CSEN (KCNIP3) (NM_001034914) Human Mass Spec Standard

Specifications

Product Data
Description	KCNIP3 MS Standard C13 and N15-labeled recombinant protein (NP_001030086)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC224492
Predicted MW	26.2 kDa
Protein Sequence	Sequence Link (showhide) >RC224492 representing NM_001034914 Red=Cloning site Green=Tags(s) MGIQGMELCAMAVVVLLFIAVLKQFGILEPISMEDSSDSELELSTVRHQPEGLDQLQAQTKFTKKELQSL YRGFKNECPTGLVDEDTFKLIYAQFFPQGDATTYAHFLFNAFDADGNGAIHFEDFVVGLSILLRGTVHEK LKWAFNLYDINKDGYITKEEMLAIMKSIYDMMGRHTYPILREDAPAEHVERFFEKMDRNQDGVVTIEEFL EACQKDENIMSSMQLFENVI TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_001030086
RefSeq Size	2735
RefSeq ORF	690
Synonyms	CSEN; DREAM; KCHIP3
Locus ID	30818
Cytogenetics	2q11.1
Summary	This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transcription Factors, Transmembrane

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