Silencer of Death Domain (BAG4) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IF, WB
Recommend Dilution	WB: 0.5 ug/mL, ICC: 5 ug/mL, IF: 20 ug/mL
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	SODD antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD.
Formulation	PBS containing 0.02% sodium azide.
Concentration	1ug/ul
Purification	Antibody is DEAE purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	BCL2 associated athanogene 4
Database Link	AF111116 Entrez Gene 9530 Human UniProt ID O95429
Background	Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains (1). SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.
Synonyms	BAG-4; SODD
Reference Data

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