FLI1 Human Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	FLI1
Locus ID	2313
Kit Components	KN200695G1, FLI1 gRNA vector 1 in pCas-Guide CRISPR vector KN200695G2, FLI1 gRNA vector 2 in pCas-Guide CRISPR vector KN200695BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Reference Data
RefSeq	NM_001167681, NM_001271010, NM_001271012, NM_002017
Synonyms	EWSR2; SIC-1
Summary	This gene encodes a transcription factor containing an ETS DNA-binding domain. The gene can undergo a t(11;22)(q24;q12) translocation with the Ewing sarcoma gene on chromosome 22, which results in a fusion gene that is present in the majority of Ewing sarcoma cases. An acute lymphoblastic leukemia-associated t(4;11)(q21;q23) translocation involving this gene has also been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

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