Human MLH1 activation kit by CRISPRa

Specifications

Product Data
Format	3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol	MLH1
Locus ID	4292
Kit Components	GA102918G1, MLH1 gRNA vector 1 in pCas-Guide-GFP-CRISPRa GA102918G2, MLH1 gRNA vector 2 in pCas-Guide-GFP-CRISPRa GA102918G3, MLH1 gRNA vector 3 in pCas-Guide-GFP-CRISPRa 1 CRISPRa-Enhancer vector, SKU GE100056 1 CRISPRa scramble vector, SKU GE100077
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq	NM_000249, NM_001167617, NM_001167618, NM_001167619, NM_001258271, NM_001258273, NM_001258274, NM_001354615, NM_001354616, NM_001354617, NM_001354618, NM_001354619, NM_001354620, NM_001354621, NM_001354622, NM_001354623, NM_001354624, NM_001354625, NM_001354626, NM_001354627, NM_001354628, NM_001354629, NM_001354630
Synonyms	COCA2; FCC2; hMLH1; HNPCC; HNPCC2
Summary	The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017]

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