Human BRCC45 (BRE) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	BABAM2
Locus ID	9577
Kit Components	GA106412G1, BRCC45 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA106412G2, BRCC45 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA106412G3, BRCC45 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_001261840, NM_001329112, NM_001329113, NM_001329114, NM_001329115, NM_004899, NM_199191, NM_199192, NM_199193, NM_199194, NR_137437, NR_137438, NR_137439, NR_137440
Synonyms	BRCC4; BRCC45
Summary	This gene encodes an anti-apoptotic, death receptor-associated protein that interacts with tumor necrosis factor-receptor-1. The encoded protein acts as an adapter in several protein complexes, including the BRCA1-A complex and the BRISC complex. The BRCA1-A complex possesses ubiquitinase activity and targets sites of double strand DNA breaks, while the BRISC complex exhibits deubiquitinase activity and is involved in mitotic spindle assembly. This gene is upregulated in several types of cancer. [provided by RefSeq, Jun 2016]

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