IKBKE Human siRNA Oligo Duplex (Locus ID 9641)
CAT#: SR306417
IKBKE (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
4周
规格
Cited in 3 publications. |
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经常一起买 (3)
IKBKE mouse monoclonal antibody, clone OTI3C5 (formerly 3C5)
CNY 1,999.00
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Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001193321, NM_001193322, NM_014002 |
Synonyms | IKK-E; IKK-i; IKKE; IKKI |
Components | IKBKE (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 9641)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (3)
The use of this RNAi has been cited in the following citations: |
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Activated kinase screening identifies the IKBKE oncogene as a positive regulator of autophagy
,Leonardi, M;Perna, E;Tronnolone, S;Colecchia, D;Chiariello, M;,
Autophagy
,PubMed ID 30289335
[IKBKE]
|
Sphingosine 1-Phosphate Lyase Enhances the Activation of IKKε To Promote Type I IFN-Mediated Innate Immune Responses to Influenza A Virus Infection
,Vijayan, M;Xia, C;Song, YE;Ngo, H;Studstill, CJ;Drews, K;Fox, TE;Johnson, MC;Hiscott, J;Kester, M;Alexander, S;Hahm, B;,
J. Immunol.
,PubMed ID 28600291
[IKBKE]
|
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1
,Crew, AP;Raina, K;Dong, H;Qian, Y;Wang, J;Vigil, D;Serebrenik, YV;Hamman, BD;Morgan, A;Ferraro, C;Siu, K;Neklesa, TK;Winkler, JD;Coleman, KG;Crews, CM;,
J. Med. Chem.
,PubMed ID 28692295
[IKBKE]
|
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