Human C4orf27 (HPF1) activation kit by CRISPRa

CAT#: GA110414

HPF1 CRISPRa kit - CRISPR gene activation of human histone PARylation factor 1



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
Rabbit Polyclonal Anti-C4orf27 Antibody
    • 100 ul

CNY 5,250.00


C4orf27 (Myc-DDK-tagged)-Human chromosome 4 open reading frame 27 (C4orf27)
    • 10 ug

CNY 3,656.00
CNY 3,990.00


HPF1 Antibody - middle region
    • 100 ul

CNY 5,250.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol HPF1
Locus ID 54969
Kit Components

GA110414G1, C4orf27 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA110414G2, C4orf27 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA110414G3, C4orf27 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_017867
Synonyms C4orf27
Summary Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine (PubMed:28190768, PubMed:29480802). Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability (PubMed:27067600, PubMed:28190768). Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage (PubMed:29480802). HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity on PARP1 (PubMed:30257210).[UniProtKB/Swiss-Prot Function]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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