PINK1 Human siRNA Oligo Duplex (Locus ID 65018)
CAT#: SR324912
PINK1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR324912 is the updated version of SR312201.
CNY 4,090.00
货期*
4周
规格
Cited in 4 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_032409 |
Synonyms | BRPK; PARK6 |
Components | PINK1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 65018)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue
,null,
Cell metabolism
,PubMed ID 35305295
[PINK1]
|
Administration of quercetin improves mitochondria quality control and protects the neurons in 6-OHDA-lesioned Parkinson\'s disease models
,Wang, WW;Han, R;He, HJ;Li, J;Chen, SY;Gu, Y;Xie, C;,
Aging
,PubMed ID 33878030
[PINK1]
|
Chalcomoracin is a potent anticancer agent acting through triggering Oxidative stress via a mitophagy- and paraptosis-dependent mechanism
,null,
Scientific Reports
,PubMed ID 29934599
[PINK1]
|
SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation
,null,
Scientific Reports
,PubMed ID 29330382
[PINK1]
|
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