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Pstpip1 (NM_011193) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR217594L4V
- LentiORF®
-
Lenti ORF particles, Pstpip1 (GFP-tagged) - Mouse proline-serine-threonine phosphatase-interacting protein 1 (Pstpip1), 200ul, >10^7 TU/mL
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CNY 8,360.00
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Specifications
| Product Data | |
| Product Name | Pstpip1 (NM_011193) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | CD2BP1; def-2 |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | NM_011193 |
| ORF Size | 1248 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR217594).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_011193.2, NP_035323.2 |
| RefSeq Size | 1853 bp |
| RefSeq ORF | 1248 bp |
| Locus ID | 19200 |
| Gene Summary | Involved in regulation of the actin cytoskeleton. May regulate WAS actin-bundling activity. Bridges the interaction between ABL1 and PTPN18 leading to ABL1 dephosphorylation. May play a role as a scaffold protein between PTPN12 and WAS and allow PTPN12 to dephosphorylate WAS. Has the potential to physically couple CD2 and CD2AP to WAS. Acts downstream of CD2 and CD2AP to recruit WAS to the T-cell:APC contact site so as to promote the actin polymerization required for synapse induction during T-cell activation. Down-regulates CD2-stimulated adhesion through the coupling of PTPN12 to CD2. Also has a role in innate immunity and the inflammatory response. Recruited to inflammasomes by MEFV. Induces formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Binding to MEFV allows MEFV to bind to PYCARD and facilitates pyroptosome formation. Regulates endocytosis and cell migration in neutrophils.[UniProtKB/Swiss-Prot Function] |
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