SEMCAP3 (PDZRN3) Human siRNA Oligo Duplex (Locus ID 23024)
CAT#: SR307944
PDZRN3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
Product images
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001303139, NM_001303140, NM_001303141, NM_001303142, NM_015009 |
Synonyms | LNX3; SEMACAP3; SEMCAP3 |
Components | PDZRN3 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 23024)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a member of the LNX (Ligand of Numb Protein-X) family of RING-type ubiquitin E3 ligases. This protein may function in vascular morphogenesis and the differentiation of adipocytes, osteoblasts and myoblasts. This protein may be targeted for degradation by the human papilloma virus E6 protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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PDZRN3 destabilizes endothelial cell-cell junctions through a PKCζ-containing polarity complex to increase vascular permeability
,Sewduth, RN;Kovacic, H;Jaspard-Vinassa, B;Jecko, V;Wavasseur, T;Fritsch, N;Pernot, M;Jeaningros, S;Roux, E;Dufourcq, P;Couffinhal, T;Duplàa, C;,
Sci. Signal
,PubMed ID 28143902
[PDZRN3]
|
Kif26b controls endothelial cell polarity through the Dishevelled/Daam1-dependent planar cell polarity signaling pathway
,Guillabert-Gourgues, A;Jaspard-Vinassa, B;Bats, ML;Sewduth, RN;Franzl, N;Peghaire, C;Jeanningros, S;Moreau, C;Roux, E;Larrieu-Lahargue, F;Dufourcq, P;Couffinhal, T;Duplàa, C;,
Mol. Biol. Cell
,PubMed ID 26792835
[PDZRN3]
|
The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt/planar cell polarity signalling
,Sewduth, RN;Jaspard-Vinassa, B;Peghaire, C;Guillabert, A;Franzl, N;Larrieu-Lahargue, F;Moreau, C;Fruttiger, M;Dufourcq, P;Couffinhal, T;Duplàa, C;,
Nat Commun
,PubMed ID 25198863
[PDZRN3]
|
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