LMX1A Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 RFP-BSD donor, 1 scramble control
Donor DNA	RFP-BSD
Symbol	LMX1A
Locus ID	4009
Kit Components	KN215375G1, LMX1A gRNA vector 1 in pCas-Guide CRISPR vector KN215375G2, LMX1A gRNA vector 2 in pCas-Guide CRISPR vector KN215375RB-D, donor DNA containing left and right homologous arms and RFP-BSD functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_001033507, NM_001174069, NM_177398, NM_177399
Synonyms	dr; dreher; LIM homeobox transcription factor 1 alpha; LMX-1; LMX1; LMX1.1; Lmx1.1; MGC87616; MGC129356; MGC129357; OTTMUSP00000022889; OTTMUSP00000022890; shaker short-tail; sst
Summary	This gene encodes a homeodomain and LIM-domain containing protein. The encoded protein is a transcription factor that acts as a positive regulator of insulin gene transcription. This gene also plays a role in the development of dopamine producing neurons during embryogenesis. Mutations in this gene are associated with an increased risk of developing Parkinson's disease. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

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