TGF beta Receptor I (TGFBR1) Human shRNA Plasmid Kit (Locus ID 7046)
CAT#: TL320549
TGFBR1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
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CNY 5,740.00
货期*
现货
规格
Cited in 1 publication. |
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Specifications
Product Data | |
Product Name | TGF beta Receptor I (TGFBR1) Human shRNA Plasmid Kit (Locus ID 7046) |
Locus ID | 7046 |
UniProt ID | P36897 |
Synonyms | AAT5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; SKR4; tbetaR-I; TBR-i; TBRI; TGFR-1 |
Vector | pGFP-C-shLenti |
Format | Lentiviral plasmids |
Kit Components | TGFBR1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7046). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
RefSeq | NM_001130916, NM_001306210, NM_004612, NM_004612.1, NM_004612.2, NM_004612.3, NM_001130916.1, NM_001130916.2, BC071181, BC038347, BC056247, NM_004612.4, NM_001130916.3 |
Summary | The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008] |
shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
Performance Guaranteed | OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred). |
Citations (1)
The use of this RNAi has been cited in the following citations: |
---|
miR-140-5p alleviates the aggressive progression of Wilms' tumor through directly targeting TGFBR1 gene
,Wang, H;Lou, C;Ma, N;,
Cancer Manag Res
,PubMed ID 30863174
[TGFBR1]
|
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