PDE1B Human siRNA Oligo Duplex (Locus ID 5153)
CAT#: SR303418
PDE1B (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 1 publication. |
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经常一起买 (3)
PDE1B mouse monoclonal antibody, clone OTI6E4 (formerly 6E4)
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_000924, NM_001165975, NM_001288768, NM_001288769, NM_001315534, NM_001315535 |
Synonyms | HEL-S-79p; PDE1B1; PDES1B |
Components | PDE1B (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 5153)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE1 subfamily. Members of the PDE1 family are calmodulin-dependent PDEs that are stimulated by a calcium-calmodulin complex. This PDE has dual-specificity for the second messengers, cAMP and cGMP, with a preference for cGMP as a substrate. cAMP and cGMP function as key regulators of many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways
,Hung, WC;Yang, JR;Yankaskas, CL;Wong, BS;Wu, PH;Pardo-Pastor, C;Serra, SA;Chiang, MJ;Gu, Z;Wirtz, D;Valverde, MA;Yang, JT;Zhang, J;Konstantopoulos, K;,
Cell Rep
,PubMed ID 27160899
[PDE1B]
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