Sirt1 Mouse siRNA Oligo Duplex (Locus ID 93759)
CAT#: SR427400
Sirt1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each
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SR427400 is the updated version of SR419269.
CNY 4,090.00
货期*
4周
规格
Cited in 4 publications. |
Product images
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经常一起买 (2)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001159589, NM_001159590, NM_019812 |
Synonyms | AA673258; S; Si; Sir2; Sir2a; Sir2alpha; SIR2L1 |
Components | Sirt1 (Mouse) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 93759)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (4)
The use of this RNAi has been cited in the following citations: |
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Neuroprotective effects and mechanisms of action of nicotinamide mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment
,Chen, X;Amorim, JA;Moustafa, GA;Lee, JJ;Yu, Z;Ishihara, K;Iesato, Y;Barbisan, P;Ueta, T;Togka, KA;Lu, L;Sinclair, DA;Vavvas, DG;,
Aging
,PubMed ID 33373320
[SIRT1]
|
Fruit of Hovenia dulcis Thunb. induces non-shivering thermogenesis through mitochondrial biogenesis and activation by SIRT1 in high fat diet-fed obese mice and primary cultured brown adipocytes
,Song, G;Kim, HL;Jung, Y;Pa, J;Lee, JH;Ahn, KS;Kwak, HJ;Um, JY;,
J. Agric. Food Chem.
,PubMed ID 32450691
[SIRT1]
|
SIRT1 Regulates the Chemoresistance and Invasiveness of Ovarian Carcinoma Cells
,null,
Translational Oncology
,PubMed ID 28667895
[Sirt1]
|
Sirt1 deficiency protects cochlear cells and delays the early onset of age-related hearing loss in C57BL/6 mice
,null,
Neurobiology of aging
,PubMed ID 27255815
[Sirt1]
|
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