Human Activin A Receptor Type IC (ACVR1C) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ACVR1C
Locus ID	130399
Kit Components	GA115111G1, Activin A Receptor Type IC gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA115111G2, Activin A Receptor Type IC gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA115111G3, Activin A Receptor Type IC gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001111031, NM_001111032, NM_001111033, NM_145259
Synonyms	ACVRLK7; ALK7
Summary	ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

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