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Pkn1 (NM_177262) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR211277L3V
- LentiORF®
-
Lenti ORF particles, Pkn1 (Myc-DDK-tagged) - Mouse protein kinase N1 (Pkn1), transcript variant 2, 200ul, >10^7 TU/mL
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CNY 14,630.00
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Specifications
| Product Data | |
| Product Name | Pkn1 (NM_177262) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | DBK; F730027O18Rik; PAK1; Pkn; PRK1; Prkcl1; Stk3 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_177262 |
| ORF Size | 2838 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR211277).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_177262.4, NP_796236.2 |
| RefSeq Size | 3436 bp |
| RefSeq ORF | 2841 bp |
| Locus ID | 320795 |
| Gene Summary | PKC-related serine/threonine-protein kinase involved in various processes such as regulation of the intermediate filaments of the actin cytoskeleton, cell migration, tumor cell invasion and transcription regulation. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Regulates the cytoskeletal network by phosphorylating proteins such as VIM and neurofilament proteins NEFH, NEFL and NEFM, leading to inhibit their polymerization. Phosphorylates 'Ser-575', 'Ser-637' and 'Ser-669' of MAPT/Tau, lowering its ability to bind to microtubules, resulting in disruption of tubulin assembly. Acts as a key coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-11' of histone H3 (H3T11ph), a specific tag for epigenetic transcriptional activation that promotes demethylation of histone H3 'Lys-9' (H3K9me) by KDM4C/JMJD2C. Phosphorylates HDAC5, HDAC7 and HDAC9, leading to impair their import in the nucleus. Phosphorylates 'Thr-38' of PPP1R14A, 'Ser-159', 'Ser-163' and 'Ser-170' of MARCKS, and GFAP. Able to phosphorylate RPS6 in vitro.[UniProtKB/Swiss-Prot Function] |
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