of American Societies for Experimental Biology siRNA SR411977
KLF4 Macrophage MiR-34a Is A Key Regulator of Cholesterol Efflux and Atherosclerosis Molecular Therapy siRNA SR426926
KLF4 Upregulation of KLF4 by methylseleninic acid in human esophageal squamous cell carcinoma cells: Modification of histone H3 acetylation through HAT/HDAC interplay Mol. Carcinog. siRNA SR306162
KLF5 Prognostic Value and Function of KLF5 in Papillary Thyroid Cancer Cancers siRNA SR300482
KLHL15 Cullin3-KLHL15 ubiquitin ligase mediates CtIP protein turnover to fine-tune DNA-end resection Nat Commun siRNA SR312886
KLHL2 High potassium concentration regulates the WNK3‒SPAK‒NKCC1 phosphorylation cascade via kelch-like protein 2 in mouse vascular smooth muscle cells Journal of Medical and Dental Sciences siRNA SR417910
KLRD1 Regulation and Gene Expression Profiling of NKG2D Positive Human Cytomegalovirus-Primed CD4 + T-Cells PLoS ONE siRNA SR302586
KPNB1 PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1 J. Cell Biol. siRNA SR302594
KRAS EIF1AX and RAS mutations cooperate to drive thyroid tumorigenesis through ATF4 and c-MYC Cancer Discov siRNA SR320806
KRAS Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget siRNA SR320806
KRAS Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR302601
KREMEN1 DKK3 attenuates JNK and AP-1 induced inflammation via Kremen-1 and DVL-1 in mice following intracerebral hemorrhage J Neuroinflammation siRNA SR415307
L1TD1 Embryonic stem cell-related protein L1TD1 is required for cell viability, neurosphere formation and chemoresistance in medulloblastoma Stem Cells Dev. siRNA SR310168
LAMC1 Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer siRNA SR302649
LAMC2 Aberrant expression of laminin ?2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma J Surg Res. 2013 Oct 2. pii: S0022-4804(13)00850-0 siRNA SR302651
LAMP1 Dihydrolipoic acid enhances autophagy and alleviates neurological deficits after subarachnoid hemorrhage in rats Experimental neurology siRNA SR508640
Lamp1 Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat Stroke siRNA SR508640
Lamp2 Upregulated monocyte expression of PLIN2 is associated with early arterial injury in children with overweight/obesity Atherosclerosis siRNA SR426747
LAMP2 Upregulated Monocyte Expression of Plin2 Depends Upon Proteasome Impairment and is Associated with Early Atherosclerosis in Obese Children Research Square siRNA SR413786
LAMP2 Lysosome-associated membrane protein-2 deficiency increases the risk of reactive oxygen species-induced ferroptosis in retinal pigment epithelial cells Biochem. Biophys. Res. Commun. siRNA SR320822
Lamtor1 p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin FASEB J. siRNA SR513910
LAMTOR2 LAMTOR2-Mediated Modulation of NGF/MAPK Activation Kinetics during Differentiation of PC12 Cells PLoS ONE e95863 9 4. April 2014 siRNA SR309134
LAMTOR5 Complement Regulates Nutrient Influx and Metabolic Reprogramming during Th1 Cell Responses Immunity siRNA SR307168
LANCL2 Activation of LANCL2 by BT-11 Ameliorates IBD by Supporting Regulatory T Cell Stability Through Immunometabolic Mechanisms Inflammatory Bowel Diseases siRNA SR324535
LASP1 Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer siRNA SR302655
LATS1 Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ Endocr. Relat. Cancer siRNA SR503145
LATS2 miR-650 Promotes the Metastasis and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma by Directly Inhibiting LATS2 Expression Cell. Physiol. Biochem. siRNA SR308858
LCK A common signaling pathway leading to degranulation in mast cells and its regulation by CCR1-ligand Allergy siRNA SR427042
LCN2 Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection Mol. Cell siRNA SR405112
LDHA Glioblastoma-secreted soluble CD44 activates tau pathology in the brain Exp. Mol. Med. siRNA SR411129
LDLR Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor PLoS ONE siRNA SR302668
LEF1 n-Butyl Benzyl Phthalate Promotes Breast Cancer Progression by Inducing Expression of Lymphoid Enhancer Factor 1 PLoS ONE siRNA SR309597
LEFTY1 Gefitinib and Luteolin Cause Growth Arrest of Human Prostate Cancer PC-3 Cells via Inhibition of Cyclin G-Associated Kinase and Induction of miR-630 PLoS ONE siRNA SR307250
LEMD3 Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus Nat Commun siRNA SR323641
LEPR Leptin Enhances Hepatic Fibrosis and Inflammation in a Mouse Model of Cholestasis The FASEB Journal siRNA SR420378
LGALS1 Expression of galectin-1 in carcinoma-associated fibroblasts promotes gastric cancer cell invasion through upregulation of integrin ß1 Cancer Sci. siRNA SR302674
LGALS3 A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice Cell Reports Medicine siRNA SR302676
LGALS3BP Acute Hantavirus Infection Induces Galectin-3 Binding Protein J. Gen. Virol. July 2014 siRNA SR302677
Lgals8 A recombinant bovine adenoviral mucosal vaccine expressing mycobacterial antigen-85B generates robust protection against tuberculosis in mice Cell Reports Medicine siRNA SR410253
LGMN Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer/'s disease NATURE COMMUNICATIONS siRNA SR303790
LGMN Local mitochondrial-endolysosomal microfusion cleaves the voltage-dependent anion channel 1 to promote survival in hypoxia Mol. Cell. Biol. siRNA SR303790
LGR4 NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor EMBO J. siRNA SR310714
LGR5 NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor EMBO J. siRNA SR322442
LMNA Nuclear envelope structural defect underlies the main cause of aneuploidy in ovarian carcinogenesis BMC Cell Biol. siRNA SR302703
LMO2 Soluble Heparin Binding EGF-like Growth Factor (HB-EGF) is a regulator of GALGT2 expression and GALGT2-dependent muscle and neuromuscular phenotypes Mol. Cell. Biol. siRNA SR403448
LNX1 Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. Journal of proteome research siRNA SR313643
LOXL2 Lysyl oxidase-like protein-2 regulates sprouting angiogenesis and type IV collagen assembly in the endothelial basement membrane Blood, Oct 2011; 118: 3979 - 3989. siRNA SR302716
LRG1 LRG1 Suppresses Migration and Invasion of Esophageal Squamous Cell Carcinoma by Modulating Epithelial to Mesenchymal Transition J. Cancer siRNA SR314597
LRP1 Low-density lipoprotein receptor-related protein 1 (LRP1) is a novel receptor for apolipoprotein A4 (APOA4) in adipose tissue Scientific reports siRNA SR423695
LRP1 LRP1 receptor-mediated immunosuppression of α-MMC on monocytes Int. Immunopharmacol. siRNA SR302723
LRP1 Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans Arterioscler. Thromb. Vasc. Biol. siRNA SR302723
LRP1 ApoE4 and Aß Oligomers Reduce BDNF Expression via HDAC Nuclear Translocation J. Neurosci. siRNA SR302723
Lrp5 Sclerostin inhibition promotes TNF-dependent inflammatory joint destruction cience Translational Medicine siRNA SR423069
LRP6 HLY78 protects blood-brain barrier integrity through Wnt/β-catenin signaling pathway following subarachnoid hemorrhage in rats Brain Res. Bull. siRNA SR502468
LRP6 HLY78 Attenuates Neuronal Apoptosis via the LRP6/GSK3β/β-Catenin Signaling Pathway After Subarachnoid Hemorrhage in Rats Neurosci Bull siRNA SR502468
LRRC2 Transcriptome-wide co-expression analysis identifies LRRC2 as a novel mediator of mitochondrial and cardiac function PLoS ONE siRNA SR312419
LTBP4 Increased expression of latent TGF-β-binding protein 4 affects the fibrotic process in scleroderma by TGF-β/SMAD signaling Lab. Invest siRNA SR305517
LY6E LY6E: a conductor of malignant tumor growth through modulation of the PTEN/PI3K/Akt/HIF-1 axis Oncotarget siRNA SR302746
LYPLA1 Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling Cell siRNA SR307076
LYST Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci siRNA SR300809
MAD2L1 Taxifolin Enhances Andrographolide-Induced Mitotic Arrest and Apoptosis in Human Prostate Cancer Cells via Spindle Assembly Checkpoint Activation PLoS One. 2013;8(1):e54577 siRNA SR302764
MAP1LC3A Deoxyelephantopin induces ROS-mediated autophagy and apoptosis in human colorectal cancer in vitro and in vivo Asian Pac J Trop Biomed siRNA SR313569
MAP1LC3B The apoptotic effect of 1'S-1'-Acetoxychavicol Acetate (ACA) enhanced by inhibition of non-canonical autophagy in human non-small cell lung cancer cells PLoS ONE siRNA SR313079
MAP2K1 MEK1 drives oncogenic signaling and interacts with PARP1 for genomic and metabolic homeostasis in malignant pleural mesothelioma. Cell death discovery siRNA SR321446
MAP2K1 Modulation of EZH2 expression by MEK-ERK or PI3K-AKT signaling in lung cancer is dictated by different KRAS oncogene mutations Cancer Res. siRNA SR303761
MAP2K1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy siRNA SR303761
MAP2K4 Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression Theranostics siRNA SR304323
MAP2K6 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem siRNA SR303765
MAP2K7 Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. siRNA SR303766
MAP3K11 MLK3 is a newly identified microRNA-520b target that regulates liver cancer cell migration PLoS ONE siRNA SR320985
MAP3K11 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem siRNA SR302913
MAP3K13 Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53 Cancer Res. siRNA SR306071
MAP3K19 The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells J. Biol. Chem. siRNA SR325092
MAP3K3 HIV-1 and HIV-2 differentially regulate NF-κB activity during the late stages of the replication cycle through BST-2/tetherin antagonism bioRxiv siRNA SR320953
MAP3K5 Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. siRNA SR302865
MAP3K7 HIV-1 and HIV-2 differentially regulate NF-κB activity during the late stages of the replication cycle through BST-2/tetherin antagonism bioRxiv siRNA SR321958
MAPK1 Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer Cancer Cell siRNA SR412074
MAPK1 Mixed Lineage Kinase 3 Mediates the Induction of CXCL10 by a STAT1-Dependent Mechanism during Hepatocyte Lipotoxicity J. Cell. Biochem siRNA SR303751
MAPK1 MAPK1E322K mutation increases head and neck squamous cell carcinoma sensitivity to erlotinib through enhanced secretion of amphiregulin Oncotarget siRNA SR303751
MAPK10 19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer Theranostics siRNA SR303759
MAS1 20-Hydroxyecdysone activates the protective arm of the renin angiotensin system via Mas receptor bioRxiv siRNA SR410777
MAX The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR302818
MAZ The MAZ transcription factor is a downstream target of the oncoprotein Cyr61/CCN1 and promotes pancreatic cancer cell invasion via CRAF-ERK signaling J. Biol. Chem. siRNA SR302819
MCL1 Autophagy inhibition by sustained over-production of IL-6 contributes to arsenic-induced carcinogenesis Cancer Res. siRNA SR302834
MCM2 MCM2-regulated functional networks in lung cancer by multi-dimensional proteomic approach Sci Rep siRNA SR302835
MCU The whole cell Ca2+ release-activated Ca2+ current ICRAC is regulated by the mitochondrial Ca2+ uniporter channel and is independent of extracellular and cytosolic Na J. Physiol. (Lond.) 2018 siRNA SR508660
Mcu Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun siRNA SR508660
Mcu Mitochondrial Calcium Uniporter MCU Supports Cytoplasmic Ca2+ Oscillations, Store-Operated Ca2+ Entry and Ca2+-Dependent Gene Expression in Response to Receptor Stimulation PLoS ONE July 2014 siRNA SR508660
MDM2 Loss of peptidase D binding restores the tumor suppressor functions of oncogenic p53 mutants Communications Biology siRNA SR302849
MDM2 PEPD is a pivotal regulator of p53 tumor suppressor Nature Communications siRNA SR302849
MDM2 Loss of LZAP inactivates p53 and regulates sensitivity of cells to DNA damage in a p53-dependent manner Oncogenesis siRNA SR302849
MECOM The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia PLoS Genet. siRNA SR301479
Mef2a Chronic oxytocin-driven alternative splicing of Crfr2α induces anxiety. Molecular psychiatry siRNA SR504191
Mef2a Oxytocin alters the morphology of hypothalamic neurons via the transcription factor myocyte enhancer factor 2A (MEF-2A). Molecular and cellular endocrinology siRNA SR504191
MEF2A p38MAPK Signaling Enhances Glycolysis Through the Up-Regulation of the Glucose Transporter GLUT-4 in Gastric Cancer Cells Cell. Physiol. Biochem. siRNA SR302855
MEMO1 HRG/HER2/HER3 signaling promotes AhR-mediated Memo-1 expression and migration in colorectal cancer Oncogene siRNA SR309508
MEN1 Menin Associates with the Mitotic Spindle and is Important for Cell Division Endocrinology siRNA SR302867
Meox2 Regulation of mesenchymal signaling in palatal mucosa differentiation Histochem. Cell Biol. siRNA SR408862
MET Oncogenic properties of the antisense lncRNA COMET in BRAF- and RET-driven papillary thyroid carcinomas Cancer Res. siRNA SR302873
MET Inhibiting crosstalk between MET signaling and mitochondrial dynamics and morphology: a novel therapeutic approach for lung cancer and mesothelioma Cancer Biol. Ther. siRNA SR302873
Met p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial to Mesenchymal Transition Mol. Cell. Biol. July 2014 siRNA SR422761
MET 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met. Biochemical and biophysical research communications siRNA SR302873
METTL3 N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis Nat. Struct. Mol. Biol. siRNA SR311159
METTL7B Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril Scientific reports siRNA SR316261
MFAP5 Stromal fibroblast-derived MFAP5 promotes the invasion and migration of breast cancer cells via Notch1/slug signaling Clin Transl Oncol siRNA SR305355
MFN1 Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging Aging Cell siRNA SR310844
MFN2 MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α Biochim. Biophys. Acta siRNA SR419873
MGAT5 Terminally sialylated and fucosylated complex N-glycans are involved in the malignant behavior of high-grade glioma Oncotarget siRNA SR320966
MGAT5 Epithelial-to-Mesenchymal Transition of RPE Cells In Vitro Confers Increased ß1,6-N-Glycosylation and Increased Susceptibility to Galectin-3 Binding PLoS ONE siRNA SR302886
MICAL1 Sema6A and Mical1 control cell growth and survival of BRAF V600E human melanoma cells Oncotarget siRNA SR312119
MIF Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells Cancer Sci. siRNA SR302900
MIOX Modulation of Renal Injury by Variable Expression of Myo-Inositol Oxygenase (MIOX) via Perturbation in Metabolic Sensors Biomedicines siRNA SR310776
MIOX Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule J. Clin. Invest. siRNA SR310776
MIOX Beneficial Effects of Myo-Inositol Oxygenase Deficiency in Cisplatin-Induced AKI J. Am. Soc. Nephrol. siRNA SR310776
Mkx Cardiolipin metabolism regulates expression of muscle transcription factor MyoD1 and muscle development The Journal of Biological Chemistry siRNA SR411975
MLXIP TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion J. Biochem. siRNA SR307841
MLXIPL TXNIP induced by MondoA, rather than ChREBP, suppresses cervical cancer cell proliferation, migration and invasion J. Biochem. siRNA SR309520
MLXIPL Oncogene-dependent addiction to carbohydrate-responsive element binding protein in hepatocellular carcinoma Cell Cycle siRNA SR309520
MMP11 miR-125a-3p suppresses the growth and progression of papillary thyroid carcinoma cell by targeting MMP11. Journal of cellular biochemistry siRNA SR302931
MMP2 A Key Role of microRNA-29b for the Suppression of Colon Cancer Cell Migration by American Ginseng PLoS One. 2013 Oct 9;8(10):e75034 siRNA SR302925
MMP3 MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment Lasers in medical science siRNA SR302926
MMP3 Prostate cancer-derived MMP-3 controls intrinsic cell growth and extrinsic angiogenesis Neoplasia (New York, N.Y.) 2020 siRNA SR302926
MMP7 Role of Matrix Metalloproteinases 7 in the Pathogenesis of Laryngopharyngeal Reflux: Decreased E-cadherin in Acid exposed Primary Human Pharyngeal Epithelial Cells Int J Mol Sci siRNA SR302927
Mmp9 2-Methoxyestradiol Causes MMP 9 Mediated Transactivation of EGFR and Angiotensin Type 1 Receptor Downregulation in Rat Aortic Smooth Muscle Cells Am. J. Physiol., Cell Physiol. siRNA SR513162
MPO Effect of myeloperoxidase inhibition on gene expression profiles in HL-60 cells exposed to 1, 2, 4,-benzenetriol Toxicology, Feb 2014. siRNA SR302954
MPV17L2 MPV17L2 is required for ribosome assembly in mitochondria Nucleic Acids Res. siRNA SR313662
MRI1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. siRNA SR313419
MSRA Targeting tyrosine kinase inhibitor resistant non-small-cell lung cancer by inducing EGFR degradation via methionine 790 oxidation Antioxid. Redox Signal. siRNA SR302974
MST1R Macrophage Stimulating Protein (MSP) Preserves Blood Brain Barrier Integrity After Intracerebral Hemorrhage Through RON Dependent GAB1/Src/β-catenin Pathway Activation in a Mouse Model J. Neurochem. siRNA SR422760
Msx1 Overexpression of Msx1 in Mouse Lung Leads to Loss of Pulmonary Vessels Following Vascular Hypoxic Injury Cells siRNA SR408612
MSX1 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma Leuk. Lymphoma siRNA SR302977
MSX2 Oncogenic deregulation of NKL homeobox gene MSX1 in mantle cell lymphoma Leuk. Lymphoma siRNA SR302978
MTHFR A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells Pharmacology siRNA SR302994
MTOR Activation of MTOR in pulmonary epithelium promotes LPS-induced acute lung injury Autophagy siRNA SR301656
MTRF1 BRE/BRCC45 regulates CDC25A stability by recruiting USP7 in response to DNA damage Nat Commun siRNA SR306396
MUC1 The MUC1 Extracellular Domain Subunit Is Found in Nuclear Speckles and Associates with Spliceosomes PLoS ONE siRNA SR303004
MUC20 MUC20 expression marks the receptive phase of the human endometrium Reproductive BioMedicine Online siRNA SR316364
MVK DNAJA1 controls the fate of misfolded mutant p53 through the mevalonate pathway Nat. Cell Biol siRNA SR303014
MVK Knockdown of MVK does not lead to changes in NALP3 expression or activation J Inflamm (Lond) siRNA SR413228
MX1 MicroRNA-211 promotes non-small-cell lung cancer proliferation and invasion by targeting MxA Onco Targets Ther siRNA SR303015
Myb AML suppresses hematopoiesis by releasing exosomes that contain microRNAs targeting c-MYB Sci Signal siRNA SR418501
MYBL2 A novel microRNA, hsa-miR-6852 differentially regulated by Interleukin-27 induces necrosis in cervical cancer cells by downregulating the FoxM1 expression Sci Rep siRNA SR303021
MYC The ABL-MYC axis controls WIPI1-enhanced autophagy in lifespan extension Communications Biology siRNA SR321047
MYC Superior inhibitory efficacy of butyrate over propionate and acetate against human colon cancer cell proliferation via cell cycle arrest and apoptosis: Linking dietary fiber to cancer prevention Nutrition Research siRNA SR321047
MYC Myc-dependent endothelial proliferation is controlled by phosphotyrosine 1212 in VEGF receptor-2 EMBO Rep. siRNA SR321047
MYC The Histone Deacetylase SIRT6 Restrains Transcription Elongation via Promoter-Proximal Pausing Mol. Cell siRNA SR321047
