Liprin alpha 2 (PPFIA2) Human shRNA Plasmid Kit (Locus ID 8499)

Specifications

Product Data
Product Name	Liprin alpha 2 (PPFIA2) Human shRNA Plasmid Kit (Locus ID 8499)
Locus ID	8499
UniProt ID	O75334
Vector	pGFP-C-shLenti
Format	Lentiviral plasmids
Kit Components	PPFIA2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 8499). 5µg purified plasmid DNA per construct 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq	NM_001220473, NM_001220474, NM_001220475, NM_001220476, NM_001220477, NM_001220478, NM_001220479, NM_001220480, NM_001282536, NM_003625, NR_038265, NM_003625.1, NM_003625.2, NM_003625.3, NM_003625.4, NM_001220480.2, NM_001220479.1, NM_001220479.2, NM_001220478.1, NM_001220478.2, NM_001220477.1, NM_001220477.2, NM_001220474.1, NM_001220474.2, NM_001220475.1, NM_001220475.2, NM_001220473.1, NM_001220473.2, NM_001220476.1, NM_001220476.2, NM_001282536.1, BC104912, BC143485, BM661844, BM689808, NM_001220473.3, NM_001220479.3, NM_001220474.3, NM_003625.5
Summary	The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
shRNA Design	These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Performance Guaranteed	OriGene guarantees that the sequences in the shRNA expression cassettes are verified to correspond to the target gene with 100% identity. One of the four constructs at minimum are guaranteed to produce 70% or more gene expression knock-down provided a minimum transfection efficiency of 80% is achieved. Western Blot data is recommended over qPCR to evaluate the silencing effect of the shRNA constructs 72 hrs post transfection. To properly assess knockdown, the gene expression level from the included scramble control vector must be used in comparison with the target-specific shRNA transfected samples. For non-conforming shRNA, requests for replacement product must be made within ninety (90) days from the date of delivery of the shRNA kit. To arrange for a free replacement with newly designed constructs, please contact Technical Services at techsupport@origene.com. Please provide your data indicating the transfection efficiency and measurement of gene expression knockdown compared to the scrambled shRNA control (Western Blot data preferred).

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.