Silencer of Death Domain (BAG4) Human siRNA Oligo Duplex (Locus ID 9530)
CAT#: SR306332
BAG4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each
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CNY 4,090.00
货期*
7周
规格
Cited in 78 publications. |
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经常一起买 (3)
Specifications
Product Data | |
Purity | HPLC purified |
Quality Control | Tested by ESI-MS |
Sequences | Available with shipment |
Stability | One year from date of shipment when stored at -20°C. |
# of transfections | Approximately 330 transfections/2nmol in 24-well plate under optimized conditions (final conc. 10 nM). |
Note | Single siRNA duplex (10nmol) can be ordered. |
Reference Data | |
RefSeq | NM_001204878, NM_004874 |
Synonyms | BAG-4; SODD |
Components | BAG4 (Human) - 3 unique 27mer siRNA duplexes - 2 nmol each (Locus ID 9530)Included - SR30004, Trilencer-27 Universal Scrambled Negative Control siRNA Duplex - 2 nmolIncluded - SR30005, RNAse free siRNA Duplex Resuspension Buffer - 2 ml |
Summary | The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
Performance Guranteed | OriGene guarantees that at least two of the three Dicer-Substrate duplexes in the kit will provide at least 70% or more knockdown of the target mRNA when used at 10 nM concentration by quantitative RT-PCR when the TYE-563 fluorescent transfection control duplex (cat# SR30002) indicates that >90% of the cells have been transfected and the HPRT positive control (cat# SR30003) provides 90% knockdown efficiency. For non-conforming siRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the siRNA kit. To arrange for a free replacement with newly designed duplexes, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled siRNA control (quantitative RT-PCR data required). |
Citations (78)
The use of this RNAi has been cited in the following citations: |
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Progerin mislocalizes myocardin-related transcription factor in Hutchinson–Guilford Progeria syndrome
,null,
Vascular Biology
,PubMed ID 35441125
[BAG4]
|
Advanced Oxidation Protein Product Promotes Oxidative Accentuation in Renal Epithelial Cells via the Soluble (Pro)renin Receptor-Mediated Intrarenal Renin-Angiotensin System and Nox4-H2O2 Signaling
,null,
Oxidative Medicine and Cellular Longevity
,PubMed ID 34873430
[BAG4]
|
Atypical cyclin P regulates cancer cell stemness through activation of the WNT pathway
,null,
Cellular Oncology (Dordrecht)
,PubMed ID 34604945
[BAG4]
|
Characterization and prognostic value of LXR splice variants in triple-negative breast cancer
,null,
iScience
,PubMed ID 34755086
[BAG4]
|
αTAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion
,null,
Laboratory Investigation; a Journal of Technical Methods and Pathology
,PubMed ID 34508164
[BAG4]
|
IL-27 Derived From Macrophages Facilitates IL-15 Production and T Cell Maintenance Following Allergic Hypersensitivity Responses
,null,
Frontiers in Immunology
,PubMed ID 34659203
[BAG4]
|
Desmoglein‐2 expression is an independent predictor of poor prognosis patients with multiple myeloma
,null,
Molecular Oncology
,PubMed ID 34245117
[BAG4]
|
Human METTL7B is an alkyl thiol methyltransferase that metabolizes hydrogen sulfide and captopril
,null,
Scientific Reports
,PubMed ID 33649426
[BAG4]
|
Tauroursodeoxycholic acid attenuates neuronal apoptosis via the TGR5/ SIRT3 pathway after subarachnoid hemorrhage in rats
,null,
Biological Research
,PubMed ID 33261652
[BAG4]
|
HDAC7 is an actionable driver of therapeutic antibody resistance by macrophages from CLL patients.
,null,
Oncogene
,PubMed ID 32709923
[BAG4]
|
Energy Shortage in Human and Mouse Models of SLC4A11-Associated Corneal Endothelial Dystrophies
,null,
Investigative Ophthalmology & Visual Science
,PubMed ID 32721020
[BAG4]
|
The protein kinase MAP3K19 phosphorylates MAP2Ks and thereby activates ERK and JNK kinases and increases viability of KRAS-mutant lung cancer cells
,null,
The Journal of Biological Chemistry
,PubMed ID 32358059
[BAG4]
|
Transcription factor AP2A affects sFLT1 expression and decidualization in decidual stromal cells: Implications to preeclampsia pathology.