MYC Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression Sci Rep siRNA SR321047
MYC Energy stress-induced lncRNA FILNC1 represses c-Myc-mediated energy metabolism and inhibits renal tumor development Nat Commun siRNA SR321047
MYC Human prostate luminal cell differentiation requires NOTCH3 induction by p38-MAPK and MYC J. Cell. Sci. siRNA SR303025
MYC Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer Biochem. Biophys. Res. Commun. siRNA SR303025
MYC Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports siRNA SR303025
MYC Transient Induction of ING4 by MYC Drives Prostate Epithelial Cell Differentiation and its Disruption Drives Prostate Tumorigenesis Cancer Res. April 2014 siRNA SR303025
MYCN MYCN expression induces replication stress and sensitivity to PARP inhibition in neuroblastoma Oncotarget siRNA SR321048
MYCN JQ1 synergizes with the Bcl-2 inhibitor ABT-263 against MYCN-amplified small cell lung cancer Oncotarget siRNA SR303027
MYCN The Role of Histone Demethylase KDM4B in Myc Signaling in Neuroblastoma J. Natl. Cancer Inst. siRNA SR303027
MYCN Defining the role of oxygen tension in human neural progenitor fate Stem Cell Reports siRNA SR303027
MYD88 MicroRNA-214 promotes the calcification of human aortic valve interstitial cells through the acceleration of inflammatory reactions with activated MyD88/NF-κB signaling Clin Res Cardiol siRNA SR321049
MYD88 Cytomegalovirus promotes intestinal macrophage-mediated mucosal inflammation through induction of Smad7 Mucosal Immunol siRNA SR303028
MYF5 Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues Endocrinology siRNA SR407227
Myh11 Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene siRNA SR423332
MYH9 PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding Hepatology siRNA SR303039
MYLIP Effects of statins on the inducible degrader of low-density lipoprotein receptor in familial hypercholesterolemia Endocrine Connections siRNA SR309214
MYOD1 Dystrobrevin alpha gene is a direct target of the vitamin D receptor in muscle J. Mol. Endocrinol. siRNA SR410431
MYOD1 Regulation of the Antioxidant Response by MyoD Transcriptional Coactivator in Castration-resistant Prostate Cancer Cells Urology siRNA SR303062
MYOD1 Epicatechin elicits MyoD-dependent myoblast differentiation and myogenic conversion of fibroblasts PLoS ONE siRNA SR410431
MZF1 SCAND1 suppresses CDC37 gene transcription by repressing MZF1 bioRxiv siRNA SR305183
NAIP MicroRNA-4328 promotes lens epithelial cell apoptosis by targeting NLR family, apoptosis inhibitory protein in age-related cataract Cell Biochem. Funct. siRNA SR303073
NAMPT Small interfering RNA-mediated silencing of nicotinamide phosphoribosyltransferase (NAMPT) and lysosomal trafficking regulator (LYST) induce growth inhibition and apoptosis in human multiple myeloma cells: A preliminary study Bosn J Basic Med Sci siRNA SR306835
NAMPT Endogenous NAMPT dampens chemokine expression and apoptotic responses in stressed tubular cells Biochim. Biophys. Acta siRNA SR306835
NAPEPLD A protective role for N-acylphosphatidylethanolamine phospholipase D in 6-OHDA-induced neurodegeneration Sci Rep siRNA SR413245
NAT1 Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway Biochem. Pharmacol. siRNA SR300003
Nat1 Nat1 Deficiency Is Associated with Mitochondrial Dysfunction and Exercise Intolerance in Mice Cell Rep siRNA SR408355
NAT2 Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction Nature Communications siRNA SR300004
NAT2 Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages Biochem. Biophys. Res. Commun. siRNA SR300004
NAT2 BAG3-mediated Mcl-1 stabilization contributes to drug resistance via interaction with USP9X in ovarian cancer. International journal of oncology siRNA SR300004
NAT8L Cancer-specific production of N-acetylaspartate via NAT8L overexpression in non-small cell lung cancer and its potential as a circulating biomarker Cancer Prev Res (Phila) siRNA SR317479
NCAN Antihypoxic effect of miR-24 in SH-SY5Y cells under hypoxia via downregulating expression of neurocan Biochem. Biophys. Res. Commun. siRNA SR301035
NCK1 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. siRNA SR303089
NCK1 The adapter proteins ADAP and Nck cooperate in T cell adhesion Mol. Immunol. 72-79 60 1. April 2014 siRNA SR303089
Nck2 Nck2 deficiency in mice results in increased adiposity associated with adipocyte hypertrophy and enhanced adipogenesis Diabetes siRNA SR412820
NCL Cell surface nucleolin interacts with and internalizes Bothrops asper Lys49 phospholipase A2 and mediates its toxic activity Sci Rep siRNA SR321073
NCL Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription Nucleic Acids Res. siRNA SR303090
NCL Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-a-inducing protein of Helicobacter pylori Int. J. Cancer siRNA SR303090
NDRG1 iTRAQ‑based proteomic analysis of the interaction of A549 human lung epithelial cells with Aspergillus fumigatus conidia Mol Med Rep siRNA SR307046
NDRG2 Suppression of NDRG2 alleviates brain injury after intracerebral hemorrhage through mitigating astrocyte-drived glutamate neurotoxicity via NF-κB/GLT1 signaling Brain Res. siRNA SR412508
Ndufaf1 Mitochondrial reactive oxygen is critical for IL-12/IL-18-induced IFN-γ production by CD4 + T cells and is regulated by Fas/FasL signaling Cell Death & Disease siRNA SR410958
NDUFV1 Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells Elife siRNA SR415063
NECTIN2 MPDZ promotes DLL4-induced Notch signaling during angiogenesis Elife siRNA SR321541
NEDD4 NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts Bone Res siRNA SR420988
NEDD9 Computational Reconstruction of NF?B Pathway Interaction Mechanisms during Prostate Cancer PLoS Comput. Biol. siRNA SR303132
Negative Control Promoting effects of MiR-135b on human multiple myeloma cells via regulation of the Wnt/β-catenin/Versican signaling pathway Cytokine siRNA SR30004
Negative Control Down-regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1 Inflammation siRNA SR30004
Negative Control Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway Biomedicines siRNA SR30004
Negative Control Geometric regulation of histone state directs melanoma reprogramming Commun Biol siRNA SR30004
Negative Control Molecular characterization of the calcium release channel deficiency syndrome JCI Insight siRNA SR30004
Negative Control Role of FOXM1 in vascular smooth muscle cell survival and neointima formation following vascular injury Heliyon siRNA SR30004
Negative Control Melatonin improves uterine-conceptus interaction via regulation of SIRT1 during early pregnancy J. Pineal Res. siRNA SR30004
Negative Control FAM110B Inhibits Non-Small Cell Lung Cancer Cell Proliferation and Invasion Through Inactivating Wnt/β-Catenin Signaling OncoTargets and Therapy siRNA SR30004
Negative Control TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination Nat Commun siRNA SR30004
Negative Control The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype bioRxiv siRNA SR30004
Negative Control Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells J. Biomed. Sci. siRNA SR30004
Negative Control Arachidonate 12-Lipoxygenase and 12-Hydroxyeicosatetraenoic acid contribute to stromal aging-induced progression of pancreatic cancer J. Biol. Chem. siRNA SR30004
Negative Control Myo-Inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulo-Interstitial Injury in Diabetes Diabetes siRNA SR30004
negative Control (-)-Epigallocatechin gallate inhibits stemness and tumourigenicity stimulated by AXL receptor tyrosine kinase in human lung cancer cells Sci Rep siRNA SR30004
Negative Control Upregulation of the Coatomer Protein Complex Subunit beta 2 (COPB2) Gene Targets microRNA-335-3p in NCI-H1975 Lung Adenocarcinoma Cells to Promote Cell Proliferation and Migration Med. Sci. Monit. siRNA SR30004
Negative Control PARP1 enhances influenza A virus propagation by facilitating degradation of host type I interferon receptor J. Virol. siRNA SR30004
Negative Control Autophagy inhibition blunts PDGFRA adipose progenitors\' cell-autonomous fibrogenic response to high-fat diet Autophagy siRNA SR30004
Negative Control YAP-dependent necrosis occurs in early stages of Alzheimer\'s disease and regulates mouse model pathology Nat Commun siRNA SR30004
Negative Control Geometric regulation of histone state directs melanoma reprogramming bioRxiv siRNA SR30004
Negative Control Myricetin inhibits Endometriosis growth through Cyclin E1 Downregulation In Vitro and In Vivo The Journal of Nutritional Biochemistry siRNA SR30004
Negative Control Fam20C‐mediated phosphorylation of osteopontin is critical for its secretion but dispensable for its action as a cytokine in the activation of hepatic stellate cells in liver fibrogenesis FASEB j. siRNA SR30004
Negative Control PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Oncotarget siRNA SR30004
Negative Control IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells AIDS siRNA SR30004
Negative Control Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology Nat Commun siRNA SR30004
Negative Control Prostate tumor cell-derived IL-1β induces an inflammatory phenotype in bone marrow adipocytes and reduces sensitivity to docetaxel via lipolysis-dependent mechanisms Mol. Cancer Res. siRNA SR30004
Negative Control RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model bioRxiv siRNA SR30004
Negative Control PARPi synthetic lethality derives from replication-associated single-stranded DNA gaps bioRxiv siRNA SR30004
Negative Control HELLS and PRDM9 form a Pioneer Complex to Open Chromatin at Meiotic Recombination Hotspots bioRxiv siRNA SR30004
Negative Control MicroRNA-519c-3p promotes tumor growth and metastasis of hepatocellular carcinoma by targeting BTG3 Biomed. Pharmacother. siRNA SR30004
Negative Control SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma Cancer Gene Ther. siRNA SR30004
Negative Control FAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma Onco Targets Ther siRNA SR30004
Negative Control TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation Int J Mol Sci siRNA SR30004
Negative Control Knockdown Rab11-FIP2 inhibits migration and invasion of nasopharyngeal carcinoma via suppressing Rho GTPase signaling J. Cell. Biochem. siRNA SR30004
Negative Control Macrophage migration inhibitory factor-CD74 interaction regulates the expression of programmed cell death ligand 1 in melanoma cells Cancer Sci. siRNA SR30004
Negative Control E2F1 activates MFN2 expression by binding to the promoter and decreases mitochondrial fission and mitophagy in HeLa cells FEBS J. siRNA SR30004
Negative Control FGF-2 Attenuates Neuronal Apoptosis via FGFR3/PI3k/Akt Signaling Pathway After Subarachnoid Hemorrhage Mol. Neurobiol. siRNA SR30004
Negative Control Menin Associates with the Mitotic Spindle and is Important for Cell Division Endocrinology siRNA SR30004
Negative Control Effect of haptoglobin on the treatment of chronic hepatitis B with interferon Exp Ther Med siRNA SR30004
Negative Control miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN Onco Targets Ther siRNA SR30004
Negative Control INPP4B exerts a dual function in the stemness of colorectal cancer stem-like cells through regulating Sox2 and Nanog expression Carcinogenesis siRNA SR30004
Negative Control Involvement of Akt-dependent CREB signaling pathway in hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>)-induced early growth response protein-1 (Egr-1) expression in vascular smooth muscle cells Can. J. Physiol. Pharmacol. siRNA SR30004
Negative Control Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR Cell siRNA SR30004
Negative Control MicroRNA‑214 upregulates HIF‑1α and VEGF by targeting ING4 in lung cancer cells Mol Med Report siRNA SR30004
Negative Control Immunoglobulin light chains generate pro-inflammatory and pro-fibrotic kidney injury Journal of Clinical Investigation siRNA SR30004
Negative Control CACNA2D3 Enhances the Chemosensitivity of Esophageal Squamous Cell Carcinoma to Cisplatin via Inducing Ca2+-Mediated Apoptosis and Suppressing PI3K/Akt Pathways Front Oncol siRNA SR30004
Negative Control An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar J. Cell. Physiol. siRNA SR30004
Negative Control Ameliorative effects of luteolin against endometriosis progression in vitro and in vivo J. Nutr. Biochem. siRNA SR30004
Negative Control Oncogenic properties of the antisense lncRNA COMET in BRAF- and RET-driven papillary thyroid carcinomas Cancer Res. siRNA SR30004
Negative Control Protein kinase B mediates insulin-like growth factor 1-induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells J. Cell. Physiol. siRNA SR30004
Negative Control Nkx2-5 Second Heart Field Target Gene Ccdc117 Regulates DNA Metabolism and Proliferation Sci Rep siRNA SR30004
Negative Control The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice Mol Metab siRNA SR30004
Negative Control 4-Methylbenzylidene-camphor inhibits proliferation and induces reactive oxygen species-mediated apoptosis of human trophoblast cells Reprod. Toxicol. siRNA SR30004
Negative Control Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness Oncogenesis siRNA SR30004
Negative Control Macrophage Stimulating Protein (MSP) Preserves Blood Brain Barrier Integrity After Intracerebral Hemorrhage Through RON Dependent GAB1/Src/β-catenin Pathway Activation in a Mouse Model J. Neurochem. siRNA SR30004
Negative Control Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy Autophagy siRNA SR30004
Negative Control Quercetin inhibits proliferation of endometriosis regulating cyclin D1 and its target microRNAs in vitro and in vivo J. Nutr. Biochem. siRNA SR30004
Negative Control Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology bioRxiv siRNA SR30004
Negative Control Curcumin analog, GO-Y078, overcomes resistance to tumor angiogenesis inhibitors Cancer Sci. siRNA SR30004
Negative Control Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells Sci Rep siRNA SR30004
Negative Control A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome Neuronal Signal. siRNA SR30004
Negative Control The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling Sci Transl Med siRNA SR30004
Negative Control GPER1 promotes estrogen receptor negative breast cancer cell migration and invasion via non-genomic activation of c-Src/NF-κB/focal adhesion kinase cascade Journal of Bio-X Research siRNA SR30004
Negative Control Molecular characterization of autophagic and apoptotic signaling induced by sorafenib in liver cancer cells J. Cell. Physiol. siRNA SR30004
Negative Control The atypical cyclin CNTD2 promotes colon cancer cell proliferation and migration Sci Rep siRNA SR30004
Negative Control Knockdown RIP-1 inhibits production of oxLDL-induced inflammatory cytokines and promotes ABCA1 expression in macrophages Int J Clin Exp Med siRNA SR30004
Negative Control Self-Triggered Apoptosis Enzyme Prodrug Therapy (STAEPT): Enhancing Targeted Therapies via Recurrent Bystander Killing Effect by Exploiting Caspase-Cleavable Linker Adv. Sci. siRNA SR30004
Negative Control PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation Sci Rep siRNA SR30004
Negative Control Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells Sci Rep siRNA SR30004
Negative Control The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting EMBO Mol Med siRNA SR30004
Negative Control The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation J. Immunol. siRNA SR30004
Negative Control Fluorescence Imaging of Huntingtin mRNA Knockdown Bioconjug. Chem. siRNA SR30004
Negative Control ARHGEF39 promotes tumor progression via activation of Rac1/P38 MAPK/ATF2 signaling and predicts poor prognosis in non-small cell lung cancer patients Lab. Invest. siRNA SR30004
Negative Control Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis Oncotarget siRNA SR30004
negative control cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool Elife siRNA SR30004
negative control Regulation of mesenchymal signaling in palatal mucosa differentiation Histochem. Cell Biol. siRNA SR30004
Negative Control Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape Sci Rep siRNA SR30004
Negative Control Down-regulation of Stearoyl-CoA Desaturase-1 Increases Susceptibility to Palmitic Acid-Induced Lipotoxicity in Human Trophoblast Cells The Journal of Nutritional Biochemistry siRNA SR30004
Negative Control Knockdown of HIP1 expression promotes ligand‑induced endocytosis of EGFR in HeLa cells Oncol. Rep. siRNA SR30004
Negative Control Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR30004
Negative Control N6-methyladenosine (m6A) recruits and repels proteins to regulate mRNA homeostasis Nat. Struct. Mol. Biol. siRNA SR30004
negative control Receptor Interacting Protein-2 acts as negative regulator for nontypeable Haemophilus influenzae-induced mucin MUC5AC expression ntegrative Molecular Medicine siRNA SR30004
Negative Control cAMP Signaling Regulates DNA Demethylation by Augmenting the Intracellular Labile Ferrous Iron Pool bioRxiv siRNA SR30004
Negative Control De novo triiodothyronine formation from thyrocytes activated by Thyroid Stimulating Hormone J. Biol. Chem. siRNA SR30004
Negative Control The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function Oncogenesis siRNA SR30004
Negative Control Panobinostat Enhances Growth Suppressive Effects of Progestin on Endometrial Carcinoma by Increasing Progesterone Receptor and Mitogen-Inducible Gene-6 Horm Cancer siRNA SR30004
Negative Control Follistatin Targets Distinct Pathways To Promote Brown Adipocyte Characteristics in Brown and White Adipose Tissues Endocrinology siRNA SR30004
Negative Control TITLE: Growth hormone receptor (GHR) knockdown sensitizes human melanoma cells to chemotherapy by attenuating expression of ABC drug efflux pumps researchgate.net siRNA SR30004
Negative Control MiR-675-5p supports hypoxia induced epithelial to mesenchymal transition in colon cancer cells Oncotarget siRNA SR30004
Negative Control Oleate attenuates palmitate-induced endoplasmic reticulum stress and apoptosis in placental trophoblasts Reproduction siRNA SR30004
Negative Control 17β-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells Carcinogenesis siRNA SR30004
Negative Control CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene siRNA SR30004
Negative Control EGFR/ARF6 regulation of Hh signalling stimulates oncogenic Ras tumour overgrowth Nat Commun siRNA SR30004
Negative Control PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood siRNA SR30004
Negative Control Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47(phox) Sci Rep siRNA SR30004
Negative Control Multiple UBXN family members inhibit retrovirus and lentivirus production and canonical NFκΒ signaling by stabilizing IκBα PLoS Pathog siRNA SR30004
Negative Control Histone H1 and Chromosomal Protein HMGN2 Regulate Prolactin-Induced STAT5 Transcription Factor Recruitment and Function in Breast Cancer Cells J. Biol. Chem siRNA SR30004
