Dnmt2 (TRDMT1) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 GFP-puro donor, 1 scramble control
Donor DNA	GFP-puro
Symbol	Dnmt2
Locus ID	1787
Kit Components	KN208363G1, Dnmt2 gRNA vector 1 in pCas-Guide CRISPR vector KN208363G2, Dnmt2 gRNA vector 2 in pCas-Guide CRISPR vector KN208363-D, donor DNA containing left and right homologous arms and GFP-puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_004412, NM_176081, NM_176083, NM_176084, NM_176085, NM_176086, NM_001321006, NM_001321007, NM_001351219, NM_001351220, NM_001351221, NM_001351222, NM_001351223
Synonyms	DMNT2; DNMT2; MHSAIIP; PUMET; RNMT1
Summary	This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA, specifically at the cytosine-38 residue in the anticodon loop. This enzyme also possesses residual DNA-(cytosine-C5) methyltransferase activity. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. [provided by RefSeq, Jun 2010]

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