SLC30A10 Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	SLC30A10
Locus ID	55532
Kit Components	KN220219G1, SLC30A10 gRNA vector 1 in pCas-Guide CRISPR vector KN220219G2, SLC30A10 gRNA vector 2 in pCas-Guide CRISPR vector KN220219LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001004433, NM_018713, NR_046437
Synonyms	DKFZp547M236; solute carrier family 30 (zinc transporter), member 10; solute carrier family 30, member 10; zinc transporter 8; ZnT-10; ZNT8; ZNT8, ZnT-10, DKFZp547M236; ZNT10; ZRC1
Summary	This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Mar 2012]

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