Negative Control Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates epidermal growth factor receptor in prostate cancer Oncotarget siRNA SR30004
Negative Control ERK5 kinase activity is dispensable for cellular immune response and proliferation Proc. Natl. Acad. Sci. U.S.A. siRNA SR30004
Negative Control Crizotinib inhibits NF2-associated schwannoma through inhibition of focal adhesion kinase 1 Oncotarget siRNA SR30004
negative control siRNA Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer siRNA SR30004
NF1 Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget siRNA SR303147
NFAT5 Identification of NFAT5 as a transcriptional regulator of the EDN1gene in collecting duct Am. J. Physiol. Renal Physiol. siRNA SR423001
NFATC1 MiR-125a targets TNF receptor-associated factor 6 to inhibit osteoclastogenesis Exp. Cell Res. Dec 2013. siRNA SR303149
NFATC2 Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness Oncogenesis siRNA SR303150
NFE2L2 Blockage of Nrf2 and autophagy by L-selenocystine induces selective death in Nrf2-addicted colorectal cancer cells through p62-Keap-1-Nrf2 axis Cell Death & Disease siRNA SR321100
NFE2L2 Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice Redox Biology siRNA SR321100
NFE2L2 Compensatory expression of NRF2-dependent antioxidant genes is required to overcome the lethal effects of Kv11.1 activation in breast cancer cells and PDOs Redox biology siRNA SR321100
NFE2L2 Urea-extracted sericin is potentially better than kojic acid in the inhibition of melanogenesis through increased reactive oxygen species generation Journal of Traditional and Complementary Medicine siRNA SR321100
NFE2L2 Glia Maturation Factor-Gamma Regulates Autophagy and Scavenger Receptor-Mediated Phagocytosis in Murine Macrophages Research Square siRNA SR427248
NFE2L2 UVA Induced Oxidative Stress Was Inhibited by Paeoniflorin/Nrf2 Signaling or PLIN2 Front. Pharmacol. siRNA SR321100
NFE2L2 Metformin alleviates insulin resistance in obese-induced mice via remodeling gut microbiota and intestinal metabolites bioRxiv siRNA SR321100
NFE2L2 Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer Ther Adv Med Oncol siRNA SR321100
NFE2L2 Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats Oxid Med Cell Longev siRNA SR508224
NFE2L2 Theaflavins Alleviate Sevoflurane-induced Neurocytotoxicity via Nrf2 Signaling Pathway Int. J. Neurosci. siRNA SR321100
NFE2L2 Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2 Life Sci. siRNA SR417984
NFE2L2 Protective effects of extract of Cleistocalyx operculatus flower buds and its isolated major constituent against LPS-induced endotoxic shock by activating the Nrf2/HO-1 pathway Food Chem. Toxicol. siRNA SR417984
NFE2L2 Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism Toxicol In Vitro siRNA SR321100
NFE2L2 Euxanthone Ameliorates Sevoflurane-Induced Neurotoxicity in Neonatal Mice J. Mol. Neurosci. siRNA SR321100
NFE2L2 The Mitochondrial-Encoded Peptide MOTS-c Translocates to the Nucleus to Regulate Nuclear Gene Expression in Response to Metabolic Stress Cell Metab. siRNA SR321100
NFE2L2 Amentoflavone Ameliorates Aβ1-42-Induced Memory Deficits and Oxidative Stress in Cellular and Rat Model Neurochem. Res. siRNA SR321100
Nfe2l2 Hispidulin prevents sevoflurane- Induced memory dysfunction in aged rats Biomed. Pharmacother.2017 siRNA SR417984
NFE2L2 7-Methoxy-(9H-ß-Carbolin-1-Il)-(E)-2-Propenoic Acid, a ß-Carboline Alkaloid from Eurycoma Longifolia, Exhibits Anti-Inflammatory Effects by Activating the Nrf2/Heme Oxygenase-1 Pathway J. Cell. Biochem. siRNA SR417984
Nfe2l2 Sappanone A exhibits anti-inflammatory effects via modulation of Nrf2 and NF-?B Int. Immunopharmacol. siRNA SR417984
NFE2L2 Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo Journal of Hazardous Materials siRNA SR303156
NFE2L2 Caffeoylglycolic acid methyl ester, a major constituent of sorghum, exhibits anti-inflammatory activity via the Nrf2/heme oxygenase-1 pathway RSC Advances siRNA SR417984
Nfe2l2 Anti-inflammatory and heme oxygenase-1 inducing activities of lanostane triterpenes isolated from mushroom Ganoderma lucidum in RAW264.7 cells Toxicol. Appl. Pharmacol. siRNA SR417984
NFKB1 RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model Prostate siRNA SR321103
NFKB1 Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness Oncogenesis siRNA SR321103
NFKB1 Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus J Huntingtons Dis siRNA SR321103
NFKB2 RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model Prostate siRNA SR303162
NFKB2 Biliary tract instillation of a SMAC mimetic induces TRAIL-dependent acute sclerosing cholangitis-like injury in mice Cell Death Dis siRNA SR303162
NFKBIB Let-7e modulates the inflammatory response in vascular endothelial cells through ceRNA crosstalk Sci Rep siRNA SR303164
NGB Amyloid-β25-35 Upregulates Endogenous Neuroprotectant Neuroglobin via NFκB Activation in vitro J. Alzheimers Dis. siRNA SR403141
NGFR Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer Am. J. Pathol. siRNA SR303174
NKX2-3 Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers Proc. Natl. Acad. Sci. U.S.A. siRNA SR315976
NKX2-5 Binge Alcohol Exposure Triggers Atrial Fibrillation Through T-Type Ca2+ Channel Upregulation via Protein Kinase C (PKC) / Glycogen Synthesis Kinase 3β (GSK3β) / Nuclear Factor of Activated T-Cells (NFAT) Signaling　- An Experimental Account of Holiday Heart Syndrome Circ J siRNA SR512716
NKX3-1 OCT-4: a novel estrogen receptor-a collaborator that promotes tamoxifen resistance in breast cancer cells Oncogene siRNA SR303186
NLRP1 Ubiquitination as a key regulatory mechanism for O 3 -induced cutaneous redox inflammasome activation Redox Biology siRNA SR307826
NLRP3 HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. siRNA SR314415
NLRX1 Nucleotide-binding domain and leucine-rich-repeat-containing protein X1 deficiency induces nicotinamide adenine dinucleotide decline, mechanistic target of rapamycin activation, and cellular senescence and accelerates aging lung-like changes Aging cell siRNA SR312509
NME4 NDPK-D (NM23-H4)-mediated externalization of cardiolipin enables elimination of depolarized mitochondria by mitophagy Cell Death Differ. siRNA SR404588
NONO NonO Is a Novel Co-factor of PRDM1 and Regulates Inflammatory Response in Monocyte Derived-Dendritic Cells Front. Immunol. siRNA SR321120
NOP2 RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia Nat Commun siRNA SR303199
Nos2 The level of nitric oxide regulates lipocalin-2 expression under inflammatory condition in RINm5F beta-cells Biochem. Biophys. Res. Commun. siRNA SR500964
NOS2 Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell siRNA SR303202
NOS3 Role for reactive oxygen species in flow stimulated inner medullary collecting duct endothelin-1 production Am. J. Physiol. Renal Physiol. siRNA SR422386
NOS3 Histone deacetylase inhibitors promote eNOS expression in vascular smooth muscle cells and suppress hypoxia-induced cell growth J. Cell. Mol. Med siRNA SR515427
NOS3 MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells Sci Rep siRNA SR303203
NOTCH1 Adropin preserves the blood-brain barrier through a Notch1/Hes1 pathway after intracerebral hemorrhage in mice J. Neurochem.2017 siRNA SR303207
NOTCH1 Zinc finger RNA-binding protein promotes non-small-cell carcinoma growth and tumor metastasis by targeting the Notch signaling pathway Am J Cancer Res siRNA SR303207
NOTCH1 The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway Sci Transl Med siRNA SR303207
NOTCH1 Rhamnetin induces sensitization of hepatocellular carcinoma cells to a small molecular kinase inhibitor or chemotherapeutic agents Biochim. Biophys. Acta siRNA SR303207
NOTCH1 Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR303207
Notch1 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology siRNA SR423522
NOTCH1 cAMP-responsive Element Modulator a (CREMa) Contributes to Decreased Notch-1 Expression in T Cells from Patients with Active Systemic Lupus Erythematosus (SLE) J. Biol. Chem., Dec 2012; 287: 42525 - 42532. siRNA SR303207
NOTCH2 NOTCH2 signaling confers immature morphology and aggressiveness in human hepatocellular carcinoma cells Oncol. Rep. siRNA SR303209
Notch2 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology siRNA SR423507
NOTCH3 Mouse model of CADASIL reveals novel insights into Notch3 function in adult hippocampal neurogenesis Neurobiol. Dis. siRNA SR423462
NOX4 G Protein-Coupled Estrogen Receptor Protects From Angiotensin II-Induced Increases in Pulse Pressure and Oxidative Stress Front Endocrinol (Lausanne) 2019 siRNA SR506919
NOX4 Protein kinase B mediates insulin-like growth factor 1-induced phosphorylation and nuclear export of histone deacetylase 5 via NADPH oxidase 4 activation in vascular smooth muscle cells J. Cell. Physiol. siRNA SR506919
NOX4 NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells. Free radical biology & medicine siRNA SR323985
NOX4 Role for reactive oxygen species in flow stimulated inner medullary collecting duct endothelin-1 production Am. J. Physiol. Renal Physiol. siRNA SR417683
NOX4 Nrf2 mediates redox adaptation in NOX4-overexpressed non-small cell lung cancer cells Exp. Cell Res siRNA SR309388
NOX4 NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells Free Radical Biology and Medicine siRNA SR309388
Nox4 Nox4 contributes to the hypoxia-mediated regulation of actin cytoskeleton in cerebrovascular smooth muscle Life Sci. siRNA SR309388
NPM1 iTRAQ-based Quantitative Proteomic Analysis of Nasopharyngeal Carcinoma J. Cell. Biochem. siRNA SR303222
NPRL3 A human minisatellite hosts an alternative transcription start site for NPRL3 driving its expression in a repeat number-dependent manner Hum. Mutat. siRNA SR305374
NR1I2 Antidiuretic Action of Collecting Duct (Pro)Renin Receptor Downstream of Vasopressin and PGE2 Receptor EP4 J. Am. Soc. Nephrol. siRNA SR513127
NR1I3 Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox Sci Rep siRNA SR306706
NR3C1 Glucocorticoids Induce Stress Oncoproteins Associated with Therapy-Resistance in African American and European American Prostate Cancer Cells Sci Rep siRNA SR301960
NR4A2 Pharmacological Stimulation of Nurr1 Promotes Cell Cycle Progression in Adult Hippocampal Neural Stem Cells Int J Mol Sci siRNA SR513154
NR4A2 The pharmacological stimulation of Nurr1 improves cognitive functions via enhancement of adult hippocampal neurogenesis Stem Cell Res siRNA SR513154
Nrf1 Icariin Induces Synoviolin Expression through NFE2L1 to Protect Neurons from ER Stress-Induced Apoptosis PLoS ONE siRNA SR504532
NRP2 MUC16 Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma by Upregulating NRP2-Associated Cell Adhesion Molecular cancer research : MCR siRNA SR305825
NSD2 WHSC1/NSD2 regulates immune infiltration in prostate cancer Journal for immunotherapy of cancer siRNA SR305101
NSUN2 Epitranscriptomic Addition of m5C to HIV-1 Transcripts Regulates Viral Gene Expression Cell Host Microbe siRNA SR310319
NSUN2 Extensive Epitranscriptomic Methylation of A and C Residues on Murine Leukemia Virus Transcripts Enhances Viral Gene Expression MBio siRNA SR310319
NSUN2 Epitranscriptomic Addition of m 5C to HIV-1 Transcripts Regulates Viral Gene Expression SSRN Journal siRNA SR310319
NSUN2 RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia Nat Commun siRNA SR310319
NSUN7 ZNF750 Expression Is a Potential Prognostic Biomarker in Esophageal Squamous Cell Carcinoma Oncology siRNA SR312557
NTRK1 Neurotrophin Receptors TrkA, p75(NTR), and Sortilin are Increased and Targetable in Thyroid Cancer Am. J. Pathol. siRNA SR303249
NTRK1 Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells J. Biol. Chem., Aug 2013; 288: 23807 - 23813. siRNA SR303249
NTRK2 Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1 bioRxiv siRNA SR506114
NUAK2 The MicroRNA miR-696 is Regulated by SNARK and Reduces Mitochondrial Activity in Mouse Skeletal Muscle Through Pgc1α Inhibition Molecular Metabolism siRNA SR418439
NUAK2 E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability Cell death & disease siRNA SR418439
NUAK2 The AMPK-related kinase SNARK regulates muscle mass and myocyte survival J. Clin. Invest. siRNA SR418439
NULL A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells siRNA SR300974
NULL A novel function of HER2/Neu in the activation of G2/M checkpoint in response to ?-irradiation Oncogene siRNA SR301445
NUP62 Macroautophagy Regulates Nuclear NOTCH1 Activity Through Multiple p62 Binding Sites IUBMB Life siRNA SR308418
OAS1 Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR303266
OAS2 Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR303267
OAS3 Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR303268
OASL Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR305676
OBSCN Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis Oncogene siRNA SR313312
OCLN Occludin, caveolin-1, and Alix form a multi-protein complex and regulate HIV-1 infection of brain pericytes FASEB J siRNA SR321170
OCLN HIV alters gap junction-mediated intercellular communication in human brain pericytes Frontiers in Molecular Neuroscience siRNA SR303274
OCLN Occludin regulates glucose uptake and ATP production in pericytes by influencing AMP-activated protein kinase activity J. Cereb. Blood Flow Metab. siRNA SR303274
OGA Pharmacological inhibition and knockdown of O-GlcNAcase reduces cellular internalization of α-synuclein preformed fibrils FEBS J. siRNA SR323224
OGA Linking Cancer Metabolism to DNA Repair and Accelerated Senescence Mol. Cancer Res siRNA SR307308
OGT Linking Cancer Metabolism to DNA Repair and Accelerated Senescence Mol. Cancer Res siRNA SR305553
OMA1 The Role and Regulation of Mitochondrial Dynamics in Cisplatin Resistance in Human Gynecologic Cancer Cells Thesis siRNA SR314494
Oma1 p53 Is Required for Cisplatin-induced Processing of the Mitochondrial Fusion Protein L-Opa1 That Is Mediated by the Mitochondrial Metallopeptidase Oma1 in Gynecologic Cancers The Journal of Biological Chemistry siRNA SR416607
OMA1 p53 is required for cisplatin-induced processing of the mitochondrial fusion protein L-Opa1 that is mediated by the mitochondrial metallopeptidase Oma1 in Gynecologic Cancers J. Biol. Chem. siRNA SR314494
Opa1 Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun siRNA SR505373
OPA1 Mitofusin 1 and optic atrophy 1 shift metabolism to mitochondrial respiration during aging Aging Cell siRNA SR303287
Orai1 The Allergen Der p3 from House Dust Mite Stimulates Store-Operated Ca 2+ Channels and Mast Cell Migration through PAR4 Receptors. Molecular cell siRNA SR508429
ORAI1 Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry Sci Rep siRNA SR313705
ORAI1 Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression Cell Rep siRNA SR313705
ORAI1 A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell calcium siRNA SR313705
ORMDL3 The role of ORMDL3/ATF6 in compensated beta cell proliferation during early diabetes Aging (Albany NY) 2019 siRNA SR403232
ORMDL3 Cutting Edge: Targeting Epithelial ORMDL3 Increases, Rather than Reduces, Airway Responsiveness and Is Associated with Increased Sphingosine-1-Phosphate J. Immunol siRNA SR403232
OSR1 WNK4 is an adipogenic factor and its deletion reduces diet-induced obesity in mice EBioMedicine siRNA SR407609
OST4 OST4 is a subunit of the mammalian oligosaccharyltransferase required for efficient N-glycosylation J. Cell Sci., Jun 2013; 126: 2595 - 2606. siRNA SR319126
OXSR1 WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 Sci Rep siRNA SR416746
P2RX4 Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression Alcohol Alcohol. siRNA SR412195
P2RX7 ATP in the tumour microenvironment drives expression of nfP2X7, a key mediator of cancer cell survival Oncogene siRNA SR321204
P2RY6 Human Keratinocytes Respond to Extracellular UTP by Induction of Hyaluronan Synthase 2 Expression and Increased Hyaluronan Synthesis J. Biol. Chem siRNA SR303329
P4HB Subverted regulation of Nox1 NADPH oxidase-dependent oxidant generation by protein disulfide isomerase A1 in colon carcinoma cells with overactivated KRas Cell Death Dis siRNA SR321210
p53 SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302. siRNA SR304901
Padi2 ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation Cellular and Molecular Life Sciences siRNA SR418983
PAF1 Elevated PAF1-RAD52 axis confers chemoresistance to human cancers. Cell reports siRNA SR310177
PAF1 PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3 Gastroenterology siRNA SR310177
PAF1 Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription Radiat Oncol siRNA SR310177
PAF1 Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1 Gastroenterology siRNA SR310177
PAF1 Human RNA polymerase II associated factor 1 complex promotes tumorigenesis by activating c-MYC transcription in non-small cell lung cancer Biochem. Biophys. Res. Commun. siRNA SR310177
PANX1 Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage Biochim Biophys Acta Mol Cell Res siRNA SR308480
PANX1 Connexin 43 hemichannels and pannexin-1 channels contribute to the α-synuclein-induced dysfunction and death of astrocytes Glia siRNA SR414119
PANX1 Connexin 43 Hemichannel Activity Promoted by Pro-Inflammatory Cytokines and High Glucose Alters Endothelial Cell Function Front Immunol siRNA SR414119
Panx1 Cannabinoids prevent the amyloid ß-induced activation of astroglial hemichannels: A neuroprotective mechanism Glia siRNA SR414119
PANX1 Prenatal exposure to inflammatory conditions increases Cx43 and Panx1 unopposed channel opening and activation of astrocytes in the offspring effect on neuronal survival Glia siRNA SR414119
PANX1 Pannexin 1 Channels Mediate the Release of ATP into the Lumen of the Rat Urinary Bladder J. Physiol. (Lond.) siRNA SR513786
PANX1 Astrocytes inhibit nitric oxide-dependent Ca(2+) dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels Glia. 2013 Dec;61(12):2023-37 siRNA SR513786
PAPPA MiR-490-3p modulates the proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A Cardiovasc Res, Jul 2013; 10.1093/cvr/cvt172. siRNA SR303354
PAPPA MiR-490-3p modulates proliferation of vascular smooth muscle cells induced by ox-LDL through targeting PAPP-A Cardiovascular Research Advance Access siRNA SR303354
PARK7 The Parkinsonism-associated protein DJ-1/Park7 prevents glycation damage in human keratinocyte Biochem. Biophys. Res. Commun. siRNA SR307752
PARP1 PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells Cancer biotherapy & radiopharmaceuticals siRNA SR319280
PAX3 c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR303360
PAX3 FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR303360
PAX4 PAR2 regulates regeneration, transdifferentiation, and death Cell Death Dis siRNA SR303361
PAX6 ADAR1-mediated regulation of melanoma invasion Nat Commun siRNA SR303363
PCNA Proliferating cell nuclear antigen promotes cell proliferation and tumorigenesis by up-regulating STAT3 in non-small cell lung cancer Biomed. Pharmacother. siRNA SR303386
