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C3orf37 (HMCES) (NM_001006109) Human Untagged Clone
CAT＃: SC322022
C3orf37 (untagged)-Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1
CNY 3,656.00
CNY 7,220.00
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | C3orf37; DC12; SRAPD1 |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for SC322022
GCGAGCTGACAGAGGGGAGCAGAGGCCCGAGCGGACGCGAGGCGACGCGGAGAGGGCGGC
CTGGGCCGAAGTGAGGCGACGCGGGGCGGCGGAGTCTGAGGGCCGGAGCGGAGCGGAGGC GACGCGGGGAGGGGCGAGGGATCGCGGCCGGTGGCTGGGGGCCACCTGCTCCCCGAGCAC CGGCCCCCGCTCCGGGGAGCAGAGTCCGGAGCGGGATCCGCGGCCCACAGGTTCGCAGGT TGCGAGGGGCGGTGTTGAAGAATGTGTGGGCGAACATCCTGTCACTTACCTAGAGATGTT CTCACGAGAGCTTGCGCCTACCAGGATCGGCGGGGCCAGCAGCGGCTCCCGGAGTGGAGG GACCCTGATAAGTACTGCCCCTCTTACAACAAGAGTCCTCAATCCAACAGCCCAGTGCTT CTGTCTCGACTGCACTTTGAGAAGGATGCAGACTCATCTGAGCGTATCATTGCTCCCATG CGCTGGGGCTTGGTCCCTTCTTGGTTCAAAGAAAGTGATCCTTCCAAGCTGCAGTTCAAT ACTACCAACTGTCGTAGTGATACCGTAATGGAGAAACGGTCATTTAAGGTGCCTCTGGGA AAGGGAAGACGCTGTGTCGTTTTAGCAGATGGATTCTATGAGTGGCAGCGATGTCAGGGA ACAAACCAGAGGCAGCCATACTTCATCTATTTTCCTCAAATCAAGACAGAGAAGTCAGGT AGCATTGGTGCTGCAGATAGTCCTGAGAACTGGGAGAAAGTCTGGGACAACTGGAGGCTG CTGACAATGGCCGGGATCTTTGACTGCTGGGAGCCCCCAGAGGGAGGAGATGTCCTGTAT TCCTATACCATCATCACAGTGGATTCCTGCAAAGGCTTGAGTGACATCCACCACAGGATG CCTGCCATATTAGATGGAGAGGAGGCAGTTTCTAAATGGCTTGACTTTGGTGAAGTCTCA ACTCAGGAAGCTCTGAAATTAATCCACCCAACAGAGAACATCACCTTCCATGCAGTCTCT TCTGTGGTGAACAACTCGCGAAACAACACTCCTGAGTGTCTGGCTCCTGTCGACTTGGTG GTCAAAAAGGAGCTCAGGGCAAGTGGCAGTAGCCAGAGGATGTTGCAGTGGTTGGCCACA AAGTCACCCAAAAAGGAAGACTCAAAAACACCTCAAAAGGAAGAGTCAGATGTTCCCCAG TGGTCCAGTCAGTTCCTGCAGAAGAGTCCACTCCCCACCAAGAGAGGCACTGCAGGACTC CTAGAGCAATGGCTGAAGCGGGAGAAGGAGGAGGAACCTGTGGCCAAGCGTCCTTACAGC CAGTGACACAGGACTTTCAGAGACCAAGGCCAGGGTCTGCTGCACTGCTGTTCTGATAAT AGGTTCTTAACATTGTATGTATATGTGTTTGCTTTGGGAGGAGGTGGTACTGTGTTAGTT GACAGTTGTGGGCTCATGTAGTCTTTTTTGCCATGAGTAGGAGCCCCTAGTGGGGCTGGT GGACAGCTTTGGAAGAGGTGTCCTGCTGCTGTTACCAGCCATGTGGGCCCCATAGGGGCA CTGCGCCTGCTGCCCTTTCCTGGCAGGGCTGGTGGAGTCTTCCCTCAAAGCATGCCTTAC CCAGCTGGGAAGTCTCTGCCCTGATCTGGTACTCCTTGTAGTAAGCTGTTTTCTGCTCAG CCACTGGGCTCTTTCAGTTTTTTAGTTCTTAAAAATTTATTTTTAAGTTCTAAAATAAAA TAAAAATAAGTTCTTAAAATTTAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001006109 |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001006109.1, NP_001006109.1 |
| RefSeq Size | 1809 bp |
| RefSeq ORF | 1065 bp |
| Locus ID | 56941 |
| UniProt ID | Q96FZ2 |
| Gene Summary | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (PubMed:30554877). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).[UniProtKB/Swiss-Prot Function] Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 both encode the same isoform (a). |
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC208710 | C3orf37 (Myc-DDK-tagged)-Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1 |
CNY 3,656.00 |
|
| RC208710L1 | Lenti ORF clone of Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208710L2 | Lenti ORF clone of Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RC208710L3 | Lenti ORF clone of Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1, Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC208710L4 | Lenti ORF clone of Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1, mGFP tagged |
CNY 5,890.00 |
|
| RG208710 | C3orf37 (tGFP-tagged) - Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1 |
CNY 4,370.00 |
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