United States
Germany
Japan
United Kingdom
China
C3orf37 (HMCES) (NM_001006109) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC208710L3V
- LentiORF®
-
Lenti ORF particles, HMCES (Myc-DDK tagged) - Human chromosome 3 open reading frame 37 (C3orf37), transcript variant 1, 200ul, >10^7 TU/mL
Need custom lentivirus service?
Get a free quote
CNY 8,930.00
货期*
详询
规格
Product images
经常一起买 (3)
Specifications
| Product Data | |
| Product Name | C3orf37 (HMCES) (NM_001006109) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | C3orf37; DC12; SRAPD1 |
| Vector | pLenti-C-Myc-DDK-P2A-Puro |
| ACCN | NM_001006109 |
| ORF Size | 1062 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC208710).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_001006109.1, NP_001006109.1 |
| RefSeq Size | 1809 bp |
| RefSeq ORF | 1065 bp |
| Locus ID | 56941 |
| MW | 40.6 kDa |
| Gene Summary | Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA (PubMed:30554877). The HMCES DNA-protein cross-link is then degraded by the proteasome (PubMed:30554877). Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity). Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells (By similarity). May act as an endonuclease that specifically cleaves 5hmC-containing DNA; additional experiments are however required to confirm this activity in vivo (By similarity).[UniProtKB/Swiss-Prot Function] |
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
You may also need
其它C3orf37产品
Customer
Reviews
Loading...
