HSD17B

HSD17B

OriGene offers a comprehensive suite of products to analyze HSD17B function. It includes cDNA clones, recombinant proteins, antibodies and other reagents for analyzing in human, mouse and rat. For details, refer to the table.

OriGene offers 4 biologically active isoforms of HSD17B protein: HSD17B2 , HSD17B4 , HSD17B10, HSD17B13

HSD17B2

HSD17B2 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence).

HSD17B2 catalyzes the interconversion of testosterone and androstenedione, as well as estradiol and estrone; in addition to having 20-alpha-HSD activity. It uses NADH as its substrate unlike HSD17B3 which uses NADPH. Studies show that it might play a role in the pathology of breast cancer, prostate cancer, endometriosis and osteoporosis.

Tissue distribution: Liver, Intestine, Endometrium, Placenta, Pancreas, Prostate, Colon, Bone.

Other HSD17B2 reagents:
Clones Proteins Antibodies Lentivirus & siRNA

HSD17B4

HSD17B4 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence).

HSD17B4 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids and as a catalyst in the formation of 3-ketoacyl-CoA. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). In addition defects in this enzyme is associated with Perrault syndrome and prostate cancer.

Tissue distribution: Ubiquitous including liver, heart, kidney, pancreas and more.

Other HSD17B4 reagents:
Clones Proteins Antibodies Lentivirus & siRNA

HSD17B10

HSD17B10 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence).

HSD17B10 is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency.

Tissue distribution: Ubiquitous including liver, heart, intestine, kidney, sebaceous gland, ovary and more.

Other HSD17B10 reagents:
Clones Proteins Antibodies Lentivirus & siRNA

HSD17B13

HSD17B13 enzymatic activity with 75μM β-estradiol as a substrate, measured by NADH production (indicated by luminescence).

HSD17B13 is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids and as a catalyst in the formation of 3-ketoacyl-CoA. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). In addition defects in this enzyme is associated with Perrault syndrome and prostate cancer.

Tissue distribution: liver, bone marrow, lung, ovary, testis, kidney, brain, bladder, nasal epithelia, skeletal muscle.

Other HSD17B13 reagents:
Clones Proteins Antibodies Lentivirus & siRNA

14 Isoforms of HSD17B

Gene name Cellular location Tissue distribution Pathology
HSD17B1 Cytosol Ovary, endometrium, breast, brain, prostate, placenta Breast cancer, prostate cancer, endometriosis
HSD17B2 ER Liver, intestine, endometrium, placenta, pancreas, prostate, colon, bone Breast cancer, prostate cancer, endometriosis, osteoporosis
HSD17B3 ER Testis, ovary, blood, saliva, skin, adipose tissue, brain, bone 17β-HSD3 deficiency, prostate cancer
HSD17B4
(DBP, MFP2)		 PXS Liver, heart, prostate, testis, lung, skeletal muscle, kidney, pancreas, thymus, ovary, intestine, placenta, brain, spleen, colon, lymphocytes 17β-HSD3 deficiency, prostate cancer
HSD17B5
(AKR1C3)		 Nucleus, cytosol Prostate, mammary gland, liver, kidney, lung, heart, small intestine, colon, uterus, testis, brain, skeletal muscle, adipose tissue Breast cancer, prostate cancer
HSD17B6 Endosomes Liver, testis, lung, spleen, brain, ovary, kidney, adrenal, prostate Hypotrichosis2, Cortisone reductase deficiency, ovary sarcoma, ovarian endometrioid stromal sarcoma
HSD17B7 PM, ER Ovary, corpus luteum, uterus, placenta, liver, breast, testis, brain, adrenal gland, small intestine, lung, thymus, prostate, adipose tissue, others Breast cancer
HSD17B8 MC Prostate, placenta, kidney, brain, cerebellum, heart, lung, small intestine, ovary, testis, adrenal, stomach Polycystic kidney disease
HSD17B9
(RDH5)		 ER Retina, liver, adipose tissue, blood, others Fundus albipunctatus
HSD17B10 MC Liver, small intestine, colon, kidney, heart, brain, placenta, lung, ovary, testis, spleen, thymus, prostate, peripheral blood leukocytes 17β-HSD10 deficiency, MRXS10, Alzheimer's disease
HSD17B11 ER, EP Liver, pancreas, intestine, kidney, adrenal gland, heart, lung, testis, ovary, placenta, sebaceous gland Lymphoma, cutaneous t-cell lymphoma
HSD17B12 ER Heart, skeletal muscle, liver, kidney, adrenal gland, testis, placenta, cerebellum, pancreas, stomach, small intestine, large intestine, trachea, lung, thyroid, esophagus, prostate, aorta, urinary bladder, spleen, skin, brain, ovary, breast, uterus, vagina Neuroblastoma, central hypoventilation syndrome, qualitative platelet defect, Ovarian cancer
HSD17B13 ER, EP Liver, bone marrow, lung, ovary, testis, kidney, skeletal muscle, brain, bladder, nasal epithelia Mucopolysaccharidosis Iii, Pseudohermaphroditism, Benign Meningioma
HSD17B14 Cytosol Liver, kidney, brain, gallbladder, breast, adrenal, placenta Breast cancer (prognostic)