p16INK4A (CDKN2A) Rabbit Polyclonal Antibody

CAT＃: TA351069S

Rabbit Polyclonal Anti-CDKN2A Antibody

Size: 25 ul 100 ul

Datasheet
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CN¥ 800.00

CN¥ 1,280.00

货期*
2周
规格
    • 25 ul

Product images

经常一起买 (3)
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TP320937
Recombinant protein of human cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1, 20 µg
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LY400022
Transient overexpression lysate of cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) (CDKN2A), transcript variant 1
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添加到购物车

Specifications

Product Data
Applications IHC
Recommend Dilution IHC: 50-200
Positive control: Human brain
Predicted cell location: Cytoplasm or Nucleus
Reactivity Human
Host Rabbit
Clonality Polyclonal
Immunogen Synthetic peptide of human CDKN2A
Formulation pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification Antigen affinity purification
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name cyclin-dependent kinase inhibitor 2A
Database Link
Background This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53.
Synonyms ARF; CDK4I; CDKN2; CMM2; INK4; INK4A; MLM; MTS-1; MTS1; P14; P14ARF; P16; P16-INK4A; P16INK4
Reference Data
Protein Families Druggable Genome
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, p53 signaling pathway, Pancreatic cancer, Pathways in cancer
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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