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Pik3r2 (NM_008841) Mouse Tagged ORF Clone Lentiviral Particle
CAT＃: MR210283L3V
- LentiORF®
-
Lenti ORF particles, Pik3r2 (Myc-DDK-tagged) - Mouse phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 2 (p85 beta) (Pik3r2), 200ul, >10^7 TU/mL
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CNY 12,065.00
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Specifications
| Product Data | |
| Product Name | Pik3r2 (NM_008841) Mouse Tagged ORF Clone Lentiviral Particle |
| Synonyms | p85beta |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_008841 |
| ORF Size | 2166 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(MR210283).
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| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_008841.2 |
| RefSeq Size | 3159 bp |
| RefSeq ORF | 2169 bp |
| Locus ID | 18709 |
| Gene Summary | Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (By similarity). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348926).[UniProtKB/Swiss-Prot Function] |
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