ATF 4 (ATF4) Human siRNA Oligo Duplex (Locus ID 468)
CAT#: SR319410
ATF4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR319410 is the updated version of SR300328.
CNY 4,090.00
货期*
5周
规格
Cited in 4 publications. |
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经常一起买 (3)
ATF4 mouse monoclonal antibody, clone OTI1H9
CNY 1,999.00
CNY 3,600.00
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001675, NM_182810 |
Synonyms | CREB-2; CREB2; TAXREB67; TXREB |
Components | ATF4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 468)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromosome at q28 in a region containing a large inverted duplication. [provided by RefSeq, Sep 2011] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
---|
CCDC106 promotes the proliferation and invasion of ovarian cancer cells by suppressing p21 transcription through a p53-independent pathway
,null,
Bioengineered
,PubMed ID 35484984
[ATF4]
|
Tetracyclines promote survival and fitness in mitochondrial disease models
,Perry, EA;Bennett, CF;Luo, C;Balsa, E;Jedrychowski, M;O'Malley, KE;Latorre-Muro, P;Ladley, RP;Reda, K;Wright, PM;Gygi, SP;Myers, AG;Puigserver, P;,
Nature metabolism
,PubMed ID 33462515
[ATF4]
|
Therapeutic potential of targeting HSPA5 through dual regulation of two candidate prognostic biomarkers ANXA1 and PSAT1 in osteosarcoma
,null,
Aging (Albany NY)
,PubMed ID 33291071
[ATF4]
|
GCN2 reduces inflammation by p-eIF2α/ATF4 pathway after intracerebral hemorrhage in mice.
,null,
Experimental neurology
,PubMed ID 30529503
[ATF4]
|
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