Human ARHGAP10 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	ARHGAP10
Locus ID	79658
Kit Components	GA112525G1, ARHGAP10 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA112525G2, ARHGAP10 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA112525G3, ARHGAP10 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_024605
Synonyms	GRAF2; PS-GAP; PSGAP
Summary	GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).[UniProtKB/Swiss-Prot Function]

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