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APE1 (APEX1) (NM_001641) Human Recombinant Protein
CAT＃: TP720082
Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1
View other "APE1" proteins (13)
|
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CNY 1,800.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
热销推荐Specifications
| Product Data | |
| Species | Human |
| Expression cDNA Clone or AA Sequence |
Pro2-Leu318
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| Tag | Tag Free |
| Predicted MW | 35.6 kDa |
| Concentration | lot specific |
| Purity | >95% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | Supplied as a 0.2 um filtered solution of 10mM HEPES, 100mM KCl, 50% Glycerol, pH 7.4. |
| Storage | Store at < -20°C, stable for 6 months after receipt. Please minimize freeze-thaw cycles. |
| Stability | Stable for at least 3 months from date of receipt under proper storage and handling conditions. |
| Bioactivity | Co-immunoprecipitation (PMID: 27808278) |
| Endotoxin | < 0.1 EU per µg protein as determined by LAL test |
| Reference Data | |
| RefSeq | |
| Locus ID | 328 |
| UniProt ID | P27695 |
| Cytogenetics | 14q11.2 |
| Synonyms | APE; APE1; APEN; APEX; APX; HAP1; REF1 |
| Summary | The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019] |
| Protein Families | Druggable Genome, Stem cell - Pluripotency, Transcription Factors |
| Protein Pathways | Base excision repair |
Citations (1)
| The use of this Proteins has been cited in the following citations: |
|---|
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Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics
,Szczesny, B;Marcatti, M;Zatarain, JR;Druzhyna, N;Wiktorowicz, JE;Nagy, P;Hellmich, MR;Szabo, C;,
Sci Rep
,PubMed ID 27808278
[APEX1]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC400618 | APEX1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC409118 | APEX1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC409119 | APEX1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC429949 | APEX1 HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY400618 | Transient overexpression lysate of APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1 |
CNY 3,080.00 |
|
| LY409118 | Transient overexpression lysate of APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2 |
CNY 3,080.00 |
|
| LY409119 | Transient overexpression lysate of APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3 |
CNY 3,080.00 |
|
| LY429949 | Transient overexpression lysate of APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3 |
CNY 3,080.00 |
|
| PH301208 | APEX1 MS Standard C13 and N15-labeled recombinant protein (NP_542379) |
CNY 19,520.00 |
|
| PH313298 | APEX1 MS Standard C13 and N15-labeled recombinant protein (NP_542380) |
CNY 19,520.00 |
|
| TP301208 | Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 2, 20 µg |
CNY 2,900.00 |
|
| TP313298 | Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 3, 20 µg |
CNY 2,900.00 |
|
| TP760021 | Recombinant protein of human APEX nuclease (multifunctional DNA repair enzyme) 1 (APEX1), transcript variant 1, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug |
CNY 2,040.00 |
APEX1 mouse monoclonal antibody, clone OTI6E10 (formerly 6E10)