PCSK5 Extracellular processing of lysyl oxidase-like 2 and its effect on amine oxidase activity Biochemistry siRNA SR303392
PCSK6 Extracellular processing of lysyl oxidase-like 2 and its effect on amine oxidase activity Biochemistry siRNA SR303337
PCSK6 PACE4 Proteolytically Processes LOXL2 with little impact on its catalytic activity J. Biol. Chem. siRNA SR303337
PCSK9 (Pro)renin receptor mediates albumin-induced cellular responses: role of site-1 protease-derived soluble (pro)renin receptor in renal epithelial cells American Journal of Physiology - Cell Physiology siRNA SR316837
PCYT1A MYC is a positive regulator of choline metabolism and impedes mitophagy-dependent necroptosis in diffuse large B-cell lymphoma Blood Cancer J siRNA SR303397
PCYT1A Hepatitis C virus induced changes in cellular lipids-identifying novel host antiviral drug target Thesis siRNA SR303397
PD-L1 Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition J. Clin. Invest. siRNA SC115168
PDCD10 miRNA-24-3p promotes cell proliferation and regulates chemosensitivity in head and neck squamous cell carcinoma by targeting CHD5 Future Oncol siRNA SR307707
PDCD10 MicroRNA-425-5p regulates chemoresistance in colorectal cancer cells via regulation of Programmed Cell Death 10 J. Cell. Mol. Med. siRNA SR307707
PDE1B Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways Cell Rep siRNA SR303418
PDE3B Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight adipocyte biology Nat Commun siRNA SR422062
PDE3B Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology bioRxiv siRNA SR422062
Pde5a Inhibition of phosphodiesterase 5A by tadalafil improves SIRT1 expression and activity in insulin-resistant podocytes. Cellular signalling siRNA SR506246
PDGFD Molecular mechanisms of coronary artery disease risk at the PDGFD locus Nature Communications siRNA SR312885
Pdgfd Role of PDGF-D and PDGFR-ß in neuroinflammation in experimental ICH mice model Exp. Neurol. siRNA SR407408
Pdgfrb PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats J. Cereb. Blood Flow Metab. siRNA SR510985
Pdgfrb Inhibition of stress fiber formation preserves blood-brain barrier after intracerebral hemorrhage in mice J. Cereb. Blood Flow Metab. siRNA SR422058
Pdgfrb Platelet-Derived Growth Factor Receptor-β Regulates Vascular Smooth Muscle Cell Phenotypic Transformation and Neuroinflammation After Intracerebral Hemorrhage in Mice Crit. Care Med. siRNA SR422058
PDIA2 Inhibition of protein disulfide isomerase in glioblastoma causes marked downregulation of DNA repair and DNA damage response genes Theranostics siRNA SR312088
PDLIM2 Klotho ameliorates cyclosporine A-induced nephropathy via PDLIM2/NF-kB p65 signaling pathway Biochem. Biophys. Res. Commun siRNA SR411767
Pdlim3 Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma. Oncogene siRNA SR410257
PDZRN3 PDZRN3 destabilizes endothelial cell-cell junctions through a PKCζ-containing polarity complex to increase vascular permeability Sci. Signal siRNA SR307944
PDZRN3 Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity signaling pathway Mol. Biol. Cell siRNA SR307944
PDZRN3 The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling Nat Commun siRNA SR307944
PECAM1 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development siRNA SR303439
PELI3 TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of Caspase-8/NLRP3 after middle cerebral artery occlusion in rats Research Square siRNA SR512499
PEMT Hepatitis C virus induced changes in cellular lipids-identifying novel host antiviral drug target Thesis siRNA SR307049
PFKFB3 Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR Cell siRNA SR416726
PFKFB3 GM-CSF Enhances Macrophage Glycolytic Activity In Vitro and Improves Detection of Inflammation In Vivo J. Nucl. Med. siRNA SR416726
PFKFB3 Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity The Journal of Biological Chemistry siRNA SR321285
PFKFB3 Bioenergetic mechanisms in astrocytes may contribute to amyloid plaque deposition and toxicity JBC Papers in Press siRNA SR303464
PGR Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation Laboratory investigation; a journal of technical methods and pathology siRNA SR510584
PGRMC1 Crosstalk between progesterone receptor membrane component 1 and estrogen receptor α promotes breast cancer cell proliferation Laboratory investigation; a journal of technical methods and pathology siRNA SR503385
PGRMC1 Progesterone receptor membrane component 1 promotes the growth of breast cancers by altering the phosphoproteome and augmenting EGFR/PI3K/AKT signalling Br. J. Cancer siRNA SR323253
PHB Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells J. Biomed. Sci. siRNA SR303488
PHB The Role and Regulation of Mitochondrial Dynamics in Cisplatin Resistance in Human Gynecologic Cancer Cells Thesis siRNA SR303488
PHB2 Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells J. Biomed. Sci. siRNA SR307765
PHB2 Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats Exp. Neurol. siRNA SR307765
PHB2 Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone J. Biol. Chem. siRNA SR307765
PHF8 c-MYC drives histone demethylase PHF8 during neuroendocrine differentiation and in castration-resistant prostate cancer Oncotarget siRNA SR308029
PHLPP1 Role of PHLPP1 in inflammation response: Its loss contributes to gliomas development and progression Int. Immunopharmacol. siRNA SR308119
PIAS1 Stress-induced nuclear condensation of NELF drives transcriptional downregulation Molecular cell siRNA SR305620
PIAS4 Stress-induced nuclear condensation of NELF drives transcriptional downregulation Molecular cell siRNA SR309861
PIK3C2A A Flat BAR Protein Promotes Actin Polymerization at the Base of Clathrin-Coated Pits Cell siRNA SR303516
PIK3C2A PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. siRNA SR303516
Pik3c2b PI3 kinases p110a and PI3K-C2ß negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets Molecular Metabolism siRNA SR423087
PIK3C3 Insulin activation of vacuolar protein sorting 34 mediates localized phosphatidylinositol 3-phosphate production at lamellipodia and activation of mTOR/S6K1 Cell. Signal. siRNA SR303519
Pik3ca Abl-mediated PI3K activation regulates macrophage podosome formation. Journal of cell science siRNA SR421939
PIK3CA PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia Leukemia siRNA SR303520
Pik3cb Abl-mediated PI3K activation regulates macrophage podosome formation. Journal of cell science siRNA SR421863
PIK3CB PI3K-p110δ contributes to antibody responses by macrophages in chronic lymphocytic leukemia Leukemia siRNA SR303521
PIM1 Pim1 kinase is upregulated in glioblastoma multiforme and mediates tumor cell survival Neuro-oncology siRNA SR303522
PINK1 Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue Cell metabolism siRNA SR324912
PINK1 Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson\'s disease models Aging siRNA SR324912
PINK1 Chalcomoracin is a potent anticancer agent acting through triggering Oxidative stress via a mitophagy- and paraptosis-dependent mechanism Sci Rep siRNA SR417710
PINK1 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep siRNA SR312201
PINK1 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell siRNA SR312201
PIP Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells Bioengineered siRNA SR303531
PIP Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. siRNA SR303531
PITX2 PITX2 induction leads to impaired cardiomyocyte function in arrhythmogenic cardiomyopathy Stem Cell Reports siRNA SR321325
PKD2 The tumor promoter-activated protein kinase Cs are a system for regulating filopodia Cytoskeleton (Hoboken) 2017 siRNA SR421480
PKD2L1 TRP channels in brown and white adipogenesis from human progenitors: new therapeutic targets and the caveats associated with the common antibiotic, streptomycin FASEB J. siRNA SR305958
PLA2R1 Diverse effects of phospholipase A2 receptor expression on LNCaP and PC-3 prostate cancer cell growth in vitro and in vivo Oncotarget siRNA SR307882
PLAC1 Plac1 promotes nasopharyngeal carcinoma cells proliferation, migration and invasion via Furin/NICD/PTEN pathway Tissue & cell siRNA SR307335
PLAC1 Declined placental PLAC1 expression is involved in preeclampsia Medicine (Baltimore) 2019 siRNA SR307335
PLCG1 MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration Frontiers in immunology siRNA SR321342
PLCG1 MCAM/CD146 Signaling via PLCγ1 Leads to Activation of β1-Integrins in Memory T-Cells Resulting in Increased Brain Infiltration Frontiers in immunology siRNA SR422621
PLD2 Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment Oncogene siRNA SR421360
PLEKHG3 PLEKHG3 enhances polarized cell migration by activating actin filaments at the cell front Proc. Natl. Acad. Sci. U.S.A. siRNA SR308671
PLIN2 Hepatitis B virus X induces inflammation and cancer in mice liver through dysregulation of cytoskeletal remodeling and lipid metabolism Oncotarget siRNA SR300083
PLK4 Role for polo-like kinase 4 in mediation of cytokinesis Proc. Natl. Acad. Sci. U.S.A. siRNA SR307314
PLOD2 Lysyl hydroxylases are transcription targets for GATA3 driving lung cancer cell metastasis Sci Rep siRNA SR303576
PLOD3 Recruitment of Matrix Metalloproteinase-9 (MMP-9) to the fibroblast cell surface by Lysyl Hydroxylase-3 (LH3) triggers TGF-ß activation and fibroblast differentiation J. Biol. Chem. siRNA SR305927
Plxdc2 Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF eLife siRNA SR416812
PLXNB3 Glycoproteomics Identifies Plexin-B3 as a Targetable Cell Surface Protein Required for the Growth and Invasion of Triple-Negative Breast Cancer Cells Journal of Proteome Research siRNA SR303587
PML Reversal of Epigenetic Silencing Allows Robust HIV-1 Replication in the Absence of Integrase Function mBio siRNA SR321357
PNPLA8 SREBP-2/PNPLA8 axis improves non-alcoholic fatty liver disease through activation of autophagy Sci Rep siRNA SR309408
POLA1 DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA PLoS Pathog. siRNA SR303612
POLA2 DNA Polymerase alpha is essential for intracellular amplification of hepatitis B virus covalently closed circular DNA PLoS Pathog. siRNA SR308429
POLDIP2 Poldip2 mediates blood-brain barrier disruption and cerebral edema by inducing AQP4 polarity loss in mouse bacterial meningitis model CNS Neurosci Ther siRNA SR412409
POLR1G Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer Nat Commun siRNA SR307394
POLR3A Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR307620
PON1 Resveratrol exhibits an effect on attenuating retina inflammatory condition and damage of diabetic retinopathy via PON1 Exp. Eye Res. siRNA SR515335
POR The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells The Journal of Biological Chemistry siRNA SR303637
PORCN Importin α Partitioning to the Plasma Membrane Regulates Intracellular Scaling Cell siRNA SR324902
Positive Control Promoting effects of MiR-135b on human multiple myeloma cells via regulation of the Wnt/β-catenin/Versican signaling pathway Cytokine siRNA SR30002
Positive Control Down-regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1 Inflammation siRNA SR30002
Positive Control The N-recognin UBR4 of the N-end rule pathway is targeted to and required for the biogenesis of the early endosome J. Cell. Sci. siRNA SR30003
POTEA Cell membrane-bound CD200 signals both via an extracellular domain and following nuclear translocation of a cytoplasmic fragment Leuk. Res. siRNA SR317504
POTEH The C-terminal common to group 3 POTES (CtG3P): a newly discovered nucleolar marker associated with malignant progression and metastasis American Journal of Cancer Research siRNA SR308469
POU5F1 Female sex hormones activate HERV-K through the OCT4 transcription factor in T47D breast cancer cells AIDS Res. Hum. Retroviruses siRNA SR303649
POU5F1 Integrated regulation of class II human endogenous retroviruses in a breast cancer cell line The Proceedings of the International Conference on Creationism siRNA SR303649
PPARG PPARɣ drives IL-33-dependent ILC2 pro-tumoral functions Nature communications siRNA SR321378
PPARG Molecular mechanisms underlying eicosapentaenoic acid inhibition of HDAC1 and DNMT expression and activity in carcinoma cells Biochim Biophys Acta Gene Regul Mech siRNA SR500194
PPARG Alpha-Tocopherol prevents esophageal squamous cell carcinoma by modulating PPARγ-Akt signaling pathway at the early stage of carcinogenesis Oncotarget siRNA SR303655
PPARGC1A Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action Proc. Natl. Acad. Sci. U.S.A. siRNA SR427524
PPARGC1A MitoQ protects dopaminergic neurons in a 6-OHDA induced PD model by enhancing Mfn2-dependent mitochondrial fusion via activation of PGC-1α Biochim. Biophys. Acta siRNA SR420231
PPARGC1A Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes Cell siRNA SR420231
PPARGC1A The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent Biochim. Biophys. Acta siRNA SR420231
Ppargc1a Rosiglitazone promotes neurite outgrowth and mitochondrial function in N2A cells via PPARgamma pathway Mitochondrion Dec 2013. siRNA SR420231
PPFIA1 Characterization of the polarized endothelial secretome FASEB J. siRNA SR305572
PPIC Systems analysis identifies miR-29b regulation of invasiveness in melanoma Mol. Cancer siRNA SR303664
PPP1CA CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation J. Cell Biol. siRNA SR303671
PPP1CA MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability Nat Commun siRNA SR303671
PPP1CB CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation J. Cell Biol. siRNA SR303672
PPP1CB MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability Nat Commun siRNA SR303672
PPP1CC CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation J. Cell Biol. siRNA SR410723
PPP1CC MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability Nature Communications siRNA SR303673
PPP2CA Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity Sci Adv siRNA SR409313
PPP2CA PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine siRNA SR303682
PPP2R2C A conserved long-distance telomeric silencing mechanism suppresses mTOR signaling in aging human fibroblasts Science Advances siRNA SR303688
PPP3CA GNAQ Negatively Regulates Antiviral Innate Immune Responses in a Calcineurin-Dependent Manner J. Immunol. siRNA SR416619
PPP3CA Kisspeptin/GPR54 signaling restricts antiviral innate immune response through regulating calcineurin phosphatase activity Sci Adv siRNA SR416619
PPP5C Structural and functional basis of protein phosphatase 5 substrate specificity Proc. Natl. Acad. Sci. U.S.A. siRNA SR303702
PPT1 PPT1 inhibition enhances the antitumor activity of anti-PD-1 antibody in melanoma JCI Insight siRNA SR409088
PPTC7 The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis Biochim Biophys Acta Bioenerg siRNA SR315995
PRDM1 NonO Is a Novel Co-factor of PRDM1 and Regulates Inflammatory Response in Monocyte Derived-Dendritic Cells Front. Immunol. siRNA SR300437
PRDM1 Interleukin 21 Receptor/Ligand Interaction Is Linked to Disease Progression in Pancreatic Cancer Cells siRNA SR300437
Prdm1 Increased cathepsin S in Prdm1-/- dendritic cells alters the TFH cell repertoire and contributes to lupus Nat. Immunol. siRNA SR420429
PRDM1 Cellular differentiation regulator BLIMP1 induces Epstein-Barr virus lytic reactivation in epithelial and B cells by activating transcription from both the R and Z promoters J. Viro siRNA SR300437
PRDM14 Geometric regulation of histone state directs melanoma reprogramming Commun Biol siRNA SR417406
PRDX1 Peroxiredoxin 1, a novel HBx-interacting protein, interacts with Exosc5 and negatively regulates HBV propagation through degradation of HBV RNA J. Virol. siRNA SR303343
PRKAA1 The AMPK agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation-associated cachectic muscle wasting EMBO Mol Med siRNA SR417172
PRKAA1 Re-sensitization of radiation resistant colorectal cancer cells to radiation through inhibition of AMPK pathway Oncol Lett siRNA SR303721
PRKAA1 LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress Nat. Cell Biol. siRNA SR303721
PRKAA2 LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress Nat. Cell Biol. siRNA SR303722
PRKACA Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism Sci Signal siRNA SR411864
PRKACA Regulation of Mitochondrial poly (ADP-ribose) Polymerase Activation by the ß-adrenoceptor/cAMP/Protein Kinase A Axis During Oxidative Stress Molecular PHARMACOLOGY July 2014 siRNA SR303725
PRKAR2B Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts Oncotarget siRNA SR303734
PRKCA The Syndecan-4/Protein Kinase Ca Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo J. Biol. Chem., May 2013; 288: 12712 - 12721. siRNA SR303735
PRKCA Protein Kinases D2 and D3 Are Novel Growth Regulators in HCC1806 Triple-negative Breast Cancer Cells Anticancer Res, Feb 2013; 33: 393 - 399. siRNA SR303735
Prkce Huntington disease oligodendrocyte maturation deficits revealed by single-nucleus RNAseq are rescued by thiamine-biotin supplementation Nature Communications siRNA SR427452
PRKCE Rise and Fall of Kir2.2 Current by TLR4 Signaling in Human Monocytes: PKC-Dependent Trafficking and PI3K-Mediated PIP2 Decrease J. Immunol. siRNA SR303738
PRKCI Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion Cell adhesion & migration siRNA SR321426
PRKCI The interruption of atypical PKC signaling and Temozolomide combination therapy against glioblastoma Cellular Signalling siRNA SR321426
PRKCI c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR321426
PRKCI The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells Cell Adh Migr siRNA SR321426
PRKCI Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors Cell Adh Migr siRNA SR321426
PRKCI FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR321426
PRKCZ Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion Cell adhesion & migration siRNA SR321432
PRKCZ The modulation of actin dynamics via atypical Protein Kinase-C activated Cofilin regulates metastasis of colorectal cancer cells Cell Adh Migr siRNA SR321432
PRKCZ Analysis of PKC-ζ protein levels in normal and malignant breast tissue subtypes Oncol Lett siRNA SR321432
PRKCZ Analysis of PKC‑ζ protein levels in normal and malignant breast tissue subtypes Oncol Lett siRNA SR321432
PRKCZ Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors Cell Adh Migr siRNA SR321432
PRKD1 A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets Physiol Rep siRNA SR421194
Prkd1 The tumor promoter-activated protein kinase Cs are a system for regulating filopodia Cytoskeleton (Hoboken) 2017 siRNA SR421194
PRKDC Identification of PRKDC (protein kinase, DNA-activated, catalytic polypeptide) as an essential gene for colorectal cancer (CRCs) cells Gene siRNA SR303748
PRKN Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson\'s disease models Aging siRNA SR303355
PRKN Type 2 diabetes-induced hyposalivation of the submandibular gland through PINK1/Parkin-mediated mitophagy J. Cell. Physiol. siRNA SR303355
PRKN Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell siRNA SR303355
