Beclin 1 (BECN1) Human siRNA Oligo Duplex (Locus ID 8678)
CAT#: SR322490
BECN1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR322490 is the updated version of SR305711.
CNY 4,090.00
货期*
4周
规格
Cited in 5 publications. |
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经常一起买 (3)
BECN1 (Beclin 1) mouse monoclonal antibody, clone OTI1F1 (formerly 1F1)
CNY 1,999.00
CNY 2,700.00
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001313998, NM_001313999, NM_001314000, NM_003766 |
Synonyms | ATG6; beclin1; VPS30 |
Components | BECN1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 8678)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (5)
The use of this RNAi has been cited in the following citations: |
---|
Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis
,null,
Frontiers in Immunology
,PubMed ID 35757769
[BECN1]
|
ZBTB28 induces autophagy by regulation of FIP200 and Bcl-XL facilitating cervical cancer cell apoptosis
,Li, L;Gong, Y;Xu, K;Chen, W;Xia, J;Cheng, Z;Li, L;Yu, R;Mu, J;Le, X;Xiang, Q;Peng, W;Tang, J;Xiang, T;,
Journal of experimental & clinical cancer research : CR
,PubMed ID 33931087
[BECN1]
|
Suppression of autophagy facilitates hydrogen gas-mediated lung cancer cell apoptosis
,Liu, L;Yan, Z;Wang, Y;Meng, J;Chen, G;,
Oncol Lett
,PubMed ID 32863925
[BECN1]
|
Junín virus induces autophagy in human A549 cells
,null,
PLoS ONE
,PubMed ID 31216340
[BECN1]
|
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
,Kumar, A;Shaha, C;,
Sci Rep
,PubMed ID 29330382
[BECN1]
|
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