Human Ancient ubiquitous protein 1 (AUP1) activation kit by CRISPRa
CAT#: GA100380
AUP1 CRISPRa kit - CRISPR gene activation of human AUP1 lipid droplet regulating VLDL assembly factor
CN¥ 12,255.00
Specifications
Product Data | |
Format | 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug) |
Symbol | AUP1 |
Locus ID | 550 |
Kit Components | GA100380G1, Ancient ubiquitous protein 1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA100380G2, Ancient ubiquitous protein 1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA100380G3, Ancient ubiquitous protein 1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077 |
Reference Data | |
RefSeq | NM_012103, NM_181575, NM_181576, NR_126510, NR_126511 |
Synonyms | ancient ubiquitous protein 1 |
Summary | The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014] |
Documents
Resources
基因表达相关资源 |
Other Versions
SKU | Description | Size | Price |
---|---|---|---|
KN422822 | AUP1 - KN2.0, Human gene knockout kit via CRISPR, non-homology mediated. |
CN¥ 8,680.00 |