Human NIRF (UHRF2) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	UHRF2
Locus ID	115426
Kit Components	GA114528G1, NIRF gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA114528G2, NIRF gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA114528G3, NIRF gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_152306, NM_152896, NR_046386
Synonyms	NIRF, URF2, RNF107, MGC33463, DKFZp434B0920, DKFZp686G0837, RP11-472F14.2
Summary	This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

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