Treacher Collins syndrome protein (TCOF1) Human siRNA Oligo Duplex (Locus ID 6949)
CAT#: SR304758
TCOF1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 1 publication. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_000356, NM_001008656, NM_001008657, NM_001135243, NM_001135244, NM_001135245, NM_001195141 |
Synonyms | MFD1; TCS; TCS1; treacle |
Components | TCOF1 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 6949)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | This gene encodes a nucleolar protein with a LIS1 homology domain. The protein is involved in ribosomal DNA gene transcription through its interaction with upstream binding factor (UBF). Mutations in this gene have been associated with Treacher Collins syndrome, a disorder which includes abnormal craniofacial development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
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Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
,Scheibye-Knudsen, M;Tseng, A;Borch Jensen, M;Scheibye-Alsing, K;Fang, EF;Iyama, T;Bharti, SK;Marosi, K;Froetscher, L;Kassahun, H;Eckley, DM;Maul, RW;Bastian, P;De, S;Ghosh, S;Nilsen, H;Goldberg, IG;Mattson, MP;Wilson, DM;Brosh, RM;Gorospe, M;Bohr, VA;,
Proc. Natl. Acad. Sci. U.S.A.
,PubMed ID 27791127
[TCOF1]
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