United States
Germany
Japan
United Kingdom
China
MLH1 Mouse Monoclonal Antibody [Clone ID: OTI4H4]
CAT＃: TA813718S
MLH1 mouse monoclonal antibody, clone OTI4H4
View other "OTI4H4" antibodies (4)
Need it in bulk or conjugated?
Get a free quote
CNY 800.00
Product images
CNY 300.00
CNY 1,430.00
CNY 2,900.00
CNY 6,650.00
CNY 3,080.00
Specifications
| Product Data | |
| Clone Name | OTI4H4 |
| Applications | IHC |
| Recommend Dilution | IHC 1:1000 |
| Reactivity | Human, Mouse, Rat |
| Host | Mouse |
| Clonality | Monoclonal |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 339-558 of human MLH1 (NP_000240) produced in E.coli. |
| Formulation | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage Condition | Shipped at -20°C or with ice packs, Upon delivery store at -20°C. Dilute in PBS(pH7.3) if necessary. Stable for 12 months from date of receipt. Avoid repeated freeze-thaws. |
| Predicted Protein Size | 84.6 kDa |
| Gene Name | mutL homolog 1 |
| Database Link | |
| Background | The protein encoded by this gene can heterodimerize with mismatch repair endonuclease PMS2 to form MutL alpha, part of the DNA mismatch repair system. When MutL alpha is bound by MutS beta and some accessory proteins, the PMS2 subunit of MutL alpha introduces a single-strand break near DNA mismatches, providing an entry point for exonuclease degradation. The encoded protein is also involved in DNA damage signaling and can heterodimerize with DNA mismatch repair protein MLH3 to form MutL gamma, which is involved in meiosis. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). [provided by RefSeq, Aug 2017] |
| Synonyms | COCA2; FCC2; hMLH1; HNPCC; HNPCC2; MMRCS1 |
| Reference Data | |
| Protein Families | Druggable Genome |
| Protein Pathways | Colorectal cancer, Endometrial cancer, Mismatch repair, Pathways in cancer |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
| 抗体相关资料 |
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| CF813718 | Carrier-free (BSA/glycerol-free) MLH1 mouse monoclonal antibody, clone OTI4H4 |
CNY 3,999.00 |
|
| TA813718 | MLH1 mouse monoclonal antibody, clone OTI4H4 |
CNY 1,999.00 |
|
| TA813718AM | MLH1 mouse monoclonal antibody, clone OTI4H4, Biotinylated |
CNY 3,990.00 |
|
| TA813718BM | MLH1 mouse monoclonal antibody, clone OTI4H4, HRP conjugated |
CNY 3,990.00 |
