TRPM7 Human siRNA Oligo Duplex (Locus ID 54822)
CAT#: SR310261
TRPM7 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 4 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001301212, NM_017672, NR_149152, NR_149153, NR_149154 |
Synonyms | ALSPDC; CHAK; CHAK1; LTrpC-7; LTRPC7; TRP-PLIK |
Components | TRPM7 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 54822)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
,null,
Nature Communications
,PubMed ID 34001887
[TRPM7]
|
TRPM7 kinase-mediated immunomodulation in macrophage plays a central role in magnesium ion-induced bone regeneration
,Qiao, W;Wong, KHM;Shen, J;Wang, W;Wu, J;Li, J;Lin, Z;,
bioRxiv
[TRPM7]
|
Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7
,Qiao, W;Lan, XM;Ma, HX;Chan, JYK;Lui, VWY;Yeung, KWK;Kwong, DLW;Hu, Z;Tsoi, JKH;Matinlinna, JP;Su, YX;,
J. Dent. Res.
,PubMed ID 30513244
[TRPM7]
|
KCa3.1 and TRPM7 Channels at the Uropod Regulate Migration of Activated Human T Cells
,null,
PLoS ONE
,PubMed ID 22952790
[TRPM7]
|
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