,null,
Pregnancy hypertension
,PubMed ID 32535226
[BAG4]
|
Role of the nuclear membrane protein Emerin in front-rear polarity of the nucleus
,null,
Nature Communications
,PubMed ID 32358486
[BAG4]
|
Serelaxin alleviates cardiac fibrosis through inhibiting endothelial-to-mesenchymal transition via RXFP1
,null,
Theranostics
,PubMed ID 32226528
[BAG4]
|
Recombinant OX40 attenuates neuronal apoptosis through OX40-OX40L/PI3K/AKT signaling pathway following subarachnoid hemorrhage in rats.
,null,
Experimental neurology
,PubMed ID 31930990
[BAG4]
|
Physiological roles of the GIP receptor in murine brown adipose tissue
,null,
Molecular Metabolism
,PubMed ID 31451430
[BAG4]
|
Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy, et al. Type 2 diabetes‐induced hyposalivation of the submandibular gland through PINK1/Parkin‐mediated mitophagy
,null,
Journal of Cellular Physiology
,PubMed ID 31190343
[BAG4]
|
Manganese Uptake by A549 Cells is Mediated by Both ZIP8 and ZIP14
,null,
Nutrients
,PubMed ID 31261654
[BAG4]
|
Muscle A-kinase–anchoring protein-β–bound calcineurin toggles active and repressive transcriptional complexes of myocyte enhancer factor 2D
,null,
The Journal of Biological Chemistry
,PubMed ID 30523159
[BAG4]
|
The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice
,null,
Molecular Metabolism
,PubMed ID 30772257
[BAG4]
|
Loss of human ICOSL results in combined immunodeficiency
,null,
The Journal of Experimental Medicine
,PubMed ID 30498080
[BAG4]
|
ROCK Inhibitor Y27632 Induced Morphological Shift and Enhanced Neurite Outgrowth-Promoting Property of Olfactory Ensheathing Cells via YAP-Dependent Up-Regulation of L1-CAM
,null,
Frontiers in Cellular Neuroscience
,PubMed ID 30618636
[BAG4]
|
Tumor cell-secreted PLD increases tumor stemness by senescence-mediated communication with microenvironment.
,null,
Oncogene
,PubMed ID 30305726
[BAG4]
|
The mitochondrial phosphatase PPTC7 orchestrates mitochondrial metabolism regulating coenzyme Q10 biosynthesis.
,null,
Biochimica et biophysica acta. Bioenergetics
,PubMed ID 30267671
[BAG4]
|
Ubiquitin-conjugating enzyme E2 D1 (Ube2D1) mediates lysine-independent ubiquitination of the E3 ubiquitin ligase March-I
,null,
The Journal of Biological Chemistry
,PubMed ID 29414787
[BAG4]
|
Arylamine N-acetyltransferase 1 protects against reactive oxygen species during glucose starvation: Role in the regulation of p53 stability
,null,
PLoS ONE
,PubMed ID 29518119
[BAG4]
|
TRPV4 Blockade Preserves the Blood–Brain Barrier by Inhibiting Stress Fiber Formation in a Rat Model of Intracerebral Hemorrhage
,null,
Frontiers in Molecular Neuroscience
,PubMed ID 29636662
[BAG4]
|
PDGFR-β modulates vascular smooth muscle cell phenotype via IRF-9/SIRT-1/NF-κB pathway in subarachnoid hemorrhage rats
,null,
Journal of Cerebral Blood Flow & Metabolism
,PubMed ID 29480757
[BAG4]
|
Hemicentin 1 influences podocyte dynamic changes in glomerular diseases.
,null,
American journal of physiology. Renal physiology
,PubMed ID 29488390
[BAG4]
|
Suppressor of fused (Sufu) promotes epithelial-mesenchymal transition (EMT) in cervical squamous cell carcinoma
,null,
Oncotarget
,PubMed ID 29371981
[BAG4]
|
Elucidating the molecular basis of PPCD: Effects of decreased ZEB1 expression on corneal endothelial cell function
,null,
Molecular Vision
,PubMed ID 29046608
[BAG4]
|
Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells
,null,
BMC Nephrology
,PubMed ID 28882112
[BAG4]
|
Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity
,null,
Nature Communications
,PubMed ID 28916756
[BAG4]
|
Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox
,null,
Scientific Reports
,PubMed ID 28947831
[BAG4]
|
Hypoxia‐induced activin A diminishes endothelial cell vasculogenic activity
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 28834227
[BAG4]
|
Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1.