PRKN Mitochondria directly donate their membrane to form autophagosomes during a novel mechanism of parkin-associated mitophagy Cell Biosci 16 4 1. April 2014 siRNA SR303355
PRNP The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through Dipeptidyl Aminopeptidase-like protein 6 J. Biol. Chem. siRNA SR303776
PROM1 Astrocytes influence medulloblastoma phenotypes and CD133 surface expression PLoS ONE siRNA SR305838
PROM1 Silencing of CD133 inhibits GLUT1-mediated glucose transport through downregulation of the HER3/Akt/mTOR pathway in colon cancer FEBS Lett. siRNA SR305838
PROM1 Nerve growth factor regulates CD133 function to promote tumor cell migration and invasion via activating ERK1/2 signaling in pancreatic cancer Pancreatology siRNA SR305838
PS100001 Macrophage-Derived Delta-like 1 Enhances Interleukin-6 and Matrix Metalloproteinase-3 Production by Fibroblast-Like Synoviocytes in Arthritic Mice Arthritis & rheumatology siRNA SR30004
PS100020 SDF1a-induced interaction of the adapter proteins Nck and HS1 facilitates actin polymerization and migration in T cells Eur. J. Immunol. siRNA SR30004
Psmb5 Autophagy mediates the clearance of oligodendroglial SNCA/alpha-synuclein and TPPP/p25A in multiple system atrophy models Autophagy siRNA SR512544
Psmd13 Pharmacological Amelioration of Cone Survival and Vision in a Mouse Model for Leber Congenital Amaurosis J. Neurosci. siRNA SR412711
PSMD13 Functional Rescue of Retinal Degeneration-Associated Mutant RPE65 Proteins Advances in experimental medicine and biology siRNA SR303852
PSMD13 Temperature-sensitive retinoid isomerase activity of RPE65 mutants associated with Leber Congenital Amaurosis J. Biochem. siRNA SR303852
PSMD13 Rescue of enzymatic function for disease-associated RPE65s containing various missense mutations in non-active sites J. Biol. Chem. siRNA SR303852
PSMD2 Angiopoietin-2 secretion by endothelial cells exosome: regulation by the PI3K/Akt/eNOS and syndecan 4/syntenin pathways J. Biol. Chem. siRNA SR303842
PSMD3 The transition zone protein Rpgrip1l regulates proteasomal activity at the primary cilium J. Cell Biol. siRNA SR416821
PSME3 PSME3 Promotes TGFB1 Secretion by Pancreatic Cancer Cells to Induce Pancreatic Stellate Cell Proliferation J. Cancer siRNA SR323025
PSMF1 Molecular and Cellular Roles of PI31 (PSMF1) in Regulation of Proteasome Function J. Biol. Chem. April 2014 siRNA SR306299
PTEN miR-3691-5p promotes hepatocellular carcinoma cell migration and invasion through activating PI3K/Akt signaling by targeting PTEN Onco Targets Ther siRNA SR321496
PTEN Jarid2 enhances the progression of bladder cancer through regulating PTEN/AKT signaling Life Sci. siRNA SR321496
PTEN T cells transduce T cell receptor signal strength by generating different phosphatidylinositols J. Biol. Chem. siRNA SR426694
PTEN SIX1 reduces the expression of PTEN via activating PI3K/AKT signal to promote cell proliferation and tumorigenesis in osteosarcoma Biomed. Pharmacother. siRNA SR321496
PTEN Neuronal RARß Signaling Modulates PTEN Activity Directly in Neurons and via Exosome Transfer in Astrocytes to Prevent Glial Scar Formation and Induce Spinal Cord Regeneration J. Neurosci. siRNA SR413443
PTEN PI3K/AKT pathway mediates induction of IL-1RA by TSH in fibrocytes: Modulation by PTEN J. Clin. Endocrinol. Metab. siRNA SR303860
PTEN NVP-BEZ235, a dual PI3K/mTOR inhibitor, induces cell death through alternate routes in prostate cancer cells depending on the PTEN genotype Apoptosis siRNA SR303860
PTGES miR-21 modulates prostaglandin signaling and promotes gastric tumorigenesis by targeting 15-PGDH Biochem. Biophys. Res. Commun.2017 siRNA SR306338
PTGS2 3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway J. Exp. Clin. Cancer Res. siRNA SR303873
PTGS2 Differential expression of cyclooxygenase-2 in metastatic melanoma affects progression free survival Oncotarget siRNA SR303873
PTGS2 Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity Phytomedicine siRNA SR303873
PTGS2 MiR-21 Targets 15-PGDH and Promotes Cholangiocarcinoma Growth Mol. Cancer Res. April 2014 siRNA SR303873
PTGS2 Ubiquitin-Proteasomal Degradation of COX-2 in TGF-ß Stimulated Human Endometrial Cells Is Mediated Through Endoplasmic Reticulum Mannosidase I Endocrinology, Jan 2012; 153: 426 - 437. siRNA SR303873
PTK2 A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis bioRxiv siRNA SR303877
PTK2 T cells transduce T cell receptor signal strength by generating different phosphatidylinositols J. Biol. Chem. siRNA SR421142
PTK2 Phosphoinositide 3-kinase p85beta regulates invadopodium formation Biol Open siRNA SR421142
PTPN14 miR-4516 predicts poor prognosis and functions as a novel oncogene via targeting PTPN14 in human glioblastoma Oncogene siRNA SR303895
PTX3 K284-6111 Alleviates Memory Impairment and Neuroinflammation in Tg2576 Mice by Inhibition of Chitinase-3-like 1 Regulating ERK Dependent PTX3 Pathway Research Square siRNA SR412848
PTX3 Constitutive Expression of PTX3 by Human Amniotic Membrane Cells Leads to Formation of the HC-HA/PTX3 Complex J. Biol. Chem. siRNA SR303915
PTX3 PTX3 Controls Activation of Matrix Metalloproteinase 1 and Apoptosis in Conjunctivochalasis Fibroblasts Invest. Ophthalmol. Vis. Sci., Jun 2012; 53: 3414 - 3423. siRNA SR303915
PUM1 PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood siRNA SR306467
PUM2 PUMILIO/FOXP1 signaling drives expansion of hematopoietic stem/progenitor and leukemia cells Blood siRNA SR308223
PURB MaTAR25 LncRNA Regulates the Tensin1 Gene to Impact Breast Cancer Progression bioRxiv siRNA SR410793
PXN Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells ONCOLOGY REPORTS siRNA SR303929
PYM1 CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. siRNA SR313474
RAB27B Hypomethylated Rab27b is a progression-associated prognostic biomarker of glioma regulating MMP-9 to promote invasion Oncol. Rep. siRNA SR303953
RAB31 LRG‐1 promotes fat graft survival through the RAB31‐mediated inhibition of hypoxia‐induced apoptosis Journal of Cellular and Molecular Medicine siRNA SR307545
RAB3A Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP J. Neurosci. siRNA SR402766
RAC1 Knockdown of RhoGDI2 represses human gastric cancer cell proliferation, invasion and drug resistance via the Rac1/Pak1/LIMK1 pathway Cancer Lett. siRNA SR321562
RAC1 Modulation of the Pol II CTD Phosphorylation Code by Rac1 and Cdc42 Small GTPases in Cultured Human Cancer Cells and Its Implication for Developing a Synthetic-Lethal Cancer Therapy Cells siRNA SR321562
RAC1 MicroRNA-141 suppresses prostate cancer stem cells and metastasis by targeting a cohort of pro-metastasis genes Nat Commun siRNA SR303958
RACK1 Trafficking, localization and degradation of the Na+,HCO3- co-transporter NBCn1 in kidney and breast epithelial cells Sci Rep siRNA SR307048
RAD18 Impacts of Arsenic on Rad18 and Translesion Synthesis Toxicology and applied pharmacology siRNA SR311213
RAD51 New RAD51 Inhibitors to Target Homologous Recombination in Human Cells Genes siRNA SR321568
RAD51B Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis bioRxiv siRNA SR303968
RAD51C Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis bioRxiv siRNA SR303967
RAD51D Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis bioRxiv siRNA SR303970
RAF1 The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux Autophagy siRNA SR303972
RALA Ral A, via activating the mitotic checkpoint, sensitizes cells lacking a functional Nf1 to apoptosis in the absence of protein kinase C Oncotarget siRNA SR303975
RAMAC RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs Nucleic Acids Research siRNA SR313193
RARA Regulation of myelination by exosome associated retinoic acid release from NG2-positive cells J. Neurosci. siRNA SR414999
RARB RARβ acts as both an upstream regulator and downstream effector of miR-22, which epigenetically regulates NUR77 to induce apoptosis of colon cancer cells FASEB J. siRNA SR414645
RARRES1 Retinoic acid receptor responder1 promotes development of glomerular diseases via the Nuclear Factor-κB signaling pathway Kidney international siRNA SR303993
RB1CC1 ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis Journal of experimental & clinical cancer research : CR siRNA SR306576
RBFOX2 Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors Cellular and Molecular Life Sciences siRNA SR308351
Rbpj A genetic cell context-dependent role for ZEB1 in lung cancer Nat Commun siRNA SR415718
RBPMS Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors Cellular and Molecular Life Sciences siRNA SR307544
Re-suspension Buffer Clinicopathological features and prognostic value of SOX11 in childhood acute lymphoblastic leukemia Sci Rep siRNA SR30005
Re-suspension Buffer Knockdown RIP-1 inhibits production of oxLDL-induced inflammatory cytokines and promotes ABCA1 expression in macrophages Int J Clin Exp Med siRNA SR30005
Re-suspension Buffer Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox Sci Rep siRNA SR30005
REG3B REG3A/REG3B promotes acinar to ductal metaplasia through binding to EXTL3 and activating the RAS-RAF-MEK-ERK signaling pathway Communications biology siRNA SR404149
REL RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model Prostate siRNA SR304027
REL NPD1-mediated stereoselective regulation of BIRC3 expression through cREL is decisive for neural cell survival Cell Death Differ. siRNA SR304027
Rela ROS-induced PADI2 downregulation accelerates cellular senescence via the stimulation of SASP production and NFκB activation Cellular and Molecular Life Sciences siRNA SR427138
RELA Cytomegalovirus infection of glioblastoma cells leads to NF-κB dependent upregulation of the c-MET oncogenic tyrosine kinase Cancer letters siRNA SR321602
RELA c‑Jun and FOXO1 mediate the expression of oncogenic PKC‑ι in human prostate cancer cells with an interplay between NF‑κB, IL‑8 and ICAM‑1 World Acad Sci J siRNA SR321602
RELA The Harsh Microenvironment in Early Breast Cancer Selects for a Warburg Phenotype bioRxiv siRNA SR321602
RELA RELA is Sufficient to Mediate Interleukin-1 (IL-1) Repression of Androgen Receptor Expression and Activity in LNCaP Disease Progression Model bioRxiv siRNA SR321602
RELA Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness Oncogenesis siRNA SR321602
RELA Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR304030
RELA FOXO1 regulates oncogenic PKC-ι expression in melanoma inversely to c-Jun in an autocrine manner via IL-17E and ICAM-1 activation wasj siRNA SR321602
RELA ELF4 is critical for induction of type I interferon and the host antiviral response Nat. Immunol. 1237-46 siRNA SR304030
RELB RELA is sufficient to mediate interleukin-1 repression of androgen receptor expression and activity in an LNCaP disease progression model Prostate siRNA SR304031
REST Perturbations of Neuron-Restrictive Silencing Factor Modulate Corticotropin-Releasing Hormone Gene Expression in the Human Cell Line BeWo Mol Neuropsychiatry siRNA SR321606
REST Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease J. Cell. Mol. Med. siRNA SR427708
REST Epigenetic gene regulation by TET3 and 5-hydroxymethylcytosine during retinal maturation Thesis siRNA SR304036
REST TET3 Is Recruited by REST for Context-Specific Hydroxymethylation and Induction of Gene Expression Cell Rep siRNA SR304036
Rgcc Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease Cell Transplant siRNA SR402545
RHEB Role of RHEB in Regulating Differentiation Fate of Mesenchymal Stem Cells for Cartilage and Bone Regeneration Int J Mol Sci siRNA SR304066
RHEB RHEB: a potential regulator of chondrocyte phenotype for cartilage tissue regeneration J Tissue Eng Regen Med siRNA SR304066
RHOBTB1 The tumor suppressor gene RhoBTB1 is a novel target of miR-31 in human colon cancer. International journal of oncology siRNA SR306632
RICTOR mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer Oncogene siRNA SR316744
RICTOR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR316744
RIPK1 RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis NPJ breast cancer siRNA SR418761
RIPK1 Knockdown RIP-1 inhibits production of oxLDL-induced inflammatory cytokines and promotes ABCA1 expression in macrophages Int J Clin Exp Med siRNA SR418761
RIPK2 Receptor Interacting Protein-2 acts as negative regulator for nontypeable Haemophilus influenzae-induced mucin MUC5AC expression ntegrative Molecular Medicine siRNA SR305775
RIPK3 RIP3 facilitates necroptosis through CaMKII and AIF after intracerebral hemorrhage in mice Neuroscience Letters siRNA SR323326
RIPK3 Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape Sci Rep siRNA SR307548
RMDN3 Altered Protein Interactions of the Endogenous Interactome of PTPIP51 towards MAPK Signaling Biomolecules siRNA SR310551
RNASEL Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR304081
RNMT RNA guanine-7 methyltransferase catalyzes the methylation of cytoplasmically recapped RNAs Nucleic Acids Research siRNA SR305750
ROBO1 Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo Biomaterials siRNA SR321632
ROCK1 3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway J. Exp. Clin. Cancer Res. siRNA SR304092
ROCK1 Targeting the Metastasis Suppressor, NDRG1, Using Novel Iron Chelators: Regulation of Stress Fiber-Mediated Tumor Cell Migration via Modulation of the ROCK1/pMLC2 Signaling Pathway Mol. Pharmacol., Feb 2013; 83: 454 - 469. siRNA SR422726
ROCK2 Inhibition of Rho-Associated Kinase Suppresses Medulloblastoma Growth Cancers (Basel) 2019 siRNA SR306287
ROCK2 Rho-associated kinase is a therapeutic target in neuroblastoma Proc. Natl. Acad. Sci. U.S.A. siRNA SR306287
RORA Molecular Mechanisms of Control of Differentiation of Regulatory T-Lymphocytes by Exogenous Melatonin Dokl. Biochem. Biophys. siRNA SR304094
RPS19 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR304179
RPS6 Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS -mutant lung cancer Journal of Experimental & Clinical Cancer Research : CR siRNA SR304160
RPS6KA1 A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity Science (New York, N.Y.) siRNA SR304161
RPS6KB1 Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection Mol. Cell siRNA SR304164
RPS6KB1 Multisite Phosphorylation of S6K1 Directs a Kinase Phospho-code that Determines Substrate Selection Mol. Cell siRNA SR416706
RPS6KB1 TAK1 inhibition by natural cyclopeptide RA-V promotes apoptosis and inhibits protective autophagy in Kras-dependent non-small-cell lung carcinoma cells RSC Adv. siRNA SR304164
RPS6KB1 Nox4 is a Target for Tuberin Deficiency Syndrome Sci Rep siRNA SR304164
RPTOR mTOR mediates a mechanism of resistance to chemotherapy and defines a rational combination strategy to treat KRAS-mutant lung cancer Oncogene siRNA SR324724
RPTOR Follicular Stimulating Hormone Accelerates Atherogenesis by Increasing Endothelial VCAM-1 Expression Theranostics siRNA SR311531
RSPO1 The role of R-spondin 1 through activating Wnt/β-catenin in the growth, survival and migration of ovarian cancer cells Gene siRNA SR317182
RSPO1 Sirtuin-6 Preserves R-spondin-1 Expression and Increases Resistance of Intestinal Epithelium to Injury in Mice Mol Med. siRNA SR407587
RUNX2 Synergistic effect of JQ1 and rapamycin for treatment of human osteosarcoma Int. J. Cancer siRNA SR300606
RUNX3 MicroRNA‑629 inhibition suppresses the viability and invasion of non‑small cell lung cancer cells by directly targeting RUNX3 Mol Med Rep siRNA SR108475
RXFP1 Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1 Theranostics siRNA SR419891
RYR2 Molecular characterization of the calcium release channel deficiency syndrome JCI Insight siRNA SR304208
S100A4 miR-187-3p inhibits the metastasis and epithelial-mesenchymal transition of hepatocellular carcinoma by targeting S100A4 Cancer Lett. siRNA SR304214
S100A8 Peripheral immune tolerance by prolactin-induced protein originated from human invariant natural killer T cells Bioengineered siRNA SR304218
S100A8 Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance J. Leukoc. Biol. siRNA SR304218
S100A8 Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell siRNA SR304218
S100A9 Target-Selective Protein S-Nitrosylation by Sequence Motif Recognition Cell siRNA SR304219
S1PR2 Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells Allergy July 2014 siRNA SR306152
S1pr3 Smad3 Deficiency Leads to Mandibular Condyle Degradation via the Sphingosine 1-Phosphate (S1P)/S1P3 Signaling Axis Am. J. Pathol. siRNA SR412767
SC319768 TLR2 signaling directs NO-dependent MMP-9 induction in mouse microglia Neurosci. Lett. April 2014 siRNA SR304856
SCARB1 High-density lipoprotein and apolipoprotein A-I inhibit palmitate-induced translocation of toll-like receptor 4 into lipid rafts and inflammatory cytokines in 3T3-L1 adipocytes Biochem. Biophys. Res. Commun siRNA SR416342
SCD IDH1 mutations induce organelle defects via dysregulated phospholipids Nature communications siRNA SR304248
SCD Down-regulation of stearoyl-CoA desaturase-1 increases susceptibility to palmitic-acid-induced lipotoxicity in human trophoblast cells The Journal of nutritional biochemistry siRNA SR304248
SCD 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer siRNA SR304248
SCD1 Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins Cell Rep. 2013 Sep 26;4(6):1072-81 siRNA SR411990
SCLY Diet-induced obesity in the selenocysteine lyase knockout mouse Antioxid. Redox Signal. siRNA SR414271
SCN3B Biphasic voltage-dependent inactivation of human NaV1.3, 1.6 and 1.7 Na+channels expressed in rodent insulin-secreting cells J. Physiol. (Lond.) 2018 siRNA SR505961
SCO2 SCO2 Induces p53-Mediated Apoptosis by Thr845 Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex Mol. Cell. Biol., Apr 2013; 33: 1285 - 1302. siRNA SR306726
Scrambled Control Sodium bicarbonate transporter NBCe1 regulates proliferation and viability of human prostate cancer cells LNCaP and PC3 Oncology reports siRNA SR30004
Scrambled Control PARP1 Is Targeted by miR-519a-3p and Promotes the Migration, Invasion, and Tube Formation of Ovarian Cancer Cells Cancer biotherapy & radiopharmaceuticals siRNA SR30004
Scrambled Control N-cadherin mediates the migration of bone marrow-derived mesenchymal stem cells toward breast tumor cells Theranostics siRNA SR30004
Scrambled Control Dihydrolipoic acid enhances autophagy and alleviates neurological deficits after subarachnoid hemorrhage in rats Experimental neurology siRNA SR30004
Scrambled Control RIPK1 is a negative mediator in Aquaporin 1-driven triple-negative breast carcinoma progression and metastasis NPJ breast cancer siRNA SR30004
Scrambled Control Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson\'s disease models Aging siRNA SR30004
Scrambled Control Human colorectal cancer-associated carbohydrate antigen on annexin A2 protein Journal of molecular medicine (Berlin, Germany) 2021 siRNA SR30004
Scrambled Control Pharmacological Inhibition of Brain EGFR Activation By a BBB-penetrating Inhibitor, AZD3759, Attenuates α-synuclein Pathology in a Mouse Model of α-Synuclein Propagation Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics siRNA SR30004
