Helb (NM_080446) Mouse Tagged ORF Clone Lentiviral Particle
CAT#: MR211593L3V
- LentiORF®
-
Lenti ORF particles, Helb (Myc-DDK-tagged) - Mouse helicase (DNA) B (Helb), 200ul, >10^7 TU/mL
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CNY 16,055.00
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Specifications
Product Data | |
Product Name | Helb (NM_080446) Mouse Tagged ORF Clone Lentiviral Particle |
Synonyms | AI447783; D10Ertd664e |
Vector | pLenti-C-Myc-DDK-P2A-Puro |
ACCN | NM_080446 |
ORF Size | 3222 bp |
Sequence Data |
The ORF insert of this clone is exactly the same as(MR211593).
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OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
Reference Data | |
RefSeq | NM_080446.2, NP_536694.2 |
RefSeq Size | 4540 bp |
RefSeq ORF | 3225 bp |
Locus ID | 117599 |
Gene Summary | 5'-3' DNA helicase involved in DNA damage response by acting as an inhibitor of DNA end resection (PubMed:26774285). Recruitment to single-stranded DNA (ssDNA) following DNA damage leads to inhibit the nucleases catalyzing resection, such as EXO1, BLM and DNA2, possibly via the 5'-3' ssDNA translocase activity of HELB (PubMed:26774285). As cells approach S phase, DNA end resection is promoted by the nuclear export of HELB following phosphorylation (PubMed:26774285). Acts independently of TP53BP1 (PubMed:26774285). Unwinds duplex DNA with 5'-3' polarity. Has single-strand DNA-dependent ATPase and DNA helicase activities. Prefers ATP and dATP as substrates. During S phase, may facilitate cellular recovery from replication stress (PubMed:11557815, PubMed:7596831, PubMed:7794903).[UniProtKB/Swiss-Prot Function] |
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