Dystrophia myotonica protein kinase (DMPK) (NM_004409) Human Mass Spec Standard

CAT#: PH309151

DMPK MS Standard C13 and N15-labeled recombinant protein (NP_004400)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

Cited in 1 publication.

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Specifications

Product Data
Description DMPK MS Standard C13 and N15-labeled recombinant protein (NP_004400)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC209151
Predicted MW 69.4 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004400
RefSeq Size 2874
RefSeq ORF 1887
Synonyms DM; DM1; DM1PK; DMK; MDPK; MT-PK
Locus ID 1760
Cytogenetics 19q13.32
Summary The protein encoded by this gene is a serine-threonine kinase that is closely related to other kinases that interact with members of the Rho family of small GTPases. Substrates for this enzyme include myogenin, the beta-subunit of the L-type calcium channels, and phospholemman. The 3' untranslated region of this gene contains 5-38 copies of a CTG trinucleotide repeat. Expansion of this unstable motif to 50-5,000 copies causes myotonic dystrophy type I, which increases in severity with increasing repeat element copy number. Repeat expansion is associated with condensation of local chromatin structure that disrupts the expression of genes in this region. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2016]
Protein Families Druggable Genome, Protein Kinase
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Citations (1)

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