,null,
Journal of medicinal chemistry
,PubMed ID 28692295
[BAG4]
|
A novel microRNA regulator of prostate cancer epithelial–mesenchymal transition
,null,
Cell Death and Differentiation
,PubMed ID 28498363
[BAG4]
|
Modulation of nuclear REST by alternative splicing: a potential therapeutic target for Huntington's disease
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 28524599
[BAG4]
|
Regulator of Cell Cycle (RGCC) Expression during the Progression of Alzheimer's Disease
,null,
Cell Transplantation
,PubMed ID 27938491
[BAG4]
|
Histone deacetylase inhibitors promote eNOS expression in vascular smooth muscle cells and suppress hypoxia‐induced cell growth
,null,
Journal of Cellular and Molecular Medicine
,PubMed ID 28266122
[BAG4]
|
Transcriptomic Profiling of Posterior Polymorphous Corneal Dystrophy
,null,
Investigative Ophthalmology & Visual Science
,PubMed ID 28654985
[BAG4]
|
SHANK3 deficiency impairs heat hyperalgesia and TRPV1 signaling in primary sensory neurons
,null,
Neuron
,PubMed ID 27916453
[BAG4]
|
MALAT1 and HOTAIR Long Non-Coding RNAs Play Opposite Role in Estrogen-Mediated Transcriptional Regulation in Prostate Cancer Cells
,null,
Scientific Reports
,PubMed ID 27922078
[BAG4]
|
Role of dendritic cell maturation factors produced by human invariant NKT cells in immune tolerance
,null,
Journal of Leukocyte Biology
,PubMed ID 27837018
[BAG4]
|
Role for human arylamine N-acetyltransferase 1 in the methionine salvage pathway.
,null,
Biochemical pharmacology
,PubMed ID 27865712
[BAG4]
|
Relative Role of Akt, ERK and CREB in Alcohol-Induced Microglia P2X4R Receptor Expression
,null,
Alcohol and Alcoholism (Oxford, Oxfordshire)
,PubMed ID 26946194
[BAG4]
|
Identification of Bisindolylmaleimide IX as a potential agent to treat drug-resistant BCR-ABL positive leukemia
,null,
Oncotarget
,PubMed ID 27564101
[BAG4]
|
Novel tumor suppressor microRNA at frequently deleted chromosomal region 8p21 regulates Epidermal Growth Factor Receptor in prostate cancer
,null,
Oncotarget
,PubMed ID 27611943
[BAG4]
|
The pharmacological stimulation of Nurr1 improves cognitive functions via enhancement of adult hippocampal neurogenesis.
,null,
Stem cell research
,PubMed ID 27788475
[BAG4]
|
Desmoglein 2 promotes vasculogenic mimicry in melanoma and is associated with poor clinical outcome
,null,
Oncotarget
,PubMed ID 27340778
[BAG4]
|
Role of PDGF-D and PDGFR-β in neuroinflammation in experimental ICH mice model ☆
,null,
Experimental neurology
,PubMed ID 27302678
[BAG4]
|
Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor
,null,
PLoS ONE
,PubMed ID 27171436
[BAG4]
|
Role of flotillins in the endocytosis of GPCR in salivary gland epithelial cells.
