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Mcm8 (BC046780) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210873L4V
- LentiORF®
-
Lenti ORF particles, Mcm8 (GFP-tagged) - Mouse minichromosome maintenance deficient 8 (S, 200ul, >10^7 TU/mL
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CNY 13,205.00
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Specifications
| Product Data | |
| Product Name | Mcm8 (BC046780) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | 5730432L01Rik |
| Vector | pLenti-C-mGFP-P2A-Puro |
| ACCN | BC046780 |
| ORF Size | 2499 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210873).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | BC046780, AAH46780 |
| RefSeq Size | 2908 bp |
| RefSeq ORF | 2501 bp |
| Locus ID | 66634 |
| Gene Summary | Component of the MCM8-MCM9 complex, a complex involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity. Probably by regulating the localization of the MNR complex, indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs. The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression. However, may play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (By similarity). Probably by regulating HR, plays a key role during gametogenesis (PubMed:22771120). Stabilizes MCM9 protein (By similarity).[UniProtKB/Swiss-Prot Function] |
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