Scrambled Control Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril Scientific reports siRNA SR30004
Scrambled Control MiR-205 Promotes the Viability, Migration, and Tube Formation of Cervical Cancer Cells In Vitro by Targeting GATA3 Cancer biotherapy & radiopharmaceuticals siRNA SR30004
Scrambled Control The MicroRNA miR-696 is Regulated by SNARK and Reduces Mitochondrial Activity in Mouse Skeletal Muscle Through Pgc1α Inhibition Molecular Metabolism siRNA SR30004
Scrambled Control E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability Cell death & disease siRNA SR30004
Scrambled Control Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Nature communications siRNA SR30004
Scrambled Control WHSC1/NSD2 regulates immune infiltration in prostate cancer Journal for immunotherapy of cancer siRNA SR30004
Scrambled Control Angiotensin II-Induced Histone Deacetylase 5 Phosphorylation, Nuclear Export and Egr-1 Expression is mediated by Akt Pathway in A10 Vascular Smooth Muscle Cells American journal of physiology. Heart and circulatory physiology siRNA SR30004
Scrambled Control Efficient Ocular Delivery of VCP siRNA via Reverse Magnetofection in RHO P23H Rodent Retina Explants Pharmaceutics siRNA SR30004
Scrambled Control ErbB3 is a critical regulator of cytoskeletal dynamics in brain microvascular endothelial cells: Implications for vascular remodeling and blood-brain-barrier modulation Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism siRNA SR30004
Scrambled Control The calcium-activated chloride channel-associated protein rCLCA2 is expressed throughout rat epidermis, facilitates apoptosis and is downmodulated by UVB Histochemistry and cell biology siRNA SR30004
Scrambled Control The translocon-associated protein (TRAP) complex regulates quality control of N-linked glycosylation during ER stress Science Advances siRNA SR30004
Scrambled Control Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo Cancers siRNA SR30004
Scrambled Control Autophagy alleviates hypoxia-induced blood-brain barrier injury via regulation of CLDN5 (claudin 5) Autophagy siRNA SR30004
Scrambled Control A miR-494 dependent feedback loop regulates ER stress bioRxiv siRNA SR30004
Scrambled Control Chronic morphine-mediated upregulation of high mobility group box 1 in the spinal cord contributes to analgesic tolerance and hyperalgesia in rats Neurotherapeutics siRNA SR30004
Scrambled Control CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies Cell Rep siRNA SR30004
Scrambled Control STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle Cells siRNA SR30004
Scrambled Control Role for polo-like kinase 4 in mediation of cytokinesis Proc. Natl. Acad. Sci. U.S.A. siRNA SR30004
Scrambled Control Nuclear localization of LDL receptor-related protein 1B in mammary gland carcinogenesis J. Mol. Med. siRNA SR30004
Scrambled Control MicroRNA-101 inhibits cell migration and invasion in bladder cancer via targeting FZD4 Exp Ther Med siRNA SR30004
Scrambled Control Autophagy activation contributes to glutathione transferase Mu 1‑mediated chemoresistance in hepatocellular carcinoma Oncol Lett siRNA SR30004
Scrambled Control Hyaluronan metabolism enhanced during epidermal differentiation is suppressed by vitamin C Br. J. Dermatol. siRNA SR30004
Scrambles Control Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer Cancers (Basel) 2020 siRNA SR30004
SDC2 N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization Nat Commun siRNA SR321721
SDC4 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development siRNA SR304301
SDCBP Syntenin promotes VEGF-induced VEGFR2 endocytosis and angiogenesis by increasing ephrin-B2 function in endothelial cells Oncotarget siRNA SR321723
SDHA Alternative assembly of respiratory complex II connects energy stress to metabolic checkpoints Nat Commun siRNA SR304305
SDHC Horizontal transfer of whole mitochondria restores tumorigenic potential in mitochondrial DNA-deficient cancer cells Elife siRNA SR403916
SEMA3F Neuropilin-2 interacts with VEGFR-2 and VEGFR-3 and promotes human endothelial cell survival and migration. Blood siRNA SR304318
SERPINB2 Identification of BAG3 target proteins in anaplastic thyroid cancer cells by proteomic analysis Oncotarget siRNA SR303346
SERPINE2 Regulation of tumor growth by circulating full-length chromogranin A Oncotarget siRNA SR303504
SESN1 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep siRNA SR309047
SESN2 Sestrin2 facilitates glutamine dependent transcription of PGC-1α and survival of liver cancer cells under glucose limitation FEBS J. siRNA SR313205
SESN2 SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation Sci Rep siRNA SR313205
SETD1A Global Reduction of H3K4me3 Improves Chemotherapeutic Efficacy for Pediatric Ependymomas Neoplasia siRNA SR306505
SETD2 Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing bioRxiv siRNA SR423523
SFN CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. siRNA SR301875
SFRP2 Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis Human Reproduction siRNA SR304328
SFTPA1 Annexin A2 Mediates Mycoplasma pneumoniae Community-Acquired Respiratory Distress Syndrome Toxin Binding to Eukaryotic Cells mBio siRNA SR318909
SGPL1 SGPL1321 mutation: one main trigger for invasiveness of pediatric alveolar rhabdomyosarcoma Cancer Gene Ther. siRNA SR305866
SGPL1 Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection J. Immunol. siRNA SR305866
SH2B3 Selective Interference Targeting of Lnk in Umbilical Cord-Derived Late Endothelial Progenitor Cells Improves Vascular Repair, Following Hind Limb Ischemic Injury, via Regulation of JAK2/STAT3 Signaling. Stem cells (Dayton, Ohio) siRNA SR306745
SH3GL1 miR-218 is downregulated and directly targets SH3GL1 in childhood medulloblastoma. Molecular medicine reports siRNA SR304356
SH3PXD2A The genomic landscape of schwannoma Nat. Genet. siRNA SR306419
SHANK3 SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons Neuron siRNA SR313832
SHH Widespread expression of Sonic hedgehog (Shh) and Nrf2 in patients treated with cisplatin predicts outcome in resected tumors and are potential therapeutic targets for HPV-negative head and neck cancer Ther Adv Med Oncol siRNA SR304363
SI Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors Cell Adhesion & Migration siRNA SR321762
SI Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis International Journal of Oncology siRNA SR321762
Siah1 Disruption of the nuclear p53-GAPDH complex protects against ischemia-induced neuronal damage Mol Brain siRNA SR304369
SIAH2 Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells Int. J. Biochem. Cell Biol. siRNA SR304370
Sigmar1 The Sigma-1 Receptor Mediates Pridopidine Rescue of Mitochondrial Function in Huntington Disease Models Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics siRNA SR426072
SIK1 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. siRNA SR315713
SIK2 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. siRNA SR308116
SIK3 The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling Sci Transl Med siRNA SR323570
SIK3 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. siRNA SR308237
siRNA MicroRNA-708 Induces Apoptosis and Suppresses Tumorigenicity in Renal Cancer Cells Cancer Res., Oct 2011; 71: 6208 - 6219. siRNA
siRNA Long-chain acyl-CoA synthetase 4 modulates prostaglandin E2 release from human arterial smooth muscle cells J. Lipid Res., Apr 2011; 52: 782 - 793 siRNA
siRNA Scrambled Control Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR30004
SIRT1 Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment Aging siRNA SR427400
SIRT1 Down-regulating miR-217-5p Protects Cardiomyocytes against Ischemia/Reperfusion Injury by Restoring Mitochondrial Function via Targeting SIRT1 Inflammation siRNA SR323581
SIRT1 Fruit of Hovenia dulcis Thunb. induces non-shivering thermogenesis through mitochondrial biogenesis and activation by SIRT1 in high fat diet-fed obese mice and primary cultured brown adipocytes J. Agric. Food Chem. siRNA SR427400
SIRT1 Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD(+)/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats Stroke siRNA SR419269
SIRT1 TRPV1 activation counters diet-induced obesity through sirtuin-1 activation and PRDM-16 deacetylation in brown adipose tissue Int J Obes (Lond) 2017 siRNA SR308256
Sirt1 Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice Neurobiology of Aging siRNA SR419269
SIRT1 Sirtuin 1 promotes the growth and cisplatin resistance of endometrial carcinoma cells: a novel therapeutic target Lab. Invest. siRNA SR308256
SIRT1 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell siRNA SR308256
SIRT2 A Succinate Ether Derivative of Tocotrienol Enhances Dickkopf-1 Gene Expression through Epigenetic Alterations in Malignant Mesothelioma Cells. Pharmacology siRNA SR323460
SIRT4 MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4 Aging (Albany NY) siRNA SR308254
SIRT6 Sirtuin-6 Preserves R-spondin-1 Expression and Increases Resistance of Intestinal Epithelium to Injury in Mice Mol Med. siRNA SR411215
SIRT6 The RUNX2 Transcription Factor Negatively Regulates SIRT6 Expression to Alter Glucose Metabolism in Breast Cancer Cells J. Cell. Biochem. siRNA SR309840
SIVA1 Plumbagin inhibits proliferation and induces apoptosis of hepatocellular carcinoma by downregulating the expression of SIVA Drug Des Devel Ther siRNA SR307193
SKP2 Down-regulation of Skp2 expression inhibits invasion and lung metastasis in osteosarcoma Sci Rep siRNA SR304388
SLC12A2 Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo Biomaterials siRNA SR304439
SLC12A7 Insulin-Like Growth Factor and SLC12A7 Dysregulation: A Novel Signaling Hallmark of Non-Functional Adrenocortical Carcinomas J. Am. Coll. Surg. siRNA SR307307
SLC12A7 SLC12A7 alters adrenocortical carcinoma cell adhesion properties to promote an aggressive invasive behavior Cell Commun. Signal siRNA SR307307
SLC1A5 Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer Front Oncol siRNA SR321780
SLC25A25 Transcriptome-wide analysis of PGC-1α-binding RNAs identifies genes linked to glucagon metabolic action Proc. Natl. Acad. Sci. U.S.A. siRNA SR412336
Slc2a1 Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism Frontiers in Physiology siRNA SR503164
Slc2a3 Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism Frontiers in Physiology siRNA SR502308
Slc2a4 Glucose transporters GLUT1, GLUT3, and GLUT4 have different effects on osteoblast proliferation and metabolism Frontiers in Physiology siRNA SR515187
SLC30A8 Down-regulation of the islet-specific zinc transporter-8 (ZnT8) protects human insulinoma cells against inflammatory stress J. Biol. Chem. siRNA SR325944
SLC31A1 Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells Sci Rep siRNA SR300931
SLC31A1 Dextran-Catechin: An anticancer chemically-modified natural compound targeting copper that attenuates neuroblastoma growth Oncotarget siRNA SR300931
SLC35B4 SLC35B4, an Inhibitor of Gluconeogenesis, Responds to Glucose Stimulation and Downregulates Hsp60 among Other Proteins in HepG2 Liver Cell Lines Molecules siRNA SR313733
SLC39A14 Localization of ZIP14 and ZIP8 in HIBCPP Cells Brain Sciences siRNA SR308328
SLC39A14 Astrocytic expression of ZIP14 (SLC39A14) is part of the inflammatory reaction in chronic neurodegeneration with iron overload Glia siRNA SR506875
SLC39A14 Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14 Nutrients siRNA SR308328
SLC39A8 Localization of ZIP14 and ZIP8 in HIBCPP Cells Brain Sci siRNA SR311962
SLC39A8 Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14 Nutrients siRNA SR311962
SLC43A3 Transport Characteristics of 6-Mercaptopurine in Brain Microvascular Endothelial Cells Derived from Human Induced Pluripotent Stem Cells Journal of pharmaceutical sciences siRNA SR309168
SLC4A11 Energy Crisis in Human and Mouse Models of SLC4A11-associated Corneal Endothelial Dystrophies bioRxiv siRNA SR313298
SLC7A11 Cystine/Glutamate Antiporter (xCT) Is Required for Chief Cell Plasticity After Gastric Injury Cell Mol Gastroenterol Hepatol siRNA SR416143
SLC7A2 Degradation of AMPK-α1 sensitizes BRAF inhibitor-resistant melanoma cells to arginine deprivation Mol Oncol siRNA SR304426
SLC7A5 SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1) BioRxiv siRNA SR305376
SLC8A1 Sodium-calcium exchanger 1 is the key molecule for urinary potassium excretion against acute hyperkalemia PLoS ONE siRNA SR304429
SLC8B1 Na+ controls hypoxic signalling by the mitochondrial respiratory chain Nature siRNA SR504963
SLC8B1 Sequential forward and reverse transport of the Na+ Ca2+ exchanger generates Ca2+ oscillations within mitochondria Nat Commun siRNA SR312772
SLCO2B1 Association of SLCO2B1 Genotypes With Time to Progression and Overall Survival in Patients Receiving Androgen-Deprivation Therapy for Prostate Cancer J. Clin. Oncol. siRNA SR307748
SLIT3 Tissue-specific angiogenic and invasive properties of human neonatal thymus and bone MSCs: Role of SLIT3-ROBO1 Stem Cells Transl Med siRNA SR304465
SMAD3 Evaluation of the antifibrotic potency by knocking down SPARC, CCR2 and SMAD3 bioRxiv siRNA SR414095
SMAD3 Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus Proc. Natl. Acad. Sci. U.S.A siRNA SR320898
SMAD4 Hypoxia-inducible factor-1α activates transforming growth factor-β1/Smad signaling and increases collagen deposition in dermal fibroblasts Oncotarget siRNA SR320899
SMAD7 YAP/TAZ regulates TGF-β/Smad3 signaling by induction of Smad7 via AP-1 in human skin dermal fibroblasts Cell Commun. Signal siRNA SR302771
Smarca1 Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation Nat Commun siRNA SR421862
SMN1 Spinal astrocyte dysfunction drives motor neuron loss in late-onset spinal muscular atrophy Acta Neuropathologica siRNA SR304480
SMN1 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. siRNA SR304480
Smpd3 Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue Cell metabolism siRNA SR427338
SMURF1 SMURF1 and SMURF2 in Progenitor Cells from Articular Cartilage and Meniscus during Late-Stage Osteoarthritis Cartilage siRNA SR311389
SMURF2 The E3 Ubiquitin Ligase SMAD Ubiquitination Regulatory Factor 2 Negatively Regulates Krüppel-like Factor 5 Protein J. Biol. Chem., Nov 2011; 286: 40354 - 40364. siRNA SR312096
SMURF2 TRB3 interacts with SMAD3 promoting tumor cell migration and invasion J. Cell Sci., Oct 2011; 124: 3235 - 3246. siRNA SR312096
SNAI1 Atypical PKCs activate Vimentin to facilitate prostate cancer cell motility and invasion Cell adhesion & migration siRNA SR304489
SNAI1 Epithelial-to-mesenchymal transition contributes to the downregulation of progesterone receptor expression in endometriosis lesions The Journal of steroid biochemistry and molecular biology siRNA SR304489
SNAI2 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. siRNA SR304468
SNCB Age-related Beta-synuclein Alters the p53/Mdm2 Pathway and Induces the Apoptosis of Brain Microvascular Endothelial Cells In Vitro Cell Transplant siRNA SR514215
SNW1 RNA binding protein RALY promotes Protein Arginine Methyltransferase 1 alternatively spliced isoform v2 relative expression and metastatic potential in breast cancer cells Int. J. Biochem. Cell Biol. siRNA SR307894
Snx17 SNX17 protects the heart from doxorubicin-induced cardiotoxicity by modulating LMOD2 degradation. Pharmacological research siRNA SR515149
Socs1 Breast cancer cell–derived microRNA-155 suppresses tumor progression via enhancing immune cell recruitment and antitumor function The Journal of Clinical Investigation siRNA SR426031
SOCS2 Suppressor of cytokine signaling 2 is induced in Huntington\'s disease and involved in autophagy Biochemical and biophysical research communications siRNA SR405008
SOCS3 Suppressor of Cytokine Signaling 1 Is a Positive Regulator of TGF-ß-Induced Prostaglandin Production in Human Follicular Dendritic Cell-like Cells J. Immunol. siRNA SR305948
SOCS5 Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5 Sci Rep siRNA SR306430
SORT1 Sortilin inhibition limits secretion-induced progranulin-dependent breast cancer progression and cancer stem cell expansion Breast Cancer Res. siRNA SR304211
SOST Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness JCI Insight siRNA SR309452
SOX18 Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells Differentiation siRNA SR310056
SOX2 CHI3L1 results in poor outcome of ovarian cancer by promoting properties of stem-like cells Endocr. Relat. Cancer siRNA SR304528
SOX2 Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation Sci Rep siRNA SR304528
SOX2 CEACAM1 Promotes Melanoma Cell Growth through Sox-2 Neoplasia siRNA SR304528
SOX3 Overexpression of microRNA-194 suppresses the epithelial-mesenchymal transition in targeting stem cell transcription factor Sox3 in endometrial carcinoma stem cells. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine siRNA SR304529
SOX9 Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis Oncogene siRNA SR304532
SOX9 SOX9 indirectly regulates CEACAM1 expression and immune resistance in melanoma cells Oncotarget siRNA SR304532
SOX9 Sry-type HMG box 18 contributes to the differentiation of bone marrow-derived mesenchymal stem cells to endothelial cells Differentiation siRNA SR304532
SOX9 In vitro osteogenic potential of human bone marrow derived MSCs is predicted by Runx2/Sox9 Ratio Tissue Eng Part A July 2014 siRNA SR304532
SP1 Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus J Huntingtons Dis siRNA SR304537
SP1 MicroRNA-29b Regulates Ethanol-induced Neuronal Apoptosis in the Developing Cerebellum through Sp1/Rax/PKR J. Biol. Chem., Feb 2014. siRNA SR420087
SP1 A possible gene silencing mechanism: Hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells Biochem Biophys Res Commun. 2012 Nov 9;428(1):80-5 siRNA SR304537
SP6 Pannexin 3 regulates skin development via Epiprofin Scientific Reports siRNA SR312895
SPARC Glioblastoma-secreted soluble CD44 activates tau pathology in the brain Exp. Mol. Med. siRNA SR408816
SPARC Enhancing Docetaxel Delivery to Multidrug-Resistant Cancer Cells with Albumin-Coated Nanocrystals Mol. Pharm. siRNA SR321872
SPIC Spi-C positively regulates RANKL-mediated osteoclast differentiation and function Exp. Mol. Med. siRNA SR406758
Spns2 Sphingosine-1-phosphate lyase downregulation promotes colon carcinogenesis through STAT3-activated microRNAs J. Clin. Invest. siRNA SR417168
SPP1 Secreted phosphoprotein-1 accelerates the progression of human colorectal cancer through activating β-catenin signaling Oncology letters siRNA SR304557
Spry1 Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer Mol. Carcinog. siRNA SR405932
SPRY1 Atypical role of sprouty in p21 dependent inhibition of cell proliferation in colorectal cancer Mol. Carcinog. siRNA SR306938
SPRY2 microRNA-23a promotes cell growth and metastasis in gastric cancer via targeting SPRY2-mediated ERK signaling Oncol Lett siRNA SR306939
