Nesprin 2 (SYNE2) Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA	Luciferase-Puro
Symbol	Nesprin 2
Locus ID	23224
Kit Components	KN213843G1, Nesprin 2 gRNA vector 1 in pCas-Guide CRISPR vector KN213843G2, Nesprin 2 gRNA vector 2 in pCas-Guide CRISPR vector KN213843LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_015180, NM_182910, NM_182912, NM_182913, NM_182914
Synonyms	EDMD5; Nesp2; Nesprin-2; NUA; NUANCE; SYNE-2; TROPH
Summary	The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

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