REA (PHB2) Human siRNA Oligo Duplex (Locus ID 11331)
CAT#: SR307765
PHB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001144831, NM_001267700, NM_007273 |
Synonyms | BAP; Bap37; BCAP37; hBAP; p22; PNAS-141; REA |
Components | PHB2 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 11331)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases (By similarity). Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. In mitochondria, regulates cytochrome-c oxidase assembly (COX) and mitochondrial respiration. Binding to sphingoid 1-phosphate (SPP) modulates its regulator activity (PubMed:20959514).[UniProtKB/Swiss-Prot Function] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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Prohibitin 1/2 mediates Dengue-3 entry into human neuroblastoma (SH-SY5Y) and microglia (CHME-3) cells
,Sharma, A;Vasanthapuram, R;M Venkataswamy, M;Desai, A;,
J. Biomed. Sci.
,PubMed ID 32306962
[PHB2]
|
Mitoquinone attenuates blood-brain barrier disruption through Nrf2/PHB2/OPA1 pathway after subarachnoid hemorrhage in rats
,Zhang, T;Xu, S;Wu, P;Zhou, K;Wu, L;Xie, Z;Xu, W;Luo, X;Li, P;Ocak, U;Ocak, PE;Travis, ZD;Tang, J;Shi, H;Zhang, JH;,
Exp. Neurol.
,PubMed ID 30779914
[PHB2]
|
Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone
,Perron, A;Nishikawa, Y;Iwata, J;Shimojo, H;Takaya, J;Kobayashi, K;Imayoshi, I;Mbenza, NM;Takenoya, M;Kageyama, R;Kodama, Y;Uesugi, M;,
J. Biol. Chem.
,PubMed ID 29523683
[PHB2]
|
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