Human C11orf73 (HIKESHI) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	HIKESHI
Locus ID	51501
Kit Components	GA109838G1, C11orf73 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA109838G2, C11orf73 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA109838G3, C11orf73 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_001322404, NM_001322407, NM_001322409, NM_016401, NR_024596, NR_024597, NR_024598, NR_136324
Synonyms	C11orf73; HLD13; HSPC138; HSPC179; L7RN6; OPI10
Summary	This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]

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