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UNC13B (NM_006377) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC219186L4V
- LentiORF®
-
Lenti ORF particles, UNC13B (mGFP-tagged)-Human unc-13 homolog B (C. elegans) (UNC13B), 200ul, >10^7 TU/mL
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CNY 24,035.00
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规格
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Specifications
| Product Data | |
| Product Name | UNC13B (NM_006377) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | MUNC13; munc13-2; UNC13; Unc13h2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_006377 |
| ORF Size | 4773 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC219186).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_006377.2 |
| RefSeq Size | 6328 bp |
| RefSeq ORF | 4776 bp |
| Locus ID | 10497 |
| Domains | C2, DAG_PE-bind |
| Protein Families | Druggable Genome |
| MW | 180.5 kDa |
| Gene Summary | This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq, Jul 2008] |
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