SPSB1 SPSB1, a Novel Negative Regulator of the TGF-ß Signaling Pathway Targeting the Type II Receptor J. Biol. Chem. siRNA SR312825
SPTBN1 IL-27 inhibits HIV-1 infection in human macrophages by down-regulating host factor SPTBN1 during monocyte to macrophage differentiation J. Exp. Med., Mar 2013; 210: 517 - 534. siRNA SR304571
SQSTM1 IL-1ß induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells J. Cell. Biochem. siRNA SR305865
SQSTM1 p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines Prostate. 2013 Sep 30. doi: 10.1002/pros.22737 siRNA SR305865
SR30004 Nuclear TRAF3 is a negative regulator of CREB in B cells Proc. Natl. Acad. Sci. U.S.A. siRNA SR30004
SR30004 SMN affects membrane remodelling and anchoring of the protein synthesis machinery J. Cell. Sci. siRNA SR30004
SR30004 SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype J. Leukoc. Biol. siRNA SR30004
SR30004 Phosphatidic acid (PA) increases EGF receptor (EGFR) expression by stabilizing mRNA, inhibiting RNAse-A, and by inhibiting lysosomal and proteasomal degradation of the internalized EGFR Mol. Cell. Biol. siRNA SR30004
SR30004 SPSB1, a Novel Negative Regulator of the TGF-ß Signaling Pathway Targeting the Type II Receptor J. Biol. Chem. siRNA SR30004
SR30004 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap PLoS Genet. siRNA SR30004
SR30004 Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. siRNA SR30004
SR30004 Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene J. Clin. Invest. siRNA SR30004
SR30004 S100B is required for high glucose-induced pro-fibrotic gene expression and hypertrophy in mesangial cells Int. J. Mol. Med. siRNA SR30004
SR30004 Effects of obesity on severity of colitis and cytokine expression in mouse mesenteric fat. Potential role of adiponectin receptor 1 Am. J. Physiol. Gastrointest. Liver Physiol. siRNA SR30004
SR30004 BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization J. Pathol. siRNA SR30004
SR30005 Post-transcriptional regulation of Rbm5 expression in undifferentiated H9c2 myoblasts In Vitro Cell. Dev. Biol. Anim. siRNA SR30005
SRC PTPRS drives adaptive resistance to MEK/ERK inhibitors through SRC Oncotarget siRNA SR321884
SRC SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC Autophagy siRNA SR321884
SRC GPER1 promotes estrogen receptor negative breast cancer cell migration and invasion via non-genomic activation of c-Src/NF-κB/focal adhesion kinase cascade Journal of Bio-X Research siRNA SR304574
SRC Calcium-Ask1-MKK7-JNK2-c-Src Signaling Cascade Mediates Disruption of Intestinal Epithelial Tight Junctions by Dextran Sulfate Sodium Biochem. J. siRNA SR304574
SRC The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression Cancer Res., Jul 2013; 73: 4521 - 4532. siRNA SR416929
SRC miR-23b Represses Proto-oncogene Src Kinase and Functions as Methylation-Silenced Tumor Suppressor with Diagnostic and Prognostic Significance in Prostate Cancer Cancer Res., Dec 2012; 72: 6435 - 6446. siRNA SR304574
Src MicroRNA-205 Inhibits Src-Mediated Oncogenic Pathways in Renal Cancer Cancer Res., Apr 2011; 71: 2611 - 2621 siRNA SR304574
SREBF1 17ß-estradiol induces stearoyl-CoA desaturase-1 expression in estrogen receptor-positive breast cancer cells BMC Cancer siRNA SR304579
SRRM2 The intellectual disability gene PQBP1 rescues Alzheimer's disease pathology Mol. Psychiatry siRNA SR308336
SRSF1 PPARγΔ5, a Naturally Occurring Dominant-Negative Splice Isoform, Impairs PPARγ Function and Adipocyte Differentiation Cell Rep siRNA SR304331
SSTR5 On The Mechanism Of Tumor Cell Entry Of Aloe-Emodin, A Natural Compound Endowed With Anticancer Activity International journal of cancer siRNA SR304609
ST8SIA2 Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res siRNA SR305373
ST8SIA4 Insulin promotes cell migration by regulating PSA-NCAM Exp. Cell Res siRNA SR305305
STAT1 Free light chains injure proximal tubule cells through STAT1-HMGB1-TLR axis JCI Insight siRNA SR304620
STAT1 IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection Sci Adv siRNA SR304620
STAT1 Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus J Huntingtons Dis siRNA SR304620
STAT2 IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection Sci Adv siRNA SR304621
STAT3 Mesenchymal stem cell-derived interleukin-28 drives the selection of apoptosis resistant bone metastatic prostate cancer Nature communications siRNA SR321907
STAT3 Dual specificity phosphatase (DUSP)-4 is induced by platelet-derived growth factor -BB in an Erk1/2-, STAT3- and p53-dependent manner Biochem. Biophys. Res. Commun. siRNA SR304622
STAT3 Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells J. Exp. Clin. Cancer Res. siRNA SR419981
STAT3 Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway Evid Based Complement Alternat Med siRNA SR321907
STAT3 Proliferating cell nuclear antigen promotes cell proliferation and tumorigenesis by up-regulating STAT3 in non-small cell lung cancer Biomed. Pharmacother. siRNA SR321907
STAT3 B-cell CLL/lymphoma 3 promotes glioma cell proliferation and inhibits apoptosis through the oncogenic STAT3 pathway Int. J. Oncol. siRNA SR419981
STAT3 p-21 activated kinase 4 (PAK4) maintains stem cell-like phenotypes in pancreatic cancer cells through activation of STAT3 signaling Cancer letters siRNA SR304622
STAT3 Modulation of STAT3 and STAT5 activity rectifies the imbalance of Th17 and Treg cells in patients with acute coronary syndrome Clin. Immunol. siRNA SR304622
STAT3 Concerted Suppression of STAT3 and GSK3ß Is Involved in Growth Inhibition of Non-Small Cell Lung Cancer by Xanthatin PLOS ONE e81945 siRNA SR304622
STAT5A Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells J. Exp. Clin. Cancer Res. siRNA SR420193
STAT5B Epithelial CD80 promotes immune surveillance of colonic preneoplastic lesions and its expression is increased by oxidative stress through STAT3 in colon cancer cells J. Exp. Clin. Cancer Res. siRNA SR420132
STEAP4 Discovery and Pharmacological Evaluation of STEAP4 as a Novel Target for HER2 Overexpressing Breast Cancer Frontiers in Oncology siRNA SR312522
STIM1 Role of calcium in adult onset polycystic kidney disease Cell. Signal. siRNA SR419122
STIM1 Ca(2+) Channel Re-localization to Plasma-Membrane Microdomains Strengthens Activation of Ca(2+)-Dependent Nuclear Gene Expression Cell Rep siRNA SR304633
STIM1 A relay mechanism between EB1 and APC facilitate STIM1 puncta assembly at endoplasmic reticulum-plasma membrane junctions. Cell calcium siRNA SR304633
Sting1 Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. Journal of advanced research siRNA SR507303
STK3 LATS1/2 kinases trigger self-renewal of cancer stem cells in aggressive oral cancer Oncotarget siRNA SR304635
STK3 Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis Cell Cycle siRNA SR304635
STK33 STK33 promotes growth and progression of pancreatic cancer as a critical downstream mediator of HIF-1α Cancer Res. siRNA SR312240
STK4 STK3/4 Expression Is Regulated in Uterine Endometrial Cells during the Estrous Cycle Cells siRNA SR415716
STRN 17ß-Estradiol inhibits vascular smooth muscle cell migration via up-regulation of striatin protein Gynecol. Endocrinol. siRNA SR304644
STRN4 17β-estradiol upregulates striatin protein levels via Akt pathway in human umbilical vein endothelial cells PLoS ONE siRNA SR309258
STX3 Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting bioRxiv siRNA SR321926
SULF2 Evaluating Tumor-Associated Activity of Extracellular Sulfatase by Analyzing Naturally-Occurring Substrate in Tumor Microenvironment of Hepatocellular Carcinoma Analytical Chemistry siRNA SR311046
SULT1A3 Cytosolic sulfotransferase 1A3 is induced by dopamine and protects neuronal cells from dopamine toxicity: role of D1 receptor-NMDA receptor coupling J Biol Chem. 2013 Oct 17 siRNA SR304654
SULT4A1 Interaction of the Brain-Selective Sulfotransferase SULT4A1 with Other Cytosolic Sulfotransferases: Effects on Protein Expression and Function. Drug metabolism and disposition: the biological fate of chemicals siRNA SR308535
SUMO1 Natural and Induced Mitochondrial Phosphate Carrier Loss: DIFFERENTIAL DEPENDENCE OF MITOCHONDRIAL METABOLISM AND DYNAMICS AND CELL SURVIVAL ON THE EXTENT OF DEPLETION J. Biol. Chem siRNA SR322139
SUSD2 Prospective isolation of mesenchymal stem cells from human bone marrow using novel antibodies directed against Sushi domain containing 2. Stem cells and development siRNA SR311132
SYNGAP1 Melatonin safeguards against fatty liver by antagonizing TRAFs-mediated ASK1 deubiquitination and stabilization in a β-arrestin-1 dependent manner. Journal of pineal research siRNA SR305827
SYNGAP1 Tumor Suppression of Ras GTPase-Activating Protein RASA5 through Antagonizing Ras Signaling Perturbation in Carcinomas iScience siRNA SR305827
SYT5 Components of genetic associations across 2,138 phenotypes in the UK Biobank highlight novel adipocyte biology bioRxiv siRNA SR412988
TAF1 A novel variant in TAF1 affects gene expression and is associated with X-linked TAF1 intellectual disability syndrome Neuronal Signal. siRNA SR304693
TAFAZZIN Poly(rC)-binding Protein 2 regulates Hippo signaling to control growth in breast epithelial cells Mol. Cell. Biol. siRNA SR304719
TAS2R38 Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways. Biochemical pharmacology siRNA SR321494
TAS2R38 Berberine induces GLP-1 secretion through activation of bitter taste receptor pathways Biochem. Pharmacol. siRNA SR303858
TBP Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR304726
TBX2 A Pathway for the Control of Anoikis Sensitivity by E-Cadherin and Epithelial-to-Mesenchymal Transition Mol. Cell. Biol., Oct 2011; 31: 4036 - 4051. siRNA SR304727
TBX4 Transcription factor TBX4 regulates myofibroblast accumulation and lung fibrosis The Journal of Clinical Investigation siRNA SR306302
TBXAS1 Glycyrrhizin suppresses lung adenocarcinoma cell growth through inhibition of thromboxane synthase Cell. Physiol. Biochem., Feb 2014. siRNA SR304732
TCF21 The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions biorxiv.org siRNA SR321985
TCF21 The environment-sensing aryl-hydrocarbon receptor inhibits the chondrogenic fate of modulated smooth muscle cells in atherosclerotic lesions bioRxiv siRNA SR321985
TCF21 TCF21 and AP-1 interact through epigenetic modifications to regulate coronary artery disease gene expression Genome Med siRNA SR321985
TCF21 TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells PLoS Genet. siRNA SR304753
TCF21 Coronary Artery Disease AssociatedTranscription Factor TCF21 Regulates SmoothMuscle Precursor Cells That Contribute to theFibrous Cap Genomics Data siRNA SR304753
TCF21 Coronary Artery Disease Associated Transcription Factor TCF21 Regulates Smooth Muscle Precursor Cells That Contribute to the Fibrous Cap PLoS Genet. siRNA SR304753
TCF3 Knockdown of Tcf3 enhances the wound healing effect of bone marrow mesenchymal stem cells in rats Biosci. Rep. siRNA SR500098
TCF7 TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. siRNA SR304744
TCF7 TCF1 links GIPR signaling to the control of beta cell function and survival Nat. Med. siRNA SR408887
Tcf7l2 Macrophage TCF-4 Coactivates p65 to Potentiate Chronic Inflammation and Insulin Resistance in Mice Clin. Sci. siRNA SR414923
TCIRG1 The Vacuolar H+ ATPase α3 Subunit Negatively Regulates Migration and Invasion of Human Pancreatic Ductal Adenocarcinoma Cells Cells siRNA SR306986
TCN1 Transcobalamin I: a novel prognostic biomarker of neoadjuvant chemotherapy in locally advanced hypopharyngeal squamous cell cancers Onco Targets Ther siRNA SR304756
TCOF1 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR304758
TCOL shRNA Functional analysis of mutant FAM20C in Raine syndrome with FGF23-related hypophosphatemia Bone July 2014 siRNA SR30004
TDG TDG Regulates Cell Cycle Progression In Human Neural Progenitors bioRxiv siRNA SR304768
TDGF1 CRIPTO and its signaling partner GRP78 drive the metastatic phenotype in human osteotropic prostate cancer Oncogene siRNA SR304769
Tead2 The Transcription Factor Protein Sox11 Enhances Early Osteoblast Differentiation by Facilitating Proliferation and the Survival of Mesenchymal and Osteoblast Progenitors J. Biol. Chem., Aug 2013; 288: 25400 - 25413. siRNA SR305547
TERF1 PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment Communications Biology siRNA SR322000
TERF1 The telomeric protein TERF2/TRF2 impairs HMGB1-driven autophagy Autophagy siRNA SR322000
TERT Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2 Proceedings of the National Academy of Sciences siRNA SR322002
TERT Telomerase reverse transcriptase mutations are independent predictor of disease-free survival in Middle Eastern papillary thyroid cancer Int. J. Cancer siRNA SR417770
Tet1 Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health Cell metabolism siRNA SR423353
Tet1 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423353
TET2 Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health Cell metabolism siRNA SR423294
Tet2 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423294
Tet3 Cytosine modifications modulate the chromatin architecture of transcriptional enhancers Genome Res.2017 siRNA SR423108
Tfam Redox regulation by pitx2 and pitx3 is critical for fetal myogenesis Dev. Cell siRNA SR406788
TFAP2A Transcription factor AP2A affects sFLT1 expression and decidualization in decidual stromal cells: Implications to preeclampsia pathology Pregnancy Hypertens siRNA SR304787
TFAP2A Defects in placental stromal cell decidualization in preeclampsia are mediated by transcription Factor AP2A American Journal of Obstetrics and Gynecology siRNA SR304787
TFAP4 Soluble Heparin Binding EGF-like Growth Factor (HB-EGF) is a regulator of GALGT2 expression and GALGT2-dependent muscle and neuromuscular phenotypes Mol. Cell. Biol. siRNA SR411368
TFDP1 Recurrent Amplification at 13q34 Targets at CUL4A, IRS2, and TFDP1 As an Independent Adverse Prognosticator in Intrahepatic Cholangiocarcinoma PLoS ONE siRNA SR304794
TFDP3 TFDP3 confers chemoresistance in minimal residual disease within childhood T-cell acute lymphoblastic leukemia Oncotarget siRNA SR309663
THAP11 Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression Cell siRNA SR311427
TICAM1 TLR4-Mediated Pathway Triggers Interferon-Independent G0 Arrest and Antiviral SAMHD1 Activity in Macrophages Cell Rep siRNA SR315629
TIGAR Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway J. Cell. Mol. Med. siRNA SR311348
TIMP2 TIMP-2 regulates proliferation, invasion and STAT3-mediated cancer stem cell-dependent chemoresistance in ovarian cancer cells BMC Cancer siRNA SR304838
TINCR miR‑589‑3p sponged by the lncRNA TINCR inhibits the proliferation, migration and invasion and promotes the apoptosis of breast cancer cells by suppressing the Akt pathway via IGF1R Int. J. Mol. Med. siRNA SR316884
Tissue Lysate Endothelial Nitric-oxide Synthase (eNOS) Is Activated through G-protein-coupled Receptor Kinase-interacting Protein 1 (GIT1) Tyrosine Phosphorylation and Src Protein J. Biol. Chem. siRNA SR30004
TJP1 Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family Molecular Neurobiology siRNA SR322042
TLE3 Differential Regulation of TLE3 in Sertoli Cells of the Testes during Postnatal Development Cells siRNA SR420092
TLR2 Complement Component C3 Promotes Cerebral Ischemia/Reperfusion Injury Mediated by TLR2/NFκB Activation in Diabetic Mice Neurochem. Res. siRNA SR322049
TLR4 Stearic Acid and TNF-α Co-Operatively Potentiate MIP-1α Production in Monocytic Cells via MyD88 Independent TLR4/TBK/IRF3 Signaling Pathway Biomedicines siRNA SR322051
TLR4 MIP-1α Expression Induced by Co-Stimulation of Human Monocytic Cells with Palmitate and TNF-α Involves the TLR4-IRF3 Pathway and Is Amplified by Oxidative Stress Cells siRNA SR322051
TLR4 The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways Int J Mol Sci siRNA SR322051
TLR4 TNF-α in Combination with Palmitate Enhances IL-8 Production via The MyD88- Independent TLR4 Signaling Pathway: Potential Relevance to Metabolic Inflammation Int J Mol Sci siRNA SR322051
TLR4 MIP-1α Induction by Palmitate in the Human Monocytic Cells Implicates TLR4 Signaling Mechanism Cell. Physiol. Biochem. siRNA SR322051
TLR4 Palmitate Activates CCL4 Expression in Human Monocytic Cells via TLR4/MyD88 Dependent Activation of NF-κB/MAPK/ PI3K Signaling Systems Cell. Physiol. Biochem. siRNA SR322051
TLR4 The Synergy between Palmitate and TNF-α for CCL2 Production Is Dependent on the TRIF/IRF3 Pathway: Implications for Metabolic Inflammation J. Immunol. siRNA SR322051
TLR4 Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia Brain Behav. Immun. siRNA SR420542
TLR4 Palmitate-Induced MMP-9 Expression in the Human Monocytic Cells is Mediated through the TLR4-MyD88 Dependent Mechanism Cell. Physiol. Biochem. siRNA SR304858
TLR9 Toll-Like Receptor 9 Signaling Regulates Tissue Factor and Tissue Factor Pathway Inhibitor Expression in Human Endothelial Cells and Coagulation in Mice Critical Care Medicine siRNA SR310036
TLR9 HIV and HCV Activate the Inflammasome in Monocytes and Macrophages via Endosomal Toll-Like Receptors without Induction of Type 1 Interferon PLoS Pathog. siRNA SR310036
TM4SF1 Transmembrane-4 L-six family member-1 (TM4SF1) promotes non-small cell lung cancer proliferation, invasion and chemo-resistance through regulating the DDR1/Akt/ERK-mTOR axis Respir. Res. siRNA SR320889
TMBIM6 An endoplasmic reticulum stress regulator, Tmbim6, modulates secretory stage of mice molar J. Cell. Physiol. siRNA SR406571
TMEM97 NO1, a New Sigma 2 Receptor/TMEM97 Fluorescent Ligand, Downregulates SOCE and Promotes Apoptosis in the Triple Negative Breast Cancer Cell Lines Cancers (Basel) 2020 siRNA SR309105
TMPO Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus Nat Commun siRNA SR304871
TNF Transmembrane TNF- α Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy Journal of the American Society of Nephrology : JASN siRNA SR322065
TNF Transmembrane TNF-a Facilitates HIV-1 Infection of Podocytes Cultured from Children with HIV-Associated Nephropathy J. Am. Soc. Nephrol siRNA SR304877
TNFAIP6 TSG-6 Controls Transcription and Activation of Matrix Metalloproteinase 1 in Conjunctivochalasis Investigative Ophthalmology & Visual Science siRNA SR304882
TNFRSF11B Androgen deprivation therapy sensitizes triple negative breast cancer cells to immune-mediated lysis through androgen receptor independent modulation of osteoprotegerin Oncotarget siRNA SR303289
TNFRSF1A A novel role for the apoptosis inhibitor ARC in suppressing TNFα-induced regulated necrosis Cell Death Differ., Jan 2014. siRNA SR304883
TNFRSF1A Constitutive expression of inter-α-inhibitor (IαI) family proteins and tumor necrosis factor-stimulated gene-6 (TSG-6) by human amniotic membrane epithelial and stromal cells supporting formation of the heavy chain-hyaluronan (HC-HA) complex The Journal of Biological Chemistry siRNA SR304883
TNFSF4 Recombinant OX40 attenuates neuronal apoptosis through OX40-OX40L/PI3K/AKT signaling pathway following subarachnoid hemorrhage in rats Exp. Neurol. siRNA SR500332
