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Dystrophia myotonica protein kinase (DMPK) (NM_001081562) Human Recombinant Protein
CAT＃: TP323643
Recombinant protein of human dystrophia myotonica-protein kinase (DMPK), transcript variant 4, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC223643 representing NM_001081562
Red=Cloning site Green=Tags(s) MSAEVRLRRLQQLVLDPGFLGLEPLLDLLLGVHQELGASELAQDKYVADFLQWAEPIVVRLKEVRLQRDD FEILKVIGRGAFSEVAVVKMKQTGQVYAMKIMNKWDMLKRGEVSCFREERDVLVNGDRRWITQLHFAFQD ENYLYLVMEYYVGGDLLTLLSKFGERIPAEMARFYLAEIVMAIDSVHRLGYVHRDIKPDNILLDRCGHIR LADFGSCLKLRADGTVRSLVAVGTPDYLSPEILQAVGGGPGTGSYGPECDWWALGVFAYEMFYGQTPFYA DSTAETYGKIVHYKEHLSLPLVDEGVPEEARDFIQRLLCPPETRLGRGGAGDFRTHPFFFGLDWDGLRDS VPPFTPDFEGATDTCNFDLVEDGLTAMETLSDIREGAPLGVHLPFVGYSYSCMALRDSEVPGPTPMELEA EQLLEPHVQAPSLEPSVSPQDETAEVAVPAAVPAAEAEAEVTLRELQEALEEEVLTRQSLSREMEAIRTD NQNFASQLREAEARNRDLEAHVRQLQERMELLQAEGATAVTGVPSPRATDPPSHMAPRPWLWASARWWGQ APCTAATCCSLPGSLGLAYRRRFPCSCSPLFCLVPPPWAALGWWPTPANSPQSGAAQEPPALPEP TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 69.4 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_001075031 |
| Locus ID | 1760 |
| UniProt ID | Q09013 |
| Refseq Size | 2873 |
| Cytogenetics | 19q13.32 |
| Refseq ORF | 1875 |
| Synonyms | DM; DM1; DM1PK; DMK; MDPK; MT-PK |
| Summary | The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016] |
| Protein Families | Druggable Genome, Protein Kinase |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC418004 | DMPK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC421164 | DMPK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC421165 | DMPK HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LY418004 | Transient overexpression lysate of dystrophia myotonica-protein kinase (DMPK), transcript variant 2 |
CNY 3,080.00 |
|
| LY421164 | Transient overexpression lysate of dystrophia myotonica-protein kinase (DMPK), transcript variant 3 |
CNY 4,840.00 |
|
| LY421165 | Transient overexpression lysate of dystrophia myotonica-protein kinase (DMPK), transcript variant 4 |
CNY 4,840.00 |
|
| PH309151 | DMPK MS Standard C13 and N15-labeled recombinant protein (NP_004400) |
CNY 19,520.00 |
|
| PH323643 | DMPK MS Standard C13 and N15-labeled recombinant protein (NP_001075031) |
CNY 19,520.00 |
|
| TP309151 | Recombinant protein of human dystrophia myotonica-protein kinase (DMPK), transcript variant 2, 20 µg |
CNY 2,900.00 |
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