Human Acid sphingomyelinase (SMPD1) activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	SMPD1
Locus ID	6609
Kit Components	GA104522G1, Acid sphingomyelinase gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA104522G2, Acid sphingomyelinase gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA104522G3, Acid sphingomyelinase gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Reference Data
RefSeq	NM_000543, NM_001007593, NM_001318087, NM_001318088, NR_027400, NR_134502, NM_001365135
Synonyms	ASM; ASMASE; NPD
Summary	The protein encoded by this gene is a lysosomal acid sphingomyelinase that converts sphingomyelin to ceramide. The encoded protein also has phospholipase C activity. Defects in this gene are a cause of Niemann-Pick disease type A (NPA) and Niemann-Pick disease type B (NPB). Multiple transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]

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