TOP1 MUS81 cleaves TOP1-derived lesions and other DNA–protein cross-links BMC Biology siRNA SR322073
TOP1 Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA J. Virol. siRNA SR304897
TOP2A TOP2A Promotes Cell Migration, Invasion and Epithelial–Mesenchymal Transition in Cervical Cancer via Activating the PI3K/AKT Signaling Cancer Management and Research siRNA SR322074
TOP2A Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA J. Virol. siRNA SR322074
Top2a Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia Oncotarget siRNA SR422969
TOP2B Cellular DNA topoisomerases are required for the synthesis of hepatitis B virus covalently closed circular DNA J. Virol. siRNA SR304899
TOX TOX expression and role in CTCL J Eur Acad Dermatol Venereol siRNA SR306524
TP53 Computational Analysis of Transcriptional Regulation Sites at the HTT Gene Locus J Huntingtons Dis siRNA SR322075
TP53 Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability PLoS ONE siRNA SR322075
TP53 RASSF10 is Epigenetically Inactivated and Suppresses Cell Proliferation and Induces Cell Apoptosis by Activating the p53 Signalling Pathway in Papillary Thyroid Carcinoma Cancer Cell. Physiol. Biochem siRNA SR322075
TP53 Multisite aggregation of p53 and implications for drug rescue Proc. Natl. Acad. Sci. U.S.A siRNA SR413083
TP53 Very Low Doses of Ionizing Radiation and Redox Associated Modifiers Affect Survivin-Associated Changes in Radiation Sensitivity Free Radic. Biol. Med. siRNA SR413083
TP63 Multisite aggregation of p53 and implications for drug rescue Proc. Natl. Acad. Sci. U.S.A siRNA SR305666
TP73 Modulation of p73 isoforms expression induces anti-proliferative and pro-apoptotic activity in mantle cell lymphoma independent of p53 status Leuk. Lymphoma siRNA SR304904
Tra2b Transformer 2 beta homolog (Drosophila) (TRA2B) regulates Protein Kinase C deltaI (PKCdI) splice variant expression during 3T3L1 pre-adipocyte cell cycle J. Biol. Chem. siRNA SR408282
Traf2 Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. Journal of advanced research siRNA SR505994
TRAF3 The adaptor protein TRAF3 inhibits interleukin-6 receptor signaling in B cells to limit plasma cell development Sci Signal siRNA SR304928
TRAF3 The adaptor TRAF3 restrains the lineage determination of thymic regulatory T cells by modulating signaling via the receptor for IL-2 Nat. Immunol. July 2014 siRNA SR304928
TRAF3IP3 TRAF3IP3 negatively regulates cytosolic RNA induced anti-viral signaling by promoting TBK1 K48 ubiquitination Nat Commun siRNA SR312910
TRAF6 HIV-1 and HIV-2 differentially regulate NF-κB activity during the late stages of the replication cycle through BST-2/tetherin antagonism bioRxiv siRNA SR322090
TRAF6 RIP2 Gates TRAF6 Interaction with Death Receptor p75NTR to Regulate Cerebellar Granule Neuron Survival Cell Rep siRNA TG515356
TRAIP The TRAF-interacting protein (TRAIP) is a regulator of the spindle assembly checkpoint J. Cell. Sci. siRNA SR306973
TRDMT1 RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia Nat Commun siRNA SR301245
TREM2 TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice J Neuroinflammation siRNA SR406200
TRIM21 The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ. International journal of molecular sciences siRNA SR321894
TRIM21 The E3 Ubiquitin Ligase TRIM21 Regulates Basal Levels of PDGFRβ. International journal of molecular sciences siRNA SR304594
TRIM21 Regulatory role of TRIM21 in the type-I interferon pathway in Japanese encephalitis virus-infected human microglial cells J Neuroinflammation, Feb 2014. siRNA SR304594
TRIM22 TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment J. Virol., Jan 2014. siRNA SR307012
TRIM28 Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy PNAS, Apr 2013; 110: 6841 - 6846. siRNA TG320633
TRIM29 TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma Disease Markers 2014 . April 2014 siRNA SR308430
TRIM3 Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development Scand. J. Gastroenterol. siRNA SR307227
TRIP10 Podosome formation promotes plasma membrane invagination and integrin-β3 endocytosis on a viscous RGD-membrane Commun Biol siRNA SR514456
TRIP4 ASC-1 Is a Cell Cycle Regulator Associated with Severe and Mild Forms of Myopathy Ann. Neurol. siRNA SR427213
TRPC1 Inhibition of RhoA/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1α-dependent functional TRPC channels Toxicol. Appl. Pharmacol. siRNA SR420328
TRPC6 Inhibition of RhoA/ROCK signaling pathway ameliorates hypoxic pulmonary hypertension via HIF-1α-dependent functional TRPC channels Toxicol. Appl. Pharmacol. siRNA SR421279
TRPC6 The TRPC6-AMPK pathway is involved in cytoskeleton reorganization and glucose uptake in podocytes bioRxiv siRNA SR506194
TRPC6 Insulin increases filtration barrier permeability via TRPC6-dependent activation of PKGIα signaling pathways Biochim. Biophys. Acta siRNA MR225311
TRPM7 TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration Nature Communications siRNA SR310261
TRPM7 TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration bioRxiv siRNA SR310261
TRPM7 Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7 J. Dent. Res. siRNA SR310261
TRPM8 Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation Biochem. Biophys. Res. Commun. siRNA SR511054
TRPV4 Translocation of TRPV4-PI3Kγ complexes to the plasma membrane drives myofibroblast transdifferentiation Sci Signal siRNA SR311803
TRPV4 The TRPV4-TAZ Mechanotransduction Signaling Axis in Matrix Stiffness- and TGFβ1-Induced Epithelial-Mesenchymal Transition Cel. Mol. Bioeng. siRNA SR311803
TRPV4 TRPV4 Blockade Preserves the Blood-Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage Front Mol Neurosci siRNA SR514696
TRPV4 TRPV4 Mechanosensitive Ion Channel Regulates Lipopolysaccharide-Stimulated Macrophage Phagocytosis J. Immunol. siRNA SR420901
TRPV4 TRPV4 mediates myofibroblast differentiation and pulmonary fibrosis in mice J. Clin. Invest. siRNA SR311803
TRPV6 The low PLC-δ1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity. Cell calcium siRNA SR310734
TRPV6 The low PLC-d1 expression in cystic fibrosis bronchial epithelial cells induces upregulation of TRPV6 channel activity Cell Calcium siRNA SR310734
TSC1 PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine siRNA SR304945
TSC2 PP2AC Level Determines Differential Programing of p38-TSC-mTOR Signaling and Therapeutic Response to p38-Targeted Therapy in Colorectal Cancer EBioMedicine siRNA SR304946
TSC22D3 L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells Cell Death Differ. siRNA SR301284
TT300001 IL-1ß induces p62/SQSTM1 and represses androgen receptor expression in prostate cancer cells J. Cell. Biochem. siRNA SR30004
TWIST1 ETS2 and Twist1 promote invasiveness of Helicobacter pylori-infected gastric cancer cells by inducing Siah2 Biochem. J. siRNA SR304977
TXN2 Txn2 haplodeficiency does not affect cochlear antioxidant defenses or accelerate the progression of cochlear cell loss or hearing loss across the lifespan Exp. Gerontol. siRNA SR403788
TXNIP Low expression of the PPARγ-regulated gene thioredoxin-interacting protein accompanies human melanoma progression and promotes experimental lung metastases Scientific reports siRNA SR307241
TXNIP Protein acyltransferase DHHC3 regulates breast tumor growth, oxidative stress and senescence Cancer Res. siRNA SR307241
TYMS DHFR/TYMS are positive regulators of glioma cell growth and modulate chemo-sensitivity to temozolomide Eur. J. Pharmacol. siRNA SR304984
UBE2M CALML5 is a ZNF750- and TINCR-induced protein that binds stratifin to regulate epidermal differentiation Genes Dev. siRNA SR305963
UCK1 Expression of nucleoside-metabolizing enzymes in myelodysplastic syndromes and modulation of response to azacitidine Leukemia Dec 2013. siRNA SR313172
UCK2 Resistance to Azacitidine Is Determined at Cellular Level By Lower Expression of Nucleoside Metabolizing Enzymes Blood siRNA SR322152
UCP2 The mitochondrial uncoupling protein-2 is a master regulator of both M1 and M2 microglial responses J. Neurochem. siRNA SR504079
UCP2 Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD(+)/SIRT1 Reduction Cell siRNA SR305019
UGT1A9 Dapagliflozin Inhibits Cell Adhesion to Collagen I and IV and Increases Ectodomain Proteolytic Cleavage of DDR1 by Increasing ADAM10 Activity Molecules siRNA SR310169
Ulk1 Metrnl ameliorates diabetic cardiomyopathy via inactivation of cGAS/STING signaling dependent on LKB1/AMPK/ULK1-mediated autophagy. Journal of advanced research siRNA SR514693
URI1 URI knockdown induces autophagic flux in gastric cancer cells Am J Cancer Res siRNA SR322507
URI1 URI prevents potassium dichromate-induced oxidative stress and cell death in gastric cancer cells Am J Transl Res siRNA SR305745
URI1 URI expression in cervical cancer cells is associated with higher invasion capacity and resistance to cisplatin Am J Cancer Res siRNA SR305745
USP1 A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer iScience siRNA SR305052
USP1 A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis bioRxiv siRNA SR305052
USP18 Acetaldehyde Disrupts Interferon Alpha Signaling in Hepatitis C Virus-Infected Liver Cells by Up-Regulating USP18 Alcohol. Clin. Exp. Res. siRNA SR307736
USP34 Inhibition of ubiquitin-specific protease 34 (USP34) induces epithelial-mesenchymal transition and promotes stemness in mammary epithelial cells Cell. Signal. siRNA SR400002
USP4 The deubiquitinating enzymes USP4 and USP17 target hyaluronan synthase 2 and differentially affect its function Oncogenesis siRNA SR305038
USP7 The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure The Journal of biological chemistry siRNA SR305301
USP8 Down-regulation of USP8 Inhibits Cholangiocarcinoma Cell Proliferation and Invasion Cancer Manag Res siRNA SR306014
USP8 Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer Nat Commun siRNA SR306014
USP9X BAG3-mediated Mcl-1 stabilization contributes to drug resistance via interaction with USP9X in ovarian cancer. International journal of oncology siRNA SR305407
UTP4 Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA Proc. Natl. Acad. Sci. U.S.A. siRNA SR313737
VANGL2 Syndecan-4 controls lymphatic vasculature remodeling during embryonic development Development siRNA SR311428
VASP The PKGIα/VASP pathway is involved in insulin- and high glucose-dependent regulation of albumin permeability in cultured rat podocytes J. Biochem. siRNA SR515513
VDAC1 A Non-genetic Mechanism Involving the Integrin β4/Paxillin Axis Contributes to Chemoresistance in Lung Cancer iScience siRNA SR305067
VDAC1 A Non-genetic Mechanism for Chemoresistance in Lung Cancer: The Role of Integrin β4/Paxillin Axis bioRxiv siRNA SR305067
VDR Inhibition of Antiestrogen-Promoted Pro-Survival Autophagy and Tamoxifen Resistance in Breast Cancer through Vitamin D Receptor Nutrients siRNA SR322180
VDR Vitamin D attenuates cerebral artery remodeling through VDR/AMPK/eNOS dimer phosphorylation pathway after subarachnoid hemorrhage in rats J. Cereb. Blood Flow Metab. siRNA SR508804
VDR Intranasal administration of vitamin D attenuates blood-brain barrier disruption through endogenous upregulation of osteopontin and activation of CD44/P-gp glycosylation signaling after subarachnoid hemorrhage in rats J. Cereb. Blood Flow Metab. siRNA SR508804
VEGFA MiR-205-5p suppresses angiogenesis in gastric cancer by downregulating the expression of VEGFA and FGF1 Experimental Cell Research siRNA SR322181
VIM Loss of SOX2 expression induces cell motility via vimentin up-regulation and is an unfavorable risk factor for survival of head and neck squamous cell carcinoma Molecular Oncology siRNA SR305078
VRK1 VRK1 and AURKB form a complex that cross inhibit their kinase activity and the phosphorylation of histone H3 in the progression of mitosis Cell. Mol. Life Sci. siRNA SR322192
VTCN1 B7-H4 overexpression is essential for early hepatocellular carcinoma progression and recurrence Oncotarget siRNA SR312516
VTCN1 B7-H4 expression by nonhematopoetic cells in the tumor microenvironment promotes anti-tumor immunity Cancer Immunol Res siRNA SR312516
Wdr1 A Serine/Threonine Kinase 16-Based Phospho-Proteomics Screen Identifies WD Repeat Protein-1 As A Regulator Of Constitutive Secretion Scientific Reports siRNA SR510518
WFS1 Pancreatic stone protein/regenerating protein is a potential biomarker for endoplasmic reticulum stress in beta cells Sci Rep siRNA SR504899
WIPI1 Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation Autophagy siRNA SR310458
WIPI2 Resveratrol-mediated autophagy requires WIPI-1-regulated LC3 lipidation in the absence of induced phagophore formation Autophagy siRNA SR308719
WNK1 WNK1 regulates skeletal muscle cell hypertrophy by modulating the nuclear localization and transcriptional activity of FOXO4 Sci Rep siRNA SR423399
WNT3A A switch from canonical to noncanonical Wnt signaling mediates early differentiation of human neural stem cells Stem Cells siRNA SR313904
WNT5A Decreased DNA methylation in the promoter region of the WNT5A and GDNF genes may promote the osteogenicity of mesenchymal stem cells from patients with ossified spinal ligaments J. Pharmacol. Sci. siRNA SR305106
WRN PARP1 allows proper telomere replication through TRF1 poly (ADP-ribosyl)ation and helicase recruitment Communications Biology siRNA SR322215
WRN NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome Nat Commun siRNA SR322215
WWOX Inhibition of miR-24 suppresses malignancy of human non-small cell lung cancer cells by targeting WWOX in vitro and in vivo Thorac Cancer siRNA SR309942
WWP1 MiR-21 suppresses endothelial progenitor cell proliferation by activating the TGFß signaling pathway via downregulation of WWP1 Int J Clin Exp Pathol siRNA SR307565
XBP1 MYC regulates the unfolded protein response and glucose and glutamine uptake in endocrine resistant breast cancer Mol. Cancer siRNA SR305120
XIST Overexpression of long non-coding RNA XIST promotes IL-1β-induced degeneration of nucleus pulposus cells through targeting miR-499a-5p Molecular and cellular probes siRNA SR305123
XRCC2 Fallopian tube precursor lesions of serous ovarian carcinoma require L1CAM for dissemination and metastasis bioRxiv siRNA SR322227
YAP1 Salvianolic acid B ameliorates atherosclerosis via inhibiting YAP/TAZ/JNK signaling pathway in endothelial cells and pericytes Biochim Biophys Acta Mol Cell Biol Lipids siRNA SR505344
YAP1 Role of Hippo/YAP signaling in irradiation-induced glioma cell apoptosis Cancer Manag Res siRNA SR323110
YAP1 Cancer-selective nanoparticles for combinatorial siRNA delivery to primary human GBM in vitro and in vivo Biomaterials siRNA SR323110
YAP1 Spliceosome-associated factor catenin b-like 1 accelerates ovarian cancer progression by inducing expression and nuclear accumulation of yes-associated protein Int J Clin Exp Med siRNA SR323110
YAP1 ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM Front. Cell. Neurosci. siRNA SR323110
YAP1 COPB2 promotes cell proliferation and tumorigenesis through up-regulating YAP1 expression in lung adenocarcinoma cells Biomed. Pharmacother. siRNA SR323110
YAP1 Poly(rC)-binding Protein 2 regulates Hippo signaling to control growth in breast epithelial cells Mol. Cell. Biol. siRNA SR307060
YBX1 IL-27 posttranslationally regulates Y-box binding protein-1 to inhibit HIV-1 replication in human CD4+ T cells AIDS siRNA SR303243
YTHDC1 Epitranscriptomic addition of m 6 A regulates HIV-1 RNA stability and alternative splicing Genes & Development siRNA SR314128
YWHAB FAM163A, a positive regulator of ERK signaling pathway, interacts with 14-3-3β and promotes cell proliferation in squamous cell lung carcinoma Onco Targets Ther siRNA SR305137
YY1 Myocardial BDNF regulates cardiac bioenergetics through the transcription factor Yin Yang 1 bioRxiv siRNA SR501936
YY1 CLTRN, regulated by NRF1/RAN/DLD protein complex, enhances radiation sensitivity of hepatocellular carcinoma cells through ferroptosis pathway International journal of radiation oncology, biology, physics siRNA SR305136
YY1 Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1 Biochem. Cell Biol. siRNA SR305136
ZBP1 ZBP1 (DAI/DLM-1) promotes osteogenic differentiation while inhibiting adipogenic differentiation in mesenchymal stem cells through a positive feedback loop of Wnt/β-catenin signaling Bone Res siRNA SR413638
ZBP1 miR-222 Represses Expression of Zipcode Binding Protein-1 and Phospholipase C-γ1 in Intestinal Epithelial Cells Am. J. Physiol., Cell Physiol. siRNA SR312989
ZBP1 Mitochondrial DNA damage and subsequent activation of Z-DNA binding protein 1 links oxidative stress to inflammation in epithelial cells Sci Rep siRNA SR312989
ZC3H12A An effective and efficient method of transfecting primary human chondrocytes in suspension Anal. Biochem siRNA SR312813
ZC3H12A MicroRNA-9 promotes IL-6 expression by inhibiting MCPIP1 expression in IL-1ß-stimulated human chondrocytes Arthritis & rheumatology siRNA SR312813
ZC3H12A MCPIP1 restricts HIV infection and is rapidly degraded in activated CD4+ T cells Proc. Natl. Acad. Sci. U.S.A. 19083-8 siRNA SR312813
ZDHHC17 Activation of JNK and p38 MAPK Mediated by ZDHHC17 Drives Glioblastoma Multiforme Development and Malignant Progression Theranostics siRNA SR323571
ZEB1 Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function Mol. Vis. siRNA SR304746
ZEB1 A novel microRNA regulator of prostate cancer epithelial-mesenchymal transition Cell Death Differ. siRNA SR304746
Zeb1 A genetic cell context-dependent role for ZEB1 in lung cancer Nat Commun siRNA SR422122
ZEB1 Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1a-ZEB1 axis Cancer Lett. siRNA SR304746
Zeb1 Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression Nat Commun siRNA SR422122
ZEB1 TGF-ß is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion Cell Death Dis siRNA SR304746
ZEB2 Cardiomyocytes stimulate angiogenesis after ischemic injury in a ZEB2-dependent manner Nature communications siRNA SR511798
ZFHX4 Systematic Discovery of the Functional Impact of Somatic Genome Alterations in Individual Tumors through Tumor-specific Causal Inference bioRxiv siRNA SR312589
Zfp281 ZFP281 drives a mesenchymal-like dormancy program in early disseminated breast cancer cells that prevents metastatic outgrowth in the lung. Nature cancer siRNA SR421015
Zfp36 Beta-hydroxybutyrate dampens adipose progenitors’ profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36 -dependent mechanisms Molecular Metabolism siRNA SR426376
Zfp451 The SUMO2/3 specific E3 ligase ZNF451-1 regulates PML stability Int. J. Biochem. Cell Biol. siRNA SR417359
Zfp521 Zfp521 promotes B-cell viability and cyclin D1 gene expression in a B cell culture system Leuk. Res. siRNA SR422637
ZNF365 Lack of ZNF365 Drives Senescence and Exacerbates Experimental Lung Fibrosis Cells siRNA SR307854
ZNF471 19q13 KRAB zinc-finger protein ZNF471 activates MAPK10/JNK3 signaling but is frequently silenced by promoter CpG methylation in esophageal cancer Theranostics siRNA SR311575