,null,
Biochemical and biophysical research communications
,PubMed ID 27221048
[BAG4]
|
PI3 kinases p110 α and PI3K-C2 β negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets
,null,
Molecular Metabolism
,PubMed ID 27408772
[BAG4]
|
Myofibroblasts are distinguished from activated skin fibroblasts by the expression of AOC3 and other associated markers
,null,
Proceedings of the National Academy of Sciences of the United States of America
,PubMed ID 27036009
[BAG4]
|
Stem cell and neurogenic gene-expression profiles link prostate basal cells to aggressive prostate cancer
,null,
Nature Communications
,PubMed ID 26924072
[BAG4]
|
GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells
,null,
Oncotarget
,PubMed ID 26646587
[BAG4]
|
TRPV4 Mechanosensitive Ion Channel Regulates LPS-Stimulated Macrophage Phagocytosis
,null,
Journal of immunology (Baltimore, Md. : 1950)
,PubMed ID 26597012
[BAG4]
|
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells
,null,
Molecular Brain
,PubMed ID 26521126
[BAG4]
|
A STAT3-NFkB/DDIT3/CEBPβ axis modulates ALDH1A3 expression in chemoresistant cell subpopulations
,null,
Oncotarget
,PubMed ID 25868979
[BAG4]
|
The Role of Misshapen NCK-related kinase (MINK), a Novel Ste20 Family Kinase, in the IRES-Mediated Protein Translation of Human Enterovirus 71
,null,
PLoS Pathogens
,PubMed ID 25747578
[BAG4]
|
Local Mitochondrial-Endolysosomal Microfusion Cleaves Voltage-Dependent Anion Channel 1 To Promote Survival in Hypoxia
,null,
Molecular and Cellular Biology
,PubMed ID 25691661
[BAG4]
|
Synergistic effect of angiotensin II on vascular endothelial growth factor-A-mediated differentiation of bone marrow-derived mesenchymal stem cells into endothelial cells
,null,
Stem Cell Research & Therapy
,PubMed ID 25563650
[BAG4]
|
Tumor necrosis-initiated complement activation stimulates proliferation of medulloblastoma cells
,null,
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
,PubMed ID 25603857
[BAG4]
|
Harnessing the p53-PUMA Axis to Overcome DNA Damage Resistance in Renal Cell Carcinoma
,null,
Neoplasia (New York, N.Y.)
,PubMed ID 25499216
[BAG4]
|
MicroRNA-93 activates c-Met/PI3K/Akt pathway activity in hepatocellular carcinoma by directly inhibiting PTEN and CDKN1A
,null,
Oncotarget
,PubMed ID 25633810
[BAG4]
|
IDH1 Regulates Phospholipid Metabolism in Developing Astrocytes
,null,
Neuroscience letters
,PubMed ID 25218477
[BAG4]
|
Pannexin1 hemichannels are critical for HIV infection of human primary CD4+ T lymphocytes
,null,
Journal of Leukocyte Biology
,PubMed ID 23456773
[BAG4]
|
Rescue of Enzymatic Function for Disease-associated RPE65 Proteins Containing Various Missense Mutations in Non-active Sites *
,null,
The Journal of Biological Chemistry
,PubMed ID 24849605
[BAG4]
|
ELF4 is critical for induction of type I interferon and the host antiviral response
,null,
Nature immunology
,PubMed ID 24185615
[BAG4]
|
MicroRNA-4723 Inhibits Prostate Cancer Growth through Inactivation of the Abelson Family of Nonreceptor Protein Tyrosine Kinases
,null,
PLoS ONE
,PubMed ID 24223753
[BAG4]
|
Aberrant expression of laminin γ2 correlates with poor prognosis and promotes invasion in extrahepatic cholangiocarcinoma.
,null,
The Journal of surgical research
,PubMed ID 24124977
[BAG4]
|
Epigenetic identification of receptor tyrosine kinase-like orphan receptor 2 as a functional tumor suppressor inhibiting β-catenin and AKT signaling but frequently methylated in common carcinomas.
,null,
Cellular and molecular life sciences : CMLS
,PubMed ID 24158497
[BAG4]
|
Noncanonical Control of Vasopressin Receptor Type 2 Signaling by Retromer and Arrestin *
,null,
The Journal of Biological Chemistry
,PubMed ID 23935101
[BAG4]
|
The Syndecan-4/Protein Kinase C? Pathway Mediates Prostaglandin E2-induced Extracellular Regulated Kinase (ERK) Activation in Endothelial Cells and Angiogenesis in Vivo *
,null,
The Journal of Biological Chemistry
,PubMed ID 23525101
[BAG4]
|
The Induction of microRNA-16 in Colon Cancer Cells by Protein Arginine Deiminase Inhibition Causes a p53-Dependent Cell Cycle Arrest
,null,
PLoS ONE
,PubMed ID 23308284
[BAG4]
|
A Role for Myosin VI in the Localization of Axonal Proteins
,null,
PLoS Biology
,PubMed ID 21390300
[BAG4]
|
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